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研究生:李雁鈴
論文名稱:台灣地區Riemerellaanatipestifer質體核酸序列分析與抗藥性基因檢測應用
論文名稱(外文):Sequence analysis of plasmids and application to detection of antibiotics resistance genes in riemerella anatipestifer isolated in Taiwan
指導教授:謝快樂謝快樂引用關係
學位類別:碩士
校院名稱:國立中興大學
系所名稱:獸醫學系
學門:獸醫學門
學類:獸醫學類
論文種類:學術論文
論文出版年:2004
畢業學年度:92
語文別:中文
論文頁數:75
中文關鍵詞:質體核酸序列抗藥性基因
外文關鍵詞:Riemerella anatipestifer
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Riemerella anatipestifer(RA)為革蘭氏陰性短桿菌,其可造成鴨傳染性漿膜炎或稱新鴨病,在鵝則可造成鵝傳染性感冒或滲出性敗血症。RA主要經由呼吸道感染後造成急性或慢性的傳染性敗血症,耐過之病禽常呈現生長遲鈍、發育不良,可造成嚴重的經濟損失。截至目前為止RA真正的毒力因子及抗藥性基因尚未被鑑定出來。本實驗由台灣地區六個縣市收集到66株RA菌株,首先分析收集菌株之質體相,發現有84.9%(56/66)菌株含有質體,質體相共分七型。除原有發表之質體外,另有分子量約為7 kb及9 kb的質體尚未被定序,遂著手進行定序並分別命名為pY1及pY2。結果pY1核酸序列全長6849 bp,pY2核酸序列全長8745 bp,其上除含有已發表之RA質體蛋白基因序列外,於此兩質體中各發現一新的蛋白基因序列,其所轉譯之蛋白分別命名為ORF651及ORF1233。隨後進行表現ORF651蛋白及製備抗血清以檢測其功能及位置,結果顯示其為可溶性蛋白且為質體相關蛋白,將此蛋白序列於NCBI網站上比對後得知其具有與FemABX family相似性之功能蛋白序列,含有可與雙糖六月生月太脂質結合的區域。由於此兩個質體上並無任何抗藥性基因存在,所以利用於GenBank已發表不同藥物之抗藥性基因,設計引子偵測RA基因體是否含有類似或相同片段,將增幅出之片段加以定序及比對,結果可成功增幅出兩種基因型之dihydropeteroate synthase片段,證實RA基因體上具有抗磺胺劑基因,此為第一個被發現的RA抗藥性基因。實驗中不論是分自鴨源或鵝源的菌株皆含有此兩型抗磺胺劑基因,且大部分的菌株具有第二型抗磺胺劑基因可抵抗磺胺劑。比較菌株PCR檢測基因型結果與抗生素感受性試驗結果,發現菌株抗磺胺劑之基因型與表型達90.3%之吻合度,故實驗中所建立之引子可對RA菌株以PCR方法進行初步之磺胺劑抗性檢測,有利於縮短檢測菌株抗藥性之時間。

Riemerella anatipestifer is a Gram-negative rod-shaped bacterium and may cause epizootic infections mostly in water fowls and others. R. anatipestifer infection characterized by infectious serositis, new duck syndrome in duck or exudative septicaemia, infectious influenza in geese. This disease causes acute or chronic contagious septicemic disease and accounts for major economic losses in industrialized duck forms due to weight loss. There has been little work on the molecular basis of the pathogenesis of this organism, and so far no virulence factors or drug resistance genes have been established. This study sixty-six strains of R. anatipestifer were isolated from ducks with infectious serositis and geese in Taiwan. All strains contain seven differently sized plasmids ,and eighty-five percent of the ioslates(56/66)contained plasmids. In this study find the new plasmids, 7-kb and 9-kb plasmids in R. anatipestifer strains. The 7-kb plasmid(designated as pY1)and the 9-kb plasmid(designated as pY2)were completely sequenced to determine if they encoded virulence factors or drug resistance genes. pY1 had 6849 bp and pY2 had 8745 bp. Six ORFs(open reading frames) were identified in the pY1 and eight ORFs were identified in the pY2. There were a new ORF(ORF651)in pY1 and a new ORF(ORF1233)in pY2. The results indicated that ORF651 was a plasmid-associated protein, and it was a water-soluble protein. After blasting ORF651 with other proteins, indicated that ORF651 has disaccharide hexapeptide lipid substrate binding site. There was no drug resistance gene in pY1 and pY2. Then designated PCR primers to amplify the drug resistance gene of R. anatipestifer genome. The results of PCR indicated that R. anatipestifer genome has encoded two types of dihydropeteroate synthase. This is the first report that R. anatipestifer genome encoded drug resistance gene, dihydropeteroate synthase. Compared the PCR results with antibiotic susceptibility test , there were 90.3% similarity. Thus, using the PCR method could be short the testing time of antibiotic susceptibility.

