跳到主要內容

臺灣博碩士論文加值系統

(18.208.126.232) 您好!臺灣時間:2022/08/12 01:38
字體大小: 字級放大   字級縮小   預設字形  
回查詢結果 :::

詳目顯示

: 
twitterline
研究生:江慧琪
研究生(外文):huei-chi chiang
論文名稱:高壓氧氣治療及氧游離反應物清除劑對大白鼠島狀皮瓣缺血再灌流傷害的作用
論文名稱(外文):Effects of Hyperbaric Oxygen Therapy and Free Radical Scavengers on Ischemia-reperfusion Injury of Skin Island Flaps in Rats
指導教授:林燈賦林燈賦引用關係
學位類別:碩士
校院名稱:國防醫學院
系所名稱:海底醫學研究所
學門:醫藥衛生學門
學類:醫學學類
論文種類:學術論文
論文出版年:2002
畢業學年度:90
語文別:中文
論文頁數:88
中文關鍵詞:高壓氧氣氧游離反應物清除劑島狀皮瓣缺血再灌流
外文關鍵詞:HBO2free radical scavengersisland flapischemia-reperfusion
相關次數:
  • 被引用被引用:0
  • 點閱點閱:178
  • 評分評分:
  • 下載下載:29
  • 收藏至我的研究室書目清單書目收藏:0
在近十多年來,許多醫師和研究學者在鑽研身體內氧化壓力的問題。而其中更多的注意力集中在自由基與疾病的關係上。根據研究顯示:很多疾病的發生及進行的過程與活性氧有密切相關。自由基在生物體內不斷的產生也不斷的被清除,這些清除物質以直接方式、或作用在離子以減少與自由基發生反應。近年來,高壓氧氣已普遍應用在許多疾病上,其中包括組織缺血再灌流傷害,但高壓氧所造成的氧毒性,被認為可能與過多的氧游離基形成有關。目前對這方面的瞭解,仍未清楚。本實驗即利用大白鼠島狀皮瓣建立長時間缺血後、再灌流所引起的組織傷害模型,探討氧游離反應物清除劑與高壓氧氣對組織的影響。
手術大白鼠腹部一長 5 公分、寬 4 公分的島狀皮瓣,在皮瓣和其下方滋養層之間放置一片生物膜,以確保此皮瓣的循環供應僅來自唯一的腹上動、靜脈,實驗共分十三組,第一組是皮瓣有分離,但未經缺血-再灌流傷害的控制組;第二組是以血管夾夾住唯一營養皮瓣的腹上動、 靜脈,造成長時間缺血,八小時後放開血管夾開始再灌流的缺血組;第三組是繼缺血八小時再灌流後,接受三大氣壓 ( 3 ATA )之高壓氧( HBO2)治療,每天一次,連續治療五天的高壓氧組;第四、六、八、十、十一組的實驗步驟同第三組,但在再灌流時給予單一劑量之氧游離物清除劑(依序是 Allopurinol、Carnosine、Mannitol、Catalase、SOD),另外第五、七、九、十一、十三組的實驗步驟同第二組,但在再灌流時給予氧游離物清除劑的步驟則相同。以再灌流開始時間為基準點,前二十四小時為第一日,以此類推至第七日。在第七日計算皮瓣的存活率,在皮瓣掀起前、八小時缺血後及再灌流一小時,測量體循環血漿中細胞激素介白素-1β和腫瘤壞死因子-α濃度變化;在再灌流二十四小時,取部分遠端皮瓣組織,偵測組織中 MPO 的活性。控制組皮瓣存活率為99.97%,缺血組的皮瓣存活率為3.05 %,高壓氧組的皮瓣存活率則提高為56.25%,氧游離反應物清除劑合併高壓氧氣各組的皮瓣存活率,均比高壓氧組提高,但與單一劑量各組比較,則無顯著差異。在 MPO 活性測定上,高壓氧組含量顯著低於缺血組,Catalase和SOD此兩種氧游離物清除劑,無論有無合併高壓氧氣治療,其 MPO 活性都顯著低於高壓氧組,Mannitol無論有無合併高壓氧氣治療,其 MPO 活性都顯著高於高壓氧組,在體循環血漿中介白素-1β濃度方面,高壓氧組顯著低於缺血組,Catalase無論有無合併高壓氧氣治療,其介白素-1β濃度顯著高於高壓氧組,SOD和Carnosine之合併高壓氧氣治療組,及Mannitol之單一劑量組的介白素-1β濃度也顯著高於高壓氧組;在體循環血漿中腫瘤壞死因子-α濃度方面,高壓氧組顯著低於缺血組,氧游離物清除劑合併高壓氧氣治療各組,以及Catalase、Carnosine和Mannitol之單一劑量組,其濃度均顯著高於高壓氧組。
由實驗結果得知皮瓣組織缺血─再灌流後,給予高壓氧氣治療,可降低血漿中細胞激素的濃度、抑制中性球入侵皮瓣組織及增加皮瓣存活率。單一劑量給予氧游離反應物清除劑之結果,亦可看到相類似的結果;若將兩者合併治療,雖然增加了皮瓣的存活率,似乎有加成的作用,但與單一劑量給予氧游離反應物清除劑之比較,卻沒有太大的差異,因此,還需要更進一步的評估。
目錄
圖次
縮寫表
中文摘要
英文摘要
第一章 緒言
第一節、前言
第二節、自由基的定義
第三節、缺血再灌流之自由基產生機制
第四節、氧游離自由基之清除劑
第五節、島狀/自由 皮瓣模型
第六節、細胞激素與缺血再灌流
第七節、高壓氧氣治療
第八節、研究動機
第九節、研究目的
第二章 材料與方法
第一節、實驗動物
第二節、實驗相關藥品
第三節、腹部島狀皮瓣手術
第四節、靜脈抽血及給藥
第五節、高壓氧氣暴露程序
第六節、實驗分組
第七節、氧游離物清除劑實驗劑量
第八節、測定方法
第九節、資料處理及統計方法
第三章 結果
第一節、體循環血漿中細胞激素介白素-1β濃度的測定
第二節、體循環血漿中細胞激素腫瘤壞死因子-α濃度的測定
第三節、皮瓣組織 MPO 活性的測定
第四節、皮瓣存活率的測定
第四章 討論
第一節、細胞激素與高壓氧氣對缺血再灌流之間的關係
第二節、MPO 活性與高壓氧氣對缺血再灌流之間的關係
第三節、高壓氧氣暴露劑量及方式的選取
第五章 結論

參 考 文 獻
圖 次
頁次
圖一:大白鼠腹部島狀皮瓣的血管解剖圖
圖二:大白鼠腹部一長方形島狀皮瓣( 4 X 5 cm )之標示
圖三:掀起大白鼠腹部島狀皮瓣的輪廓
圖四:將生物膜( Biobrane )置於皮瓣及其下方滋養層之間
圖五:大白鼠腹部島狀皮瓣缺血再灌流之實驗模型概要圖解
圖六:用5-O 尼龍線將皮瓣縫回表皮的原始位置
圖七:在石膏上開一天窗,以利每日觀察皮瓣變化
圖八:各組合併高壓氧氣治療其血漿中介白素-1β濃度變化情形
圖九:各單一劑量實驗組其血漿中介白素-1β濃度變化情形
圖十:氧游離物清除劑對於有(無)合併高壓氧氣治療其血漿中介白素-1β濃度變化的情形
圖十一:各組合併高壓氧氣治療其血漿中腫瘤壞死因子-α ( TNF-α )濃度變化的情形
圖十二:各單一劑量實驗組其血漿中腫瘤壞死因子-α ( TNF-α )濃度變化的情形
圖十三:氧游離物清除劑對於有(無)合併高壓氧氣治療其血漿中腫瘤壞死因子-α ( TNF-α )濃度變化的情形
圖十四:皮瓣組織中MPO活性之影響
圖十五:各組合併高壓氧氣治療對於皮瓣組織中MPO活性之影響
圖十六:各單一劑量實驗組對於皮瓣組織中MPO活性之影響
圖十七:皮瓣在再灌流七日後的照片
