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研究生:姚承義
研究生(外文):Yau, Chen-Yu
論文名稱:抗氧化劑增補對激烈運動及魚油引發之氧化壓力的影響
論文名稱(外文):The Effects of Antioxidant Supplementation on High-Intensity Exercise and Fish Oil-Induced Oxidative Stress
指導教授:謝伸裕謝伸裕引用關係
指導教授(外文):Hsieh, Sandy
學位類別:博士
校院名稱:國立臺灣師範大學
系所名稱:體育研究所
學門:教育學門
學類:專業科目教育學類
論文種類:學術論文
論文出版年:2002
畢業學年度:90
語文別:中文
論文頁數:119
中文關鍵詞:魚油自由基抗氧化劑氧化性傷害激烈運動
外文關鍵詞:fish oilantioxidantslipids peroxidationoxidative stresshigh-intensity exercise
相關次數:
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運動與魚油對生理具有相當的影響,特別是降低TG及LDL-血脂質的部份,於學界及臨床上已具共識,但魚油富含多元不飽和脂肪酸的特性及高強度運動容易造成細胞蒙受氧自由基攻擊,可能導致氧化壓力昇高;抗氧化劑對消除有害自由基有明顯效果。本研究主要目的1)探討服用魚油與單次激烈運動形成之氧化壓力的差異,且兩者是否具有加成性。2)瞭解抗氧化劑增補對魚油與運動引致氧化性壓力,是否有減輕消除的效果,俾使運動與魚油皆能充分發揮對健康的好處。研究以33位未曾接受過運動訓練之健康男性,依平衡次序分為8組:運動組、運魚組、運抗組、三合組、魚油組、抗氧組、魚抗組及控制組。研究者操控運動、魚油及抗氧化劑,分別以單純或同時介入之不同條件;運動者得接受2次近乎衰竭的間歇運動評估;魚油組與抗氧化劑組,每日服用魚油9公克、500mg維生素C及400IU維生素E錠片並持續四週。運動前後均抽血檢驗:包含TAA(total antioxidant ability)、SOD(superoxide dismutase)、t-GSH(total glutathione)、GSH-Px(glutathione peroxidase)、MDA(malondialdehyde)等濃度或活性、維生素C、E及血脂質濃度。所得資料採用廣義估計方程式(generalized estimating equations,GEE)分析各依變項間之差異顯著性。
四週實驗前後,八組受試者身體型態及組成沒有明顯差異。由於統計分析顯示運動、魚油及維生素三者不存在交互作用,故影響效應具有加成性。抗氧化方面:魚油組SOD活性較未服明顯多11.27 kU/g-HB(P <.05),魚抗組及三合組SOD之加成效益亦明顯較多(P <.05)足見魚油對SOD有顯著影響。運動、魚油及維生素三者對TAA、GSH-Px均不具影響力。抗氧化物質:魚油組與運魚組之t-GSH分別明顯多及36.61(34.2%)及37.03Ug/ml(P <.05)。除單純運動或魚油分別造成MDA明顯增加0.12及0.27 nmol/ml(P <.05)外,運魚組、魚抗組及三合組之MDA加成均明顯增加(P <.05)且以三合組的增幅42.9%最多。血脂質評估方面:魚油組之TG顯著減少8.85 mg/dl(P <.05),證明操控的魚油劑量確實已造成生理的顯著效果。
結論:單純一次衰竭性激烈運動及單純服用魚油四週後,造成相當程度的氧化壓力,致脂質過氧化壓力明顯昇高;且兩者同時介入具加成性;抗氧化系統亦隨之部份打調昇現象。單獨或併服抗氧化劑,對運動與魚油引致之氧化性壓力,不具有消除的效益,原因尚待進一步的研究釐清。
Exercise can improve performance, fitness, and metabolism, as well as modify body-fat ratio. But high-intensity exercise may also induce active oxygen species (AOS). Fish oil, which is one of the ω-3 PUFA series that can decrease TG and influence other plasma lipids, appears to prevent arteriosclerosis and CHD, but some evidence suggests it increases the lipid peroxidation in the cell membrane. Fish oil would then seem to influence the antioxidant defense system that causes injury or disease. This study investigates the effects on the antioxidant defence system of combining high-intensity exercise with fish oil supplementation.
Thirty-three healthy males were randomly assigned into eight groups (20.3±1.4 yrs; 64.3±7.9 kg), which were given set combinations of dietary fish oil (9 g per day), exercise (intensity 85-90 % HRmax reserve), anti-oxident supplementation (500 mg Vitamin C and 400 IU Vitamin E per day), and placebos. The experiment lasted 4 weeks in total. Venous samples were obtained prior to exercise and within 5 min after. 4 venous samples were also taken from fish oil groups during the four-week period. Blood from all groups was analyzed for sesuperoxide dismutase (SOD), glutathione peroxidase (GSH-Px), total glutathione (T-GSH), total antioxidant ability (TAA), malodialdehyde (MDA), vitamin C & E, TG, HDL-C, LDL-C from forearm vein. A Generalized Estimating Equations (GEE) method was used for data analysis. Result: in no group was there a significant change in the body weight and body composition of the subjects. In the fish oil groups SOD activity significantly increased 11.27 kU/g-HB(P<.05). Fish oil and vitamin C & E groups saw a decrease in GSH-Px levels, which did not appear in the exercise groups. However, statistical evidence is not sufficient to draw solid conclusions in this area. MDA change increased significantly after exercise in both exercise and dietary fish oil groups (values: 0.12 and 0.27 mmole/ml [P<.05] respectively). The evidence shows that the dosage of fish oil decreased the values of LDL-C and TG (-4.61 mg/dl and -8.85 mg/dl [P <.05] respectively). Exercise increased LDL-C levels (+2.27 mg/dl). Following exercise in the fish oil group, t-GSH increased significantly (36.61Ug/ml [34.2%] [P<.05]). MDA increased significantly after exercise in both exercise-alone and exercise/fish oil groups (+0.12 and +0.27 mmole/ml [P<.05] respectively). Height intensity exercise and fish oil is a real factor that induced more oxidative stress in this study. There is not sufficient evidence to support the claim that oxidative stress decreases after antioxidant supplementation, although there is some indication that this may be true. More research is required. The study concludes that exercise and fish oil separately causes an increase in oxidative stress, and this increase is greater when they are combined. It is also conclude that antioxidant supplementation has no effect on oxidative stress, although it is possible that a larger dosage may produce such an effect.