第一章 序言…………………………………………………… 1
第二章 文獻探討……………………………………………… 2
第一節Riemerella anatipestifer分類學簡介與生物學特性……2
第二節Riemerella anatipestifer 感染症……………… 4
第三節 細菌質體探討…………………………… 5
第四節 Riemerella anatipestifer抗藥性…………………………………8
第三章 材料與方法…………………………………………………………10
第一節Riemerella anatipestifer之分離……………………………10
第二節Riemerella anatipestifer之鑑定…………………………………10
3-2.1聚合酶連鎖反應…………………………………………………..10
3-2.2 BIOLOG 96項生化測定鑑定試驗………………………………..12
第三節 質體相分析…………………………………………………………12
第四節 質體核酸序列定序分析……………………………………………13
3-4.1質體片段之分子選殖……………………………………………..13
3-4.2 質體核酸片段定序與整合分析…………………………………..14
第五節 重組質體蛋白之表現………………………………………………15
3-5.1重組表現載體之構築……………………………………………..15
3-5.2重組質體之表現與確認…………………………………………..16
第六節 表現蛋白抗血清製備及RA質體蛋白檢測……………………….18
3-6.1表現蛋白抗血清製備……………………………………………...18
3-6.2應用Western blot檢測RA質體蛋白表現……………………….19
第七節 藥物感受性試驗……………………………………………………20
3-7.1紙錠瓊脂擴散試驗………………………………………………..20
3-7.2微量培養液稀釋試驗……………………………………………..20
第八節 抗藥性基因偵測……………………………………………………21
3-8.1抗藥性基因引子之設計…………………………………………..21
3-8.2 PCR偵測RA抗藥性基因…………………………………………21
第四章 結果………………………..………………………………………24
第一節Riemerella anatipestifer之分離與鑑定…………………………24
4-1.1引子特異性分析…………………………………………………..24
4-1.2 分離鑑定結果…………………………………………………….24
第二節 質體相分析…………………………………………………………24
第三節 質體核酸序列定序分析……………………………………………25
4-3.1質體DNA內核酸限制酶圖譜分析………………………………25
4-3.2質體核酸序列分析………………………………………………..25
第四節 重組質體蛋白之表現………………………………………………26
4-4.1重組表現載體之構築……………………………………………..26
4-4.2重組質體之表現與純化…………………………………………..26
第五節 應用Western blot檢測RA質體蛋白表現………………………..27
4-5.1 RA菌株表現檢測………………………………………………….27
4-5.2 RA-ORF651蛋白可溶及不可溶性檢測…………………………27
第六節 藥物感受性試驗……………………………………………………27
4-6.1紙錠瓊脂擴散試驗………………………………………………..27
4-6.2微量培養液稀釋試驗……………………………………………...28
第七節 抗藥性基因偵測……………………………………………………28
第五章 討論………………………………………………………………53
參考文獻………………………………………………………………………61

洪伯懿。Riemerella anatipestifer之生物學特性。碩士論文,國立台灣大學獸醫學研究所,台北,台灣。1996。
洪信雄、黃旭田、陳文烈、李明廉、莊啟增。屏東縣水禽傳染性漿膜炎之流行病學調查。台灣省81年度家禽流行病學研討會專輯31-33,台灣省政府農林廳,1992。
張照夫。Pasteurella anatipestifer 對鴨之感染機序及其藥物感受性。台灣畜牧獸醫學會會報 43: 40-45, 1984。
黃旭田、徐華山、莊啟增、蔡睦宗、陳文烈、洪信雄、張榮儒。屏東縣水禽傳染性漿膜炎之調查研究-關於病原分離、肉眼及組織病理學變化、血清凝集抗體分析調查。台灣畜牧獸醫學會會報 57: 63-70, 1991。
黃國安。鴨疫黎氏桿菌(Riemerella anatipestifer)毒力相關蛋白基因vapD1之次單位疫苗及DNA疫苗建構及對鴨隻免疫保護效果。碩士論文,國立台灣大學獸醫學研究所,台北,台灣。2002。
劉育宗。鴨Riemerella anatipestifer感染症之研究:保菌及排菌研究、聚合酶連鎖反應診斷技術之建立及外膜蛋白A基因序列分析。碩士論文,國立台灣大學獸醫學研究所,台北,台灣。2002。
劉育宗、蔡向榮。鴨人工感染Riemerella anatipestifer之保菌及排菌與抗體反應。
台灣獸醫誌29: 205-213, 2003。
蔡貴雄。雲林縣水禽傳染性漿膜炎發生疫情報告。台灣省81年度家禽流行病學研討會專輯21-25,台灣省政府農林廳,1992。
翁淑娟。Riemerella anatipestifer pCFC2質體之基因分析及毒力相關蛋白之研究。碩士論文,國立台灣大學獸醫學研究所,台北,台灣。1998。
