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研究生:花志鋒
研究生(外文):Jr-Feng Hua
論文名稱:肺孢子蟲肺炎與肺結核在慢性咳嗽病人中的相關性
論文名稱(外文):Study of correlation between Pneumocystis carinii pneumonia and pulmonary tuberculosis in patients with chronic cough
指導教授:鍾文政鍾文政引用關係
指導教授(外文):Wen-Cheng Chung
學位類別:碩士
校院名稱:臺北醫學大學
系所名稱:醫學研究所
學門:醫藥衛生學門
學類:醫學學類
論文種類:學術論文
論文出版年:2003
畢業學年度:91
語文別:中文
論文頁數:51
中文關鍵詞:免疫缺陷傑母沙染色法肺孢子蟲雙重感染
外文關鍵詞:immunodeficiencyGiemsa stainPneumocystis cariniidual infection
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肺孢子蟲肺炎好發於免疫缺陷(immunodeficiency)病人,於一般健康病人當中並不多見,但鑒於有研究曾經指出肺孢子蟲肺炎有偽裝成肺結核的臨床症狀出現,及共同感染肺孢子蟲與肺結核的情形,加上國內曾對學齡前兒童普檢肺孢子蟲血清抗體,其血清流行率高達56.6%,是促成本次對於慢性咳嗽病人篩檢肺孢子蟲感染的最大因素。
自2001年5月至2001年8月間陸續在台北市慢性病防治院以隨機方式採集206支慢性咳嗽病人痰液檢體,以傑母沙染色法(Giemsa stain)進行肺孢子蟲(Pneumocystis carinii)鏡檢,陽性或疑似之檢體利用照相機拍照進行二次確認,206支作業完成之檢體中42支呈現肺孢子蟲陽性反應,總體陽性率為20.39%;肺結核菌的培養則屬台北市慢性病防治院的業務範圍,在經由兩個月的培養之後,203支檢體中13支培養出肺結核菌,總體陽性率為6.40%;經由交叉比對之後,有2支檢體呈現雙重感染(dual infection)的現象。
經由這次的調查顯示,在這些懷疑為肺結核的慢性咳嗽病人中,事實上有高達19.42%(40/206)的病人是單一感染肺孢子蟲,比5.42% (11/203)的病人單一感染肺結核高出許多,由於肺孢子蟲肺炎與肺結核同樣是肺部疾病,臨床症狀極易混淆,容易造成誤診,所以本篇研究建議醫院檢驗部門或醫師在民眾因疑似肺結核就診時,除了做有關肺結核菌的檢查或培養之外,肺孢子蟲的鏡檢也是需要納入考量的。

Pneumocystis carinii pneumonia (PCP) prefers to occur in patients with immunodeficiency than normal ones. Recent studies pointed out that PCP might masquerade pulmonary tuberculosis and PCP and pulmonary tuberculosis might dual infect in lung. In addition, the seroprevalence of P. carinii infection among preschool children in central Taiwan was up to 56.6%. These all pushed us to make this study of investigating the PCP infection among the patients with chronic cough.
Since May to August 2001, we had collected 206 random specimens of sputum successively from Taipei Municipal Hospital for Chronic Diseases. By means of Giemsa staining for first confirming P. carinii cysts by microscopy, doubly confirmed by photo picturing, 42 of 206(20.39%) specimens presented positive results. TB culturing in Taipei Municipal Hospital for Chronic Diseases for two months, 13 of 203(6.40%) specimens presented positive results for Mycobacterium tuberculosis. After cross-matching, 2 specimens presented dual infection for PCP and TB.
This investigation revealed that among these patients with chronic cough suspected as TB infection, actually 19.42% (40/206) patients were single infected with PCP, much higher than 5.42% (11/203) patients single infected with TB. Because PCP and TB are both diseases in lung and their clinical symptoms are so similar to be miss-diagnosed, we suggest that in addition to TB culture, the Giemsa staining of sputum for
P. carinii is recommended when people see a doctor for chronic cough.

致謝 ---------------------------------------------------- I
中文摘要 ------------------------------------------------- III
英文摘要 ------------------------------------------------- V
目錄 ---------------------------------------------------- VII
圖表目次 ------------------------------------------------- 27
第一章 緒論 --------------------------------------------- 1
第二章 文獻查證 ----------------------------------------- 6
第三章 研究材料與方法 ------------------------------------ 10
第四章 分析與結果 --------------------------------------- 14
第五章 討論 --------------------------------------------- 16
第六章 結論與建議 --------------------------------------- 20
參考資料 ------------------------------------------------- 21

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