跳到主要內容

臺灣博碩士論文加值系統

(18.204.56.185) 您好!臺灣時間:2022/08/14 02:46
字體大小: 字級放大   字級縮小   預設字形  
回查詢結果 :::

詳目顯示

: 
twitterline
研究生:劉樹玉
研究生(外文):Shu-Yu Liu
論文名稱:腦幹聽性誘發電位波間潛時延長之語言發展遲緩兒童其變頻耳聲傳射之對側抑制
論文名稱(外文):Contralateral suppression of distortion products of otoacoustic emissions in language developmental delayed children with prolonged interpeak latencies of brainstem auditory evoked potential
指導教授:許權振許權振引用關係
指導教授(外文):Chuan-Jen Hsu
學位類別:碩士
校院名稱:國立台北護理學院
系所名稱:聽語障礙科學研究所
學門:醫藥衛生學門
學類:復健醫學學類
論文種類:學術論文
論文出版年:2002
畢業學年度:90
語文別:中文
論文頁數:69
中文關鍵詞:腦幹聽性誘發電位變頻耳聲傳射變頻耳聲傳射之對側抑制語言發展遲緩兒童
外文關鍵詞:Brainstem auditory evoked potential(BAEP)distortion products of otoacoustic emissions(DPOAE)contralateral suppression of distortion products of otoacoustic emissionslanguage developmental delayed children
相關次數:
  • 被引用被引用:1
  • 點閱點閱:686
  • 評分評分:
  • 下載下載:79
  • 收藏至我的研究室書目清單書目收藏:5
過去研究顯示,對側耳施予連續寬帶噪音可以激發內側橄欖-耳蝸束(medial olivocochlear bundle; MOCB)與耳蝸外毛細胞的突觸連結,此下行徑路會抑制變頻耳聲傳射之振幅。本研究的目的在探討:當上行聽覺神經傳導時間延宕時,是否會影響MOCB的抑制功能?本文中將無噪音時測得之變頻耳聲傳射(distortion products otoacoustic emissions; DPOAE)振幅減去噪音(連續白噪音50dBHL)下之DPOAE振幅,定義為對側抑制值(contralateral suppression)。
實驗組為腦幹聽性誘發電位(brainstem auditory evoked potential; BAEP)單側波間潛時延長的語言發展遲緩兒童八名,比較異常耳與正常耳間之DPOAE振幅及其對側抑制是否有差異? 研究結果發現:BAEP波間潛時異常耳與正常耳之DPOAE振幅兩耳間無顯著差異。而DPOAE在2000Hz 和4000Hz之對側抑制值有顯著差異(2kHz/p=0.036; 4kHz/p=0.017; 顯著水準為0.05)。在控制組方面則發現,正常兒童與成人之DPOAE及其對側抑制兩耳間皆無顯著差異。
本論文為首度報告:單側BAEP波間潛時延長可能影響該側MOCB抑制的功能,並提出生理解剖徑路可能的解釋。研究結果支持MOCB對耳蝸外毛細胞之回饋迴路(feedback loop)可能在腦幹上行與下行聽覺徑路的交互影響中扮演重要的角色。
同時,本研究發現,為數不少的語言發展遲緩兒童(31.66%)出現BAEP波間潛延長,有些為單側延長,有些則為雙側延長。聽力師對於這些兒童進行聽覺評估時,有必要檢視其BAEP的傳導時間,以瞭解他們腦幹聽覺徑路的成熟度。

The suppression of distortion products of otoacoustic emissions
(DPOAEs) by contralateral auditory stimulation can assess the activity of the efferent pathway from the superior olivary complex to outer hair cells of cochlea via the medial olivo-cochlear bundle(MOCB). The purpose of this study is to investigate if the suppressive effect of MOCB is abnormal in language developmental delayed children with unilateral prolonged interpeak latencies(IPL) of brainstem auditory evoked potentials. Contralateral suppression (CS) was defined in the present study as the amplitude change of DPOAEs with and without contralateral white noise of 50dBHL. CS of DPOAEs at 1k, 1.5k, 2k, 3k and 4kHz in one ear with unilateral prolonged IPL of BAEP were compared to those of the other healthy ear. In addition, CS between two ears in two control groups , fourteen normal children and twenty five adults, were compared.
The results showed that the contralateral suppression of DPOAEs at 2000 and 4000Hz were significantly different between the ears with prolonged IPLs of BAEP and the normal ears . This finding indicated that the efferent pathway of uncrossed MOCB as well as afferent pathway in brainstem was abnormal in children with prolonged IPLs of BAEP. Furthermore, contralateral suppression of DPOAEs measurement can be
clinically valuable in understanding the interaction between afferent and efferent auditory pathway, and dysfunction of efferent pathway as well as poor neural synchrony of afferent pathway may be implicated in language developmental delayed children.