廖彥華。Riemerella anatipestifer外膜蛋白基因之選殖,表現與其重組蛋白對鴨隻之免疫試驗。碩士論文,國立台灣大學獸醫學研究所,台北,台灣。2001。
龔順榮。台灣地區家禽霍亂菌之藥物感受性試驗、分子特性及疫苗效力研究。碩士論文,國立中興大學獸醫學系碩士班,台中,台灣。2000。
Abeles AL, Reaves LD, Austin SJ. Protein-DNA interactions in the regulation of P1 plasmid origin. Journal of Bacteriology 171: 43-52, 1989.
Aarestrup FM, Agerso Y, Christensen JC, Madsen M, Jensen LB. Antimicrobial susceptibility and presence of resistance genes in Staphylococci from poultry. Veterinary Microbiology 74: 353-364, 2000.
Aarestrup FM, Jensen LB. Trends in antimicrobial susceptibility in relation to antimicrobial usage and presence of resistance genes in Staphylococcus hyicus isolated from exudative epidermitis in pigs. Veterinary Microbiology 89: 83-94, 2002.
Ahmed AM, Nakagawa T, Arakawa E, Ramamurthy T, Shinoda S, Shimamoto T. New aminoglycoside acetyltransferase gene, aac(3)-Id, in a class 1 integron from a multiresistant strain of Vibrio fluvialis isolated from an infant aged 6 months. Journal of Antimicrobial Chemotherapy 29: 2010-2011, 2004.
Andreason JR, Sandhu T. Pasteurella anatipestifer-like bacteria associated with respiratory disease in pigeons. Avian Diseases 37: 908-911, 1993.
Ash WJ. Antibiotics and infectious serositis in White Pekin ducklings. Avian Diseases 11: 38-40, 1967.
Asplin FD. A septicemic disease of ducklings. Veterinary Research 67: 854-858, 1955.
Asplin FD. Experiments on the transmission of a septicemiac disease of duckling. Veterinary Research 68: 588-590, 1956.
Astorga RJ, Cubero MJ, Leon L, Maldonado A, Arenas A, Tarradas MC, Perea A. Serological survey of infections in water fowl in the Guadalquivir marshes (Spain). Avian Diseases 38: 371-375, 1994.
Baba T, Odagiri Y, Morimoto T, Yamamoto S. An outbreak of Moraxella (Pasteurella) anatipestifer infection in duckings in Japan. Japan Journal of Veterinary Science 49: 939-941, 1987.
Bangun A, Johnson JL, Tripathy DN. Taxonomy of Pasteurella anatipestifer. 1. DNA base composition and DNA-DNA hybridization analysis. Avian Diseases 31: 43-5, 1987.
Bangun A, Tripathy DN. Taxonomy of Pasteurella anatipestifer. 2. Cellular fatty-acid profile by gas chromatography. Avian Diseases 31: 46-51, 1987.
Bangun A, Tripathy DN, Hanson L E. Studies of Pasteurella anatipestifer: an approach to its classification. Avian Diseases 25: 326-337, 1981.
Barlow RS, Pemberton JM, Desmarchelier PM, Gobius KS. Isolation and characterization of integron-containing bacteria without antibiotic selection. Antimicrobial Agents and Chemotherapy 48: 838-842, 2004.
