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研究生:劉偉廣
研究生(外文):Wei-Kuang Liu
論文名稱:ABIN-2蛋白抑制NF-κB活化作用的機制及其功能之探討
論文名稱(外文):Study of Inhibitory Mechanism and Function of ABIN-2 to
指導教授:周成功
指導教授(外文):Chen-Kung Chou
學位類別:博士
校院名稱:國立陽明大學
系所名稱:微生物及免疫學研究所
學門:生命科學學門
學類:微生物學類
論文種類:學術論文
論文出版年:2004
畢業學年度:92
語文別:英文
論文頁數:154
中文關鍵詞:A20 binding inhibitor of nuclear factor κB 2 (ABIN-2)apoptosisinhibitory κB kinase (IKKγ )NEMOnuclear factor κB (NF-κB)receptor-interacting protein (RIP)Tie2Transcriptional coactivatorFLIP1Chromatin-remodeling complexBAF60aMEKK3LKB1
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細胞核因子-κB (NF-κB)是細胞內一個可誘發的轉錄因子,它調控了許多細胞對外在刺激所應產生的反應,包括發炎等免疫反應相關基因的表現。NF-κB訊息傳遞路徑的活化是由許多不同蛋白間互相結合作用所形成的複雜網路來調控。最近的研究發現許多NF-κB的負向調節蛋白,但這些蛋白抑制NF-κB活化的機制則尚未確定。
近期我們及其他研究團隊已分離出一新穎蛋白ABIN-2,並證實ABIN-2是一個NF-κB活化的抑制蛋白。而本論文中我們將證實ABIN-2蛋白抑制NF-κB活化作用的一作用方式是藉由阻斷另一NF-κB活化蛋白RIP與其下源結合蛋白IKKγ間的結合作用。在實驗中我們證實增加ABIN-2蛋白會競爭抑制RIP蛋白與IKKγ蛋白間的結合。同時藉由deletion mapping我們分析出RIP蛋白與ABIN-2蛋白上同時具有一約50個胺基酸片段具序列及結構特性的相似。刪除RIP蛋白及ABIN-2蛋白上這一段片段相似胺基酸序列將造成RIP蛋白與ABIN-2蛋白在細胞中與IKKγ結合及對NF-κB作用的損害。綜合這些實驗我們提供一可信的結果證實ABIN-2蛋白和RIP蛋白上的這一段片段相似胺基酸序列可被定義為一可調控NF-κB活化的新蛋白結構區域。許多實驗研究顯示像RIP蛋白和IKKγ蛋白等NF-κB路徑的重要作用分子,對於決定細胞走向活化NF-κB或是導致細胞凋亡有著決定性的角色。而我們的實驗指出RIP蛋白和ABIN-2蛋白藉由與IKKγ蛋白結合與否,會決定細胞訊息路徑是選擇走向活化NF-κB或是導致細胞凋亡方向。
由於NF-κB在許多生理及病理的進程中扮演極為重要的角色。因此我們試著從RIP蛋白上的這一段片段相似胺基酸序列中截取必要作用的最簡單peptide,以測試其開發作為抑制NF-κB活化而作為對抗腫瘤或抑制發炎分子藥物的潛能。而初步結果顯示將其中含有11個胺基酸的短peptides送進人類293細胞株內表現時,可成功阻斷TNFα及RIP蛋白對NF-κB的活化作用。因此我們認為這11個peptides片段及其衍生物,或合成的摹傚短鏈胺基酸將極有開發作為TNFα或IKKγ蛋白相關疾病治療用藥的潛力。
Nuclear factor-κB (NF-κB) proteins are key transcription factors that regulate gene expression in response to various extracellular stimuli. The pathway leading to the
activation of NF-κB involves a complicated network that includes a number of signaling molecules. The recent identification of a wide range of negative regulators
of NF-κB has given another layer of complexity in NF-κB activation. We and others have previously identified the protein ABIN-2, also known as FLIP1, as an inhibitor
of NF-κB activation. Here we demonstrate that ABIN-2 exerts its inhibitory function by blocking the interaction of RIP (receptor-interacting protein) with the downstream
effector IKKγ, a non-kinase component of IκB kinase complex. When overexpressed in cells, ABIN-2 bound to IKKγ and prevented the association of IKKγ with RIP. By
a deletion mapping, a stretch of 50 amino acids on ABIN-2 is found to be essential for its interaction with IKKγ. The ABIN-2 mutant that lacked these 50 amino acids did
not interact with IKKγ and, consequently, failed to inhibit NF-κB activation.
