跳到主要內容

臺灣博碩士論文加值系統

(44.210.21.70) 您好!臺灣時間:2022/08/11 16:12
字體大小: 字級放大   字級縮小   預設字形  
回查詢結果 :::

詳目顯示

: 
twitterline
研究生:宋佩盈
研究生(外文):Pei-Ying Sung
論文名稱:綠島產叢狀穗花珊瑚與多刺棘穗軟珊瑚化學成分及癌細胞毒殺活性之研究
論文名稱(外文):Chemical Constituents and Cytotoxicity of Formosan Soft Corals Lemnalia Cervicorni and Dendronephthya spinifera
指導教授:杜昌益杜昌益引用關係
指導教授(外文):Ching-Yih Duh
學位類別:碩士
校院名稱:國立中山大學
系所名稱:海洋資源學系研究所
學門:自然科學學門
學類:海洋科學學類
論文種類:學術論文
論文出版年:2002
畢業學年度:90
語文別:中文
論文頁數:68
中文關鍵詞:綠島產多刺棘穗軟珊瑚化學成分及綠島產叢狀穗花珊瑚
外文關鍵詞:Chemical Constituents and CytotoxicityFormosan soft coral Dendronephthya spiniferaFormosan soft coral Lemnalia cervicorni
相關次數:
  • 被引用被引用:0
  • 點閱點閱:251
  • 評分評分:
  • 下載下載:38
  • 收藏至我的研究室書目清單書目收藏:1
綠島產叢狀穗花珊瑚(Lemnalia cervicorni May)之二氯甲烷層粗萃物,經層析分離後得到4個sesquiterpenoids化合物,分別為GN40-29 (1)、GN40-79 (3)、GN40-169 (4)、GN40-173 (5)。而GN40-29a (2)是GN40-29 (1)乙醯化反應得到的產物。其中GN40-79 (3)、GN40-169 (4)、GN40-173 (5)為ylangene骨架的新化合物。
綠島產多刺棘穗軟珊瑚(Dendronephthya spinifera Holm) 之二氯甲烷層粗萃物,經層析分離後得到1個cadinene骨架的sesquiterpene化合物GN43-4 (6),為一新化合物。
Chromatographic separation of methylene chloride extracts of Formosan soft coral Lemnalia cervicorni May (collected at Green Island off Taiwan) led to the isolation of four ylangene sesquiterpenoids, GN40-29 (1), GN40-79 (3), GN40-169 (4), and GN40-173 (5). Acetylation of GN40-29 (1) gave a derivative GN40-29a (2). Compounds 3-5 were new compounds. Compound 1 showed cytotoxicity against HT-29 cell, while compound 5 was cytotoxic to P-388 cells.
The methylene chloride extracts of Formosan soft coral Dendronephthya spinifera Holm (collected at Green Island off Taiwan) were found to contain a new cadinene sesquiterpene, GN43-4 (6).
目錄

