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研究生:吳佩毓
論文名稱:通草(Tetrapanaxpapyriferus)莖部(去髓)之成分研究
論文名稱(外文):Studies on the Constituents of the Heartwood(pith removed) of Tetrapanax papyriferus
指導教授:陳秋明陳秋明引用關係
學位類別:碩士
校院名稱:國立清華大學
系所名稱:化學系
學門:自然科學學門
學類:化學學類
論文種類:學術論文
論文出版年:2002
畢業學年度:90
語文別:中文
論文頁數:64
中文關鍵詞:通草苯基丙烷類香豆素木酚素新木酚素
外文關鍵詞:Tetrapanax papyriferusscopolectinscoporoneconiferualdehydepinoresinolbalanophonin
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摘要
將通草莖部( tetrapanax papyriferus)去髓並加以乾燥粉碎後,以甲醇萃取,萃取液經各種色層方法分離,得到七種成份Tpa-1~7,經光譜分析鑑定出Tpa-1~6,Tpa-7尚待進一步的鑑定,已鑑定之結構如下。
Tpa-1: scopeletin Tpa-2: scoporone
Tpa-3: coniferualdehyde Tpa-4: pinoresinol
Tpa-5: balanophonin Tpa-6: phytosterols

Abstract
Seven compounds were isolated from the dried and powered
stems (pith removed) of tetrapanax papyriferus (HOOK.) K. KOCH.
Six compounds were identified as: scopeletin(Tpa-1), scoporone(Tpa-2), coniferualdehyde(Tpa-3), pinoresinol(Tpa-4), balanophonin(Tpa-5) and phytosterols(Tpa-6).

目錄
壹、 緒論……………………………………………………………01
貳、 結果與討論……………………………………………………10
Tap-1的構造決定…………………………………………….13
Tap-2的構造決定…………………………………………….18
Tap-3的構造決定…………………………………………….22
Tap-4的構造決定…………………………………………….28
Tap-5的構造決定…………………………………………….34
Tap-6的構造決定…………………………………………….42
參、 結論……………………………………………………………55
肆、 實驗部份………………………………………………………56
伍、 參考文獻………………………………………………………63
Chart 2-1 通草莖部(去髓)之分離流程………………………………..12
Table 2-1 1H-NMR and 13C-NMR spectral data for Tpa-1 and scopoletin ………………………………………………….14
Table 2-2 1H-NMR and 13C-NMR spectral data for Tpa-2 and scoporone…………………………………………………..19
Table 2-3 1H-NMR and 13C-NMR spectral data for Tpa-3 and coniferualdehyde…………………………………………..23
Table 2-4 HMQC correlation of Tpa-4……………………………….28
Table 2-5 1H-NMR and 13C-NMR spectral data for Tpa-4 and pinoresinol…………………………………………………29
Table 2-6 HMQC data for Tpa-5(500MHz, CDCl3)………………….35
Table 2-7 1H-NMR and 13C-NMR spectral data for Tpa-5 and balanophonin………………………………………………36
Table 3-1 通草成份分佈比較………………………………………...55
Fig. 1-1 通草[Tetrapanax papyriferus (HOOK.) K. KOCH ]…...……….01
Fig. 2-1 通草莖部(去髓)所含成份之結構…………………………….11
Fig. 2-2 EI-MS spectrum of Tpa-1……………………………………..15
Fig. 2-3 IR spectrum of Tpa-1(KBr)……………………………………15
Fig. 2-3’ IR spectrum of scopoletin(NUJOL)…………………………..16
Fig. 2-4 1H-NMR spectrum of Tpa-1 (400MHz, CDCl3)………………16
Fig. 2-5 13C-NMR and DEPT spectrum of Tpa-1 (100MHz, CDCl3)….17
Fig. 2-6 IR spectrum of Tpa-2(KBr)……………………………………20
Fig. 2-6’ IR spectrum of scoporone(NUJOL)…………………………..20
Fig. 2-7 1H-NMR spectrum of Tpa-2 (400MHz, CDCl3)………………21
Fig. 2-8 13C-NMR and DEPT spectrum of Tpa-2 (100MHz, CDCl3)….21
Fig. 2-9 EI-MS spectrum of Tpa-3……………………………………..24
Fig. 2-10 IR spectrum of Tpa-3(Neat)……………………..…………...24
Fig. 2-11 1H-NMR spectrum of Tpa-3 (400MHz, CDCl3)……………..25
Fig. 2-12 1H-NMR spectrum of Tpa-3………………………………….25
Fig. 2-13 13C-NMR spectrum of Tpa-3 (100MHz, CDCl3)…………….26
Fig. 2-14 ESI-MS spectrum (negative) of Tpa-4……………………….30
Fig. 2-15 IR spectrum of Tpa-4(KBr)………………………………….30
Fig. 2-16 1H-NMR spectrum of Tpa-4 (400MHz, CDCl3).…………….31
Fig. 2-17 13C-NMR and DEPT spectrum of Tpa-4(100MHz, CDCl3)…31
Fig. 2-18 HMQC spectrum of Tpa-4 (500MHz, CDCl3)……………….32
Fig. 2-19 HMBC spectrum of Tpa-4 (500MHz, CDCl3)……………….32
Fig.2-20 NOESY correlation of Tpa-5 (H→H)……………………...…35
Fig. 2-21 EI-MS spectrum of Tpa-5……………………………………37
Fig. 2-22 IR spectrum of Tpa-5(KBr)………………………………….37
Fig. 2-23 1H-NMR spectrum of Tpa-5 (500MHz, CDCl3)……………..38
Fig. 2-24 13C-NMR and DEPT spectrum of Tpa-5(125MHz, CDCl3)…38
Fig. 2-25 HMQC spectrum of Tpa-5 (500MHz, CDCl3)……………….39
Fig. 2-26 HMBC spectrum of Tpa-5 (500MHz, CDCl3)……………….39
Fig. 2-27 NOESY spectrum of Tpa-5 (400MHz, CDCl3)…...…………40
Fig. 2-28 1H-1H COSY spectrum of Tpa-5(400MHz, CDCl3)...………..40
Fig. 2-29 Long-range correlations observed in HMBC spectrum of Tpa-5………………………………………………………....41
Fig. 2-30 EI-MS spectrum of Tpa-6……………………………………43
Fig. 2-31 IR spectrum of Tpa-6(KBr)………………………………….43
Fig. 2-32 1H-NMR spectrum of Tpa-6 (400MHz, CDCl3)…………….44
Fig. 2-33 13C-NMR and DEPT spectrum of Tpa-6(100MHz, CDCl3)…44
Fig. 2-36 IR spectrum of Tpa-7………………………………………...45
Fig. 2-37 1H-NMR spectrum of Tpa-7 (500MHz, CDCl3)…………….46
Fig. 2-38 13C-NMR spectrum of Tpa-7 (125MHz, CDCl3)…………….47
Fig. 2-39 DEPT spectrum of Tpa-7 (125Hz, CDCl3)…...…………...…48
Fig. 2-40 HMQC spectrum of Tpa-7 (500MHz, CDCl3)……………….49
Fig. 2-41 HMQC spectrum of Tpa-7 (500MHz, CDCl3)……………….50
Fig. 2-42 HMQC spectrum of Tpa-7 (500MHz, CDCl3)……………….51
Fig. 2-43 HMBC spectrum of Tpa-7 (500MHz, CDCl3)……………….52
Fig. 2-44 HMBC spectrum of Tpa-7 (500MHz, CDCl3)……………….53
Fig. 2-45 HMBC spectrum of Tpa-7 (500MHz, CDCl3)……………….54

伍、參考文獻
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