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研究生:林世仁
研究生(外文):Shyh-jen Lin
論文名稱:單核細胞增多性李斯特菌之特性與檢驗
論文名稱(外文):Characterization and Diagnosis of Listeria monocytogenes
指導教授:劉仲康劉仲康引用關係
指導教授(外文):Jong-Kang Liu
學位類別:碩士
校院名稱:國立中山大學
系所名稱:生物科學系研究所
學門:生命科學學門
學類:生物學類
論文種類:學術論文
論文出版年:2004
畢業學年度:92
語文別:中文
論文頁數:78
中文關鍵詞:檢驗單核細胞增多性李斯特菌
外文關鍵詞:diagnosis methodListeria monocytogens
相關次數:
  • 被引用被引用:0
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  • 下載下載:56
  • 收藏至我的研究室書目清單書目收藏:0
Listeria moncytogens廣泛存在大自然,它能生長在冰箱冷藏溫度、低酸、和高鹽環境中。Listeria monocytogens所引起的李斯特症有高達百分之二十或更高的致死率,使得Listeria monocytogens變成一株重要而著名的食品中毒病原菌。最近經歷一連串食品中毒事件,證明了這株菌具有危害健康的潛在性,因而引起食品安全專家,和公共衛生官員的注意。本論文旨在介紹此株菌的一般特性包括生理和生化特性、致病因子、感染途徑、病徵、治療和流行病學概況。本論文尤其要引介並比較有關Listeria monocytogens傳統和快速檢測方法的優點與缺點。根據美國FDA細菌分析手冊,有關Listeria monocytogens之快速檢測方法主要有三類: 迷你生化檢測套組,免疫化學檢測套組,和基因檢測套組。本論文將各檢測套組所依據的原理、分析方式、技術、商業產品和產品製售的公司均納入討論,各種方法的優缺點和他們的應用範圍也一併討論評估。最後,我們評估傳統檢測和快速檢測方法目前在全世界各地,尤其在美國和歐洲的使用情形與現況。總之,對於Listeria monocytogens這株重要食品中毒菌的診斷,我們相信快速檢測方法和發展中的基因晶片及生物感測器,隨著市場發展和成本降低未來將會持續的成長。
Listeria monocytogens can be found widely in nature. It can grow at refrigeration temperature, low pH, and high salt. The disease that it caused a fatality rate of 20% or higher makes L. monocytogens to be a famous foodborn pathogen. After a number of recent foodborn outbreaks, it has been demonstrated that this bacterium poses a significant health risk and has attracted the attention of the food safety professionals and public health officers. This thesis introduces the general characteristics of this bacterium, including its physiological and biochemical traits, virulent factors, infection routes, symptoms, therapy, and epidemiology. This thesis is also especially emphasized on the introduction and comparison of the differences, the advantages, as well as the disadvantages between the traditional and rapid diagnosis methods. According to the US FDA Bacterial Analytical Manual, the rapid tests had been classified into three classes: miniaturized biochemical kits, immunochemical kits, and genetic kits. The principles, formats, techniques, commercial products and its production companies of each diagnosis methods are also incorporated in this thesis. The advantages and disadvantages of these methods and their applications have been assessed. Finally, we also evaluated the market of the traditional methods being used and the rapid tests in the world, including the US, and European Union. In conclusion, the diagnosis of this important bacterium both by rapid methods or newly developed biochip and sensor will continue to grow in the future.
中文摘要 ……………………………………………………………………IV
ABSTRACT ……………………………………………………………….. V
目錄 …………………………………………………………………….. VI
圖目錄 ……………………………………………………………………. VII
表目錄……………………………………………………………………….VIII
第一章 單核細胞增多性李斯特菌背景介紹 ………………………………1
第二章 李斯特菌特性與分類 ………………………………………….6
第三章 李斯特菌之致病途徑、特性、與控制及預防 …………………12
第四章 檢驗方法 …………………………………………………………19
第五章 結論與展望 ……………………………………………………….. 45
參考文獻 ……………………………………………………………………48
附錄1 ………………………………………………………………………..67
附錄2 ………………………………………………………………………..71
附錄3 ………………………………………………………………………..76
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