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研究生:楊勝文
論文名稱:可攜式智慧型腦波記錄器
論文名稱(外文):Portable EEG Recorder
指導教授:王正一王正一引用關係趙福杉
學位類別:碩士
校院名稱:國立臺灣大學
系所名稱:醫學工程學研究所
學門:工程學門
學類:綜合工程學類
論文種類:學術論文
論文出版年:2002
畢業學年度:90
語文別:中文
中文關鍵詞:可攜式腦波記錄器
外文關鍵詞:portableEEGrecorder
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為了提供醫師診斷癲癇之直接、客觀的資料,本文開發一個可攜式的腦波記錄器,可以將癲癇在發作時的腦波記錄下來。要達到可攜式的目的,記錄器的體積大小與省電特性是首要考量,於是我們使用一組低功率且體積小的腦波放大器與單晶片系統完成這個記錄器。除了離線可攜式的記錄模式外,本記錄器還有與電腦直接連線的工作模式,可以長時間監測腦波,在此模式下為了避免因漏電流而傷害到患者,所以在記錄器與電腦之間有電氣隔離之設計。
以此記錄器記錄1Hz的正弦波或將記錄的腦波與直接在示波器上顯示的波形進行比對,發現結果十分一致,因此證明此記錄器確實可正常運作。在±3V的供應電壓下,整組放大器電路的靜態電流約為90μA,而單晶片電路平常閒置時所消耗的電流約為2.1 mA,將資料寫入 flash memory的瞬間峰值電流會達到2.7 mA,但只有持續3.7 ms左右,實際上一組電池可以進行多次的EEG信號記錄,這個結果已符合省電的目標。
A portable EEG recorder was designed. This device can record
EEG signals when epilepsy happened, thus, providing the doctor direct and objective data for diagnosis. The size and power consumption of this device are the most important factors of all for the purpose of portability. We accomplish this aim with a low-power yet compact amplifier and a microcontroller system. In addition to the off-line mode of operation, this recorder can be on-line operated with a PC for long-time monitoring of EEG signals. An isolation circuit is then necessary in the on-line mode of operation to prevent hazards of patients caused by the leakage currents.
For test, an 1Hz sine wave is recorded or the acquired EEG signals were compared with those displayed on the oscilloscope. It is found that
there are no significant errors between the data sampled by the EEG recorder and those on the oscilloscope. Hence, it is concluded that this device can function properly. The total static current of the designed amplifier is only 90μA under the supply voltage of ±3V. The static current of the microcontroller is about 2.1 mA in idle mode; whereas it become 2.7 mA during the period (about 3.7 ms) of writing data into the flash memory. Practically, many times of EEG recording can be performed without the need to change batteries.Thus, the low-power aim has been achieved.
圖表目錄………………………………………………………………Ⅱ
中文摘要………………………………………………………………Ⅲ
英文摘要………………………………………………………………Ⅳ
第一章 簡介……………………………………………………..1~10
1-1. 腦波……………………………………………………1
1-2. 癲癇……………………………………………………4
1-3. 研究動機………………………………………………5
第二章 電路設計………………………………………………11~23
2-1. 儀表放大器…………………………………………..12
2-2. 積分器回授電路……………………………………..14
2-3. 濾波器及後端保護電路……………………………..15
2-4. 離線記錄功能………………………………………..16
2-5. 連線記錄功能………………………………………..17
2-6. 單晶片韌體程式……………………………………..18
第三章 結果……………………………………………………24~34
3-1. 正弦波之記錄測試…………………………………..25
3-2. 示波器上信號與記億體內資料的比對……………..25
3-3. 離線記錄……………………………………………..26
3-4. 連線監測……………………………………………..26
3-5. 正常腦波記錄之範例………………………………..27
3-6. 硬體規格……………………………………………..27
第四章 討論……………………………………………………35~36
參考文獻……………………………………………………………....37
H. H. Jasper, “Report of the Committee on Method of Clinical Examination in Electroencephalography,” Electroencephalography and Clinical Neurophysiology, Vol. 10, pp. 370, 1958.
2. A. C. Guyton, “Textbook of Medical Phyiology,” 7th ed., ch. 55, 1985.
3. GA. Worrell, EL. So, J. Kazemi, TJ. O''Brien, RK. Mosewich, GD. Cascino, FB. Meyer and WR. Marsh, “Focal ictal beta discharge on scalp EEG predicts excellent outcome of frontal lobe epilepsy surgery,” Epilepsia. 43(3): 277-82, 2002.
4. M. Grunwald, F. Busse, A. Hensel, S. Riedel-Heller, F. Kruggel, T. Arendt, H. Wolf and HJ. Gertz, “Theta-power differences in patients with mild cognitive impairment under rest condition and during haptic tasks,” Alzheimer Disease & Associated Disorders. 16(1): 40-8, 2002.
5. ME. Hasselmo, C. Bodelon and BP. Wyble, “A proposed function for hippocampal theta rhythm: separate phases of encoding and retrieval enhance reversal of prior learning,” Neural Computation,14(4): 793-817, 2002.
6. JP. Gambini, RA. Velluti and M.Pedemonte, “Hippocampal theta rhythm synchronizes visual neurons in sleep and waking.” Brain Research, 926(1-2): 137-41, 2002.
7. F. Nishihara and S. Saito, “ Pre-ictal bispectral index has a positive correlation with seizure duration during electroconvulsive therapy,” Anesthesia & Analgesia, 94(5): 1249-52, 2002.
8. N. Bednarek, “Video-EEG monitoring in neonates: indications,” Epileptic Disorders, 3 Spec No 2: SI21-4, French, 2001.
9. J. G. Webster, “Medical Instrumentation,” John Wiley & Sons, New York, 1998.
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