圖十八:給予 Allopurinol 之有(無)合併高壓氧氣治療之皮瓣,在再灌流七日後的照片
圖十九:給予 Carnosine之有(無)合併高壓氧氣治療之皮瓣,在再灌流七日後的照片
圖二十:給予 Mannitol 之有(無)合併高壓氧氣治療之皮瓣,在再灌流七日後的照片
圖二十一:給予 Catalase 之有(無)合併高壓氧氣治療之皮瓣,在再灌流七日後的照片
圖二十二:給予 SOD之有(無)合併高壓氧氣治療之皮瓣,在再灌流七日後的照片
圖二十三:各組合併高壓氧氣治療對於皮瓣經缺血八小時再灌流七日後,其皮瓣組織存活面積的百分比之一
圖二十四:各單一劑量實驗組對於皮瓣經缺血八小時再灌流七日後,其皮瓣組織存活面積的百分比之一
圖二十五:各組合併高壓氧氣治療對於皮瓣經缺血八小時再灌流七日後,其皮瓣組織存活面積的百分比之二
圖二十六:各單一劑量實驗組對於皮瓣經缺血八小時再灌流七日後,其皮瓣組織存活面積的百分比之二
圖二十七:皮瓣組織經缺血八小時再灌流七日後,其皮瓣組織存活面積的百分比之三
圖二十八:大白鼠腹部島狀皮瓣缺血再灌流傷害可能的機轉…………
圖二十九:各種氧游離反應物清除劑參與大白鼠腹部島狀皮瓣缺血再灌流傷害的可能機轉

參考文獻
Aitasalo K. Niinikoski J. Grenman R. Virolainen E. A modified protocol for early treatment of osteomyelitis and osteoradionecrosis of the mandible. Head & Neck. 20(5):411-7, 1998
Atalla SL. Toledo-Pereyra LH. MacKenzie GH. Cederna JP. Influence of oxygen-derived free radical scavengers on ischemic livers. Transplant. 40(6):584-90, 1985
Baykal K. Albayrak S. Inal H. Elbuken E. Onol SY. Fournier's disease: adjunctive hyperbaric oxygen therapy (HBO) to classic therapy. Intl Urol Nephrol. 28(4):539-41, 1996
Boldyrev A. Carnosine as a modulator of endogenous Zn(2+) effects. Trends in Pharmacol Sci. 22(3):112-3, 2001
Boldyrev A. Song R. Lawrence D. Carpenter DO. Carnosine protects against excitotoxic cell death independently of effects on reactive oxygen species. Neurosci. 94(2):571-7, 1999
Bonfanti L. Peretto P. De Marchis S. Fasolo A. Carnosine-related dipeptides in the mammalian brain. Prog Neurobiol. 59(4):333-53, 1999
Boveris A. Chance B. The mitochondrial generation of hydrogen peroxide. General properties and effect of hyperbaric oxygen. Biochem J. 134(3):707-16, 1973
Braunwald E. Kloner RA. Myocardial reperfusion: a double-edged sword?. J Clin Invest. 76(5):1713-9, 1985
Buchbinder D. Karmody AM. Leather RP. Shah DM. Hypertonic mannitol: its use in the prevention of revascularization syndrome after acute arterial ischemia. Arch Surg. 116(4):414-21, 1981
Bulkley GB. Pathophysiology of free radical-mediated reperfusion injury. J Vas Surg. 5(3):512-7, 1987
Burke AM. Quest DO. Chien S. Cerri C. The effects of mannitol on blood viscosity. J Neurosurg. 55(4):550-3, 1981
Cain BS. Meldrum DR. Dinarello CA. Meng X. Joo KS. Banerjee A. Harken AH. Tumor necrosis factor-alpha and interleukin-1beta synergistically depress human myocardial function. Critical Care Med. 27(7):1309-18, 1999
Castillo M. Toledo-Pereyra LH. Shapiro E. Guerra E. Prough D. Frantzis P. Protective effect of allopurinol, catalase, or superoxide dismutase in the ischemic rat liver. Transplant Proceedings. 22(2):490-1, 1990
Chance B. Sies H. Boveris A. Hydroperoxide metabolism in mammalian organs. Physiol Reviews. 59(3):527-605, 1979
Chen MF. Chen HM. Ueng SW. Shyr MH. Hyperbaric oxygen pretreatment attenuates hepatic reperfusion injury. Liver. 18(2):110-6, 1998
Chiu C. Toledo-Pereyra LH. Effect of catalase and/or allopurinol, or N-t-butyl-alpha-phenylnitrone on hepatic ischemia. Transplant Proceedings. 19(1 Pt 2):1077-9, 1987