目 次
中文摘要………………………………………………………………………………………Ⅰ
英文摘要………………………………………………………………………………………Ⅱ
謝誌……………………………………………………………………………………………Ⅲ
目次……………………………………………………………………………………………Ⅳ
表次……………………………………………………………………………………………Ⅶ
圖次……………………………………………………………………………………………Ⅷ
附錄……………………………………………………………………………………………Ⅸ
第壹章 緒論……………………………………………………………………………1
一、 問題背景………………………………………………………………………1
二、 研究問題…………………………………………………………5
三、 研究目的…………………………………………………………5
四、 研究假設…………………………………………………………6
五、 研究範圍限制……………………………………………………6
六、 名詞操作性定義…………………………………………………6
七、 研究的重要性……………………………………………………10
第貳章 文獻探討…………………………………………………………………11
一、 自由基與氧化性傷害……………………………………………11
二、 單次衰竭運動與氧化性壓力……………………………………14
三、 魚油與氧化壓力……………………………………………………24
(一) 魚油簡介…………………………………………………………24
(二) 魚油與氧化壓力的關係………………………………………29
(三) 魚油與運動的關係……………………………………………32
四、 運動加魚油與抗氧化劑……………………………………………35
五、本章總結……………………………………………………………46
第參章 研究方法與步驟……………………………………………………………47
一、 先前研究…………………………………………………………47
二、 受試者……………………………………………………………49
三、 實驗設計與實驗變項……………………………………………49
四、 實驗時間及地點…………………………………………………50
五、 實驗方法與步驟…………………………………………………51
第肆章 結果……………………………………………………………………………55
一、 受試者實驗前後基本特質及血液生化分析比較…………………56
二、 抗氧化酵素分析……………………………………………………………58
三、 抗氧化物質分析…………………………………………………60
四、 氧化傷害評估……………………………………………………61
五、 血脂質分析………………………………………………………62
第伍章 討論與結論……………………………………………………………………65
一、 實驗前後受試者基本形態特質的變化…………………………65
二、 單次激烈運動對抗氧化功能的影響……………………………67
三、 魚油對抗氧化功能的影響………………………………………71
四、 魚油加運動對抗氧化功能的影響………………………………73
五、 抗氧化劑對消除氧化性壓力的效果……………………………75
六、 結論………………………………………………………………77
引用文獻……………………………………………………………………………………79
附錄………………………………………………………………………………………91
表 次
表一 單次激烈運動與抗氧化功能的相關研究摘要表…………………23
表二 先前研究受試者運動測驗生理值變化狀況表……………………49
表三 受試者之基本特質描述……………………………………………49
表四 各分組受試者實驗前後之基本特質比較表………………………56
表五 實驗操控條件下各分組血液生化分析統計表……………………57
表六 運動測驗生理值變化狀況表………………………………………58
表七 各組之TAA活性之廣義估計方程式分析結果摘要表……………58
表八 各組之SOD活性之廣義估計方程式分析結果摘要表……………59
表九 各組之GSH-Px活性之廣義估計方程式分析結果摘要表…………60
表十 各組之t-GSH活性之廣義估計方程式分析結果摘要表…………60
表十一 各組之MDA活性之廣義估計方程式分析結果摘要表……………61
表十二 組之TG濃度之廣義估計方程式分析結果摘要表…………………62
表十三 各組之HDL-C濃度之廣義估計方程式分析結果摘要表…………63
表十四 各組之LDL-C濃度之廣義估計方程式分析結果摘要表…………64
表十五 不同參數加成後之廣義估計方程式顯著性分析總表………………64
圖 次
圖一 紅血球內ROS的代謝………………………………………………14
圖二 AOS、維生素E及維生素C三者間關係示意圖……………………41
圖三 實驗操作流程………………………………………………………53
圖四 運動評估及操作流程………………………………………………53
附 錄
附錄一 受試者須知及同意書…………………………………………94
附錄二 受試者健康情況調查表………………………………………95
附錄三 本研究之生化物質分析評估…………………………………96
附錄四 本研究之運動評估設計………………………………………109附錄五 受試者服用魚油及實驗後健康及體能狀況調查……………110
附錄六 受試者服用魚油及實驗後健康及體能狀況調查結果………111
附錄七 受試者原始資料總表(一∼二)………………………………112
附錄八 台灣地區市售魚油之脂肪酸分析……………………………114
附錄九 本研究魚油和葵花油脂肪酸組成份一覽……………………115
附錄十 運動組運動評估記錄表(範例) ………………………………116
附錄十一 本研究使用魚油之日本分析試驗証明書……………………117
附錄十二 受試者血液檢驗記錄報告範例……………………………118 個人小傳………………………………………………………………119
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