目 次
頁數
誌 謝 ………………………………………………………………………. I
中文摘要 ……………………………………………………………………… II
英文摘要 ………………………………………………………………………… III
目 錄 ……………………………………………………………………… IV
圖表目次 ………………………………………………………………….…… V
第一章 緒 論
第一節 前言 ………………………………………………… 1
第二節 研究目的 ………………………………………………… 2
第二章 文獻探討
第一節 特殊兒童的腦幹聽性誘發電位 …………………………… 4
第二節 腦幹聽覺傳導系統 ……..………………………………… 6
第三節 腦幹聽性誘發電位 ………………………………………… 7
第四節 耳蝸外毛細胞與耳聲傳射 ………………………………… 8
第五節 變頻耳聲傳射之對側抑制 ………………………………… 10
第三章 研究方法 …………………………………………………… 16
第四章 結 果
第一節 實驗組之腦幹聽性誘發電位潛時反應 …………………… 23
第二節 變頻耳聲傳射振幅 ………………………………………… 25
第三節 變頻耳聲傳射之對側抑制 ………………………………… 28
第四節 實驗組兒童之醫療診斷及發展評估結果 ………………… 31
第五章 討 論 …………………………………………………… 32
第六章 結 論 …………………………………………………… 38
參考文獻 ……………………………………………………………… 39
附 錄
附錄一 正常成人控制組之變頻耳聲傳射振幅 ………… 47
附錄二 正常兒童控制組之變頻耳聲傳射振幅 ………… 51
附錄三 實驗組兒童之變頻耳聲傳射振幅 ……………………… 55
附錄四 正常成人控制組在對側噪音下之變頻耳聲傳射振幅 … 57
附錄五 正常兒童控制組在對側噪音下之變頻耳聲傳射振幅 …… 61
附錄六 實驗組兒童在對側噪音下之變頻耳聲傳射振幅 ………… 65
附錄七 正常成人控制組之變頻耳聲傳射對側抑制值 …………… 67
附錄八 正常兒童控制組之變頻耳聲傳射對側抑制值 …………… 68
附錄九 實驗組兒童之變頻耳聲傳射對側抑制值 ………………… 69