Bendheim U, Even-Shoshan A. Survival of Pasteurella multocida and Pasteurella anatipestifer in various natural media. Refuah Veterinarith 32: 40-46, 1975.
Benoit S, Benachour A, Taouji S, Auffray Y, Hartke A. Induction of vap genes encoded by the virulence plasmid of Rhodococcus equi during acid tolerance response. Research Microbiology 152: 439-49, 2001.
Benson TE, Prince DB, Mutchler VT, Curry KA, Ho AM, Sarver RW, Hagadorn JC, Choi GH, Garlick RL. X-ray crystal structure of Staphylococcus aureus FemA. Structure (Camb)10: 1107-1115, 2002.
BibersteinEL, Hirsh DC. Moraxella. In: Hirsh DC, Zee YC. Veterinary Microbiology. Blackwell Science, Massachsetts, USA. 151-154, 1999.
Bisgaard M. Antigenic study on Pasteurella anatipestifer, species Incerta sedis, using slide and tube agglutination. Avian Pathology 11: 341-350, 1982.
Brogden KA, Rhoades KR, Rimler RB. Serologic types and physiologic characteristics of 46 avian Pasteurella anatipestifer culture. American Association of Avian Pathologists 26: 891-896, 1982.
Brogden KA, Adlam C, Lehmkuhl HD, Cutlip RC, Knights JM, Engen RL.Effect of Pasteurella haemolytica (A1) capsular polysaccharide on sheep lung in vivo and on pulmonary surfactant in vitro. American Journal of Veterinary Research 50: 555-559, 1989.
Bruner DW, Fabricant J. A strain of Moraxella anatipestifer(Pfeifferella anatipestifer)isolated from ducks. Cornell Veterinary 44: 461-464, 1954.
Bruner DW, Angstrom CI, Price JI. Pasteurella anatipestifer infection in pheasants. A case report. Cornell Veterinary 60: 491-494, 1970.
Bukhari AI, Shapiro JA, Adhya SL. DNA insertion elements, plasmids, and episome. Cold Spring Harbor lab, 1977.
Chang CF, Hong PE, Chang YF. Molecular characterization of a plasmid isolated from Riemerella anatipestifer. Avian Pathology 27: 339-345, 1998.
Chang CF, Ma DP, Bai HQ, Young R, Struck DK, Shin SJ, Lein DH. Characterization of plasmids with antimicrobial resistance genes in Pasteurella haemolytica A1. DNA Sequence 3: 89-97, 1992.
Chang CF, Yeh TM, Chou CC, Chang YF, Chiang TS. Antimicrobial susceptibility and plasmid analysis of Actinobacillus pleurpneumoniae isolated in Taiwan. Veterinary Microbiology 84: 169-177, 2002.
Charles SD, Nagaraja KV, Halvorson DA, Rao A. A retrospective analysis on the epizootiological aspects of outbreak of Pasteurella anatipestifer infection in turkey in Minnesota. Poutry Science 70: 1704-1708, 1991.
Clark AJ, Warren GJ. Conjugal transmission of plasmids. Annual Review of Genetics 13: 99-125, 1979.
Crasta KC, Chua KL, Subramaniam S, Frey J, Loh H, Tan HM. Identification and characterization of CAMP cohemolysin as a potential virulence factor of Riemerella anatipestifer. Journal of Bacteriology 184: 1932-1939, 2002.
Cohen SN. Transposable genetic elements and plasmid evolution. Nature 263: 731, 1976.
Cooper GL, Charlton BR. Spondylitis in turkeys associated with experimental Pasteurella anatipestifer infection. Avian Diseases 36: 290-295, 1992.
Cooper GL. Pasteurella anatipestifer infection in California turkey flocks: circumstantial evidence of a mosquito vector. Avian Diseases 33: 809-815, 1989.
Dougherty E, Saunders LZ, Parsons EH. The pathology of infectious serositis of ducks. American Journal of Pathology 31: 475-487, 1955.Duijkeren EV, Wannet WJB, Heck MEOC, Pelt WV, Oldruitenborgh-Oosterbaan MMSV, Smit JAH, Houwers DJ. Sero types, phage types and antibiotic susceptibilities of Salmonella strains isolated from horses in The Netherlands from 1993 to 2000. Veterinary Microbiology 86: 203-212, 2002.
