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研究生:倪于晴
研究生(外文):Yu-Ching Ni
論文名稱:正子乳房造影系統先期之開發研究
論文名稱(外文):Initial development of the positron emission mammography system
指導教授:莊克士莊克士引用關係
指導教授(外文):Chuang KS
學位類別:碩士
校院名稱:國立清華大學
系所名稱:原子科學系
學門:工程學門
學類:核子工程學類
論文種類:學術論文
論文出版年:2004
畢業學年度:92
語文別:中文
論文頁數:59
中文關鍵詞:乳癌正子乳房攝影MLEM重建法
外文關鍵詞:breast cancerpositron emission mammographyMLEM reconstruction
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  • 下載下載:19
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利用功能性影像及早偵測出異常的生理變化,使病人可以在癌症的早期獲得適當的治療,是值得發展的技術。在本論文中利用核研所物理組自製的旋轉式正子造影系統作為實驗平台來進行一系列假體實驗,希望藉此探討利用正子乳房造影來偵測乳癌的可行性。系統是使用一對相對1800且距離220mm的BGO偵檢器在不旋轉的情況下來擷取數據,並利用MLEM演算法處理三維數據完成影像重建的工作。從重建影像上可以分辨腫瘤假體的大小以及其在乳房假體中的位置,在腫瘤假體尺寸達2mm直徑的大小仍可清楚分辨。即使在腫瘤假體與背景單位體積活度比(tumor-to-background concentration ratio)為5:1時仍然可以顯現尺寸為10mm直徑的腫瘤假體。至於視野外射源(如:心臟)的干擾亦不會影響對於腫瘤假體大小及位置的判斷。乳癌偵測的目的,是正確的顯示有無腫瘤,以及腫瘤大小與位置,並且在可以接受的檢測時間和所接受的輻射劑量下達成。在本研究中估計可以在600秒下偵測尺寸2mm活度為22.2kBq(0.6 Ci)的腫瘤假體,並且僅花12秒的影像重建時間(疊代次數選為十)。
It is a considerable issue that how to use the functional images for early detecting breast cancer. In this thesis, the feasibility of positron emission mammography (PEM) in detecting breast tumors were investigated with a series of phantom experiments using rotational PET imager developed by Institute of Nuclear Energy Research. The PEM system understudy only uses two opposite BGO detectors, which separated by 220mm. And we employed MLEM algorithm to reconstruct the three-dimensional images. The locations and sizes of the hot spots in breast phantom can be determined from the reconstructed images. The minimum detectable sphere diameter is 2mm. At the target-to-background concentration ratio 5:1, the 10mm size sphere can be visible. And the source out of FOV dose not influence the capability of determining the locations and sizes. In our research, calculation shows that it is possible detecting 2mm size sphere with 22.2kBq in 600 seconds and spending 12 seconds to reconstruction (10 iterations).
目錄

中文摘要………………………………………………………………….I
英文摘要………………………………………………………………...II
誌謝……………………………………………………………………..III
目錄……………………………………………………………………..IV
圖目錄………………………………………………………………….VII
表目錄…………………………………………………………………..IX
第一章 緒論……………………………………………………………..1
1-1 引言………………………………………………………...1
1-2 研究動機…………………………………………………...3
1-3 論文架構…………………………………………………...4
第二章 文獻探討………………………………………………………..6
2-1 乳癌的形成及種類………………………………………...6
2-2 乳癌偵測的方法…………………………………………...8
2-2.1 X光乳房攝影……………………………………….8
2-2.2 乳房超音波…………………………………………9
2-2.3 閃爍乳房造影………………………………………9
2-2.4 正子斷層掃描用於乳房偵測……………………..10
2-3 正子乳房造影的研究…………………………………….10
第三章 研究方法………………………………………………………12
3-1 系統描述………………………………………………….12
3-1.1 偵檢器……………………………………………..12
3-1.2 數據擷取之硬體架構……………………………..13
3-1.3 數據成像處理……………………………………..13
3-2 影像重建………………………………………………….14
3-2.1 影像重建演算法…………………………………..15
3-2.2 校正………………………………………………..17
3-3 假體及實驗設計………………………………………….19
3-3.1 假體設計…………………………………………..19
3-3.2 實驗設計…………………………………………..20
3-4 實體設計………………………………………………….21
第四章 乳房假體影像測試結果………………………………………23
4-1 辨別不同位置及大小…………………………………….23
4-2 不同對比度……………………………………………….24
4-3 有無視野外射源的影響………………………………….25
4-4 使用一對偵檢器與兩對的差異………………………….25
第五章 討論……………………………………………………………27
5-1 疊代次數的選取………………………………………….27
5-2 腫瘤假體大小的評估…………………………………….28
5-3 劑量與數據擷取時間及影像重建時間的關係………….29
第六章 結論……………………………………………………………32
參考文獻………………………………………………………………..57
參考文獻

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