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研究生:何仁育
研究生(外文):Jen-Yu Ho
論文名稱:密集運動訓練對健康B型肝炎帶原者T淋巴細胞的影響
論文名稱(外文):The Effects of Consecutive Training on T-lymphocyte in Healthy Hepatitis B Carriers
指導教授:方進隆方進隆引用關係曾哲明曾哲明引用關係
學位類別:碩士
校院名稱:國立臺灣師範大學
系所名稱:體育研究所
學門:教育學門
學類:專業科目教育學類
論文種類:學術論文
論文出版年:2002
畢業學年度:90
語文別:中文
論文頁數:51
中文關鍵詞:密集運動訓練B型肝炎T淋巴細胞
外文關鍵詞:Consecutive trainingHepatitis BT-lymphocyte
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調查發現台灣成人為B型肝炎帶原的比例頗高,而國內運動選手為B型肝炎帶原的比例也不少。運動選手常在重要比賽前,會有短期的密集運動訓練,是否因此而使B型肝炎帶原之選手的免疫功能產生負面的影響,目前尚無相關的研究。本研究之目的在探討連續五天密集運動訓練對健康B型肝炎帶原之選手T淋巴細胞的影響。本研究以16位志願之運動選手為研究對象,其中8位為健康B型肝炎帶原之選手(B肝組),8位為健康之選手(控制組),平均年齡為20.7±1.6歲;身高為177.1±5.1公分;體重為71±7.9公斤;最大攝氧量為52.7±5.4 ml/kg/min。兩組受試者皆在跑步機上,從事運動強度為75%VO2max,時間為30分鐘,連續五天的跑步運動,並於第一天運動前與第五天的運動前、運動後立刻、1.5、3及24小時,抽血分析受試者體內T淋巴細胞及其亞群(CD3+、CD4+CD8-、CD4-CD8+)的數目,以及T淋巴細胞增生的功能,並以混合設計二因子共變數分析處理。結果發現,B肝組和控制組在任何時間點上,血液中白血球、T淋巴細胞及其亞群數目,以及T淋巴細胞增生功能上皆沒有顯著差異。不過所有受試者,其白血球、T淋巴細胞及其亞群的數目在第五天運動後皆明顯增加(p<.05),但在運動後的1.5小時,T淋巴細胞、CD4+CD8-細胞及CD4-CD8+細胞的數目卻都降至第一天運動前水準之下(p<.05)。而CD4/CD8比值也在第五天運動後顯著降低(p<.05)。T淋巴細胞增生功能則在第五天運動後的1.5小時降到最低值(p<.05)。經由本實驗結果可得到以下的結論:健康B型肝炎帶原者在連續五天密集的運動訓練後,其體內的免疫反應並沒有異於常人,不過所有受試者在連續五天運動後1-3小時的恢復期,其體內的免疫功能皆會受到顯著的抑制。
The purpose of this study was to investigate the effects of five-day consecutive training on T-lymphocyte in healthy hepatitis B carriers. Sixteen athletes (age=20.7±1.6 yrs, ht=177.1±5.1 cm, wt=71±7.9 kg, VO2max=52.7±5.4 ml/kg/min) from different sport teams were recruited as the subjects. Eight of the subjects who were healthy hepatitis B carriers served as the experimental group (B group), and the other eight normal healthy subjects was the Control group. All subjects were asked to run on treadmill at 75%VO2max, 30 minutes per day for five consecutive days. The blood samples were collected on day one at pre-exercise, day five at pre-exercise, post-exercise, 1.5 hr, 3 hr and 24 hr post-exercise. The T-lymphocyte number, its subpopulations (CD3+,CD4+CD8-,CD4-CD8+), and T-lymphocyte proliferation were measured and analyzed by two-way ANCOVA mixed design. The results indicated that there was no significant difference between B group and Control group on T-lymphocyte number, its subpopulations, and T-lymphocyte proliferation at any time. But the numbers of leukocyte, lymphocyte, T cell, CD4+CD8- cells and CD4-CD8+cells in all subjects were significantly increased immediately after exercise on day five. Then, those parameters were dramatically decreased at 1.5 hr post-exercise, which were significantly lower than pre-exercise on day one. In addition, the CD4/CD8 ratio was significantly decreased immediately after exercise on day five. T-lymphocyte proliferation was significantly suppressed at 1.5 hr post-exercise on day five. In summary, the immunological response to five-day consecutive training in healthy hepatitis B carriers was not different from that of normal healthy people. However, all subjects were undergone immunological suppression around 1-3 hr of recovery period after the consecutive training.
目 次
中文摘要--------------------------------------------------------------------------Ⅰ
英文摘要------------------------------------------------------------------------------Ⅱ
目次--------------------------------------------------------------------------------Ⅲ
表次--------------------------------------------------------------------------------Ⅴ
附錄--------------------------------------------------------------------------------Ⅵ
圖次--------------------------------------------------------------------------------Ⅶ
第壹章 緒論
一、前言-----------------------------------------------------------------------------1
二、問題背景-----------------------------------------------------------------------1
三、研究目的-----------------------------------------------------------------------3
四、研究範圍與限制--------------------------------------------------------------3
五、研究重要性--------------------------------------------------------------------4
六、名詞操作性定義--------------------------------------------------------------4
第貳章 相關文獻探討
一、B型肝炎與免疫反應------------------------------------------------------------6
(一)慢性B型肝炎患者周邊血液T淋巴細胞組成變化之探討---------7
(二)慢性B型肝炎患者周邊血液淋巴細胞功能之體外測試-----------8
二、肝炎與運動------------------------------------------------------------------------8
三、T淋巴細胞及其亞群變化與運動--------------------------------------------9
(一)單次運動對T淋巴細胞及其亞群變化的影響---------------------10
(二)長期運動訓練對T淋巴細胞及其亞群變化的影響---------------11
四、淋巴細胞增生反應與運動---------------------------------------------------12
(一)單次運動對淋巴細胞增生反應的影響------------------------------13
(二)長期運動訓練對淋巴細胞增生反應的影響------------------------13
五、本章結語--------------------------------------------------------------------------14
第參章 研究方法與步驟
一、實驗設計---------------------------------------------------------------------16
二、運動測量步驟與運動訓練------------------------------------------------16
三、實驗控制---------------------------------------------------------------------18
四、血液處理與分析------------------------------------------------------------18
五、資料處理---------------------------------------------------------------------21
第肆章 結果
一、受試者基本資料------------------------------------------------------------22
二、白血球與T淋巴細胞及其亞群的數目變化----------------------------22
(一)白血球數目的變化------------------------------------------------------22
(二)淋巴細胞數目的變化---------------------------------------------------23
(三)T淋巴細胞及其亞群數目的變化------------------------------------25
(四)CD4/CD8比值的變化--------------------------------------------------28
三、T淋巴細胞的增生反應----------------------------------------------------29
第伍章 討論與結論
一、受試者------------------------------------------------------------------------31
二、白血球數目變化------------------------------------------------------------32
三、T淋巴細胞及其亞群數目的變化----------------------------------------33
四、T淋巴細胞增生功能的影響----------------------------------------------35
五、結論---------------------------------------------------------------------------36
引用文獻
一、中文部份---------------------------------------------------------------------38
二、英文部份---------------------------------------------------------------------38
附錄-------------------------------------------------------------------------------43
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