Strikingly, a portion of RIP, which is homologous to this fifty-residue domain of ABIN-2, is also essential for RIP interaction with IKKγ. The RIP mutant with deletion of this homologous region did not associate with IKKγ and had substantial reduction of its ability to mediate NF-κB activation. Taken together, these conserved 50 residues of ABIN-2 and RIP define a novel structural domain in mediating a key step in the NF-κB signaling pathway through the interaction with IKKγ. Finally, the
signaling pathway of NF-κB activation is known to promote survival in many cellular events. The mechanism for decision between cell death and survival is under finely
regulation. Here, we further demonstrated that the expression of ABIN-2 could promote the RIP-mediated apoptosis by presumably suppressing the anti-apoptotic
effect of NF-κB.
Aradhya, S. and Nelson, D.L. (2001) NF-kappaB signaling and human disease. Curr
Opin Genet Dev, 11, 300-306.
Arvelo, M.B., Cooper, J.T., Longo, C., Daniel, S., Grey, S.T., Mahiou, J., Czismadia,
E., Abu-Jawdeh, G. and Ferran, C. (2002) A20 protects mice from
D-galactosamine/lipopolysaccharide acute toxic lethal hepatitis. Hepatology,
35, 535-543.
Ashburner, B.P., Westerheide, S.D. and Baldwin, A.S., Jr. (2001) The p65 (RelA)
subunit of NF-kappaB interacts with the histone deacetylase (HDAC)
corepressors HDAC1 and HDAC2 to negatively regulate gene expression. Mol
Cell Biol, 21, 7065-7077.
Aupperle, K., Bennett, B., Han, Z., Boyle, D., Manning, A. and Firestein, G. (2001)
NF-kappa B regulation by I kappa B kinase-2 in rheumatoid arthritis
synoviocytes. J Immunol, 166, 2705-2711.
Bach, F.H., Robson, S.C., Ferran, C., Winkler, H., Millan, M.T., Stuhlmeier, K.M.,
Vanhove, B., Blakely, M.L., van der Werf, W.J., Hofer, E. and et al. (1994)
Endothelial cell activation and thromboregulation during xenograft rejection.
Immunol Rev, 141, 5-30.
Bach, F.H., Robson, S.C., Winkler, H., Ferran, C., Stuhlmeier, K.M., Wrighton, C.J.
and Hancock, W.W. (1995) Barriers to xenotransplantation. Nat Med, 1,
869-873.
Bardeesy, N., Sinha, M., Hezel, A.F., Signoretti, S., Hathaway, N.A., Sharpless, N.E.,
Loda, M., Carrasco, D.R. and DePinho, R.A. (2002) Loss of the Lkb1 tumour
suppressor provokes intestinal polyposis but resistance to transformation.
Nature, 419, 162-167.
Barkett, M. and Gilmore, T.D. (1999) Control of apoptosis by Rel/NF-kappaB
transcription factors. Oncogene, 18, 6910-6924.
Baud, V. and Karin, M. (2001) Signal transduction by tumor necrosis factor and its
relatives. Trends Cell Biol, 11, 372-377.
Beg, A.A. and Baltimore, D. (1996) An essential role for NF-kappaB in preventing
TNF-alpha-induced cell death. Science, 274, 782-784.
Beg, A.A., Sha, W.C., Bronson, R.T. and Baltimore, D. (1995) Constitutive NF-kappa
B activation, enhanced granulopoiesis, and neonatal lethality in I kappa B
alpha-deficient mice. Genes Dev, 9, 2736-2746.
Bernal, W. and Wendon, J. (1999) Acute liver failure; clinical features and
management. Eur J Gastroenterol Hepatol, 11, 977-984.
Bird, G.L., Sheron, N., Goka, A.K., Alexander, G.J. and Williams, R.S. (1990)
Increased plasma tumor necrosis factor in severe alcoholic hepatitis. Ann
Intern Med, 112, 917-920.
Blank, J.L., Gerwins, P., Elliott, E.M., Sather, S. and Johnson, G.L. (1996) Molecular
cloning of mitogen-activated protein/ERK kinase kinases (MEKK) 2 and 3.
Regulation of sequential phosphorylation pathways involving
mitogen-activated protein kinase and c-Jun kinase. J Biol Chem, 271,
5361-5368.
Boardman, L.A., Thibodeau, S.N., Schaid, D.J., Lindor, N.M., McDonnell, S.K.,
Burgart, L.J., Ahlquist, D.A., Podratz, K.C., Pittelkow, M. and Hartmann, L.C.
(1998) Increased risk for cancer in patients with the Peutz-Jeghers syndrome.
Ann Intern Med, 128, 896-899.
Bonvin, C., Guillon, A., van Bemmelen, M.X., Gerwins, P., Johnson, G.L. and
Widmann, C. (2002) Role of the amino-terminal domains of MEKKs in the
activation of NF kappa B and MAPK pathways and in the regulation of cell
proliferation and apoptosis. Cell Signal, 14, 123-131.
