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研究生:張馨尹
研究生(外文):Chang HY
論文名稱:Naltrexone對內毒素誘發敗血性休克之治療效果
論文名稱(外文):Effects of Naltrexone on Lipopolysaccharide-Induced Sepsis in Rats
指導教授:顏茂雄顏茂雄引用關係
指導教授(外文):Yen MH
學位類別:碩士
校院名稱:國防醫學院
系所名稱:藥理學研究所
學門:醫藥衛生學門
學類:藥學學類
論文種類:學術論文
論文出版年:2002
畢業學年度:90
語文別:中文
中文關鍵詞:敗血性休克
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Naltrexone 對內毒素誘發敗血性休克之治療效果

目錄
頁次
目錄………………………………………………........................................Ⅰ
圖目錄………………………………………………………………………Ⅱ
中文摘要……………………………………………………………………Ⅳ
英文摘要……………………………………………………………………Ⅵ
縮寫表………………………………………………………………………Ⅷ
第一章 緒論……………………………………………………………… 1
第二章 材料與方法……………………………………………………… 14
第三章 實驗結果………………………………………………………… 22
第四章 討論……………………………………………………………… 27
第五章 結論……………………………………………………………… 31
第六章 參考文獻………………………………………………………… 47
圖目錄
頁次
圖一 Naltrexone之結構圖………………………………...……........…....32
圖二 介白素−1和細胞腫瘤因子在內皮之作用………………...…….…33
圖三 一氧化氮酶之結構圖…………......………………………….....…..34
圖四 比較控制組、LPS組及Naltrexone預處理組於敗血症期間對
血壓變化的影響…………………………………………………….35
圖五 比較控制組、LPS組及Naltrexone治療組於敗血症期間對血
壓變化的影響………………..…………………...............................36
圖六 比較控制組、LPS組及Naltrexone預處理組於敗血症期間對
心跳變化的影響………………………………………...…………..37
圖七 比較控制組、LPS組及Naltrexone治療組於敗血症期間對心
跳變化的影響…………………………………………...…………..38
圖八 比較控制組、LPS組及Naltrexone預處理組對norepinephrine
(NE)在離體胸主動脈之濃度-反應曲線…...………………….…..39
圖九 比較控制組、LPS組及Naltrexone預處理組對acetylcholine
(ACh)在離體胸主動脈之濃度-反應曲線...……………….….…..40
圖十 比較控制組、LPS組及Naltrexone預處理組對L-arginine
在離體胸主動脈之濃度-反應曲線.…………………..…….….…..41
圖十一 比較控制組、LPS組及Naltrexone預處理與治療組對於
敗血症期間對血管組織Superoxide anion變化的影響…….…..42
圖十二 比較控制組、LPS組及Naltrexone預處理與治療組對於
敗血症期間血中TNF-α變化的影響…………………..…...…..43
圖十三 比較控制組、LPS組及Naltrexone預處理於敗血症期間
對於血中nitrate變化的影響..………...………....………..….…..44
圖十四 比較控制組、LPS組及Naltrexone預處理及治療組於敗
血症期間對SGOT的影響………...……………………..…...…..45
圖十五 比較控制組、LPS組及Naltrexone預處理及治療組於敗
血症期間對SGPT的影響………………………………..…...…..46

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