臺灣博碩士論文加值系統

日常生活中所喝的茶、咖啡中皆含有咖啡因，而此物對人體具有刺激性。傳統方法將咖啡因移除時亦會將香料移除，故物品會失去原有風味；此處我們利用分子拓印的方法，僅將咖啡因移除。
本研究首先針對塊狀聚合、懸浮聚合及溶膠凝膠法所製得之分子拓印高分子進行比較，其所得產物僅懸浮聚合是微珠；塊狀聚合所得產物為堅硬塊狀，欲使用需先經過磨碎及篩選的步驟，且所得顆粒形狀不規則；而溶膠凝膠法所得產物為多孔性塊狀結構，使用時亦需經過磨碎及篩選的步驟。另外在各別或混合之選擇性實驗中，懸浮聚合所得之產物皆有不錯之效果，且其吸附能力亦佳(每克高分子吸附0.397mmole咖啡因)，加上製程方面以懸浮聚合為最簡便，且其產物為球狀，故後續研究選擇懸浮聚合作更進一步探討。
在懸浮聚合系統中我們採用水為溶劑，並加入聚乙烯醇當穩定劑。由研究結果可發現在轉速為300rpm且Caffeine、MAA與EDMA之莫耳比為0.1：1：1.87時所得之微珠具有較高之吸附力與選擇性，而顆粒平均粒徑為70μm，系統中亦會加入氯仿當造孔劑，由產物之SEM相片可觀察到造孔劑所形成之孔洞；若將模版分子換成比咖啡因小的茶鹼或咖啡鹼進行拓印，則咖啡因會因體積較大而無法進入辨識位置，因而在選擇性測試時造成吸附咖啡因量降低；在拓印過程中模板分子與官能性單體間作用力的強弱亦很重要，故本研究選擇MMA、MAA與4-vinylpyridine三種官能性單體進行探討，結果發現鍵結強弱會直接影響到產物之吸附力與選擇性；本研究所合成之拓印高分子其熱穩定性亦不錯，可耐熱至250℃，真正應用時有一定之可靠度。

摘要-----------------------------------------------------I
總目錄--------------------------------------------------II
圖目錄--------------------------------------------------VI
表目錄------------------------------------------------ --X
第一章 緒論---------------------------------------------1
第二章 理論與文獻回顧----------------------------------3
2-1 拓印技術--------------------------------------------3
2-2 如何製備分子拓印的聚合物-----------------------------6
2-2-1 目標分子選擇 ---------------------------------------6
2-2-2 官能性單體-----------------------------------------7
2-2-3 交聯劑---------------------------------------------8
2-2-4 溶劑--------------------------------------------9
2-3 製備方法-------------------------------------------10
2-4 藥物與生化物質之分子識別（RECOGNITION）與鏡像選擇性（ENANTIOSELECTION）應用--------------------------------14
2-4-1 親和性分離（Affinity Separation）----------------14
2-4-2 擬生物感測器（Bio-mimetic sensors）與智慧型拓印聚合物
-------------------------------------------------16
2-5 食品工業之應用-------------------------------------19
2-5-1 膽固醇之移除-------------------------------------19
2-5-2 食品微生物學（microbiology）之應用---------------21
2-5-3 化學殘餘物質與污染物質之分析---------------------22
2-5-4 反應平衡轉移-------------------------------------23
2-5-5 副產物之移除（by-product removal）---------------24
2-6 分析化學上之應用-----------------------------------26
2-6-1 高效能液體層析儀（HPLC）-------------------------26
2-6-2 毛細管電泳與毛細管電層析-------------------------27
第三章 研究動機與目的---------------------------------29
第四章 實驗--------------------------------------------31
4-1 實驗藥品-------------------------------------------31
4-2 實驗儀器-------------------------------------------32
4-3 實驗流程及步驟-------------------------------------33
4-3-1 懸浮聚合-----------------------------------------34
4-3-2 塊狀聚合------------------------------------------36
4-3-3 Sol-gel-------------------------------------------37
4-4 性質測試-------------------------------------------38
4-4-1 TGA分析------------------------------------------38
4-4-2 DSC分析------------------------------------------38
4-4-3 SEM----------------------------------------------38
4-4-4 粒徑分析-----------------------------------------38
4-4-5 吸附測試-----------------------------------------38
4-4-6 選擇性測試---------------------------------------39
4-4-7 酸價---------------------------------------------40
4-4-8 表面積量測---------------------------------------41
第五章 結果與討論--------------------------------------42
5-1 懸浮聚合不同條件探討-------------------------------42
5-1-1 不同聚合方式之比較-------------------------------42
5-1-2 不同模板分子之影響-------------------------------45
5-1-3 咖啡因量之影響-----------------------------------47
5-1-4 攪拌速度之影響-----------------------------------49
5-1-5 不同官能性單體之影響-----------------------------51
5-1-6 官能性單體量所造成之影響-------------------------53
5-1-7 交聯劑量所造成之影響-----------------------------57
5-1-8 穩定劑量造成之影響-------------------------------60
5-2 吸附條件測試---------------------------------------61
5-3 顆粒結構-------------------------------------------64
5-4 TGA------------------------------------------------66
5-5 DSC------------------------------------------------69
第六章 結論-------------------------------------------70
第七章 參考文獻---------------------------------------72

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