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研究生:黃美智
研究生(外文):Mei-Chich Huang
論文名稱:血清瘦體素濃度對減重成效的影響
論文名稱(外文):Effects of serum leptin concentrations on effectiveness of weight loss
指導教授:簡怡雯簡怡雯引用關係
指導教授(外文):Yi-Wen Chien
學位類別:碩士
校院名稱:臺北醫學大學
系所名稱:保健營養學系
學門:醫藥衛生學門
學類:營養學類
論文種類:學術論文
論文出版年:2003
畢業學年度:91
語文別:中文
論文頁數:90
中文關鍵詞:肥胖基礎瘦體素濃度體重減輕低熱量飲食體重回復
外文關鍵詞:obesitybaseline leptin concentrationweight losslow caloric dietweight regain
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本研究的目的主要是探討血清瘦體素濃度與減重成效的相關性和復胖的關係。受試者分為兩組,減重組 (27<BMI<35)和控制組(18.5≦BMI<24)。減重組提供8週低熱量飲食 (1200大卡/天:醣類:55 %,脂肪:20 %,蛋白質:25 %),實驗結束後3個月,追蹤其體組成和血液生化值的改變。控制組 (n=18; 女性16位、男性2位) 平均年齡25 ± 0.8歲、身體質量指數20.2 ± 0.3公斤/公尺2以及體脂肪百分比為24.7 ± 1.3 %。減重組(n=18;女性14位、男性4位)平均年齡39 ± 1.7歲、身體質量指數28.2 ± 3.3公斤/公尺2以及體脂肪百分比為33.1 ± 1.5 %。減重組年齡、體重、身體質量指數、除脂體重、脂肪重、肌肉重、體脂肪百分比、腰臀比、血糖、總膽固醇、三酸甘油酯、低密度脂蛋白膽固醇濃度、總膽固醇/高密度脂蛋白膽固醇比值、瘦體素以及胰島素濃度均顯著大於控制組,高密度脂蛋白膽固醇濃度顯著低於控制組。減重4週和8週後,體重、脂肪重、肌肉重、身體質量指數、身體總水重、蛋白質重、基礎代謝速率、體脂肪百分比、瘦體素以及胰島素濃度均顯著的降低,但減重8週後,腰臀比均顯著的降低。追蹤三個月後,體重、脂肪重、身體質量指數、腰臀比、瘦體素以及促甲狀腺素濃度均顯著的增加。在血清瘦體素濃度與體重變化的相關性方面,4週和8週後體重變化均與基礎血清瘦體素濃度和基礎血清瘦體素濃度/身體質量指數呈顯著的正相關;追蹤三個月體重與基礎血清瘦體素濃度和基礎血清瘦體素濃度/身體質量指數無相關性。因此,減重期間,肥胖者基礎血清瘦體素濃度越高,可以減輕較多的體重,且基礎血清瘦體素濃度可以預測減重的成效,但是基礎血清瘦體素濃度不能預測體重的回復。
The purpose of this study was to assess the correlation serum leptin concentration with effectiveness of weight loss. The study was divided into two groups, one was weight loss group and another was control group. In the weight loss group, we were provided with 1200 Kcal/day (CHO: 55 %, FAT: 20 %, PRO: 25 %) for 8 weeks. After three months, we followed body composition and biochemical measurements changes. In the control group, subjects (n = 18, male = 2, female = 16) aged 25 ± 0.8 yrs, body mass index was 20.2 ± 0.3 kg/m2, body fat mass percentage was 24.7 ± 1.3 %. In the weight loss group, subjects (n = 18, male = 4, female = 14) aged 39 ± 1.7 yrs, body mass index was 28.2 ± 3.3 kg/m2, body fat mass percentage was 33.1 ± 1.5 %. The weight loss group which age, weight, BMI, fat free mass, muscle mass, body fat mass percentage, waist-hip ratio, blood sugar, total cholesterol, triacylglyceride, LDL-C and TC/HDL-C were significantly higher than control group (p < 0.05). After 4 and 8 weeks weight loss program, weight, fat mass, muscle mass, BMI, total body water, protein weight, basal metabolic rate, body fat percentage, serum leptin and insulin concentration significantly decreased (p < 0.05). But after 8 weeks weight loss program, waist-hip ratio significantly decreased (p < 0.05). After 3 months follow-up, weight, fat mass, BMI, waist-hip ratio, serum leptin and TSH concentration increased significantly (p < 0.05). The 4 and 8 weeks weight changes significantly positive correlated with baseline leptin concentration and baseline leptin/BMI, but the 3 months follow-up weight changes no significantly correlated with baseline leptin concentration and baseline leptin/BMI. Therefore, during weight loss program, subjects who lose more weight have higher baseline leptin concentration and baseline leptin concentration predicted subsequently weight loss. But baseline leptin concentration failed to predicted weight regain.
摘 要 I
英文摘要 II
致 謝 III
目 錄 IV
表 目 錄 VI
圖 目 錄 VII
附錄目錄 VIII
第一章 緒論 1
第一節 研究動機 1
第二節 研究目的 3
第二章 文獻回顧 4
第一節 肥胖的成因 4
第二節 Ob基因和瘦體素 6
第三節 胰島素 9
第四節 瘦體素調節食慾和食物攝取的作用 11
第五節 瘦體素和胰島素調節體內能量平衡的機制 13
第六節 調節瘦體素的分泌 16
第七節 瘦體素和人類肥胖的關係 18
第三章 材料與方法 20
第一節 研究執行流程圖與實驗設計 20
第二節 研究對象 21
第三節 飲食介入 22
第四節 研究工具 23
第五節 研究項目 23
第六節 統計方法: 33
第四章 結果 34
第一節 減重組和控制組資料分析 34
第二節 減重組減重前後以及追蹤三個月之比較 37
第三節 瘦體素與各變異數之間的相關性 40
第四節 膳食調查 42
第五章 討論 44
第一節 減重對體位測量值影響之探討 44
第二節 受試者血液生化值之探討 47
第三節 受試者血清瘦體素和胰島素濃度之探討 49
第四節 受試者血清甲狀腺素濃度之探討 51
第五節 血清瘦體素濃度與減重成效的相關性 53
第六章 結論 55
第七章 參考文獻 56
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