第七章 參考文獻
中華民國行政院衛生署（1998）中華民國行政院衛生署公告第三次全國營養調查結果報告。
中華民國行政院衛生署（2002）中華民國行政院衛生署公告國人肥胖定義及處理原則。
中華民國行政院衛生署（2003）中華民國行政院衛生署國人十大死因統計。
高美丁、曾明淑、葉文婷、張瑛韶、潘文涵（1998）台灣地區居民體位及肥胖狀況。國民營養現況： 1993-1996國民營養健康狀況變遷調查結果。行政院衛生署：143-171。
黃國晉（1999）婦女停經前後體脂肪及相關代謝因子之研究。國立台灣大學流行病學研究所博士論文。葉恩菱、何佳珍、吳意真、羅姮妤、吳篤安（2002）肥胖者體重下降對血清瘦體激素濃度和胰島素抗性的影響。中華民國營養學會雜誌27： 101-108。潘文涵、章雅惠、陳正義、吳幸娟、曾明淑、高美丁（1999）以二十四小時飲食回顧法評估國人膳食營養狀況。國民營養現況：1993-1999國民營養健康狀況變遷調查結果。行政院衛生署： 29-52。
鄭淑妃、周美惠、林明芳（1999）糖尿病控制展新迎姿千禧。醫院藥學雜誌16： 6-11。World Health Organization, 1979 and 2003
IUIS ( International Union of Immunological Societies ) WHO Nomenclature Committee, 1979
Ahima RS, Prabakaran D, Mantzoros C, Qu D, Lowell B, Maratos-Flier E and Flier JS (1996) Role of leptin in the neuroendocrine response to fasting. Nature 382: 250-252.
Arend WP, Malyak M, Guthridge CJ and Gabay C (1998) Interleukin-1 receptor antagonist: role in biology. Annu Rev Immunol 16: 27-55.
Arner P (2003) The adipocyte in insulin resistance: key molecules and the impact of the thiazolidinediones. Trends Endocrinol Metab 14: 137-145.
Astrup A, Ryan L, Grunwald GK, Storgaard M, Saris W, Melanson E and Hill JO (2000) The role of dietary fat in body fatness: evidence from a preliminary meta-analysis of ad libitum low-fat dietary intervention studies. Br J Nutr 83 : S25-S32.
Bado A, Levasseur S, Attoub S, Kermorgant S, Laigneau JP, Bortoluzzi MN, Moizo L, Lehy T, Guerre-Millo M, Le Marchand-Brustel Y and Lewin MJ (1998) The stomach is a source of leptin. Nature 394: 790-793.
Bai Y, Zhang S, Kim KS, Lee JK and Kim KH (1996) Obese gene expression alters the ability of 30A5 preadipocytes to respond to lipogenic hormones. J Biol Chem 271: 13939-13942.
Bailie MB, Standiford TJ, Laichalk LL, Coffey MJ, Strieter R and Peters-Golden M (1996) Leukotriene-deficient mice manifest enhanced lethality from Klebsiella pneumonia in association with decreased alveolar macrophage phagocytic and bactericidal activities. J Immunol 157: 5221-5224.
Banks WA, Kastin AJ, Huang W, Jaspan JB and Maness LM (1996) Leptin enters the brain by a saturable system independent of insulin. Peptides 17: 305-11.
Barone J, Hebert JR and Reddy MM (1989) Dietary fat and natural-killer-cell activity. Am J Clin Nutr 50: 861-867.
Bastard JP, Maachi M, Van Nhieu JT, Jardel C, Bruckert E, Grimaldi A, Robert JJ, Capeau J and Hainque B (2002) Adipose tissue IL-6 content correlates with resistance to insulin activation of glucose uptake both in vivo and in vitro. J Clin Endocrinol Metab 87: 2084-2089.
Baumann H, Morella KK, White DW, Dembski M, Bailon PS, Kim H, Lai CF and Tartaglia LA (1996) The full-length leptin receptor has signaling capabilities of interleukin 6-type cytokine receptors. Proc Natl Acad Sci U S A 93: 8374-8378.
Beutler B and Cerami A (1989) The biology of cachectin/TNF─a primary mediator of the host response. Annu Rev Immunol 7: 625-655.
Berg AH, Combs TP and Scherer PE (2002) ACRP30/adiponectin: an adipokine regulating glucose and lipid metabolism. Trends Endocrinol Metab 13: 84-89.
Bodary PF, Westrick RJ, Wickenheiser KJ, Shen Y and Eitzman DT (2002) Effect of leptin on arterial thrombosis following vascular injury in mice. JAMA 287: 1706-1709.
Bouret SG, Draper SJ and Simerly RB (2004) Trophic action of leptin on hypothalamic neurons that regulate feeding. Science 304: 108-110.
Bovill EG, Bild DE, Heiss G, Kuller LH, Lee MH, Rock R and Wahl PW (1996) White blood cell counts in persons aged 65 years or more from the Cardiovascular Health Study. Correlations with baseline clinical and demographic characteristics. Am J Epidemiol 143: 1107-1115.
Bradley J and Xu X (1996) Diet, age, and the immune system. Nutr Rev 54: S43-S50.
Bray GA and York DA (1979) Hypothalamic and genetic obesity in experimental animals: an autonomic and endocrine hypothesis. Physiol rev 59: 719-809.
Bruun JM, Lihn AS, Verdich C, Pedersen SB, Toubro S, Astrup A and Richelsen B (2003) Regulation of adiponectin by adipose tissue-derived cytokines: in vivo and in vitro investigations in humans. Am J Physiol Endocrinol Metab 285: E527-E533.
Busso N, So A, Chobaz-Peclat V, Morard C, Martinez-Soria E, Talabot-Ayer D and Gabay C (2002) Leptin signaling deficiency impairs humoral and cellular immune responses and attenuates experimental arthritis. J Immunol 168: 875-882.
Carek PJ and Dickerson LM (1999) Current concepts in the pharmacological management of obesity. Drugs 57: 883-904.
Carel RS and Eviatar J (1985) Factors affecting leukocyte count in healthy adults. Prev Med 14: 607-619.
Carlsson B, Lindell K, Gabrielsson B, Karlsson C, Bjarnason R, Westphal O, Karlsson U, Sjostrom L and Carlsson LM (1997) Obese (ob) gene defects are rare in human obesity. Obesity Res. 5: 30-35.