Dundon WG, Marshall DG, O'Morain CA, Smyth CJ. Population characteristics of Irish Helicobacter pylori isolates: a tRNA-associated locus. Irish Journal Medicine Science 169: 137-40, 2000.
Ebner P, Garner K, Mathew A. Class 1 integrons in various Salmonella enterica serovars isolated from animals and identification of genomic island SGI1 in Salmonella enterica var. Meleagridis. Journal of Antimicrobial Chemotherapy 29:1910-1911, 2004.
Eleazer TH, Blalock HG, Harrell JS, Derieux WH. Pasteurella anatipestifer as a cause of mortality in semi-wild pen-raised mallard ducks in South Carolina. Avian Diseases 17: 855-857, 1973.
Floren U, Wiedeking B, Kissel B, Kaleta EF. Pasteurella anatipestifer infection of water fowl. Dtsch Tierarztl Wochenschr 94: 597-603. 1987.
Frommer A, Bock R, Inbar A, Zemer S. Muscovy ducks as a source of Pasteurella anatipestifer infection in turkey flocks. Avian Pathology 19: 161-163, 1990.
Gardete S, Ludovice AM, Sobral RG, Filipe SR, de Lencastre H, Tomasz A. Role of murE in the Expression of beta-lactam antibiotic resistance in Staphylococcus aureus. Journal of Bacteriology 186: 1705-1713, 2004.
Glunder G, Hinz KH. Isolation of Moraxella anatipestifer from embryonated goose eggs. Avian Pathology 18: 351-355, 1989.
Graham R, Brandly CA, Dunlap GL. Studies on duck septicemia. Cornell Veterinarian 28: 1-8, 1938.
Gromadski KB, Rodnina MV. Streptomycin interferes with conformational coupling between codon recognition and GTPase activation on the ribosome. Natural Struction Moleculus Biology 11: 316-22, 2004.
Hardy KG. Plasmids-a practical approach. Oxford University Press, New York, USA 1993.
Harry EG. Pasteurella (Pfeifferella) anatipestifer serotypes isolated from cases of anatipestifer septicemia in ducks. Veterinary Record 84: 673, 1969.
Hatfield RM, Morris BA, Henry RR. Development of an enzyme-linked immunosorbent assay for the detection of humoral antibody to Pasteurella anatipestifer. Avian Pathology 16: 123-140, 1987.
Hatfield RM, Morris BA. Influence of the route of infection of Pasteurella anatipestifer on the clinical and immune responses of white pekin ducks. Reaserch in Veterinary Science 44: 208-214, 1988.
Helfer DH, Helmboldt CF. Pasteurella anatipestifer infection in turkeys. Avian Diseases 21: 712-715, 1977.
Helinski DR. Plasmid determined resistance to antibiotics: molecular properties of R factors. Annual Review of Microbiology 27: 437-70, 1973.
Helinski DR, Blair DG, Sherratt DJ, Lovett M, Kupersztoch Y, Kingsbury DT. Replication of plasmid supercoiled DNA. Johns Hopkins Medicine Journal 2: 15-34, 1973.
Hendrickson JM, Hilbert KF. A new and serious septicemia disease of young ducks with a description of the new causative organism, Pfeifferella anatipestifer. Cornell Veterinary 22: 239-252, 1932.
Higgins DA, Henry RR, Kounev ZV. Duck immune responses to Riemerella anatipestifer vaccines. Developmental & Comparative Immunology 24: 153-167, 2000.
Hinz KH, Ryll M, Kohler B, Glunder G. Phenotypic characteristics of Riemerella anatipestifer and similar micro-organisms from various host. Avian Pathology. 27: 33-42, 1998.
Hiraga, Sota. Dynamic localication of bacterial and plasmid chromocomes. Annual Review of Genetics 34: 21-60, 2000.
Hirsh DC, Martin LD, Libal MC. Plasmid-meadiated antimicrobial resistance in Haemophilus pleurpneumoniae. American Journal of Veterinary Research 43: 269-272, 1982.
Huang B, Subramaniam S, Chua KL, Kwang J, Loh H, Frey J, Tan HM. Molecular fingerprinting of Riemerella anatipestifer by repetitive sequence PCR. Veterinary Microbiology 67: 213-219, 1999.
Hiraga B, Subramaniam S, Frey J, Loh H, Tan HM, Fernandez CJ, Kwang J and Chua KL. Vaccination of ducks with recombinant outer membrane protein (Omp A) and a 41 kDa partial protein(P45N’) of Riemerella anatipestifer. Veterinary Microbiology 84: 219-230, 2002.
