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研究生:林志銘
研究生(外文):Chih-Ming Lin
論文名稱:都會區空氣污染物與嬰兒出生體重相關性研究
論文名稱(外文):Low Birth Weight Infants in Associated with Maternal Exposure to Ambient Air Pollutants in Urban
指導教授:毛義方毛義方引用關係李中一李中一引用關係
指導教授(外文):I- Fang MaoChung-Y iLi
學位類別:博士
校院名稱:國立陽明大學
系所名稱:公共衛生研究所
學門:醫藥衛生學門
學類:公共衛生學類
論文種類:學術論文
論文出版年:2004
畢業學年度:92
語文別:中文
論文頁數:90
中文關鍵詞:足月產低出生體重空氣污染物
外文關鍵詞:term birthLow birth weightair pollutants
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目的:
本研究目的為研究孕婦暴露空氣污染物對新生兒低出生體重影響,以及對足月產(37 to 44 週)新生兒在母親不同懷孕週期暴露空氣污染物與低出生體重 ( < 2500g) 之相關性。
方法:
本研究從內政部出生登記資料中選取1995至1997年出生於台北市(非石化工業城市)及高雄市(石化工業城市)之足月產單胞胎新生兒,總計92,288人作為研究對象。藉由母親居住所在地鄰近之空氣品質監測站每日紀錄資料,計算其懷孕週期內暴露CO, SO2, O3, NO2 及PM10 空氣污染物平均值,以評估母親在不同懷孕週期之暴露情形。本研究以多變項迴歸模式控制相關干擾變項,評估空氣污染物對新生兒低出生體重之影響。
結果:
結果顯示高雄市比台北市具有較高之SO2, CO, O3 及PM10空氣污染物濃度,經多變項迴歸模式控制相關干擾變項後,出生於石化工業之高雄市新生兒,其低出生體重風險比非石化工業城市顯著高13% (odds ratio=1.13, 95% confidence interval=1.03-1.24)。本研究也顯示母親懷孕全期暴露11.4 ppb 以上SO2 將增加新生兒低出生體重26% 風險;若以懷孕週期區分,則第三週期暴露高濃度SO2 (>12.4ppb)比低濃度組(<6.8 ppb)顯著增加20%低出生體重風險(OR=1.20, 95% CI=1.01-1.41) 。除此之外,並未發現其他空氣污染物具有風險。
Purpose:
The purpose of this retrospective cohort study was to investigate the association between pollution and infant birth weight, and whether the risk is different among different trimesters.
Methods:
Infants with a birth weight lower 2500 grams were classified as LBW infants. The study infants comprised a total of 92,288 full-term live singletons identified from the Taiwan birth registry born Kaoshiung (a petrochemical industrial city) and Taipei (a non-petrochemical industrial city) metropolitans between 1995 and 1997. Maternal daily exposure levels of CO, SO2, O3, NO2 and PM10 in each trimester of pregnancy were estimated in arithmetic means based on measurements from adjacent air quality monitoring station. Multivariable logistic regression model with adjustment for potential confounders was used to assess the independent effect of specific air pollutant on the risk of LBW.
Results:
The concentrations of SO2, CO, O3 and PM10 were significantly higher in Kaohsiung than in Taipei. Multivariable logistic regression analysis after adjusting for gestation age, gender, birth order, season of birth, maternal age, and maternal education suggested that compared to those in Taipei, the infants in Kaohsiung, experienced a 13% (odds ratio=1.13, 95% confidence interval=1.03-1.24) increase in risk of LBW. The study suggested an overall 26% increase in the LBW risk in relation to maternal ambient exposure to SO2 concentration of higher than 11.4 ppb during pregnancy. As the relative risk of LBW was reassessed according to exposure level in each trimester, mothers exposed to >12.4 ppb of SO2 in the last trimester showed a 20% significantly higher risk (OR=1.20, 95% CI=1.01-1.41) of LBW delivery than mothers with low exposure (<6.8 ppb). No significantly elevated ORs were observed for other air pollutants.
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