Casabiell X, Pineiro V, Peino R, Lage M, Camina J, Gallego R, Vallejo LG, Dieguez C and Casanueva FF (1998) Gender differences in both spontaneous and stimulated leptin secretion by human omental adipose tissue in vitro: dexamethasone and estradiol stimulate leptin release in women, but not in men. J Clin Endocrinol Metab 83: 2149-2155.
Cason J, Ainley CC, Wolstencroft RA, Norton KR and Thompson RP (1986) Cell-mediated immunity in anorexia nervosa. Clin Exp Immunol 64: 370-375.
Chandra RK (1980) Cell-mediated immunity in genetically obese (C57BL/6J ob/ob) mice. Am J Clin Nutr 33: 13-16.
Chandra RK (1991) Nutrition and immunity: lessons from the past and new insights into the future. Am J Clin Nutr 53: 1087-1101.
Chandra RK and Kutty KM (1980) Immunocompetence in obesity. Acta Paediatr Scand 69: 25-30.
Clement K, Vaisse C, Lahlou N, Cabrol S, Pelloux V, Cassuto D, Gourmelen M, Dina C, Chambaz J, Lacorte JM, Basdevant A, Bougneres P, Lebouc Y, Froguel P and Guy-Grand B (1998) A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction. Nature 392: 398-401.
Cnop M, Landchild MJ, Vidal J, Havel PJ, Knowles NG, Carr DR, Wang F, Hull RL, Boyko EJ, Retzlaff BM, Walden CE, Knopp RH and Kahn SE (2002) The concurrent accumulation of intra-abdominal and subcutaneous fat explains the association between insulin resistance and plasma leptin concentrations : distinct metabolic effects of two fat compartments. Diabetes 51: 1005-1015.
Cohen B, Novick D and Rubinstein M (1996) Modulation of insulin activities by leptin. Science 274: 1185-1188.
Coleman DL (1973) Effects of parabiosis of obese with diabetes and normal mice. Diabetologia 9: 294-298.
Coleman DL (1978) Obese and diabetes: two mutant genes causing diabetes-obesity syndromes in mice. Diabetologia 14: 141-148.
Coleman DL and Hummel KP (1969) Effects of parabiosis of normal with genetically diabetic mice. Am J Physiol 217: 1298-1304.
Combs TP, Berg AH, Rajala MW, Klebanov S, Iyengar P, Jimenez-Chillaron JC, Patti ME, Klein SL, Weinstein RS and Scherer PE (2003) Sexual differentiation, pregnancy, calorie restriction, and aging affect the adipocyte-specific secretory protein adiponectin. Diabetes 52: 268-276.
Considine RV, Sinha MK, Heiman ML, Kriauciunas A, Stephens TW, Nyce MR, Ohannesian JP, Marco CC, McKee LJ, Bauer TL and Caro JF (1996) Serum immunoreactive-leptin concentrations in normal-weight and obese humans. N Engl J Med 334: 292-295.
Coppack SW (2001) Pro-inflammatory cytokines and adipose tissue. Proc Nutr Soc 60: 349-356.
Costentin J (2004) Physiological and neurobiological elements of food intake. Ann Pharm Fr 62: 92-102.
Dagogo-Jack S (1999) Regulation and possible significance of leptin in humans: leptin in health and disease. Diabetes Rev 7: 23-38.
Doring H, Schwarzer K, Nuesslein-Hildesheim B and Schmidt I (1998) Leptin selectively increases energy expenditure of food-restricted lean mice. Int J Obes Relat Metab Disord 22: 83-88.
Douchi T, Iwamoto I, Yoshimitsu N, Kosha S and Nagata Y (2002) Leptin production in pre- and postmenopausal women. Maturitas 42: 219-223.
Ebihara K, Ogawa Y, Masuzaki H, Shintani M, Miyanaga F, Aizawa-Abe M, Hayashi T, Hosoda K, Inoue G, Yoshimasa Y, Gavrilova O, Reitman ML and Nakao K (2001) Transgenic overexpression of leptin rescues insulin resistance and diabetes in a mouse model of lipoatrophic diabetes. Diabetes 50: 1440-1448.
Emilsson V, Liu YL, Cawthorne MA, Morton NM and Davenport M (1997) Expression of the functional leptin receptor mRNA in pancreatic islets and direct inhibitory action of leptin on insulin secretion. Diabetes 46: 313-316.
Erickson JC, Hollopeter G and Palmiter RD (1996) Attenuation of the obesity syndrome of ob/ob mice by the loss of neuropeptide Y. Science 274: 1704-1707.
Escobar L, Freire JM, Espinosa R, Pajares M, Giron JA, Vazquez JM, Chover A, Carrasco M, Ortero J, Gavilan I, Segura E and Aguilar M (2002) Determination of insulin, leptin and neuropeptide y by radioimmunoanalysis in patients with morbid obesity and anorexia nervosa after therapeutic intervention. Rev Esp Med Nucl 21: 3-11.
Faggioni R, Fantuzzi G, Gabay C, Moser A, Dinarello CA, Feingold KR and Grunfeld C (1999) Leptin deficiency enhances sensitivity to endotoxin-induced lethality. Am J Physiol 276: R136-R142.
Faggioni R, Jones-Carson J, Reed DA, Dinarello CA, Feingold KR, Grunfeld C and Fantuzzi G (2000) Leptin-deficient (ob/ob) mice are protected from T cell-mediated hepatotoxicity: role of tumor necrosis factor alpha and IL-18. Proc Natl Acad Sci U S A 97: 2367-2372.
Farooqi IS, Matarese G, Lord GM, Keogh JM, Lawrence E, Agwu C, Sanna V, Jebb SA, Perna F, Fontana S, Lechler RI, DePaoli AM and O’Rahilly S (2002) Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency. J Clin Invest 110: 1093-1103.
Fasshauer M, Kralisch S, Klier M, Lossner U, Bluher M, Klein J and Paschke R (2003) Adiponectin gene expression and secretion is inhibited by interleukin-6 in 3T3-L1 adipocytes. Biochem Biophys Res Commun 301: 1045-1050.
Fernandes G, Handwerger BS, Yunis EJ and Brown DM (1978) Immune response in the mutant diabetic C57BL/Ks-dt+ mouse. Discrepancies between in vitro and in vivo immunological assays. J Clin Invest 61: 243-250.
Fernandez-Real JM, Broch M, Ricart W, Casamitjana R, Gutierrez C, Vendrell J and Richart C (1998) Plasma levels of the soluble fraction of tumor necrosis factor receptor 2 and insulin resistance. Diabetes 47: 1757-1762.
Flier JS (1998) Lowered leptin slims immune response. Nat Med 4: 1124-1125.