Jortner BS, Porro R, Leibovitz L. Central-nervous-system lesion of spontaneous Pasteurella anatipestifer infection in ducklings. Avian Diseases 13 : 27-35, 1969.
Jost BH, Trinh HT, Songer JG, Billington SJ. A second tylosin resistance determinant, Erm B, in Arcanobacterium pyogenes. Antimicrobial Agents and Chemotherapy 48: 721-727, 2004.
Karstad L, Lusis P, Long JR. Pasteurella anatipestifer as a cause of mortality in captive wild waterfowl. Journal of Wildlife Disease 6: 408-413, 1970.
Katz ME, Wright CL, Gartside TS, Cheetham BF, Doidge CV, Moses EK, Rood JI. Genetic organization of the duplicated vap region of the Dichelobacter nodosus genome. Journal of Bacteriology 176: 2663-2669, 1994.
Kipp F, Becker K, Peters G, von Eiff C. Evaluation of different methods to detect methicillin resistance in small-colony variants of Staphylococcus aureus. Journal of Clinical Microbiology 42: 1277-1279, 2004.
Kleckner N. Translocatable elements in prokaryotes. Cell 11: 11, 1977.
Kohler AK, Stone DM, Hines MT, Byrne BA, Alperin DC, Norton LK, Hines SA. Rhodococcus equi secreted antigens are immunogenic and stimulate a type 1 recall response in the lungs of horses immune to R. equi infection. Infectious Immunology 71: 6329-6337, 2003.
Kumar A, Worobec EA. Fluoroquinolone resistance of Serratia marcescens: involvement of a proton gradient-dependent efflux pump. Journal of Antimicrobial Chemotherapy 50:593-596, 2002.
Lanz R, Kuhnert P, Boerlin P. Antimicrobial resistance and resistance gene determinants in clinical Escherichia coli from different animal species in Switzerland. Veterinary Microbiology 91: 73-84, 2003.
Layton HW, Sandhu TS. Protection of ducklings with a broth-grown Pasteurella anatipestifer bacterin. Avian Diseases 28: 718-726, 1984.
Leibovitz L. A survey of the so-called “anatipestifer syndrome” Avian Diseases 16: 836-851, 1972.
Levine ND. Goose influenza (septicaemia anserum exsudativa). In: Biester HE, Schwarte LH eds. Diseases of Poultry, 5th ed. Iowa State Univ Press, Ames, Iowa, USA 469-471, 1965.
Loh H, Teo TP, Tan HC. Serotype of Pasteurella anatipestifer isolate from ducks in Singapore: a proposal of new serotype. Avian Pathology 21: 453-459, 1992.
Luzzaro F, Endimiani A, Docquier JD, Mugnaioli C, Bonsignori M, Amicosante G, Rossolini GM, Toniolo A. Prevalence and characterization of metallo-beta-lactamases in clinical isolates of Pseudomonas aeruginosa. Diagnostic Microbiology and Infectious Disease48: 131-135, 2004.
Martel A, Devriese LA, Cauwerts K, De Gussem K, Decostere A, Haesebrouck F. Susceptibility of Clostridium perfringens strains from broiler chickens to antibiotics and anticoccidials. Avian Pathology 33: 3-7, 2004.
Munday BL, Corbould A, Heddleston KL, Harry EG. Isolation of Pasteurella anatipestifer from black swan (Cygnus atratus). Australian Veterinary Journal. 46: 322-325, 1970.
Mukhopadhyay G, Carr KM, Kaguni JM, Chattoraj DK. Open-complex formation by the host initiator, DnaA, at the origin of P1 replication. EMBO Journal 12: 4547-4557, 1993.
Nayak R, Stewart T, Wang RF, Lin J, Cerniglia CE, Kenney PB. Genetic diversity and virulence gene determinants of antibiotic-resistant Salmonella isolated from preharvest turkey production sources. International Journal Food Microbiology 91: 51-62, 2004.
Nevers P, Saedler H. Transposable genetic elements as agents of gene instability and chromosomal rearrangements. Nature 268: 109-115, 1977.
Pathanasophon P, Phuektes P, Tanticharoenyos T, Narongsak W, Sawada T.A potential new serotype of Riemerella anatipestifer isolated from ducks in Thailand. Avian Pathology 31: 267-70, 2002.