參考文獻:
Abdala, C., Ma, E., & Sininger, Y.S.(1999). Maturation of medial efferent system function in humans. Journal of Acoustical Society of America, 105(4), 2392-2402..
Abdala, C., Sininger, Y.S., & Starr, A.(2000). Distortion product otoacoustic emission suppression in subjects with auditory neuropathy. Ear & Hearing. 21(6), 542-553.
Arnold, J.E., & Bender, D. R. (1983). BSER abnormalities in a multiple sclerosis patient with normal peripheral hearing acuity. The American Journal of Otology, 4, 235-237.
Barrs, D.M., Brackmann, D.E., Olson, J.E., & House, W. F. (1985). Changing concepts of acoustic tumor diagnosis. Archives of Otolaryngology, 111, 17-21.
Bauch, C.D., Rose, D.E., & Harner, S. G. (1982). Auditory brainstem response results from 255 patients with suspected retrocochlear involvement. Ear and Hearing, 3, 83-86.
Berlin, C.I.(1999a). The olivocochlear system and protection from acoustic injury: acute and chronic effects. In C.I. Berlin (Ed.), The efferent auditory system. (pp.2). Singular Publishing Group, Inc.
Berlin, C.I.(1999b). Recording and analyzing efferent suppression of transient-evoked otoacoustic emissions. In C.I. Berlin (Ed.), The efferent auditory system. (pp.89). Singular Publishing Group, Inc.,.
Berlin, C.I., Hood, L.J., Cecola, RP., Jackson, D.F., & Szabo, P. (1993). Does type I afferent neuron dysfunction reveal itself through lack of efferent suppression? Hearing Research, 65, 40-50.
Berlin, C.I., Hood, L.J., Hurley, A.E., Wen, H., & Kemp, D.T.(1995). Binaural noise suppression linear click-evoked otoacoustic emssions more than ipsilateral or contralateral noise. Hearing Research, 87, 96-103.
Bobbin, R.P., & LeBlanc, C.S.(1999). Apamin reduces but does not abolish the effects of contralateral suppression of cubic DPOAEs. In C.I. Berlin (Ed.) The efferent auditory system. (pp.61-72). Singular Publishing Group, Inc.
Chery-Croze, S., Moulin, A., & Collet, L.(1993). Effect of contralateral sound stimulation on the distoriton product 2f1-f2 in humans: evidence of a frequency specificity. Hearing Research, 68(1),53-58.
Cottrell, G., & Gans, D.(1995). Auditory-evoked response morphology in profoundly-involed multi-handicapped children: comparisons with normal infants and children. Audiology, 34(4), 189-206.
Collet, L., Veuillet, E., Bene, J., & Morgon, A. (1992). Effects of contralateral white noise on click-evoked emissions in normal and sensorineural ears. Audiology, 31, 1-7.
Deltenre, P., Mansbach, A.L., Bozet, C., Clercx, A., & Hecox, K.E. (1997). Auditory neuropathy: A report on thress cases with early onsets and major neonatal illnesses. Electroencephalography and Clinical Neurophysiology, 104, 17-22.
Eggermont, J. J., Don, M., & Brackmann, D.E. (1980). Electrocochleography and auditory brainstem electric responses in patients with pontine angle tumors. Annals of Otology, Rhinology, and Laryngology, 89, 1-19.
Folsom, R. C., & Owsley, R.M. (1987). N1 action potentials in humans. Influence of simultaneous contralateral stimulaiton. Acta Otolaryngology (Stockholm), 103, 262-265.
Ferguson, M.A., O’Donoghue, G.M., & Owen V. (2001). Contralateral suppression of transient evoked otoacoustic emissions in patients with cerebello-pontine angle tumor. Ear & Hearing, 22;173-181.
Galambos, R. (1956). Suppression of auditory nerve activity by stimulaation of efferent fibers to cochlea. Journal of Neurophysiology, 19, 424-437.
Gelfand, S.A. (1997). Essentials of audiology. New York, Thieme Medial Publishers.
Gillberg C., Rosenhall U., & Johansson, E. (1983). Auditory brainstem responses in childhood psychosis. Journal of Autism and Developmental Disorder, 13,181-195.
Gold, T. (1948). Hearing. II. The physical basis of the action of the cochlea. Proceedings of the Royal Society of Britain, 135, 492-498.
Hall, J.W. (1992). Handbook of auditory evoked responses. (pp. 50-55) MA: Allyn and Bacon.
Hall, J.W. (2000). Distortion product and transient evoked OAEs: nonpathologic factors influencing measurement. Handbook of otoacoustic emissions. (pp.208-216). San Diego, CA: Singular Publishing Group.