Bouchier-Hayes, L., Conroy, H., Egan, H., Adrain, C., Creagh, E.M., MacFarlane, M.
and Martin, S.J. (2001) CARDINAL, a novel caspase recruitment domain
protein, is an inhibitor of multiple NF-kappa B activation pathways. J Biol
Chem, 276, 44069-44077.
Boudeau, J., Deak, M., Lawlor, M.A., Morrice, N.A. and Alessi, D.R. (2003)
Heat-shock protein 90 and Cdc37 interact with LKB1 and regulate its stability.
Biochem J, 370, 849-857.
Brummelkamp, T.R., Nijman, S.M., Dirac, A.M. and Bernards, R. (2003) Loss of the
cylindromatosis tumour suppressor inhibits apoptosis by activating
NF-kappaB. Nature, 424, 797-801.
Burdick, D. and Prior, J.T. (1982) Peutz-Jeghers syndrome. A clinicopathologic study
of a large family with a 27-year follow-up. Cancer, 50, 2139-2146.
Campbell, I.K., Gerondakis, S., O'Donnell, K. and Wicks, I.P. (2000) Distinct roles
for the NF-kappaB1 (p50) and c-Rel transcription factors in inflammatory
arthritis. J Clin Invest, 105, 1799-1806.
Carter, A.B., Knudtson, K.L., Monick, M.M. and Hunninghake, G.W. (1999) The p38
mitogen-activated protein kinase is required for NF-kappaB-dependent gene
expression. The role of TATA-binding protein (TBP). J Biol Chem, 274,
30858-30863.
Chariot, A., Leonardi, A., Muller, J., Bonif, M., Brown, K. and Siebenlist, U. (2002)
Association of the adaptor TANK with the I kappa B kinase (IKK) regulator
NEMO connects IKK complexes with IKK epsilon and TBK1 kinases. J Biol
Chem, 277, 37029-37036.
Chen, G., Cao, P. and Goeddel, D.V. (2002) TNF-induced recruitment and activation
of the IKK complex require Cdc37 and Hsp90. Mol Cell, 9, 401-410.
Chen, L., Fischle, W., Verdin, E. and Greene, W.C. (2001) Duration of nuclear
NF-kappaB action regulated by reversible acetylation. Science, 293,
1653-1657.
Cheng, Q., Cant, C.A., Moll, T., Hofer-Warbinek, R., Wagner, E., Birnstiel, M.L.,
Bach, F.H. and de Martin, R. (1994) NK-kappa B subunit-specific regulation
of the I kappa B alpha promoter. J Biol Chem, 269, 13551-13557.
Chien, C.Y., Liu, W.K., Chou, C.K. and Su, J.Y. (2003) The A20-binding protein
ABIN-2 exerts unexpected function in mediating transcriptional coactivation.
FEBS Lett, 543, 55-60.
Codd, J.D., Salisbury, J.R., Packham, G. and Nicholson, L.J. (1999) A20 RNA
expression is associated with undifferentiated nasopharyngeal carcinoma and
poorly differentiated head and neck squamous cell carcinoma. J Pathol, 187,
549-555.
Collins, S.P., Reoma, J.L., Gamm, D.M. and Uhler, M.D. (2000) LKB1, a novel
serine/threonine protein kinase and potential tumour suppressor, is
phosphorylated by cAMP-dependent protein kinase (PKA) and prenylated in
vivo. Biochem J, 345 Pt 3, 673-680.
Cooper, J.T., Stroka, D.M., Brostjan, C., Palmetshofer, A., Bach, F.H. and Ferran, C.
(1996) A20 blocks endothelial cell activation through a NF-kappaB-dependent
mechanism. J Biol Chem, 271, 18068-18073.
de Martin, R., Vanhove, B., Cheng, Q., Hofer, E., Csizmadia, V., Winkler, H. and
Bach, F.H. (1993) Cytokine-inducible expression in endothelial cells of an I
kappa B alpha-like gene is regulated by NF kappa B. Embo J, 12, 2773-2779.
De Valck, D., Jin, D.Y., Heyninck, K., Van de Craen, M., Contreras, R., Fiers, W.,
Jeang, K.T. and Beyaert, R. (1999) The zinc finger protein A20 interacts with
a novel anti-apoptotic protein which is cleaved by specific caspases. Oncogene,
18, 4182-4190.
Deacon, K. and Blank, J.L. (1999) MEK kinase 3 directly activates MKK6 and
MKK7, specific activators of the p38 and c-Jun NH2-terminal kinases. J Biol
Chem, 274, 16604-16610.