Finer N (2001) Low-calorie diets and sustained weight loss. Obes Res 9: 290S-294S.
Forbes S, Bui S, Robinson BR, Hochgeschwender U and Brennan MB (2001) Integrated control of appetite and fat metabolism by the leptin-proopiomelanocortin pathway. Proc Natl Acad Sci U S A 98: 4233-4237.
Frederich RC, Hamann A, Anderson S, Lollmann B, Lowell BB and Flier JS (1995) Leptin levels reflect body lipid content in mice: evidence for diet-induced resistance to leptin action. Nat Med 1: 1311-1314.
Freedson PS, Mihevic PM, Loucks AB and Girandola RN (1983) Physique, body composition, and psychological characteristics of competitive female body builders. Phys Sportsmed 11: 85-90.
Friedman JM (1998) Leptin, leptin receptors, and the control of body weight. Nutr Rev 56: s38-s46
Friedman JM (2002) The function of leptin in nutrition, weight, and physiology. Nutr Rev 60: S1-S14.
Friedman JM and Leibel RL (1992) Tackling a weighty problem. Cell 69: 217-220.
Froidevaux F, Schutz Y, Christin L and Jequier E (1993) Energy expenditure in obese women before and during weight loss, after refeeding, and in the weight-relapse period. Am J Clin Nutr 57: 35-42.
Gabay C, Dreyer M, Pellegrinelli N, Chicheportiche R and Meier CA (2001) Leptin directly induces the secretion of interleukin 1 receptor antagonist in human monocytes. J Clin Endocrinol Metab 86: 783-791.
Gaillard RC, Spinedi E, Chautard T and Pralong FP (2000) Cytokines, leptin, and the hypothalamo-pituitary-adrenal axis. Ann N Y Acad Sci 917: 647-657.
Gainsford T, Willson TA, Metcalf D, Handman E, McFarlane C, Ng A, Nicola NA, Alexander WS and Hilton DJ (1996) Leptin can induce proliferation, differentiation, and functional activation of hemopoietic cells. Proc Natl Acad Sci U S A 93: 14564-14568.
Ghilardi N and Skoda RC (1997) The leptin receptor activates janus kinase 2 and signals for proliferation in a factor-dependent cell line. Mol Endocrinol 11: 393-399.
Girard J (1997) Is leptin the link between obesity and insulin resistance? Diabetes Metab 23: 16-24.
Golden PL, Maccagnan TJ and Pardridge WM (1997) Human blood-brain barrier leptin receptor. Binding and endocytosis in isolated human brain microvessels. J Clin Invest 99: 14-18.
Granger GA (1972) Lymphokines─the mediators of cellular immunity. Ser Haematol 5: 8-40.
Grimm RH Jr, Neaton JD and Ludwig W (1985) Prognostic importance of the white blood cell count for coronary, cancer, and all-cause mortality. JAMA 254: 1932-1937.
Grinspoon S, Gulick T, Askari H, Landt M, Lee K, Anderson E, Ma Z, Vignati L, Bowsher R, Herzog D and Klibanski A (1996) Serum leptin levels in women with anorexia nervosa. J Clin Endocrinol Metab 81: 3861-3863.
Grio R and Porpiglia M (1994) Obesity: internal medicine, obstetric and gynecological problems related to overweight. Panminerva Med 36: 138-141.
Grunfeld C and Feingold KR (1991) The metabolic effects of tumor necrosis factor and other cytokines. Biotherapy 3: 143-158.
Groop LC, Bonadonna RC, Simonson DC, Petrides AS, Shank M and DeFronzo RA (1992) Effect of insulin on oxidative and nonoxidative pathways of free fatty acid metabolism in human obesity. Am J Physiol 263: E79-E84.
Guerre-Millo M (2004) Adipose tissue and adipokines: for better or worse. Diabetes Metab 30: 13-19.
Hadji P, Hars O, Bock K, Sturm G, Bauer T, Emons G and Schulz KD (2000) The influence of menopause and body mass index on serum leptin concentrations. Eur J Endocrinol 143: 55-60.
Halaas JL, Boozer C, Blair-West J, Fidahusein N, Denton DA and Friedman JM (1997) Physiological response to long-term peripheral and central leptin infusion in lean and obese mice. Proc Natl Acad Sci U S A 94: 8878-8883.
Halaas JL, Gajiwala KS, Maffei M, Cohen SL, Chait BT, Rabinowitz D, Lallone RL, Burley SK and Friedman JM (1995) Weight-reducing effects of the plasma protein encoded by the obese gene. Science 269: 543-546.
Hanggi W, Lippuner K, Riesen W, Jaeger P and Birkhauser MH (1997) Long-term influence of different postmenopausal hormone replacement regimens on serum lipids and lipoprotein(a): a randomised study. Br J Obstet Gynaecol 104: 708-717.
Harris RB, Hervey E, Hervey GR and Tobin G (1987) Body composition of lean and obese Zucker rats in parabiosis. Int J Obes 11: 275-283.
Hasty AH, Shimano H, Osuga J, Namatame I, Takahashi A, Yahagi N, Perrey S, Iizuka Y, Tamura Y, Amemiya-Kudo M, Yoshikawa T, Okazaki H, Ohashi K, Harada K, Matsuzaka T, Sone H, Gotoda T, Nagai R, Ishibashi S and Yamada N (2001) Severe hypercholesterolemia, hypertriglyceridemia, and atherosclerosis in mice lacking both leptin and the low density lipoprotein receptor. J Biol Chem 276: 37402-37408.
He Y, Chen H, Quon MJ and Reitman M (1995) The mouse obese gene. Genomic organization, promoter activity, and activation by CCAAT/enhancer-binding protein alpha. J Biol Chem 270: 28887-28891.
Herberg L and Coleman DL (1977) Laboratory animals exhibiting obesity and diabetes syndromes. Metabolism 26: 59-99.
Heymsfield SB, Greenberg AS, Fujioka K, Dixon RM, Kushner R, Hunt T, Lubina JA, Patane J, Self B, Hunt P and McCamish M (1999) Recombinant leptin for weight loss in obese and lean adults: a randomized, controlled, dose-escalation trial. JAMA 282: 1568-1575.
Hickey MS, Israel RG, Gardiner SN, Considine RV, McCammon MR, Tyndall GL, Houmard JA, Marks RH and Caro JF (1996) Gender differences in serum leptin levels in humans. Biochem Mol Med 59: 1-6.
