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研究生:林中仁
研究生(外文):Chung-Ren Lin
論文名稱:神經病變性疼痛的細胞及基因療法
論文名稱(外文):Exploiting the Potential Therapy for Neuropathic Pain Through Cellular and Molecular Approaches
指導教授:陳 錦 翠
指導教授(外文):Jiin-Tsuey Cheng
學位類別:博士
校院名稱:國立中山大學
系所名稱:生物科學系研究所
學門:生命科學學門
學類:生物學類
論文種類:學術論文
論文出版年:2002
畢業學年度:90
語文別:英文
論文頁數:107
中文關鍵詞:基因治療細胞療法電穿孔椎管內非病毒性基因轉殖神經病變性疼痛
外文關鍵詞:gene therapyneuropathic paincell therapyelectroporationnon-viral gene transferintrathecal
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論文口試委員審定書

摘要
Abstract
Contents
Abbreviations
1.0 Background
1.1 Neuropathic Pain
1.2 Cell Therapy for Neuropathic Pain
1.3 Gene therapy for Neuropathic Pain
2.0 General Research Objectives
2.1 Specific Aims
3.0 Experimental Design
3.1 Intrathecal Spinal Progenitor Cell Therapy
3.2 Intrathecal Electroporation Therapy
4.0 Materials and Methods
4.1 Animal Preparation
4.2 Animal Model of Neuropathic Pain
4.3 Intrathecal Catheterization
4.4 Electrode-Catheter Construction
4.5 Mini Osmotic Pump Implantation
4.6 Behavioral Assessment
4.7 CSF Microdialysis
4.8 Preparation of SPCs
4.9 Flow Cytometry Analysis
4.10 Amino Acid Analysis
4.11 RT-PCR for Ribonucleic Acid (RNA) Analysis
4.12 Western Blotting
4.13 Human Pro-opiomelanocortin (POMC) cDNA Expression Plasmid Construction
4.14 Perfusion-Fixation in vivo
4.15 Immunohistochemical Staining
4.16 Immunoreactive Cells Counting
4.17 c-Fos Antibody Electroporation
4.18 Luciferase Assay for AP-1 Promoter Activity
4.19 Data Analysis
5.0 Results
5.1 Intrathecal Spinal Progenitor Cell Therapy
5.2 Intrathecal Electroporation Therapy
6.0 Discussion
7.0 References
8.0 Table
9.0 Figures and Legends
Appendix
Publications and Presetations Related to this Thesis
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