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研究生:李宛倩
研究生(外文):Lee WC
論文名稱:評估混合療法對敗血性休克鼠的作用
論文名稱(外文):Effects of Cocktail Therapy on Rats with Endotoxin Shock
指導教授:吳錦楨
指導教授(外文):Wu CC
學位類別:碩士
校院名稱:國防醫學院
系所名稱:藥理學研究所
學門:醫藥衛生學門
學類:藥學學類
論文種類:學術論文
論文出版年:2002
畢業學年度:90
語文別:中文
論文頁數:109
中文關鍵詞:敗血性休克
相關次數:
  • 被引用被引用:0
  • 點閱點閱:129
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  • 下載下載:0
  • 收藏至我的研究室書目清單書目收藏:0
評估混合療法對敗血性休克鼠的作用

目錄
頁次
目錄………………………………………………………………………….Ⅰ
表次………………………………………………………………………….Ⅱ
圖次………………………………………………………………………….Ⅲ
中文摘要…………………………………………………………………….Ⅴ
英文摘要…………………………………………………………………….Ⅷ
第一章 緒言…………………………………………………………………1
第二章 混合 melatonin、aminoguanidine 和 terbutaline 三種藥物
對敗血性休克鼠的作用……………………………………..….…23
材料與方法………………………………………………………...24
結果………………………………………………………………...36
討論………………………………………………………………...46
第三章 敗血性休克動物經三種藥物治療後對血管收縮劑產生的
血管低反應性之改善情形……………………………………..….62
材料與方法………………………………………………………...63
結果………………………………………………………………...66
討論………………………………………………………………...67
第四章 結論………………………………………………………………...70第五章 參考文獻…………………………………………………………...97
表次
頁次
表1 、實驗各組血漿中氣體含量和酸鹼值的變化。…………………..96
圖次
頁次
圖1、Melatonin、aminoguanidine、terbutaline 之化學結構式。…………….22
圖2、各組間血糖的變化。…………………………………………………...71
圖3、各組間體溫的變化。…………………………………………………...72
圖4、各組間平均動脈壓的變化。…………………………………………...73
圖5、各組間心跳的變化。…………………………………………………...74
圖6、各組間血管對 NE 的反應性變化。………………………………….75
圖7、各組間的血漿中 NO 變化。………………………………………….76
圖8、各組間肝臟中 iNOS 蛋白質的表現。……………………………….77
圖9、各組間的血漿中 TNF-a 的變化。…………………………………...78
圖10、各組間的血漿中 superoxide 的變化。……………………………...79
圖11、各組間的血漿中 GOT 濃度的變化。……………………………….80
圖12、各組間的血漿中 GPT 濃度的變化。……………………………….81
圖13、各組間的血漿中 TP 濃度的變化。……………………………….82
圖14、各組間的血漿中 ALB 濃度的變化。………………………………83
圖15、各組間的血漿中 A/G ratio 的變化。……………………………….84
圖16、各組間的血漿中 CRE 濃度的變化。……………………………….85
圖17、各組間的血漿中 BUN 濃度的變化。…………………………….86
圖18、各組間的血漿中 LDH 濃度的變化。……………………………....87
圖19、各組間的肺臟組織切片圖。………………………………………….88
圖20、各組間的肺臟組織 PMN 浸潤程度。………………………………89
圖21、各組間的肝臟組織切片圖。………………………………………….90
圖22、各組間的肝臟組織 PMN 浸潤程度。………………………………91
圖23、各組間的腎臟組織切片圖。………………………………………….92
圖24、各組間的腎臟組織 PMN 浸潤程度。………………………………93
圖25、各組間的血管對 NE 之收縮反應。………………………………...94
圖26、各組間的血管加入 ODQ 和 TEA 對 NE
所引起的收縮反應。………………………………………………...95

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