Hecox, K., Cone, B., & Blaw, M.E. (1981). Brainstem auditory evoked responses in the diagnosis of pediatric neurological disease. Neurology, 31, 832-840.
Ho, P.T., Keller, J.L., Berg, A.L., Cargan, A.L., & Haddad, J.Jr. (1999).Pervasive developmental delay in children presenting as possible hearing loss. Laryngoscope, 109(1), 129-135.
Hood, L.J., Berlin, C.I., Goforth-Barter, L., Bordelon, J., & Wen, H.(1999). Recording and analyzing efferent suppression of traisient-evoked otoacoustic emissions. In Berlin, C.I.(Ed.). The efferent auditory system. (pp.87-103). Singular Publishing Group, Inc.
Hood. L.J., & Berlin, C.I.(2001). Auditory neuropathy disables efferent suppression of otoacoustic emissions. In V. Sininger, & A. Starr (Eds.), Auditory neuropathy: A new perspective on hearing disorders. (pp. 183-202). Singular Thomson Learing.
Hsieh, Y., Chen, T.J., Lin, C.H., & Chen, S.S.(1998). Effect of olivocochlear bundle lesion on locomotor activity in rats. Physiology & Behavior, 64 (2), 179-184.
Jerger, J. F., Oliver, T. A., Chmiel, R. A., & Rivera, V. M. (1986). Patterns of auditory abnormality in multiple sclerosis. Audiology, 25, 193-209.
Jewett, D.L., & Williston, J.S. (1971). Auditory evoked far fields averaged from the scalp of humans. Brain, 4, 681-696.
Kawase, T., Delgutte, B., & Liberman, M.C. (1993). Antimasking efects of the olivocochlear reflex. II. Enhancement of auditory-nerve response to masked tones, Journal of Neurophysiology, 70(6), 2533-2549.
Kemp, D.T. (1978). Stimulated acoustic emissions from within the human auditory system. Journal of the Acoustical Society of America, 64,1386-1391.
Kemp, D. T. (1986). Otoacoustic emissions, travelling waves and cochlear mechanisms. Hearing Research, 22, 95-113.
Kemp, DT., & Chum, R.(1980). Properties of the generator of stimulated acoustic emission. Hearing Research, 2, 213-232.
Kemp, D.T., & Martin J. A. (1976). Active resonant systems in audition. 13th International Congress of Audiology, 64-65.
Killion, M.C., Wilbur, L.A., & Gudmundsen, G.I.(1985) Insert earphones for more interaural attenuation. Hearing Instrument, 36, 34-36.
Lauffer, H., Langer, A., & Proschel, U. (2000). Brainstem acoustic evoked potentials in children with developmental disabilities--a useful tool for differential diagnosis. Klinische Padiatrie., 212 (10), 16-21.
Liberman, M.C. (1988) Response properties of cochlear efferent neurons: Monaural vs. binaural stimulaiton and the effects of noise. Journal of Neurophysiology, 60, 1779-1798.
Maison, S., Micheyl, C., & Collet, L. (2001). Influence of focused auditory attention on cochlear activity in humans. Psychophysiology, 38(1), 35-40.
Maziade, M., Merette, C., & Cayer, M., et.al. (2000). Prolongation of brainstem auditory-evoked responses in autistic probands and their unaffected relatives. Archives of General Psychiatry, 57(11), 1077-1083.
McClelland, R.J., Eyre, D.G., Watson, D., Calvert, G.J., & Sherrard, E.(1992). Central conduction time in childhood autism. British Journal of Psychiatry. 160, 659-663.
Mills, D.M., & Rubel, E. W. (1996). Development of the cochlear amplifier. Journal of the Acoustical Society of America, 100, 428-441.
Moller, A. R., & Jannetta, P.J. (1982). Evoked potentials from the inferior colliculus in man. Electroencephalography and Clinical Neurophysiology, 53, 612-620.
Moore, J.K. (1987b). The human auditory brainstem as a generator of auditory evoked potentials. Hearing Research, 29, 33-43.
Moulin, A., Collet, L., & Duclaux, R. (1993). Contralateral auditory stimulation alters acoustic distortion products in humans. Hearing Research, 65, 193-210.
Mountain, D. C. (1980) Changes in endolymphaatic potential and crossed olivocochlear bundle stimulaiton alter cochlear mechanics. Science, 210 (3), 71-72.
Mulders, W. H., & Robertson, D. (2000). Effects on cochlear responses of activation of descending pathways from the inferior colliculus. Hearing Research, 149 (1-2), 11-23.
Musiek, F.E., Josey, A.F., & Glasscock, M.E., III. (1986a). Auditory brain-stem response : Interwave measurements in acoustic neuromas. Ear and Hearing, 10, 131-134.
Musiek, F.E., Josey, A.F., & Glasscock, M.E., III. (1986b). Auditory brain-stem response in patients with acoustic neuromas: Wave presence and absence. Archives of Otolaryngology Head and Neck Surgery, 112, 186-189.:
