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研究生:鄭惠裕
研究生(外文):Hui-yu Cheng
論文名稱:多環芳香烴物質模擬口腔吸附特徵之研究
論文名稱(外文):The Study of Adsorption Characteristics of Polycyclic Aromatic Hydrocarbons in mock Human Oral
指導教授:李經民李經民引用關係
指導教授(外文):James J. Lee
學位類別:碩士
校院名稱:國立雲林科技大學
系所名稱:環境與安全工程系碩士班
學門:工程學門
學類:環境工程學類
論文種類:學術論文
論文出版年:2003
畢業學年度:91
語文別:中文
論文頁數:96
中文關鍵詞:PAHs口腔癌口腔傳輸粒子沉降吸菸
外文關鍵詞:PAHs、oral cancer、transfer characteristics of t
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近年來台灣地區口腔癌占男性十大癌症死因第5位,其成長率高居國人惡性腫瘤第二位(僅次於女性肺癌);相關流行病學研究顯示單獨嚼食檳榔或吸菸者罹患口腔癌機率為正常人28或12倍,若同時嚼食檳榔和吸菸則提昇至89倍,顯現吸菸對於口腔癌病變具有明顯致癌加成效果。 相關毒理研究顯示檳榔於口腔中有氧自由基產生,煙流中 PAHs(Polycyclic Aromatic Hydrocarbons, 多環芳香烴)是健康危害主要成份之一(如 BaP 化合物經由 cytochrome P450單氧化形成致癌前驅物質)。 目前國際相關人體呼吸傳輸研究甚多,但多數僅探討氣膠粒子於鼻咽管、口腔、及肺部沉降特性,有關微粒中有機危害物質(如 PAHs)對呼吸與口腔系統之危害特性則缺乏討論。 本研究首次藉由模擬煙流探討 PAHs 危害物質於口腔沉積吸附特性,及相關呼吸傳輸係數(kc, respiratory mass transfer coefficient)與對流質傳係數(Sh, Sherwood number)以解析煙流中 PAHs 危害物質對人體口腔系統影響。 實驗結果顯示,PAHs 化合物於口腔煙流中濃度較呼吸煙流為高;ΣPAHs 吸附量隨著呼吸煙流與口腔煙流表面速度(20→60 cm/sec)增大而降低,在相同煙流表面速度下,以多環 PAHs(Ⅲ、Ⅳ類)吸附濃度最高。 口腔煙流中 PAHs 沉降速度隨煙流表面速度增大其沉降速度明顯提昇,其中第Ⅳ類多環 PAHs 最為明顯,顯現其對口腔細胞可能變異潛勢相對增大。 呼吸煙流與口腔煙流之質傳係數(kc)方面,顯示隨煙流表面速度增加,兩種煙流kc 值均增大,可能是增加煙流表面速度可提昇流動的強度和分佈,降低邊界層厚度,造成kc 值昇高。 口腔煙流中Sh值隨煙流表面速度增加( 20→60 cm/sec ),III、IV類 PAHs 之Sh增加幅度較I、II類 PAHs 顯著。 因此,本研究初步結果顯示III、IV類 PAHs 於口腔中較易沉降,會增加口腔細胞變異之可能性。
Airborne polycyclic aromatic hydrocarbons (PAHs) are mainly caused by imcomplete combustion of smoking. Parts of PAHs are mutagenic and caricinogenic matters. Recent toxicology studies have shown that chew betel nut may produce oxygen free radical in oral, and the BaP compound may become mutagenic by way of cytochrome P450. Many researches about respiratory transfer in humn, but ther only discussed about aerosol particals, nasopharynx, oral and lung precipitation. Fewly studies about organic microparticals (ex: PAHs) is danger for respiratory and oral system. In our experiment, we want to study these PAHs is relativity about oral cencer, We use the respiratory mass transfer coefficient (kc) and the local nondimensionalized transfer coefficient (Sherwood number, Sh) to explain the interation between PAHs and human oral system.
