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研究生:潘信保
論文名稱:心肌病變倉鼠左心房擴張與動作電位及收縮功能異常的藥理學研究
論文名稱(外文):Pharmacological Study on the Prolonged Action Potential and Depressed Contraction in Dilated Left Atria of Myopathic Hamsters
指導教授:林正一林正一引用關係
指導教授(外文):Lin CI
學位類別:碩士
校院名稱:國防醫學院
系所名稱:藥理學研究所
學門:醫藥衛生學門
學類:藥學學類
論文種類:學術論文
論文出版年:2002
畢業學年度:90
語文別:中文
中文關鍵詞:心肌病變動作電位收縮功能
相關次數:
  • 被引用被引用:1
  • 點閱點閱:127
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  • 下載下載:0
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心肌病變倉鼠左心房擴張與動作電位及收縮功能異常的藥理學研究

目 錄 頁次
目錄------------------------------------------------------------------------------Ι
表目錄---------------------------------------------------------------------------Ⅲ
圖目錄---------------------------------------------------------------------------Ⅳ
中文摘要------------------------------------------------------------------------ 1
英文摘要------------------------------------------------------------------------ 6
緒言------------------------------------------------------------------------------ 8
材料與方法---------------------------------------------------------------------13
一﹑實驗標本來源:動物及人------------------------------------------13
二﹑實驗試藥及溶液------------------------------------------------------13
三﹑離體心房(室)組織實驗------------------------------------------14
四﹑單一心室細胞實驗---------------------------------------------------16
五﹑實驗用藥來源---------------------------------------------------------19
六﹑實驗數據及資料統計------------------------------------------------19
實驗結果------------------------------------------------------------------------20
一﹑健康倉鼠及心肌病變倉鼠體重、左房及心室之比較---------20
二﹑CPA對健康倉鼠左心房肌的作用---------------------------------20
三﹑CPA對心肌病變倉鼠左心房肌的作用---------------------------22
四﹑CPA對大白鼠心室肌單一細胞收縮功能的影響---------------25
五﹑CPA對非病變人類心室肌的作用---------------------------------26
六﹑倉鼠心肌病變與其舌頭橫紋肌纖維化的關係------------------28
討論------------------------------------------------------------------------------45
結論------------------------------------------------------------------------------51
參考文獻------------------------------------------------------------------------52
表 目 錄 頁次
表1﹑健康倉鼠及心肌病變倉鼠體重、左房及心室之參數資料---29
表2﹑CPA對健康及心肌病變倉鼠左心房肌穩定態動作電位及
收縮力的影響--------------------------------------------------------30
圖 目 錄 頁次
圖1﹑CPA對健康倉鼠左心房電機械特性的影響---------------------31
圖2﹑CPA對健康及心肌病變倉鼠左心房不同靜息期間PRPC
的影響------------------------------------------------------------------32
圖3﹑CPA對心肌病變倉鼠左心房靜息前後電機械特性的影響---33
圖4﹑CPA對心肌病變倉鼠左心房較長靜息時間前後電機械特
性的影響---------------------------------------------------------------34
圖5﹑CPA在擴張心肌病變倉鼠左心房引起自動節律及收縮-------35
圖6﹑CPA對倉鼠左心房在2Hz及8Hz電刺激靜息後PRPC
的影響------------------------------------------------------------------36
圖7﹑健康倉鼠左心房在高頻率(32Hz)電刺激後靜息期間
產生高頻自動節律---------------------------------------------------37
圖8﹑倉鼠左心房重量大小與APD90的關係---------------------------38
圖9﹑倉鼠左心房體積大小與APD90的關係---------------------------39
圖10﹑CPA對健康大白鼠單一心室細胞收縮張力的影響-----------40
圖11﹑CPA對非病變人類心室肌電機械特性的影響-----------------41
圖12﹑CPA對非病變人類心室肌不同靜息期間PRPC的影響-----42
圖13﹑CPA對非病變人類心室肌在1Hz及4Hz電刺激靜息後
PRPC的影響----------------------------------------------------------43
圖14﹑健康及心肌病變倉鼠舌頭組織切片圖--------------------------44

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