Ozdamar, O., Kraus, N., & Stein, L. (1983). Auditory brainstem responses in infants recovering from bacteral meningitis. Archives of Otolaryngology, 109, 13-18.
Rajan, R. (1988). Effect of electrical stimulaiton of the crossed olivocochlear bundle on temporary threshold shifts in auditory sensitivity. Journal of Neurophysiology, 60, 549-568.
Rasmussen, G.L. (1946). The olivary peduncle and other fiber projections of the superior olivary complex. Journal of Comparative Neurology, 84, 141-219.
Sahley, T.L., Nodar, R.H., & Musiek, F.E. (1997). Efferent auditory system: structure and function. (pp. 7-18). Singular Publishing Group, Inc.
Scharf, B., Magnan, J., & Chays, A. (1997). The role of the olivocochlear bundle in hearing: 16 case studies. Hearing Research, 103, 101-122.
Scherg, M., & von Cramon, D. (1985a). A new interpretation of the generators of BAEP waves I-V: Results of a spatio-temporal dipole models. Electroencephalography and Clinical Neurophysiology, 62, 290-299.
Sohmer, H., & Student, M. (1978). Auditory nerve and brainstem evoked responses in normal, autistic, minimal brain dysfunction and psychomotor retarded children. Electroencephalography and Clinical Neurophysiology, 44, 380-388.
Soliman, S., Mostafa, M., Kamal, N., Raafat, M., & Hazzaa, N. (1993). Auditory evoked potentials in epileptic patients. Ear & Hearing, 14 (4), 235-241.
Starr, A., Picton, T.W., Sininger, Y., Hood, L.J., & Berlin, C.I. (1996). Auditory neuropathy. Brain, 119, 741-753.
Starr, A., & Achor, L.J. (1975). Auditory brainstem responses in neurological disease. Archives of Neurology, 32, 761-768.
Starr, A., & Hamilton, A.E. (1976). Correlation between confirmed sites of neurological lesions and abnormalities of far-field auditory brainstem responses. Electroencephalography and Clinical Neurophysiology, 41, 595-608.
Stein, L., Tremblay, K., Pasternak, J., Banerjee, S., Lindermann, K., & Kraus, N. (1996). Brainstem abnormalities in neonates with normal otoacoustic emissions. Seminars in Hearing, 17, 197-213.
Tanguay, P., Edwards, R.M., Buchwald, J., Schwafel, J., & Allen, V. (1982). Auditory brain stem responses in autistic children. Archives of General Psychiatry, 39, 174-180.
Veuillet, E., Collet, L., & Duclaux, R. (1991). Effect of contralateral acoustic stimulation on active cochlear micromechanical properties in human subjects : Dependence on stimulus variables. Journal of Neurophysilogy, 65, 724-735.
Warr, W.B., & Guinan, J.J. (1978). Efferent innervation of the organ of Corti: two different systems. Brain Research, 173, 152-155.
Warr, W.B., Guinan, J.J., & White, J.S. (1986). Organization of the efferent fibers: The lateral and medial olivocochlear system. In R.A. Altschuler, R.P. Bobbin, D.W. Hoffman. (Eds.), Neurobiology of hearing: The cochlea (pp. 333-348). New York: Raven Press.
Warren, E.H., & Liberman, M.C. (1989). Effects of contralateral sound on auditory-nerve responses. I. Contributions of cochlear efferents. Hearing Research, 37, 89-104.
Wiederhold, M.L., & Kiang, N.Y.S. (1970). Effects of electric stimulation of the crossed olivocochleaar bundle on single auditory-nerve fivers in the cat. Journal of the Acoustical Society of America, 4(2), 950-965.
Williams, E. A., Brookes, G.B., & Prasher, D. K. (1993). Effects of contralateral acoustic stimulation on otoacoustic emissions following vestibular neurectomy. Scandinavian Audiology, 22, 197-203.
Zheng, X.Y., McFadden, S.L., Henderson, D., Ding, DL., & Burkard, R.(2000). Cochlear microphonics and otoacoustic emissions in chronically de-efferented chinchilla. Hearing Research, 143(1-2), 14-22.

QRCODE
 
 
 
 
 
                                                                                                                                                                                                                                                                                                                                                                                                               
第一頁 上一頁 下一頁 最後一頁 top