Cho WH. Kim DG. Murase N. Mischinger HJ. Todo S. Starzl TE. Comparison of superoxide dismutase, allopurinol, coenzyme Q10, and glutathione for the prevention of warm ischemic injury. Transplantation. 50(2):353-5, 1990
Cote CJ. Greenhow DE. Marshall BE. The hypotensive response to rapid intravenous administration of hypertonic solutions in man and in the rabbit. Anesthesiol. 50(1):30-5, 1979
Coursin DB. Cihla HP. Will JA. McCreary JL. Adaptation to chronic hyperoxia. Biochemical effects and the response to subsequent lethal hyperoxia. Am. Rev Resp Dis. 135(5):1002-6, 1987
Crapo JD. Tierney DF. Superoxide dismutase and pulmonary oxygen toxicity. Am J Physiol. 226(6):1401-7, 1974
Crowell JW. Jones CE. Smith EE. Effect of allopurinol on hemorrhagic shock. Am J Physiol. 216(4):744-8, 1969
Davey CL. Graafhuis AE. Organization of myosin molecules in the muscle thick filament. Experientia. 32(1):32-4, 1976
Davies KJ. Protein damage and degradation by oxygen radicals. I. general aspects. J Biol Chem. 262(20):9895-901, 1987
DeWall RA. Vasko KA. Stanley EL. Kezdi P. Responses of the ischemic myocardium to allopurinol. Am Heart J. 82(3):362-70, 1971
Dinarello CA. Proinflammatory cytokines. Chest. 118(2):503-8, 2000
Dinarello CA. The pathophysiology of the pro-inflammatory cytokines. Biotherapy. 2(3):189-91, 1990
Dunn RM. Mancoll J. Flap models in the rat: a review and reappraisal. Plast Reconst Surg. 90(2):319-28, 1992
Elion GB. Kovensky A. Hitchings GH. Metabolic studies of allopurinol, an inhibitor of xanthine oxidase. Biochem Pharmacol. 15(7):863-80, 1966
Ellis ME. Mandal BK. Hyperbaric oxygen treatment: 10 years' experience of a Regional Infectious Diseases Unit J Infection. 6(1):17-28, 1983
Flye MW. Yu S. The synergistic effect of superoxide dismutase and adenosine triphosphate-MgCl2 on acute hepatic ischemia. Transplant Proceedings. 19(1 Pt 2):1324-6, 1987
Frank L. Groseclose E. Oxygen toxicity in newborn rats: the adverse effects of undernutrition. J.Applied Physiology: Respiratory, Environ Exer Physiol 53(5):1248-55, 1982
Frank L. Yam J. Roberts RJ. The role of endotoxin in protection of adult rats from oxygen-induced lung toxicity. J Clin Invest 61(2):269-75, 1978
Fridovich I. Biological effects of the superoxide radical. Arch Biochem & Biophys. 247(1):1-11, 1986
Fridovich I. Superoxide radical: an endogenous toxicant. Ann Rev Pharmacol Toxicol. 23:239-57, 1983
Gallant S. Kukley M. Stvolinsky S. Bulygina E. Boldyrev A. Effect of carnosine on rats under experimental brain ischemia. Tohoku J. Exp Med. 191(2):85-99, 2000
Goldstein S. Czapski G. Mannitol as an OH. scavenger in aqueous solutions and in biological systems. Intl J Rad Biol Relat Studies Phys, Chem & Med. 46(6):725-9, 1984
Grace PA. Ischaemia-reperfusion injury. Brit J Surg. 81(5):637-47, 1994
Granger DN. Parks DA. Role of oxygen radicals in the pathogenesis of intestinal ischemia. Physiologist. 26(3):159-64, 1983
Grim PS. Gottlieb LJ. Boddie A. Batson E. Hyperbaric oxygen therapy. JAMA. 263(16):2216-20, 1990
