臺灣博碩士論文加值系統

將野牡丹(Melastoma candidum)葉部乾燥粉碎後，以甲醇萃取，萃取液經各種色層分析方法分離，得到七種成分MCL-1~7，其中MCL-1~3為三類化合物，MCL-4為腦甘脂(cerebrosides)成分，MCL-5、6為植物固醇類之化合物，MCL-7為α-tocopherol之衍生物。MCL-7為第一次自天然界中分離得到。另由果實的甲醇萃取液經層析分離得到一種成分MCF-1，屬於黃酮類(flavonoid)化合物。其結構如下：
MCL-1：2α,3β-dihydroxyurs-12-en-28-oic acid
MCL-2：3β-hydroxyurs-12-en-28-oic acid，即ursolic acid
MCL-3：2α,3β,23-trihydroxyurs-12-en-28-oic acid
MCL-4：cerebrosides
MCL-5：β-sitosterol和campesterol為主之植物固醇混晶
MCL-6：β-sitosteryl-β-D-glucopyranoside和campesteryl-β-D- glucopyranoside為主之植物固醇配醣體混晶
MCL-7：5-formyl-7,8-dimethyltocol
MCF-1： Kaempferol 3-O-2,6-di-O-(trans-p-coumaroyl)- β-D-glucopyranoside

Seven compounds were isolated from the leaves and one was isolated from the fruits of Melastoma candidum. These eight compounds were identified as 2α, 3β-dihydroxyurs-12-en-28-oic acid (MCL-1), 3β-hydroxyurs-12-en-28-oic acid (MCL-2), 2α, 3β, 23-trihydroxyurs- 12-en-28-oic acid (MCL-3), cerebrosides (MCL-4), mixture of β-sitosterol and campesterol(MCL-5), mixture of β-sitosteryl-β-D- glucopyranoside and campesteryl- β-D-glucopyranoside(MCL-6), 5-formyl-7,8-dimethyltocol (MCL-7) and Kaempferol 3-O-2,6-di-O- (trans-p-coumaroyl)- β-D-glucopyranoside(MCF-1) by spectroscopic evidence.

目錄
摘要…………………………………………………………………………i
英文摘要……………………………………………………………………ii
目錄…………………………………………………………………………iv
壹、 緒言………………………………………………………………01
貳、 結果與討論………………………………………………………09
一、 成分之分離………………………………………………………09
二、 構造之決定………………………………………………………11
1、 MCL-1之構造決定………………………………………………11
2、 MCL-2之構造決定………………………………………………18
3、 MCL-3之構造決定………………………………………………22
4、 MCL-4之構造決定………………………………………………28
5、 MCL-5之構造決定………………………………………………35
6、 MCL-6之構造決定………………………………………………38
7、 MCL-7之構造決定………………………………………………40
8、 MCF-1之構造決定………………………………………………49
參、 結論………………………………………………………………55
肆、 實驗部分…………………………………………………………56
一、 儀器與藥品………………………………………………………56
二、 萃取與分離………………………………………………………58
三、 光譜資料…………………………………………………………60
伍、 參考文獻…………………………………………………………67

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