The result of experiment, the PAHs compound’s concentrative of smoking fluent of oral is more than respiration fluent. The absortion of ΣPAHs decreased by dependent on increasing suface velocity of smoking in oral and respiration. The absortion of Ⅲ/Ⅳ PAHs concentration is the highest than other compound. The PAHs deposition in oral somoking is increasing by dependent on surface veloctty, especially the subclass Ⅳ PAHs. It shows the compound of Ⅳ PAHs may be relativity about the variance of oral cells. The respiratory mass transfer coefficient (kc) of smoking in respiration and oral is all increasing by dependent on increasing surface velocity. The local nondimensionalized transfer coefficient, Sherwood number (Sh)is increasing by dependent on increasing surface rate of smoking rate. The increaning values of subclass Ⅲ/Ⅳ PAHs is more obvious than subclass Ⅰ/Ⅱ PAHs. In our study, the subclass Ⅲ/Ⅳ PAHs is easy precipitated in oral. These compounds may increase variance of oral cells.
第一章 緒論………………………..…………………………. 1
第二章 文獻回顧…………………………..…………………. 4
2-1 菸之危害…………………………………..…………. 4
2-1-1 菸之煙流特性………………………………………… 4
2-1-2 吸菸對人體健康影響………………………………… 6
2-1-3 吸菸與肺癌的關係…………………………………… 6
2-1-4 吸菸與口腔癌的關係………………………………… 7
2-1-5 菸內致癌物Benzo(a)pyrene(BaP)與肺癌、口腔癌關係………………………………………………..….. 8
2-2 醋酸纖維濾嘴性質…………………………………… 9
2-2-1 醋酸纖維素之成分…………………………………… 9
2-2-2 醋酸纖維素之性質…………………………………… 10
2-3 氣懸微粒過濾機制…………………………………… 10
2-3-1 過濾機制……………………………………………… 10
2-3-2 濾材之壓降(空氣阻抗)……………………………… 13
2-3-3 過濾品質(Filter Quality)…………………………… 13
2-3-4 濾材基本資料的推算………………………………… 14
2-4 多環芳香烴化合物(PAHs)………………………… 15
2-4-1 PAHs形成機制……………………………………….. 15
2-4-2 PAHs之特性………………………………………….. 17
2-4-3 PAHs在人體內之轉換……………………………….. 18
2-5 質傳特性之計算………………………...…….……… 19
第三章 實驗設備及研究方法………………..……………….. 30
3.1 實驗參數設定………………………………..……….. 30
3-2 採樣介質製備………………………………………… 31
3-2-1 吸附介質……………………………………………… 31
3-2-2 吸附管………………………………………………… 32
3-2-3 口腔吸附劑coating步驟…………………..…………. 32
3-3 模擬吸菸煙流人體暴露實驗裝置…………………… 33
3-4 樣品分析方法與QA/QC……………………………... 34
第四章 結果與討論…………………………………………… 43
4-1 實驗結果……………………………………………… 43
4-1-1 實驗設計……………………………………………… 43
4-1-2 呼吸煙流與口腔煙流PAHs化合物之濃度分佈……. 44
4-1-3 四類PAHs 化合物之乾沉降通量與乾沉降速度分佈 45
4-1-4 呼吸與口腔煙流之質傳係數(kc)與對流擴散(Sh). 46
4-2 討論………………………………………………….... 47
4-2-1 實驗設計之討論……………………………………… 47
4-2-2 比較呼吸煙流與口腔煙流中PAHs化合物之分佈特徵……………………………………………………… 48
4-2-3 四類PAHs 化合物之乾沉降通量與乾沉降速度分佈影響………………………………………………..….. 51
4-2-4 解析呼吸與口腔煙流之質傳係數(kc)與對流擴散(Sh)…………………………………………………. 52
第五章 結論與建議…………………………………………… 84
5-1 結論………………………………………………….... 83
5-2 建議………………………………………………..….. 84
參考文獻 ……………………………………..………………….. 86
附錄一 16種PAHs化合物於三種不同呼吸煙流表面速度(20、40、60 cm/sec)之各段原始濃度(ng/cm3) 94
附錄二 16種PAHs化合物於三種不同口腔煙流表面速度(20、40、60 cm/sec)之各段原始濃度(ng/cm3) 95
自傳 96
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