Grisham MB. Jefferson MM. Thomas EL. Role of monochloramine in the oxidation of erythrocyte hemoglobin by stimulated neutrophils. J Biol Chem. 259(11):6757-65, 1984
Gute DC. Ishida T. Yarimizu K. Korthuis RJ. Inflammatory responses to ischemia and reperfusion in skeletal muscle. Mol Cell Biochem. 179(1-2):169-87, 1998
Hass MA. Iqbal J. Clerch LB. Frank L. Massaro D. Rat lung Cu,Zn superoxide dismutase. Isolation and sequence of a full-length cDNA and studies of enzyme induction. J Clin Invest. 83(4):1241-6, 1989
Hill GB. Osterhout S. Experimental effects of hyperbaric oxgen on selected clostridial species. I. In-vitro studies. J Infect Dis. 125(1):17-25, 1972
Hipkiss AR. Preston JE. Himsworth DT. Worthington VC. Keown M. Michaelis J. Lawrence J. Mateen A. Allende L. Eagles PA. Abbott NJ. Pluripotent protective effects of carnosine, a naturally occurring dipeptide. Ann New York Academy Sci. 854:37-53, 1998
Hodgson EK. Fridovich I. The interaction of bovine erythrocyte superoxide dismutase with hydrogen peroxide: chemiluminescence and peroxidation. Biochemistry. 14(24):5299-303, 1975
Im MJ. Shen WH. Pak CJ. Manson PN. Bulkley GB. Hoopes JE. Effect of allopurinol on the survival of hyperemic island skin flaps. Plast Reconstr Surg. 73(2):276-8, 1984
Inamoto Y. Okuno F. Saito K. Tanaka Y. Watanabe K. Morimoto I. Yamashita U. Eto S. Effect of hyperbaric oxygenation on macrophage function in mice. Biochem Biophys Res Commun. 179(2):886-91, 1991
Ishiyama S. Hiroe M. Nishikawa T. Abe S. Shimojo T. Ito H. Ozasa S. Yamakawa K. Matsuzaki M. Mohammed MU. Nakazawa H. Kasajima T. Marumo F. Nitric oxide contributes to the progression of myocardial damage in experimental autoimmune myocarditis in rats. Circulation. 95(2):489-96, 1997
Jain KK. Hyperbaric-oxygen therapy.. New Engl J Med. 335(22):1684
Kenward MA. Alcock SR. Brown MR. Effects of hyperbaric oxygen on the growth and properties of Pseudomonas aeruginosa. Microbios. 28(111):47-60, 1980
Kikkawa Y. Yano S. Skoza L. Protective effect of interferon inducers against hyperoxic pulmonary damage. Lab Invest. 50(1):62-71, 1984
Klebanov GI. Teselkin YuO. Babenkova IV. Lyubitsky OB. Rebrova OYu. Boldyrev AA. Vladimirov YuA. Effect of carnosine and its components on free-radical reactions. Mem Cell Biol. 12(1):89-99, 1998.
Knighton DR. Fiegel VD. Halverson T. Schneider S. Brown T. Wells CL. Oxygen as an antibiotic. The effect of inspired oxygen on bacterial clearance. Arch Surg. 125(1):97-100, 1990
Kolski JM. Mazolewski PJ. Stephenson LL. Texter J. Grigoriev VE. Zamboni WA. Effect of hyperbaric oxygen therapy on testicular ischemia-reperfusion injury. J Urol. 160(2):601-4, 1998
Kumar A. Thota V. Dee L. Olson J. Uretz E. Parrillo JE. Tumor necrosis factor alpha and interleukin 1beta are responsible for in vitro myocardial cell depression induced by human septic shock serum. J Exp Med. 183(3):949-58, 1996
