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研究生:胡國威
研究生(外文):Guo-Way Whu
論文名稱:表面修飾環糊精的金奈米應用於藥物載體與核磁共振顯影劑之研究
論文名稱(外文):Applications of Au Nanoparticles Conjugated with β-Cyclodextrin on Drug Carrier and MRI Contrast Agent
指導教授:葉晨聖
指導教授(外文):Chen-Sheng Yeh
學位類別:碩士
校院名稱:國立成功大學
系所名稱:化學系碩博士班
學門:自然科學學門
學類:化學學類
論文種類:學術論文
論文出版年:2004
畢業學年度:92
語文別:中文
論文頁數:67
中文關鍵詞:金奈米粒子環糊精
外文關鍵詞:Au nanoparticlecyclodextrin
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  隨著各種金屬奈米粒子與有機單層結合的製備方式的快速發展,增加了奈米材料表面功能化的潛力。其中,又以具有主客效應的有機物種最受到注意。將具有分子辨識能力的非生物性物種修飾在金屬奈米材料上,可賦予金屬奈米材料吾人所期望的特性。具有適當尺寸大小與作用力的藥物分子能夠藉由主客效應而崁入環糊精的分子凹槽中,而與β型的環糊精形成錯合物。我們將β型環糊精修飾在金奈米粒子上,並且加以發展此奈米混成材料的應用性。
  本研究中利用此特性發展奈米粒子作為藥物載體的功能性,期望能應用於藥物傳導的技術上。在另一部分的研究中,藉由此奈米材料的主體特性與釓形成錯合物,發展新型的核磁共振顯影劑。
  The fast development of metal nanoparticles capped with organic monolayers is opening interesting possibilities for the functionalization of their surfaces. Among these, the attachment of functional groups capable of engaging in well-defined host-guest interactions is receiving considerable attention. A range of molecular recognition interactions based on synthetic or non- biological host/guest species can be exploited to endow the metal nanoparticles with desirable features. Drug molecules with suitable size range and interaction can be embedded in the cavity of β-cyclodextrin via host-guest interaction. We focus on the gold nanoparticles modified with thiolated cyclodextrins, and develop applications of this nano-materials.
  We took advantage of their well-documented host properties to form drug carriers for the purpose of the drug delivery. On the other hand, we develop a novel MRI contrast agent base on Gadolinium conjugated with β–CD-Au nanoparticles.
目錄

目錄........................................................I
表目錄....................................................III
圖目錄.....................................................IV

第一章 序論.................................................1
1.1 奈米的時代..............................................1
1.2 奈米粒子簡介............................................4
1.3 金屬奈米粒子簡介........................................8
1.3.1 金屬奈米粒子之性質............................8
1.3.2 金屬奈米粒子之製備............................9
1.4 影響奈米粒子穩定度的因素...............................11
1.5 金屬奈米粒子的表面電漿共振.............................18
1.6 奈米粒子的修飾.........................................23
1.7 β型之環糊精...........................................26
1.8 研究動機...............................................28
1.8.1 藥物載體之應用研究...........................28
1.8.2 新型核磁共振顯影劑之研究.....................29

第二章 實驗部分............................................31
2.1 實驗藥品與儀器.........................................31
2.1.1 藥品.........................................31
2.1.2 儀器.........................................32
2.2 環糊精之衍生化.........................................34
2.2.1 合成碘化之環糊精.............................34
2.2.2 合成硫醇化之環糊精...........................35
2.3 金奈米表面修飾環糊精...................................35
2.3.1 13奈米金粒子之修飾步驟......................35
2.3.2 3奈米金粒子之修飾步驟......................36
2.4 藥物載體實驗步驟.......................................37
2.5 核磁共振顯影劑實驗步驟.................................37
2.5.1 β-CD-Au奈米粒子與釓錯合物實驗...............37
2.5.2 錯合物性質鑑定...............................38

第三章 結果與討論..........................................39
3.1 硫醇化環糊精之合成與鑑定...............................39
3.2 金奈米之表面修飾.......................................40
3.2.1 FT-IR分析...................................41
3.2.2 UV-vis 分析.................................41
3.2.3 TEM分析.....................................42
3.3 藥物載體螢光分析結果...................................43
3.4 核磁共振顯影劑.........................................44
3.4.1 TEM分析.....................................44
3.4.2 ICP-AES分析.................................44
3.4.3 XPS分析.....................................45
3.4.4 NMR T1分析..................................45
3.4.5 生物毒性與溶血測試...................................45

第四章 結論................................................47

第五章 參考文獻............................................63
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