Pathanasophon P, Sawada T, Pramoolsinsap T, Tanticharoneyos T. Immunogenicity of Riemerella anatipestifer broth culture bacterin and cell-free culture filtrate in ducks. Avian Pathology 25: 705-719, 1996.
Pathanasophon P, Sawada T, Tanticharoneyos T. New serotypes of Riemerella anatipestifer isolated from ducks in Thailand. Avian Diseases 24: 195-199, 1995.
Pathanasophon P, Tanticharoneyos T, Sawada T. Physiological characteristics, antimicrobial susceptibility and serotypes of Pasteurella anatipestifer isolated from ducks in Thailand. Veterinary Microbiology 39: 179-185, 1994.
Pickrell JA. Pathologic changes associated with experimental Pasteurella anatipestifer infection in ducklings. Avian Diseases 10: 281-288, 1966.
Piechulla K, Pohl S, Mannheim W. Phenotypic and genetic relationships of so-called Moraxella (Pasteurella) anatipestifer to the Flavobacterium/Cytophaga group. Veterinary Microbiology 11: 261-270, 1986.
Pierce RL, Vorhies MW. Pasteurella anatipestifer infection in geese. Avian Diseases 17: 868-870, 1973.
Poppe C, McFadden KA, Demczuk WH. Drug resistance, plasmids, biotypes and susceptibility to bacteriophages of Salmonella isolated from poultry in Canada. International Journal Food Microbiology 30: 325-44, 1996.
Pornpen P , Tipa T, Takuo S. Physiological characteristics, antimicrobial susceptibility
and serotypes of Pasteurella anatipestifer isolated from ducks in Thailand. Veterinary
Microbiology 39: 179-85, 1994.
Riddell C. Avian Histopathology. American Association of Avian Pathologists publications, Lawreence, Kansas 1987.
Rimler RB, Nordholm GE. DNA fingerprinting of Riemerella anatipestifer. Avian Diseases 42: 101-105, 1998.
Rimler RB, Sandhu TS, Glisson JR. Riemerella anatipestifer infection. In: Swayne DE, Glisson JR, Jackwood MW, Pearson JE, Reed WM. A laboratory manual for the isolation and identification of avian pathogens 4th Ed. Rose Printing, The American Association of Avian Pathologists, 22-23, 1998.
Rohrer S, Berger-Bachi B. FemABX peptidyl transferases: a link between branched-chain cell wall peptide formation and beta-lactam resistance in gram- positive cocci. Antimicrobial Agents and Chemotherapy 47: 837-846, 2003.
Rosenfield LE. Pasteurella anatipestifer infection in fowls in Austraria. Australian Veterinary Journal 49: 55-56, 1973.
Rossmanith SE, Wilt GR, Wu G. Characterization and comparison of antimicrobial susceptibilities and outer membrane protein and plasmid DNA profiles of Pasteurella haemolytica and certain other members of the genus Pasteurella. American Journal of Veterinary Research 52: 2016-2022, 1991.
Rowbury RJ. Bacterial plasmids with particular reference to their replication and transfer properties. Progress in Biophysics and Molecular Biology 31: 271-317, 1977.
Ryll M, Christensen H, Bisgaard M, Christensen JP, Hinz KH, Kohler B. Studies on the prevalence of Riemerella anatipestifer in the upper respiratory tract of clinically healthy ducklings and characterization of untypable strains. Journal of Veterinary Medicine Series B 48: 537-46, 2001.
Sakagami K, Atsumi K, Yoshida T, Nishihata K.Synthetic cephalosporins. III. Synthesis and antibacterial activity of 7-[2-(2-Aminothiazol-4-yl)-3-carboxy-2- propenoamido] cephalosporins and related compounds. Yakugaku Zasshi. 109: 377-87, 1989.
Sandhu TS. Immunization of white Pekin ducklings against Pasteurella anatipestifer infection. Avian Diseases 23: 662-669, 1979.
Sandhu TS. Immunogenicity and safety of a live Pasteurella anatipestifer vaccine in white Pekin ducklings: laboratory and field trials. Avian Pathology 20: 423-432, 1991.
Sandhu TS, Dean WF. Effect of chemotherapeutic agents on Pasteurella anatipestifer infection in white Pekin ducklings. Poultry Science 59: 1027-1030, 1980.