Kurella E. Kukley M. Tyulina O. Dobrota D. Matejovicova M. Mezesova V. Boldyrev A. Kinetic parameters of Na/K-ATPase modified by free radicals in vitro and in vivo. Ann New York Academy Sci. 834:661-5, 1997
Lambotte L. d'Udekem Y. Amrani M. Taper H. Free radicals and liver ischemia-reperfusion injury. Transplant Proceedings. 20(5):977, 1988
Latini R. Bianchi M. Correale E. Dinarello CA. Fantuzzi G. Fresco C. Maggioni AP. Mengozzi M. Romano S. Shapiro L. Cytokines in acute myocardial infarction: selective increase in circulating tumor necrosis factor, its soluble receptor, and interleukin-1 receptor antagonist. J Cardiovascular Pharmacol. 23(1):1-6, 1994
Lee JW. Miyawaki H. Bobst EV. Hester JD. Ashraf M. Bobst AM. Improved functional recovery of ischemic rat hearts due to singlet oxygen scavengers histidine and carnosine. J Mol Cell Cardiol. 31(1):113-21, 1999
Levine B. Kalman J. Mayer L. Fillit HM. Packer M. Elevated circulating levels of tumor necrosis factor in severe chronic heart failure. New Engl J Med. 323(4):236-41, 1990
Manson PN. Anthenelli RM. Im MJ. Bulkley GB. Hoopes JE. The role of oxygen-free radicals in ischemic tissue injury in island skin flaps. Ann Surg. 198(1):87-90, 1983
Margolis FL. Grillo M. Grannot-Reisfeld N. Farbman AI. Purification, characterization and immunocytochemical localization of mouse kidney carnosinase. Biochimica et Biophysica Acta. 744(3):237-48, 1983
Marzella L. Jesudass RR. Manson PN. Myers RA. Bulkley GB. Functional and structural evaluation of the vasculature of skin flaps after ischemia and reperfusion. Plast Reconstr Surg. 81(5):742-50, 1988
Meldrum DR. Tumor necrosis factor in the heart. Am J Physiol. 274(3 Pt 2):R577-95, 1998
Menger MD. Microcirculatory disturbances secondary to ischemia-reperfusion. Transplant Proceedings. 27(5):2863-5, 1995
Menger MD. Pelikan S. Steiner D. Messmer K. Microvascular ischemia-reperfusion injury in striated muscle: significance of "reflow paradox". Am J Physiol. 263(6 Pt 2):H1901-6, 1992
Menger MD. Steiner D. Messmer K. Microvascular ischemia-reperfusion injury in striated muscle: significance of "no reflow". Am J Physiol. 263(6 Pt 2):H1892-900, 1992
Mes LG. Improving flap survival by sustaining cell metabolism within ischemic cells: a study using rabbits. Plast Reconstr Surg. 65(1):56-65, 1980
Michie HR. Manogue KR. Spriggs DR. Revhaug A. O'Dwyer S. Dinarello CA. Cerami A. Wolff SM. Wilmore DW. Detection of circulating tumor necrosis factor after endotoxin administration. New Engl J Med. 318(23):1481-6, 1988
Moncada S. Palmer RM. Higgs EA. Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacol Rev. 43(2):109-42, 1991
Moorhouse PC. Grootveld M. Halliwell B. Quinlan JG. Gutteridge JM. Allopurinol and oxypurinol are hydroxyl radical scavengers. FEBS Letters. 213(1):23-8, 1987
Mullane KM. Westlin W. Kraemer R. Activated neutrophils release mediators that may contribute to myocardial injury and dysfunction associated with ischemia and reperfusion. Ann New York Academy Sci. 524:103-21, 1988
