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研究生:陳正浩
論文名稱:比較雌激素受體-alpha及雌激素受體-beta對肝癌細胞HA22T凋亡的影響
論文名稱(外文):Overexpressed estrogen receptor-B but not a ligand-dependently induces caspase-8-medicated apoptosis by increasing the tumor ncrosis factor-a gene expression in HA22T cells
指導教授:黃志揚黃志揚引用關係
學位類別:碩士
校院名稱:中山醫學大學
系所名稱:生物化學研究所
學門:生命科學學門
學類:生物化學學類
論文種類:學術論文
論文出版年:2004
畢業學年度:92
語文別:英文
中文關鍵詞:肝癌雌激素受體
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大致上是說,肝癌是眾多種癌症中常見的一種,全球每年約有一百萬人死於肝癌,而其中又以男性多於女性,而男女荷爾蒙本來就有著差異,且也有文獻指出,在肝癌病患中發現有雌性激素受體(Estrogen receptor)損傷的情形,因此我們欲了解Estrogen及Estrogen receptor(ER)在肝癌上所扮演的角色。首先建立Tet-on誘導ER之系統,接著觀察Estrogen、Estrogen Receptor是否能造成肝癌細胞的apoptosis,接著釐清所造成的apoptosis是否透過TNFα以及TGFβ所誘發的,而TNFα以及TGFβ在肝癌細胞apoptosis上所扮演的角色又有何不同。

Table of Contents
Abstract………………………………………………………….1
Preface…………………………………………………………...3
Introduction……………………………………………………...6
Materials and Methods………………………………………….12
Results…………………………………………………………..15
Discussion………………………………………………………19
References………………………………………………………21
Figures………………………………………………………….27

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