Horai R, Saijo S, Tanioka H, Nakae S, Sudo K, Okahara A, Ikuse T, Asano M and Iwakura Y (2000) Development of chronic inflammatory arthropathy resembling rheumatoid arthritis in interleukin 1 receptor antagonist-deficient mice. J Exp Med 191: 313-320.
Hotamisligil GS (2000) Molecular mechanisms of insulin resistance and the role of the adipocyte. Int J Obes Relat Metab Disord 24: S23-S27.
Hotamisligil GS, Arner P, Atkinson RL and Spiegelman BM (1997) Differential regulation of the p80 tumor necrosis factor receptor in human obesity and insulin resistance. Diabetes 46: 451-455.
Hotamisligil GS, Arner P, Caro JF, Atkinson RL and Spiegelman BM (1995) Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance. J Clin Inves 95: 2409-2415.
Hotta K, Funahashi T, Bodkin NL, Ortmeyer HK, Arita Y, Hansen BC and Matsuzawa Y (2001) Circulating concentrations of the adipocyte protein adiponectin are decreased in parallel with reduced insulin sensitivity during the progression to type 2 diabetes in rhesus monkeys. Diabetes 50: 1126-1133.
Howard JK, Lord GM, Matarese G, Vendetti S, Ghatei MA, Ritter MA, Lechler RI and Bloom SR (1999) Leptin protects mice from starvation-induced lymphoid atrophy and increases thymic cellularity in ob/ob mice. J Clin Invest 104: 1051-1059.
Isse N, Ogawa Y, Tamura N, Masuzaki H, Mori K, Okazaki T, Satoh N, Shigemoto M, Yoshimasa Y, Nishi S, Hosoda K, Inazawa J and Nakao K (1995) Structural organization and chromosomal assignment of the human obese gene. J Biol Chem 270: 27728-27733.
Juge-Aubry CE and Meier CA (2002) Immunomodulatory actions of leptin. Mol Cell Endocrinol 194: 1-7.
Kanaley JA, Sames C, Swisher L, Swick AG, Ploutz-Snyder LL, Steppan CM, Sagendorf KS, Feiglin D, Jaynes EB, Meyer RA and Weinstock RS (2001) Abdominal fat distribution in pre- and postmenopausal women: The impact of physical activity, age, and menopausal status. Metabolism 50: 976-982.
Kelley DS, Daudu PA, Branch LB, Johnson HL, Taylor PC and Mackey B (1994) Energy restriction decreases number of circulating natural killer cells and serum levels of immunoglobulins in overweight women. Eur J Clin Nutr 48: 9-18.
Kim KH, Lee K, Moon YS and Sul HS (2001) A cysteine-rich adipose tissue-specific secretory factor inhibits adipocyte differentiation. J Biol Chem 276: 11252-11256.
Kimura M, Tanaka S, Isoda F, Sekigawa K, Yamakawa T and Sekihara H (1998a) T lymphopenia in obese diabetic (db/db) mice is non-selective and thymus independent. Life Sci 62: 1243-1250.
Kimura M, Tanaka S, Yamada Y, Kiuchi Y, Yamakawa T and Sekihara H (1998b) Dehydroepiandrosterone decreases serum tumor necrosis factor-alpha and restores insulin sensitivity: independent effect from secondary weight reduction in genetically obese Zucker fatty rats. Endocrinology 139: 3249-3253.
Klein A, Zhadkewich M, Margolick J, Winkelstein J and Bulkley G (1994) Quantitative discrimination of hepatic reticuloendothelial clearance and phagocytic killing. J Leukoc Biol 55: 248-252.
Konstantinides S, Schafer K, Koschnick S and Loskutoff DJ (2001) Leptin-dependent platelet aggregation and arterial thrombosis suggests a mechanism for atherothrombotic disease in obesity. J Clin Invest 108: 1533-1540.
Konukoglu D, Serin O and Ercan M (2000) Plasma leptin levels in obese and non-obese postmenopausal women before and after hormone replacement therapy. Maturitas. 36: 203-207.
Kuby J (1994) Immunology 2thed. W.H. Freeman and Company. New York.
Kyzer S, Binyamini J, Chaimoff C and Fishman P (1999) The effect of surgically induced weight reduction on the serum levels of the cytokines: interleukin-3 and tumor necrosis factor. Obes Surg 9: 229-234.
Laivuori H, Koistinen HA, Karonen SL, Cacciatore B and Ylikorkala O (2001) Comparison between 1 year oral and transdermal oestradiol and sequential norethisterone acetate on circulating concentrations of leptin in postmenopausal women. Hum Reprod 16: 1632-1635.
Larson DE, Ferraro RT, Robertson DS and Ravussin E (1995) Energy metabolism in weight-stable postobese individuals. Am J Clin Nutr 62: 735-739.
Lean ME and James WP (1988) Metabolic effects of isoenergetic nutrient exchange over 24 hours in relation to obesity in women. Int J Obe 12: 15-27.
LeBlanc J, Nadeau A, Richard D and Tremblay A (1982) Variations in plasma glucose, insulin, growth hormone and catecholamines in response to insulin in trained and non-trained subjects. Metabolism 31: 453-456.
Lee FY, Li Y, Yang EK, Yang SQ, Lin HZ, Trush MA, Dannenberg AJ and Diehl AM (1999) Phenotypic abnormalities in macrophages from leptin-deficient, obese mice. Am J Physiol 276: C386-C394.
Lee GH, Proenca R, Montez JM, Carroll KM, Darvishzadeh JG, Lee JI and Friedman JM (1996) Abnormal splicing of the leptin receptor in diabetic mice. Nature 379: 632-635.
Le Lay S, Boucher J, Rey A, Castan-Laurell I, Krief S, Ferre P, Valet P and Dugail I (2001) Decreased resistin expression in mice with different sensitivities to a high-fat diet. Biochem Biophys Res Commun 289: 564-567.
Levin N, Nelson C, Gurney A, Vandlen R and de Sauvage F (1996) Decreased food intake does not completely account for adiposity reduction after ob protein infusion. Proc Natl Acad Sci U S A 93: 1726-1730.
Lindsay RS, Funahashi T, Hanson RL, Matsuzawa Y, Tanaka S, Tataranni PA, Knowler WC and Krakoff J (2002) Adiponectin and development of type 2 diabetes in the Pima Indian population. Lancet 360: 57-58.
Loetscher H, Pan YC, Lahm HW, Gentz R, Brockhaus M, Tabuchi H and Lesslauer W (1990) Molecular cloning and expression of the human 55 kd tumor necrosis factor receptor. Cell 61: 351-359.