Mullane KM. Westlin W. Kraemer R. Activated neutrophils release mediators that may contribute to myocardial injury and dysfunction associated with ischemia and reperfusion. Ann New York Academy Sci. 524:103-21, 1988
Murray DR. Freeman GL. Tumor necrosis factor-alpha induces a biphasic effect on myocardial contractility in conscious dogs. Circulation Res. 78(1):154-60, 1996
Nagai K. Suda T. Realization of spontaneous healing function by carnosine. Methods Findings Exp Clin Pharmacol. 10(8):497-507, 1988
Narayanan KK, Im MJ,Manson PN,Bulkley GB,Hoopes JE. Mechanism and prevention of ischemia/reperfusion injury in island skin flaps. Surg Forum. 36:593-5, 1985
Nathan C. Nitric oxide as a secretory product of mammalian cells. FASEB J. 6(12):3051-64, 1992
Nauta RJ. Tsimoyiannis E. Uribe M. Walsh DB. Miller D. Butterfield A. Oxygen-derived free radicals in hepatic ischemia and reperfusion injury in the rat. Surg, Gynecol Obst. 171(2):120-5, 1990
Nohl H. Jordan W. The mitochondrial site of superoxide formation. Biochem Biophysi Res.Commun. 138(2):533-9, 1986
Nylander G. Nordstrom H. Lewis D. Larsson J. Metabolic effects of hyperbaric oxygen in postischemic muscle. Plast Reconstr Surg. 79(1):91-7, 1987
Okusawa S. Gelfand JA. Ikejima T. Connolly RJ. Dinarello CA. Interleukin 1 induces a shock-like state in rabbits. Synergism with tumor necrosis factor and the effect of cyclooxygenase inhibition. J Clin Invest. 81(4):1162-72, 1988
Olivetti G. Abbi R. Quaini F. Kajstura J. Cheng W. Nitahara JA. Quaini E. Di Loreto C. Beltrami CA. Krajewski S. Reed JC. Anversa P. Apoptosis in the failing human heart. New Engl J Med. 336(16):1131-41, 1997
Oral H. Kapadia S. Nakano M. Torre-Amione G. Lee J. Lee-Jackson D. Young JB. Mann DL. Tumor necrosis factor-alpha and the failing human heart. Clin Cardiol. 18(9 Suppl 4):IV20-7, 1995
Ouriel K. Ginsburg ME. Patti CS. Pearce FJ. Hicks GL. Preservation of myocardial function with mannitol reperfusate. Circulation. 72(3 Pt 2):II254-8, 1985
Pang CY. Chiu C. Zhong A. Xu N. Pharmacologic intervention of skin vasospasm and ischemic necrosis in pigs. J Cardiovas Pharmacol. 21(1):163-71, 1993
Parks DA. Bulkley GB. Granger DN. Role of oxygen free radicals in shock, ischemia, and organ preservation. Surg. 94(3):428-32, 1983
Parks DA. Granger DN. Ischemia-induced vascular changes: role of xanthine oxidase and hydroxyl radicals. Am J Physiol. 245(2):G285-9, 1983
Pearson PJ. Schaff HV. Vanhoutte PM. Long-term impairment of endothelium-dependent relaxations to aggregating platelets after reperfusion injury in canine coronary arteries. Circulation. 81(6):1921-7, 1990
Pegova A. Abe H. Boldyrev A. Hydrolysis of carnosine and related compounds by mammalian carnosinases. Comparative Biochemistry & Physiol. Part B, Biochem Mol Biol. 127(4):443-6, 2000
Peterson DA. Kelly B. Gerrard JM. Allopurinol can act as an electron transfer agent. Is this relevant during reperfusion injury?. Biochem Biophys Res Commun. 137(1):76-9, 1986.
