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研究生:施志學
論文名稱:研究薏苡仁誘發排卵之效應
論文名稱(外文):Study on ovulatory-active effect of adlay seed
指導教授:譚世特
學位類別:碩士
校院名稱:國立清華大學
系所名稱:生物科技研究所
學門:生命科學學門
學類:生物科技學類
論文種類:學術論文
論文出版年:2004
畢業學年度:92
語文別:中文
論文頁數:31
中文關鍵詞:薏苡仁排卵
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薏苡(Coix lacryma- jobi L.)自古以來便是中藥與食材兼具的草本,傳統醫學上薏苡一直被認為具有調節女性荷爾蒙的功效。在日本有研究顯示薏苡仁萃取物在老鼠的實驗中可以有效誘發其排卵,而其他研究也顯示薏苡仁對於女性排卵障礙有其治療的效果。本研究主要目的為探討薏苡仁誘發生物體排卵之確切效應。而我們嘗試以果蠅(Drosophila melanogaster)為模式系統來研究薏苡仁萃取物之誘發排卵的功效。實驗的結果顯示在薏苡仁的萃取物中,以正己烷萃取物(HE)之誘發排卵的效果較好,其結果約比對照組增加84%左右,而甲醇萃取物(ME)的效果並沒有正己烷萃取物(HE)來得顯著。實驗所用正己烷萃取物(HE)的劑量約100~200 (�尳/vial)時會有較好的效果,且餵食5天左右的效果較好。而在果蠅的卵巢解剖圖中顯示薏苡仁正己烷萃取物(HE)可以有效促進其卵的發育與成熟。另外我們並比較餵食正己烷萃取物(HE)所產生子代果蠅與對照組的差異,結果顯示其子代不論在生殖或熱壓力的抗性都與對照組果蠅並沒有太大的差異。
Adlay (Coix lacryma- jobi L.) is traditionally consumed as a cereal for both meal and medicine in China. Adlay has long been used in traditional Chinese medicine for the dysfunction of female’s endocrine system . Adlay seed extracts was reported to have activity of ovulation in golden hamasters in Japan. The purpose of this study was to investigate the certainly effect of adlay seed on activity of ovulation in organism. We try to use Drosophila melanogaster as a model system to study the effect of adlay seed extracts on activity of ovulation. The results showed that hexane extract of adlay seed (HE) had the best effect. The percentage increase in fly number over control about 84%. Methanol extract of adlay seed (ME) had no obvious effect than hexane extract of adlay seed (HE). Treated HE about 100~200 (�愮/vial) dosage had the best effect. The best effect of feeding time was 5 days . Micrographs from the ovary of virgin females represent the hexane extract of adlay seed (HE) can improve eggs developed and matured efficiently. We try to compare the first filial generation from flies by feeding HE with control. The results showed no matter fertility or thermal stress resistance were have no difference between control.
1. Nagao, T.; Otsuka, H.; Kohda, H.; Sato, T.; Yamasaki, K. (1985) Benzoxazinones from Coix lachrymal-jobi L var. ma-yuen. Phytochemistry. 24:2959-2962.
2. Takahashi, M.; Konno, C.; Hikino, H. (1986) Isolation and hypoglycemic activity of coixan A, B, C, glycans of Coix lachrymajobi var. ma-yuen seeds. Planta Med. 52:64-65.
3. Hidaka, Y.; Kaneda, T.; Amino, N.; Miyai, K. (1992) Chinese medicine, coix seeds increase peripheral cytotoxic T and NK cells. Biotherapy. 5:201-203.
4. Ishiguro, Y.; Okamoto, K.; Sakamoto, H.; Sonoda, Y. (1993) Antimicrobial substances coixindens A and B in etiolated seedlings of adlay. Nippon Nogei Kagaku Kaish. 67:1405-1410.
5. Yang, L. J.; Tsai, C. E. (1998) Effect of adlay on plasma lipids in hamsters. Food Sci. 25:638-650.
6. Kuo, C. C.; Shih, M. C.; Kuo, Y. H. and Chiang, W. (2001) Antagonism of free-radical-induced damage of adlay seed and its antiproliferative effect in human histolytic lymphoma U937 monocytic cells. J. Agric. Food Chem. 49:1564-1570.
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