臺灣博碩士論文加值系統

由於近年來越來越多的三級結構結晶被解出來，因此我們需要一套有效率的，並且自動的工具來幫助我們找尋在三級結構中相似的區域性片段，也因此我們設計了一套LACOP軟體去偵測這些相似的區域性結構。
我們的結果同時也比較了數種目前常用比對結構的軟體以及依照結構來分類的資料庫。LACOP具備了兩個優點： 第一點，能夠快速的去搜尋整個PDB(Protein Data Bank)。第二點，LACOP能夠對於功能性區域結構(motif)進行比對。

Due to the rapid growth of 3D protein structures solved in recent years, it becomes increasingly important that we need an efficient, automated tool to search similar local 3D fragments embedded in the 3D conformation of proteins.
We designed the method of identification of the LocAl Conformations Of Proteins (LACOP) software to detect similar local sub-structure of proteins. Our result compared favorable software with fragment-search methods. There were two advantages in LACOP: First, it saved much time to scan whole PDB database. Second, it could compare motif structure.

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