臺灣博碩士論文加值系統

本研究選用塊狀聚合法製備拓印高分子(MIP)，與超臨界二氧化碳製備法比較之外，並與常用吸附劑活性碳比較吸附性和選擇性，選用的模板分子、官能性單體、交聯劑、起始劑及溶劑分別為咖啡因、甲基丙烯酸(MAA)、 乙二醇二甲醛丙酸(EGDMA)、2,2-偶氮雙異丁腈(AIBN)及氫甲烷，在萃取咖啡因的方法中，除了傳統萃取法為利用甲醇溶劑萃取外，並與超臨界二氧化碳萃取法比較。
實驗結果為超臨界聚合製備的粒子小且均勻，由洩壓後直接形成，不需經過乾燥便可直接使用，且降低有機溶劑的用量，在萃取方面，利用超臨界二氧化碳萃取的萃取時間較短且不需使用有機溶劑，在吸附效果方面:活性碳>超臨界聚合>傳統聚合，選擇性分析則選用茶鹼與咖啡因進行實驗，效果為:超臨界聚合>傳統聚合>活性碳，超臨界二氧化碳聚合的選擇性，在高溫下的效果較好，且提高的程度比傳統聚合明顯。

The molecular imprinted polymers(MIPs) are made by block polymerization at this study and we choose methacrylic acid、ethylene glycol dimethacrylate、azobis-isobutyronitrile、caffeine and acetonitrile as functional group、crosslinker、initiator、template and solvent respectively .Except traditional polymerization method ,we also use supercritical polymerization process to produce MIP and compare both methods by adsorption quality and selectivity .In selective test, theophylline is chosen to compete with caffeine.
The result of adsorption ability is: active carbon>supercritical polymerized’s particles>traditional particles and the selective ability is: supercritical polymerized’s particles>traditional particles >active carbon. The selectivity performance at higher temperature is better. The advantage of supercritical polymerization are not only its performance but also it can save time 、
organic solvent and non processibility.

目錄
圖目錄………………….………………………………………………....І
表目錄…………………………………..……………………………....Ⅲ
第一章 緒論…………………………………………………………..…1
第二章 文獻回顧………………………………………………………..3
2.1 分子拓印技術的原理…………………………………3
2.2 模板分子、單體、交聯劑、溶劑及辨識溶劑………4
2.3 MIP製備方法………………………………………………9
2.4 拓印高分子的應用…………………………………………13
2.5 超臨界二氧化碳聚合………………………………………18
2.6 超臨界二氧化碳萃取咖啡因………………………………19
第三章 實驗裝置、步驟………………………………………………..22
3.1 實驗原理……………………………………………………22
3.2 實驗流程……………………………………………………25
3.3 實驗藥品……………………………………………………26
3.4 實驗儀器……………………………………………………27
3.5 實驗方法……………………………………………………28
第四章 結果與討論………………..…………………………………..37
4.1傳統聚合與超臨界二氧化碳聚合製備粒子的比較………37
4.2 MIP中咖啡因與MAA的鍵結…………………………………38
4.3萃取方法的比較………………………………………………41
4.4 MIP的吸附性比較……………………………………………43
4.5 MIP的選擇性比較……………………………………………48
第五章 結論……………..………………………………………….….52
參考文獻………………..……………………………………..53

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