Lord G (2002) Role of leptin in immunology. Nutr Rev 60: S35- S38.
Lord GM, Matarese G, Howard JK, Baker RJ, Bloom SR and Lechler RI (1998) Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression. Nature 394: 897-901.
Lord GM, Matarese G, Howard JK, Bloom SR and Lechler RI (2002) Leptin inhibits the anti-CD3-driven proliferation of peripheral blood T cells but enhances the production of proinflammatory cytokines. J Leukoc Biol 72: 330-338.
Loffreda S, Yang SQ, Lin HZ, Karp CL, Brengman ML, Wang DJ, Klein AS, Bulkley GB, Bao C, Noble PW, Lane MD and Diehl AM (1998) Leptin regulates proinflammatory immune responses. FASEB J 12: 57-65.
Luheshi GN, Gardner JD, Rushforth DA, Loudon AS and Rothwell NJ (1999) Leptin actions on food intake and body temperature are mediated by IL-1. Proc Natl Acad Sci U S A 96: 7047-7052.
Ma Z, Gingerich RL, Santiago JV, Klein S, Smith CH and Landt M (1996) Radioimmunoassay of leptin in human plasma. Clin Chem 42: 942-946.
Mach F, Sauty A, Iarossi AS, Sukhova GK, Neote K, Libby P and Luster AD (1999) Differential expression of three T lymphocyte-activating CXC chemokines by human atheroma-associated cells. J Clin Invest 104: 1041-1050.
Maes HH, Neale MC and Eaves LJ (1997) Genetic and environmental factors in relative body weight and human adiposity. Behav Genet 27: 325-351.
Maffei M, Fei H, Lee GH, Dani C, Leroy P, Zhang Y, Proenca R, Negrel R, Ailhaud G and Friedman JM (1995a) Increased expression in adipocytes of ob RNA in mice with lesions of the hypothalamus and with mutations at the db locus. Proc Natl Acad Sci U S A 92: 6957-6960.
Maffei M, Halaas J, Ravussin E, Pratley RE, Lee GH, Zhang Y, Fei H, Kim S, Lallone R and Ranganathan S, et al. (1995b) Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects. Nat Med 1: 1155-1161.
Mancuso P, Gottschalk A, Phare SM, Peters-Golden M, Lukacs NW and Huffnagle GB (2002) Leptin-deficient mice exhibit impaired host defense in Gram-negative pneumonia. J Immunol 168: 4018-4024.
Mandel MA and Mahmoud AA (1978) Impairment of cell-mediated immunity in mutation diabetic mice (db/db). J Immunol 120: 1375-1377.
Marti A, Berraondo B and Martinez JA (1999) Leptin: physiological actions. J Physiol Biochem 55: 43-49.
Marti A, Marcos A and Martinez JA (2001) Obesity and immune function relationships. Obes Rev 2: 131-140.
Martin-Romero C, Santos-Alvarez J, Goberna R and Sanchez-Margalet V (2000) Human leptin enhances activation and proliferation of human circulating T lymphocytes. Cell Immunol 199: 15-24.
Maruyama S, Yanagisawa K, Kanamuro R, Teno S and Iwamoto Y (2001) Serum leptin level as an indicator to predict the clinical efficacy of troglitazone in patients with type 2 diabetes mellitus. Diabetes Res Clin Pract 53: 161-164.
Marx N, Mach F, Sauty A, Leung JH, Sarafi MN, Ransohoff RM, Libby P, Plutzky J and Luster AD (2000) Peroxisome proliferator-activated receptor-gamma activators inhibit IFN-gamma-induced expression of the T cell-active CXC chemokines IP-10, Mig, and I-TAC in human endothelial cells. J Immunol 164: 6503-6508.
Masuzaki H, Ogawa Y, Sagawa N, Hosoda K, Matsumoto T, Mise H, Nishimura H, Yoshimasa Y, Tanaka I, Mori T and Nakao K (1997) Nonadipose tissue production of leptin: leptin as a novel placenta-derived hormone in humans. Nat Med 3: 1029-1033.
Matarese G (2000) Leptin and the immune system: how nutritional status influences the immune response. Eur Cytokine Netw 11: 7-14.
Matarese G, La Cava A, Sanna V, Lord GM, Lechler RI, Fontana S and Zappacosta S
(2002) Balancing susceptibility to infection and autoimmunity: a role for leptin? Trends Immunol 23: 182-187.
Mercer JG, Hoggard N, Williams LM, Lawrence CB, Hannah LT and Trayhurn P (1996) Localization of leptin receptor mRNA and the long form splice variant (Ob-Rb) in mouse hypothalamus and adjacent brain regions by in situ hybridization. tu hybridization. FEBS Lett 387: 113-116.
Messinis IE, Kariotis I, Milingos S, Kollios G and Seferiadis K (2000) Treatment of normal women with oestradiol plus progesterone prevents the decrease of leptin concentrations induced by ovariectomy. Hum Reprod 15: 2383-2387.
Messinis IE, Milingos S, Zikopoulos K, Kollios G, Seferiadis K and Lolis D (1998) Leptin concentrations in the follicular phase of spontaneous cycles and cycles superovulated with follicle stimulating hormone. Hum Reprod 13: 1152-1156.
Minokoshi Y, Kim YB, Peroni OD, Fryer LG, Muller C, Carling D and Kahn BB (2002) Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase. Nature 415: 339-343.
Mohamed-Ali V, Pinkney JH and Coppack SW (1998) Adipose tissue as an endocrine and paracrine organ. Int J Obes Relat Metab Disord 22: 1145-1158.
Moller DE (2000) Potential role of TNF-alpha in the pathogenesis of insulin resistance and type 2 diabetes. Trends Endocrinol Metab 11: 212-217.
Moore SI, Huffnagle GB, Chen GH, White ES and Mancuso P (2003) Leptin modulates neutrophil phagocytosis of Klebsiella pneumoniae. Infect Immun 71: 4182-4185.
Moriguchi S, Kato M, Sakai K, Yamamoto S and Shimizu E (1998) Decreased mitogen response of splenic lymphocytes in obese Zucker rats is associated with the decreased expression of glucose transporter 1 (GLUT-1). Am J Clin Nutr 67: 1124-1129.
Moshyedi AK, Josephs MD, Abdalla EK, Mackay SL, Edwards CK 3rd, Copeland EM 3rd and Moldawer LL (1998) Increased leptin expression in mice with bacterial peritonitis is partially regulated by tumor necrosis factor alpha. Infect Immun 66: 1800-1802.