Sandhu TS, Harry EG. Serotypes of Pasteurella anatipestifer isolated from commercial white Pekin ducks in the United States. Avian Diseases 25: 497-502, 1981.
Sandhu TS, Layton HW. Laboratory and field trials with formalin-inactivaed Escherichia coli (O78)-Pasteurella anatipestifer bacterin in white Pekin ducks. Avian Diseases 29: 128-135, 1985.
Sandhu TS, Leister ML. Serotype of Pasteurella anatipestifer isolate from poultry in different countries. Avian Pathology 20: 233-239, 1991.
Sandhu TS, Rimler RB. Riemerella anatipestifer infection. Diseases of poultry, 10th ed. In: Calnek BW, Barner HJ , Beard CW, Reid WM, Yoder HW Jr., eds. Iowa State University Press, Ames, Iowa. 161-166, 1997.
Segers P, Mannheim W, Vancanneyt M, Branot K, Hinz KH, Kersters K, Vandamme P. Riemerella anatipestifer gen. nov., comb. nov., the causative agent of septicemia anserum exsudative, and its phylogenetic affiliation with the Flavobacterium-cytophaga rRNA homology group. International Journal Systematic Bacteriology 43: 768-776, 1993.
Setlow B, Cabrera-Martinez RM, Setlow P. Mechanism of the hydrolysis of 4-methylumbelliferyl-beta-d-glucoside by germinating and outgrowing spores of Bacillus species. Journal Appl Microbiology 96: 1245-1255, 2004.
Spiliopoulou I, Petinaki E, Papandreou P, Dimitracopoulos G. Erm(C) is the predominant genetic determinant for the expression of resistance to macrolides among methicillin-resistant Staphylococcus aureus clinical isolates in Greece. Journal of Antimicrobial Chemotherapy 53: 814-7, 2004.
Smith JE. Pasteurella. In:Bergey’s Manual of Determinative Bacteriology. 8th ed. Buchanan RE and Gibbon NE, (eds). Williams and Williams and Wilkins, Baltimore. 370-373, 1974.
Smith JM, Frame DD, Cooper G, Bickford AA, Ghazikhnian YG, Kelly BJ. Pasteurella anatipestifer infection in commercial meat-type turkeys in California. Avian Diseases 31: 913-917, 1987.
Starlinger P. DNA rearrangements in procaryotes. Annual Review of Genetics 11: 103-126, 1977.
Stranden AM, Ehlert K, Labischinski H, Berger-Bachi B. Cell wall monoglycine cross-bridges and methicillin hypersusceptibility in a femAB null mutant of methicillin-resistant Staphylococcus aureus. Journal of Bacteriology 179: 9-16, 1997.
Subramaniam S, Chua KL, Tan HM, Loh H, Kuhnert P, Frey J. Phylogenetic position of Riemerella anatipestifer based on 16S rRNA gene sequences. International Journal of Systematic Bacteriology 47: 562-565, 1997.
Subramaniam S, Huang B, Loh H, Kwang J, Tan HM, Chua KL, Frey J. Characterization of a predominant immunogenic outer membrane protein of Riemerella anatipestifer. Clinical & Diagnostic Laboratory Immunology 7: 168-174, 2000.
Timms LM, Marshall RN. Laboratory assessment of protection given by experimental Pasteurella anatipestifer vaccine. British Veterinary Journal 145: 483-493, 1989.
Vandamme P, Vancanneyt M, Segers P, Ryll M, Kohler B, Ludwig W, Hinz KH.Coenonia anatina gen. nov., sp. nov., a novel bacterium associated with respiratory disease in ducks and geese. International Journal of Systematic Bacteriology 49: 867-74, 1999.
Verdier I, Reverdy ME, Etienne J, Lina G, Bes M, Vandenesch F. Staphylococcus aureus isolates with reduced susceptibility to glycopeptides belong to accessory gene regulator group I or II. Antimicrobial Agents and Chemotherapy 48: 1024-1027, 2004.
Weng S, Lin W, Chang C. Identification of a virulence-associated protein homolog gene and ISRa1 in a plasmid of Riemerella anatipestifer. FEMS Microbiology Letters 179: 11-9, 1999.
Zehr WJ, Ostendorf J. Pasteurella anatipestifer in turkeys. Avian Diseases 14: 557-560, 1970.

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