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研究生:李奇翰
論文名稱:幾丁聚醣研製易剝離三層創傷敷料之研究
論文名稱(外文):Immobilized chitosan onto the surface of PP Nonwoven/ PNIPAAm composite to fabricate tri-layer easily stripped off wound dressing
指導教授:陳克紹陳克紹引用關係
學位類別:碩士
校院名稱:大同大學
系所名稱:材料工程研究所
學門:工程學門
學類:材料工程學類
論文種類:學術論文
論文出版年:2003
畢業學年度:91
語文別:中文
中文關鍵詞:電漿改質聚丙烯不織布幾丁聚醣接枝聚合創傷敷料
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幾丁聚醣(chitosan)具有生解性、抗菌性及良好的生物親和性,且在溶解狀態下帶正電,對身體具有親和性,易於被吸收,並滲透到所有細胞,增加細胞活性,因而大大的提高自然治癒力。若直接將幾丁聚醣製成不織布敷料,其強度並不理想,故本研究改以複合化,將幾丁聚醣固定於聚丙烯不織布表面以期能製成暫時性創傷敷料。聚丙烯不織布材料具有多孔性、無塵性、高透氣性、表面積大、易加工、可供表面機能化改質等特性,極適合應用於醫療器材方面,但是聚丙烯不織布為疏水性高分子,與幾丁聚醣之間的附著性差,因此必須先將不織布經電漿處理,使其表面活性化,含有氧化物或過氧化物的極性基,而變成親水性,但是電漿處理的效果會變差,所以繼續將不織布與PNIPAAm進行接枝聚合反應,形成一層與不織布有很好附著性的水膠。PNIPAAm水膠為一種感溫可逆親疏水性高分子,其最低臨界溫度(LCST)約為32℃,在32℃以下其為親水性,吸水後膨潤,而高於32℃時則有去膨潤現象。接著可利用交聯劑(戊二醛)將幾丁聚醣固定於不織布上,使其具備生醫特性,利用PNIPAAm的感溫特性,研製成感溫性易剝離創傷敷料。

Abstract
Contents
List of Figures
List of Tables
Chapter I
Hydrophilic Surface Modification of Polypropylene Nonwoven by Duplex Techniques of Plasma Treatment and Graft Polymerization
1. Introduction
2. Literature Review
2-1 Plasma chemical
2-2 Plasma surface modification
2-3 Plasma treatments
2.4 Plasma polymerization
2.5 Graft polymerization
3. Experimental
3-1 Materials
3-2 Plasma treatment
3-3 Photo-induced graft copolymerization
3.4 Wettability evaluated
3-5 Characterization
4. Results and Discussion
4.1 Surface hydrophility
4.2 Chemical structure of mofified PP nonwoven
4.3 Morphological observation
5. Conclusions
6. References
Chapter II
Immobilized Chitosan onto the Surface of PP Nonwoven/ PNIPAAm Hydrogel Composite to Fabricate Tri-layer Wound Dressing
1. Introduction
2. Literature Review
2.1 Chitosan — as a biomaterial
2.1.1 Chitin
2.1.2 Chitosan
2.1.3 Chitosan as biomedical membranes
2.1.4 Role of chitosan in drug cell targeting
2.1.5 Role of chitosan in drug delivery systems
2.1.6 Chitosan as an artificial skin
2.2 PNIPAAm-- Thermal-sensitive polymer
3. Experimental
3.1 Materials
3.2 Plasma treatment
3.3 Photo-induced graft copolymerization
3.4 Preparation of chitosan hydrogel
3.5 Preparaing of chitosan sponge
3.6 Characterization
3.7 Cell culture
3.8 MTT assay
3.9 Assay for antibacterial activity
4. Results and Discussion
4.1 Graft PNIPAAm onto PP nonwoven
4.2 Cross-link of chitosan hydrogel
4.3 FTIR analysis
4.4 Morphological observation
4.5 Cell proliferation
4.6 Antibacterial activity
5. Conclusions
6. References

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[2] 陳克紹, Tsuji O, 筏義人, 中華民國第十五屆高分子研討會論文專集, 1992; 945.
[3] Inagaki N. “Plasma surface modification and plasma polymerization.” Technomic Publishing, 1996.
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[5] 林順富, 潘俊安, 王明城, 陳克紹. “不織布材料表面改質及醫療應用.” 中華醫學工程學刊, 1993; 13:219-226.
[6] Chen KS, Yang MR, Chiou SK. “Modification of Wet Lublicativityof Polymers by Surface Graft Copolymerization.” Chinese J Medical & Biol Eng, 1994; 14:255-268.
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[9] Purna SK, Babu M. “Collagen based dressings─a review.” Burns, 2000; 26:54-62
[10] Winter GD. “Formation of the scab and the rate of epithelialization of superficial wounds in the skin of the young domestic pig.” Nature, 1962; 193:293-294.
[11] Chandy T, Sharma CP. “Chitosan as a biomaterial.” Biomater Artif Cells, Artif Org, 1990; 18:1-24.
[12] Muzzarelli RAA. “Biochemical significane of exogenous chitins and chitosan in animals and patients.” Carbohydr Polym, 1993; 20:7-16.
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[15] Radhankrishnan VV, Vijayan MS, Sambasivan M, Jamaluddin M, Rao SB. “Haemostatic Potential of chitosan.” Biomedicine, 1991; 2:3-6.
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