Muoio DM, Dohm GL, Fiedorek FT Jr, Tapscott EB, Coleman RA and Dohn GL (1997) Leptin directly alters lipid partitioning in skeletal muscle. Diabetes 46: 1360-1363.
Must A, Spadano J, Coakley EH, Field AE, Colditz G and Dietz WH (1999) The disease burden associated with overweight and obesity. JAMA 282: 1523-1529.
Newcomer JW, Selke G, Melson AK, Gross J, Vogler GP and Dagogo-Jack S (1998) Dose-dependent cortisol-induced increases in plasma leptin concentration in healthy humans. Arch Gen Psychiatry 55: 995-1000.
Nieman DC, Henson DA, Nehlsen-Cannarella SL, Ekkens M, Utter AC, Butterworth DE and Fagoaga OR (1999) Influence of obesity on immune function. J Am Diet Assoc 99: 294-299.
Nieman DC, Nehlsen-Cannarella SI, Henson DA, Butterworth DE, Fagoaga OR, Warren BJ and Rainwater MK (1996) Immune response to obesity and moderate weight loss. Int J Obes Relat Metab Disord 20: 353-60.
Nieto FJ, Szklo M, Folsom AR, Rock R and Mercuri M (1992) Leukocyte count correlates in middle-aged adults: the Atherosclerosis Risk in Communities (ARIC) Study. Am J Epidemiol 136: 525-537.
Nova E, Gomez-Martinez S, Morande G and Marcos A (2002) Cytokine production by blood mononuclear cells from in-patients with anorexia nervosa. Br J Nutr 88: 183-188.
Ostlund RE Jr, Yang JW, Klein S and Gingerich R (1996) Relation between plasma leptin concentration and body fat, gender, diet, age, and metabolic covariates. J Clin Endocrinol Metab 81: 3909-3913.
Ouchi N, Kihara S, Arita Y, Nishida M, Matsuyama A, Okamoto Y, Ishigami M, Kuriyama H, Kishida K, Nishizawa H, Hotta K, Muraguchi M, Ohmoto Y, Yamashita S, Funahashi T and Matsuzawa Y (2001) Adipocyte-derived plasma protein, adiponectin, suppresses lipid accumulation and class A scavenger receptor expression in human monocyte-derived macrophages. Circulation 103: 1057-1063.
Pajvani UB, Du X, Combs TP, Berg AH, Rajala MW, Schulthess T, Engel J, Brownlee M and Scherer PE (2003) Structure-function studies of the adipocyte-secreted hormone Acrp30/adiponectin. Implications fpr metabolic regulation and bioactivity. J Biol Chem 278: 9073-9085.
Palmblad J, Hallberg D and Engstedt L (1980) Polymorphonuclear (PMN) function after small intestinal shunt operation for morbid obesity. Br J Haematol 44: 101-108.
Parham P (2000) The immune system. Garland Publishing, Elsevier Science Ltd.
Pedersen BK, Helge JW, Richter EA, Rohde T and Kiens B (2000) Training and natural immunity: effects of diets rich in fat or carbohydrate. Eur J Appl Physiol 82: 98-102.
Pelleymounter MA, Cullen MJ, Baker MB, Hecht R, Winters D, Boone T and Collins F (1995) Effects of the obese gene product on body weight regulation in ob/ob mice. Science 269: 540-543.
Phillips MS, Liu Q, Hammond HA, Dugan V, Hey PJ, Caskey CJ and Hess JF (1996) Leptin receptor missense mutation in the fatty Zucker rat. Nat Gene 13: 18-19.
Pinto S, Roseberry AG, Liu H, Diano S, Shanabrough M, Cai X, Friedman JM and Horvath TL (2004) Rapid rewiring of arcuate nucleus feeding circuits by leptin. Science 304: 110-115.
Plotkin BJ, Paulson D, Chelich A, Jurak D, Cole J, Kasimos J, Burdick JR and Casteel N (1996) Immune responsiveness in a rat model for type II diabetes (Zucker rat, fa/fa): susceptibility to Candida albicans infection and leucocyte function. J Med Microbiol 44: 277-283.
Polack E, Nahmod VE, Emeric-Sauval E, Bello M, Costas M, Finkielman S and Arzt E (1993) Low lymphocyte interferon-gamma production and variable proliferative response in anorexia nervosa patients. J Clin Immunol 13: 445-451.
Pralong FP, Roduit R, Waeber G, Castillo E, Mosimann F, Thorens B and Gaillard RC (1998) Leptin inhibits directly glucocorticoid secretion by normal human and rat adrenal gland. Endocrinology 139: 4264-4268.
Rajala MW, Obici S, Scherer PE and Rossetti L (2003) Adipose-derived resistin and gut-derived resistin-like molecule-beta selectively impair insulin action on glucose production. J Clin Invest 111: 225-230.
Ranganathan S, Maffei M and Kern PA (1998) Adipose tissue ob mRNA expression in humans: discordance with plasma leptin and relationship with adipose TNFalpha expression. J Lipid Res 39: 724-730.
Reaven GM (1993) Role of insulin resistance in human disease (syndrome X): an expanded definition. Annu Rev Med 44: 121-131.
Roitt I, Brostoff J and Male D (1998) Immunology, 5/e. Mosby Publishing, Mosby International Ltd.
Saghizadeh M, Ong JM, Garvey WT, Henry RR and Kern PA (1996) The expression of TNF alpha by human muscle. Relationship to insulin resistance. J Clin Inves 97: 1111-1116.
Santos-Alvarez J, Goberna R and Sanchez-Margalet V (1999) Human leptin stimulates proliferation and activation of human circulating monocytes. Cell Immunol 194: 6-11.
Savage DB, Sewter CP, Klenk ES, Segal DG, Vidal-Puig A, Considine RV and O’Rahilly S (2001) Resistin / Fizz3 expression in relation to obesity and peroxisome proliferator-activated receptor-gamma action in humans. Diabetes 50: 2199-2202.
Scanga CB, Verde TJ, Paolone AM, Andersen RE and Wadden TA (1998) Effects of weight loss and exercise training on natural killer cell activity in obese women. Med Sci Sports Exerc 30: 1666-1671.
Scarpace PJ, Metheny M, Pollock BH and Tumer N (1997) Leptin increases uncoupling protein expression and energy expenditure. Am J Physiol 273: E226-230.
Schattner A, Steinbock M, Tepper R, Schonfeld A, Vaisman N and Hahn T (1990) Tumour necrosis factor production and cell-mediated immunity in anorexia nervosa. Clin Exp Immunol 79: 62-66.