壹、緒論
一、前言
二、Lemnalia屬軟珊瑚之天然物化學研究回顧
三、Dendronephthya屬軟珊瑚之天然物化學研究回顧
貳、叢狀穗花珊瑚化學成分之研究
一、材料之採集與鑑定
二、Lemnalia屬軟珊瑚之分類地位
三、叢狀穗花珊瑚化學成分之萃取與分離流程
四、叢狀穗花珊瑚化學成分之分離純化
(1) GN40-29 (1)之分離純化
(2) GN40-29a (2)之乙醯化
(3) GN40-79 (3)之分離純化
(4) GN40-169 (4)之分離純化
(5) GN40-173 (5)之分離純化
五、叢狀穗花珊瑚化學成分之結構解析
(1)GN40-29 (1)之結構解析
(2)GN40-29a (2)之結構解析
(3)GN40-79 (3)之結構解析
(4)GN40-169 (4)之結構解析
(5) GN40-173 (5)之結構解析
參、多刺棘穗軟珊瑚化學成分之研究
一、材料之採集與鑑定
二、Dendronephthya屬軟珊瑚之分類地位
三、多刺棘穗軟珊瑚化學成分之萃取與分離流程
四、多刺棘穗軟珊瑚化學成分之分離純化
(1) GN43-4 (6)之分離純化
五、多刺棘穗軟珊瑚化學成分之結構解析
(1) GN43-4 (6)之結構解析
肆、叢狀穗花珊瑚之生物活性
伍、結論
陸、參考文獻
七、附錄
一、儀器及材料
二、衍生物之製備
三、癌細胞毒殺活性測試之分析方法
四、MTT分析原理
參考文獻1. 戴昌鳳,1989,台灣的珊瑚。台灣省政府教育廳。2. 方力行,1989,珊瑚學。教育部聯合出版委員會。3. Paul J. Scheupr, “Bioorganic Marine Chemistry”, 1987, Springer-Verlag Berlin.4. B. Tursch, J. C. Braekman, D. Daloze, P. Fritz, A. Kelecom, R. Karlsson and D. Losman, “Chemical studies of marine invertebrates. Ⅷ. Africanol, an unusual sesquiterpene from Lemnalia africana (Coelenterata, Octocorallia, Alcyonacea)”, Tetrahedron Lett., 1974, 9, 747-750.5. Burce F. Bowden, John C. Coll and Sarah Jane Mitchell, “Studies of Australia soft corals. XⅥ two new sesquiterpenes from Lemnalia humesi”, Aust. J. Chem., 1980, 33, 681-684.6. Burce F. Bowden, John C. Coll and Sarah Jane Mitchell, Brian W. Skelton and Allan H. White, “Studies of Australia soft corals. XXⅠⅠ the structures of two novel sesquiterpenes and a nor sesquiterpenes from Lemnalia africana, confirmed by a single-crystal x-ray study”, Aust. J. Chem., 1980, 33, 2737-2747.7. Richard R., Willian Fenical, Bruce Tagle, John Clardy, “Neolemnaneand eremophilane sesquiterpenoids from the pacific soft coral Lemnalia africana”, Tetrahedron, 1981, 37, 2569-2573. 8. Yasuji Yamada, Kazuo Lguchi, Hiroyuki Kikuchi, Yasumasa Tsukitani, Steven A. Drexler, Jon Clardy, “Lemnalol, a new sesquiterpenoid from the soft coral Lemnalia tenuis Verseveldt”, Tetra. Lett., 1982, 23, 1063-1066.9. Hiroyuki Kikuchi, Yasuji Yamada, Kazuo Lguchi, Toshitaka Manda, Katsumasa Kobayashi, “Anti-tumor activity of lemnalol from the soft coral Lemnalia tenuis Verseveldt”, Chem. Pharm. Bull., 1983, 31, 1086-1088.10. Bruce F. Bowden, John C. Coll, Lutz M. Engelhardt, Dianne M. Tapiolas and Allan H. White, “Studies of Australian soft corals. XXXⅥ the isolation and structure determination of 11 calamenene-based sesquiterpenes from Lemnalia cervicornis”, Aust. J. Chem., 1986, 39, 103-121. 11. John R. Carney, Anthony T. Pham, Wesley Y. Yoshida, Paul J. Scheuer,“ Napaliactone, a new halogenated norsesquiterpenoid from the soft coral Lemnalia africana”, Tetra. Lett., 1992, 33, 7115-7118.12. Jaroslaw Jurek and Paul J. Scheuer, “Sesquiterpenoids and norsesquiterpenoids from the soft coral Lemnalia africana”, J. Nat. Prod., 1993, 56, 508-513.13. Min Zhang, Kanghou Long, Houming Wu, Kan Ma, “A novel diterpene glycoside from the soft coral of Lemnalia bournei”, J. Nat. Prod., 1994, 57, 155-160.14. Min Zhang and Zhishu Hung, “Two new diterpene glycosides fron the soft coral Lemnalia bournei”, J. Nat. Prod., 1998, 61, 1300-1301.15. R. B. Bates and V. P. Thalacker, “Nuclear magnetic resonance spectral parameters in bicyclo[3, 1, 1,]heptanes. α-Pinene, myrtenal, and verbenone”, J. Org. Chem., 1968, 33, 1730-1732.16. Yasuhiko Tomono, Hiroshi Hirota, Yukimitsu Imahara, and Nobuhiro Fusetani, “Isogosterones A-D, antifouling 13, 17-secosteroids from an octocoral Dendronephthya sp.”, J. Org. Chem., 1999, 64, 2272-2275.17. Yasuhiko Tomono, Hiroshi Hirota, Yukimitsu Imahara, and Nobuhiro Fusetani, “Four new steroids from two octocorals”, J. Nat. Prod., 1999, 62, 1538-1541.18. Kazuko Yoshikawa, Satoe Kanekuni, Mika Hanahusa, Shigenobu Arihara, Tomihisa Ohta, “Polyhydroxylated sterols from the octocoral Dendronephthya gigantean”, J. Nat. Prod., 2000, 63, 670-672.
QRCODE
 
 
 
 
 
                                                                                                                                                                                                                                                                                                                                                                                                               
第一頁 上一頁 下一頁 最後一頁 top
無相關論文