Poltorak A. Smirnova I. He X. Liu MY. Van Huffel C. McNally O. Birdwell D. Alejos E. Silva M. Du X. Thompson P. Chan EK. Ledesma J. Roe B. Clifton S. Vogel SN. Beutler B. Genetic and physical mapping of the Lps locus: identification of the toll-4 receptor as a candidate gene in the critical region. Blood Cells Mol Dis. 24(3):340-55, 1998
Preston JE. Hipkiss AR. Himsworth DT. Romero IA. Abbott JN. Toxic effects of beta-amyloid(25-35) on immortalised rat brain endothelial cell: protection by carnosine, homocarnosine and beta-alanine. Neuroscience Letters. 242(2):105-8, 1998
Puig JG. Mateos FA. Diaz VD. Inhibition of xanthine oxidase by allopurinol: a therapeutic option for ischaemia induced pathological processes? Ann Rheumatic Dis. 48(11):883-8, 1989
Pyatak PS. Abuchowski A. Davis FF. Preparation of a polyethylene glycol: superoxide dismutase adduct, and an examination of its blood circulation life and anti-inflammatory activity. Res Commun in Chem Pathol Pharmacol. 29(1):113-27, 1980
Quinn PJ. Boldyrev AA. Formazuyk VE. Carnosine: its properties, functions and potential therapeutic applications. Mol Aspects Med. 13(5):379-444, 1992.
Radi R. Beckman JS. Bush KM. Freeman BA. Peroxynitrite oxidation of sulfhydryls. The cytotoxic potential of superoxide and nitric oxide. J Biol Chem. 266(7):4244-50, 1991
Rhoden E. Pereira-Lima L. Lucas M. Mauri M. Rhoden C. Pereira-Lima JC. Zettler C. Petteffi L. Bello-Klein A. The effects of allopurinol in hepatic ischemia and reperfusion: experimental study in rats. Eur Surg Res. 32(4):215-22, 2000
Roberts PR. Black KW. Santamauro JT. Zaloga GP. Dietary peptides improve wound healing following surgery.. Nutrition. 14(3):266-9, 1998
Romani F. Vertemati M. Frangi M. Aseni P. Monti R. Codeghini A. Belli L. Effect of superoxide dismutase on liver ischemia-reperfusion injury in the rat: a biochemical monitoring. Euro Surg Res. 20(5-6):335-40, 1988.