Schutz Y, Tremblay A, Weinsier RL and Nelson KM (1992) Role of fat oxidation in the long-term stabilization of body weight in obese women. Am J Clin Nutr 55: 670-674.
Schwartz MW, Seeley RJ, Campfield LA, Burn P and Baskin DG (1996) Identification of targets of leptin action in rat hypothalamus. J Clin Invest 98: 1101-1106.
Seidell JC, Verschuren WM, van Leer EM and Kromhout D (1996) Overweight, underweight, and mortality. A prospective study of 48,287 men and women. Arch Intern Med 156: 958-963.
Senn JJ, Klover PJ, Nowak IA and Mooney RA (2002) Interleukin-6 induces cellular insulin resistance in hepatocytes. Diabetes 51: 3391-3399.
Senn JJ, Klover PJ, Nowak IA, Zimmers TA, Koniaris LG, Furlanetto RW and Mooney RA (2003) Suppressor of cytokine signaling-3 (SOCS-3), a potential mediator of interleukin-6-dependent insulin resistance in hepatocytes. J Biol Chem 278: 13740-13746.
Shears P (1991) Epidemiology and infection in famine and disasters. Epidemiol Infect 107: 241-251.
Shimabukuro M, Koyama K, Chen G, Wang MY, Trieu F, Lee Y, Newgard CB and Unger RH (1997) Direct antidiabetic effect of leptin through triglyceride depletion of tissues. Proc Natl Acad Sci U S A 94: 4637-4641.
Shimomura I, Hammer RE, Ikemoto S, Brown MS and Goldstein JL (1999) Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy. Natur 401: 73-76.
Sierra-Honigmann MR, Nath AK, Murakami C, Garcia-Cardena G, Papapetropoulos A, Sessa WC, Madge LA, Schechner JS, Schwabb MB, Polverini PJ and Flores-Riveros JR (1998) Biological action of leptin as an angiogenic factor. Science 281: 1683-1686.
Spicer LJ and Francisco CC (1997) The adipose obese gene product, leptin: evidence of a direct inhibitory role in ovarian function. Endocrinology 138: 3374-3379.
Spranger J, Kroke A, Mohlig M, Bergmann MM, Ristow M, Boeing H and Pfeiffer AF (2003) Adiponectin and protection against type 2 diabetes mellitus. Lancet 361: 226-228.
Stallone DD (1994) The influence of obesity and its treatment on the immune system. Nutr Rev 52: 37-50.
Stephens TW, Basinski M, Bristow PK, Bue-Valleskey JM, Burgett SG, Craft L, Hale J, Hoffmann J, Hsiung HM, Kriauciunas A, Mackellar W, Rosteck PR, Schoner B, Smith D, Tinslry FC, Zhang XY and Heiman M (1995) The role of neuropeptide Y in the antiobesity action of the obese gene product. Nature 377: 530-532.
Steppan CM, Bailey ST, Bhat S, Brown EJ, Banerjee RR, Wright CM, Patel HR, Ahima RS and Lazar MA (2001) The hormone resistin links obesity to diabetes. Nature 409: 307-312.
Steppan CM and Lazar MA (2002) Resistin and obesity-associated insulin resistance. Trends Endocrinol Metab 13: 18-23.
Stunkard AJ (1996) Current views on obesity. Am J Med 100: 230-236.
Stunkard AJ, Harris JR, Pedersen NL and McClearn GE (1990) The body-mass index of twins who have been reared apart. N Engl J Med 322: 1483-1487.
Sun R, Wei H, Zhang J, Li A, Zhang W and Tian Z (2002-2003) Recombinant human prolactin improves antitumor effects of murine natural killer cells in vitro and in vivo. Neuroimmunomodulation 10: 169-176.
Suzuki H, Katayama N, Ikuta Y, Mukai K, Fujieda A, Mitani H, Araki H, Miyashita H, Hoshino N, Nishikawa H, Nishii K, Minami N and Shiku H (2004) Activities of granulocyte-macrophage colony-stimulating factor and interleukin-3 on monocytes. Am J Hematol 75: 179-189.
Sweetnam PM, Thomas HF, Yarnell JW, Baker IA and Elwood PC (1997) Total and differential leukocyte counts as predictors of ischemic heart disease: the Caerphilly and Speedwell studies. Am J Epidemiol 145: 416-421.
Takao S, Smith EH, Wang D, Chan CK, Bulkley GB and Klein AS (1996) Role of reactive oxygen metabolites in murine peritoneal macrophage phagocytosis and phagocytic killing. Am J Physiol 271: C1278-C1284.
Tanaka S, Inoue S, Isoda F, Waseda M, Ishihara M, Yamakawa T, Sugiyama A, Takamura Y and Okuda K (1993) Impaired immunity in obesity: suppressed but reversible lymphocyte responsiveness. Int J Obes Relat Metab Disord 17: 631-636.
Tanaka S, Isoda F, Ishihara Y, Kimura M and Yamakawa T (2001) T lymphopaenia in relation to body mass index and TNF-alpha in human obesity: adequate weight reduction can be corrective. Clin Endocrinol 54: 347-354.
Tanaka S, Isoda F, Yamakawa T, Ishihara M and Sekihara H (1998) T lymphopenia in genetically obese rats. Clin Immunol Immunopathol 86: 219-225.
Tartaglia LA, Dembski M, Weng X, Deng N, Culpepper J, Devos R, Richards GJ, Campfield LA, Clark FT, Deeds J, Muir C, Sanker S, Moriarty A, Moore KJ, Smutko JS, Mays GG, Woolf EA, Monroe CA and Tepper RI (1995) Identification and expression cloning of a leptin receptor, OB-R. Cell 83: 1263-1271.
Taub DD, Lloyd AR, Conlon K, Wang JM, Ortaldo JR, Harada A, Matsushima K, Kelvin DJ and Oppenheim JJ (1993) Recombinant human interferon-inducible protein 10 is a chemoattractant for human monocytes and T lymphocytes and promotes T cell adhesion to endothelial cells. J Exp Med 177: 1809-1814.
Tomas E, Tsao TS, Saha AK, Murrey HE, Zhang Cc C, Itani SI, Lodish HF and Ruderman NB (2002) Enhanced muscle fat oxidation and glucose transport by ACRP30 globular domain: acetyl-CoA carboxylase inhibition and AMP-activated protein kinase activation. Proc Natl Acad Sci U S A 99: 16309-16313.