Rudehill A. Gordon E. Ohman G. Lindqvist C. Andersson P. Pharmacokinetics and effects of mannitol on hemodynamics, blood and cerebrospinal fluid electrolytes, and osmolality during intracranial surgery. J Neurosurg Anesthesiol. 5(1):4-12, 1993
Sagi A. Ferder M. Levens D. Strauch B. Improved survival of island flaps after prolonged ischemia by perfusion with superoxide dismutase. Plast Reconstr Surg. 77(4):639-44, 1986
Sagi A. Ferder M. Yu HL. Gordon MJ. Strauch B. pH-balanced solutions with superoxide dismutase (SOD): an attempt to increase island groin flap survival in rats. Ann Plast Surg. 24(6):521-3, 1990
Schaff HV. Goldman RA. Bulkley BH. Gott VL. Flaherty JT. Hyperosmolar reperfusion following ischemic cardiac arrest: Critical importance of the timing of mannitol administration on preservation of myocardial structure and function. Surgery. 89(2):141-50, 1981
Stewart RJ. Moore T. Bennett B. Easton M. Newton GW. Yamaguchi KT. Effect of free-radical scavengers and hyperbaric oxygen on random-pattern skin flaps. Arch Surg. 129(9):982-7, 1994
Stvolinsky S. Kukley M. Dobrota D. Mezesova V. Boldyrev A. Carnosine protects rats under global ischemia. Brain Res Bulletin. 53(4):445-8, 2000
Talbott GA. Sharar SR. Harlan JM. Winn RK. Leukocyte-endothelial interactions and organ injury: the role of adhesion molecules. New Horizons. 2(4):545-54, 1994
Thom SR. Inert gas enhancement of superoxide radical production. Arch Biochem Biophys. 295(2):391-6, 1992
Torre-Amione G. Kapadia S. Lee J. Bies RD. Lebovitz R. Mann DL. Expression and functional significance of tumor necrosis factor receptors in human myocardium. Circulation. 92(6):1487-93, 1995
Tresse O. Jouenne T. Junter GA. The role of oxygen limitation in the resistance of agar-entrapped, sessile-like Escherichia coli to aminoglycoside and beta-lactam antibiotics. J Antimicrob Chemoth. 36(3):521-6, 1995
Tsao PS. Aoki N. Lefer DJ. Johnson G 3rd. Lefer AM. Time course of endothelial dysfunction and myocardial injury during myocardial ischemia and reperfusion in the cat. Circulation. 82(4):1402-12, 1990
Tsao PS. Lefer AM. Time course and mechanism of endothelial dysfunction in isolated ischemic- and hypoxic-perfused rat hearts. Am J Physiol. 259(6 Pt 2):H1660-6, 1990
Turrens JF. Crapo JD. Freeman BA. Protection against oxygen toxicity by intravenous injection of liposome-entrapped catalase and superoxide dismutase. J Clin Invest. 73(1):87-95, 1984
Vanhoutte PM. The endothelium--modulator of vascular smooth-muscle tone. New Engl J Med. 319(8):512-3, 1988
Vaughan DL. Wickramasinghe YA. Russell GI. Thorniley MS. Houston RF. Ruban E. Rolfe P. Is allopurinol beneficial in the prevention of renal ischaemia-reperfusion injury in the rat?: evaluation by near-infrared spectroscopy. Clin Sci. 88(3):359-64, 1995
Verrier E. The microvascular cell and ischemia-reperfusion injury. J Cardiovas Pharmacol.S26-30, 1996
Verrier ED. Boyle EM Jr. Endothelial cell injury in cardiovascular surgery. Ann Thoracic Surg. 62(3):915-22, 1996
Vigers GP. Anderson LJ. Caffes P. Brandhuber BJ. Crystal structure of the type-I interleukin-1 receptor complexed with interleukin-1beta. Nature. 386(6621):190-4, 1997
Wang HJ. Chen TM. Chow LS. Cheng TY. Chen JL. Recipient bed vascularity and the survival of ischaemic flaps. British J Plast Surg. 50(4):266-71, 1997
Wang WZ. Anderson G. Fleming JT. Peter FW. Franken RJ. Acland RD. Barker J. Lack of nitric oxide contributes to vasospasm during ischemia/reperfusion injury. Plast Reconstr Surg. 99(4):1099-108, 1997
Weisiger RA. Fridovich I. Superoxide dismutase. Organelle specificity. J Biol Chem. 248(10):3582-92, 1973
Weiss SJ. Tissue destruction by neutrophils. New Engl J Med. 320(6):365-76, 1989
Yamada T. Taguchi T. Hirata Y. Suita S. Yagi H. The protective effect of hyperbaric oxygenation on the small intestine in ischemia-reperfusion injury. J Ped Surg. 30(6):786-90, 1995
Yamamoto S. Tanabe M. Wakabayashi G. Shimazu M. Matsumoto K. Kitajima M. The role of tumor necrosis factor-alpha and interleukin-1beta in ischemia-reperfusion injury of the rat small intestine. J Surg Res. 99(1):134-41, 2001
Yoon DY. Dinarello CA. Antibodies to domains II and III of the IL-1 receptor accessory protein inhibit IL-1 beta activity but not binding: regulation of IL-1 responses is via type I receptor, not the accessory protein. J Immunol. 160(7):3170-9, 1998
Zamboni WA. Roth AC. Russell RC. Graham B. Suchy H. Kucan JO. Morphologic analysis of the microcirculation during reperfusion of ischemic skeletal muscle and the effect of hyperbaric oxygen. Plast Reconstr Surg. 91(6):1110-23, 1993

QRCODE
 
 
 
 
 
                                                                                                                                                                                                                                                                                                                                                                                                               
第一頁 上一頁 下一頁 最後一頁 top