Trayhurn P, Hoggard N, Mercer JG and Rayner DV (1999) Leptin: fundamental aspects. Int J Obes Relat Metab Disord 23: S22-S28.
Tremblay A (1992) Human obesity: a defect in lipid oxidation or in thermogenesis? Int J Obes Relat Metab Disord 16: 953-957.
Tremblay A, Despres JP, Maheux J, Pouliot MC, Nadeau A, Moorjani S, Lupien PJ and Bouchard C (1991) Normalization of the metabolic profile in obese women by exercise and a low fat diet. Med Sci Sports Exerc 23: 1326-1331.
Tremblay A and Doucet E (2000) Obesity: a disease or a biological adaptation? Obes Rev 1: 27-35.
Tremblay A, Doucet E, Imbeault P, Mauriege P, Despres JP and Richard D (1999) Metabolic fitness in active reduced-obese individuals. Obes Res 7: 556-563.
Tremblay A, Sauve L, Despres JP, Nadeau A, Theriault G and Bouchard C (1989) Metabolic characteristics of postobese individuals. Int J Obes 13: 357-366.
Tucker LA and Kano MJ (1992) Dietary fat and body fat: a multivariate study of 205 adult females. Am J Clin Nutr 56: 616-622.
Valtuena S, Salas-Salvado J and Lorda PG (1997) The respiratory quotient as a prognostic factor in weight-loss rebound. Int J Obes Relat Metab Disord 21: 811-817.
Van Gaal LF, Wauters MA, Mertens IL, Considine RV and De Leeuw IH (1999) Clinical endocrinology of human leptin. Int J Obes Relat Metab Disord 23: 29-36.
Wallace AM, McMahon AD, Packard CJ, Kelly A, Shepherd J, Gaw A and Sattar N (2001) Plasma leptin and the risk of cardiovascular disease in the west of Scotland coronary prevention study (WOSCOPS). Circulation 104: 3052-3056.
Wallenius V, Wallenius K, Ahren B, Rudling M, Carlsten H, Dickson SL, Ohlsson C and Jansson JO (2002a) Interleukin-6-deficient mice develop mature-onset obesity. Nat Med 8: 75-79.
Wallenius K, Wallenius V, Sunter D, Dickson SL and Jansson JO (2002b) Intracerebroventricular interleukin-6 treatment decreases body fat in rats. Biochem Biophys Res Commun 293: 560-565.
Wang J, Liu R, Hawkins M, Barzilai N and Rossetti L (1998) A nutrient-sensing pathway regulates leptin gene expression in muscle and fat. Nature 393: 684-688.
Wang MY, Zhou YT, Newgard CB and Unger RH (1996) A novel leptin receptor isoform in rat. FEBS Lett 392: 87-90.
Way JM, Gorgun CZ, Tong Q, Uysal KT, Brown KK, Harrington WW, Oliver WR Jr, Willson TM, Kliewer SA and Hotamisligil GS (2001) Adipose tissue resistin expression is severely suppressed in obesity and stimulated by peroxisome proliferator-activated receptor gamma agonists. J Biol Chem 276: 25651-25653.
Weinstock RS, Dai H and Wadden TA (1998) Diet and exercise in the treatment of obesity: effects of 3 interventions on insulin resistance. Arch Intern Med 158: 2477-2483.
Westerterp-Plantenga MS, Lejeune MP, Nijs I, van Ooijen M and Kovacs EM (2004) High protein intake sustains weight maintenance after body weight loss in humans. Int J Obes Relat Metab Disord 28: 57-64.
Whitney EN and Rolfes SR (1996) Understanding nutrition. 7th ed. MN, USA: West Publishing Comp.
Wing RR and Jeffery RW (1995) Effect of modest weight loss on changes in cardiovascular risk factors: are there differences between men and women or between weight loss and maintenance? Int J Obes Relat Metab Disord 19: 67-73.
Wing EJ, Stanko RT, Winkelstein A and Adibi SA (1983) Fasting-enhanced immune effector mechanisms in obese subjects. Am J Med 75: 91-96.
Yang SQ, Lin HZ, Lane MD, Clemens M and Diehl AM (1997) Obesity increases sensitivity to endotoxin liver injury: implications for the pathogenesis of steatohepatitis. Proc Natl Acad Sci U S A 94: 2557-2562.
Yang WS, Lee WJ, Funahashi T, Tanaka S, Matsuzawa Y, Chao CL, Chen CL, Tai TY and Chuang LM (2001) Weight reduction increases plasma levels of an adipose-derived anti-inflammatory protein, adiponectin. J Clin Endocrinol Metab 86: 3815-3819.
Yamakawa T, Tanaka S, Yamakawa Y, Kiuchi Y, Isoda F, Kawamoto S, Okuda K and Sekihara H (1995) Augmented production of tumor necrosis factor-alpha in obese mice. Clin Immunol Immunopathol 75: 51-56.
Yamauchi T, Kamon J, Waki H, Imai Y, Shimozawa N, Hioki K, Uchida S, Ito Y, Takakuwa K, Matsui J, Takata M, Eto K, Terauchi Y, Komeda K, Tsunoda M, Murakami K, Ohnishi Y, Naitoh T, Yamamura K, Ueyama Y, Froguel P, Kimura S, Nagai R and Kadowaki T (2003) Globular adiponectin protected ob/ob mice from diabetes and ApoE-deficient mice from atherosclerosis. J Biol Chem 278: 2461-2468.
Zarkesh-Esfahani H, Pockley G, Metcalfe RA, Bidlingmaier M, Wu Z, Ajami A, Weetman AP, Strasburger CJ and Ross RJ (2001) High-dose leptin activates human leukocytes via receptor expression on monocytes. J Immunol 167: 4593-4599.
Zhang B, Graziano MP, Doebber TW, Leibowitz MD, White-Carrington S, Szalkowski DM, Hey PJ, Wu M, Cullinan CA, Bailey P, Lollmann B, Frederich R, Flier JS, Strader CD and Smith RG (1996) Down-regulation of the expression of the obese gene by an antidiabetic thiazolidinedione in Zucker diabetic fatty rats and db/db mice. J Biol Chem 271: 9455-9459.
Zhang Y, Proenca R, Maffei M, Barone M, Leopold L and Friedman JM (1994) Positional cloning of the mouse obese gene and its human homologue. Nature 372: 425-432.
Zhao Y, Sun R, You L, Gao C and Tian Z (2003) Expression of leptin receptors and response to leptin stimulation of human natural killer cell lines. Biochem Biophys Res Commun 300: 247-252.