Delhase, M., Li, N. and Karin, M. (2000) Kinase regulation in inflammatory response.
Nature, 406, 367-368.
Deshpande, S.S., Angkeow, P., Huang, J., Ozaki, M. and Irani, K. (2000) Rac1
inhibits TNF-alpha-induced endothelial cell apoptosis: dual regulation by
reactive oxygen species. Faseb J, 14, 1705-1714.
DiDonato, J.A., Hayakawa, M., Rothwarf, D.M., Zandi, E. and Karin, M. (1997) A
cytokine-responsive IkappaB kinase that activates the transcription factor
NF-kappaB. Nature, 388, 548-554.
Diehl, A.M. and Rai, R. (1996) Review: regulation of liver regeneration by
pro-inflammatory cytokines. J Gastroenterol Hepatol, 11, 466-470.
Dixit, V.M., Green, S., Sarma, V., Holzman, L.B., Wolf, F.W., O'Rourke, K., Ward,
P.A., Prochownik, E.V. and Marks, R.M. (1990) Tumor necrosis factor-alpha
induction of novel gene products in human endothelial cells including a
macrophage-specific chemotaxin. J Biol Chem, 265, 2973-2978.
Doffinger, R., Smahi, A., Bessia, C., Geissmann, F., Feinberg, J., Durandy, A.,
Bodemer, C., Kenwrick, S., Dupuis-Girod, S., Blanche, S., Wood, P., Rabia,
S.H., Headon, D.J., Overbeek, P.A., Le Deist, F., Holland, S.M., Belani, K.,
Kumararatne, D.S., Fischer, A., Shapiro, R., Conley, M.E., Reimund, E.,
Kalhoff, H., Abinun, M., Munnich, A., Israel, A., Courtois, G. and Casanova,
J.L. (2001) X-linked anhidrotic ectodermal dysplasia with immunodeficiency
is caused by impaired NF-kappaB signaling. Nat Genet, 27, 277-285.
Ellinger-Ziegelbauer, H., Kelly, K. and Siebenlist, U. (1999) Cell cycle arrest and
reversion of Ras-induced transformation by a conditionally activated form of
mitogen-activated protein kinase kinase kinase 3. Mol Cell Biol, 19,
3857-3868.
Epinat, J.C. and Gilmore, T.D. (1999) Diverse agents act at multiple levels to inhibit
the Rel/NF-kappaB signal transduction pathway. Oncogene, 18, 6896-6909.
Esteller, M., Avizienyte, E., Corn, P.G., Lothe, R.A., Baylin, S.B., Aaltonen, L.A. and
Herman, J.G. (2000) Epigenetic inactivation of LKB1 in primary tumors
associated with the Peutz-Jeghers syndrome. Oncogene, 19, 164-168.
Fujikawa, K., de Aos Scherpenseel, I., Jain, S.K., Presman, E., Christensen, R.A. and
Varticovski, L. (1999) Role of PI 3-kinase in angiopoietin-1-mediated
migration and attachment-dependent survival of endothelial cells. Exp Cell
Res, 253, 663-672.
Fukushi, M., Dixon, J., Kimura, T., Tsurutani, N., Dixon, M.J. and Yamamoto, N.
(1999) Identification and cloning of a novel cellular protein Naf1,
Nef-associated factor 1, that increases cell surface CD4 expression. FEBS Lett,
442, 83-88.
Gamble, J.R., Drew, J., Trezise, L., Underwood, A., Parsons, M., Kasminkas, L.,
Rudge, J., Yancopoulos, G. and Vadas, M.A. (2000) Angiopoietin-1 is an
antipermeability and anti-inflammatory agent in vitro and targets cell junctions.
Circ Res, 87, 603-607.
Garner, A.P., Weston, C.R., Todd, D.E., Balmanno, K. and Cook, S.J. (2002) Delta
MEKK3:ER* activation induces a p38 alpha/beta 2-dependent cell cycle arrest
at the G2 checkpoint. Oncogene, 21, 8089-8104.
Gerritsen, M.E. and Bloor, C.M. (1993) Endothelial cell gene expression in response
to injury. Faseb J, 7, 523-532.
Gerwins, P., Blank, J.L. and Johnson, G.L. (1997) Cloning of a novel
mitogen-activated protein kinase kinase kinase, MEKK4, that selectively
regulates the c-Jun amino terminal kinase pathway. J Biol Chem, 272,
8288-8295.
Ghosh, S. and Karin, M. (2002) Missing pieces in the NF-kappaB puzzle. Cell, 109
Suppl, S81-96.
Giardiello, F.M., Welsh, S.B., Hamilton, S.R., Offerhaus, G.J., Gittelsohn, A.M.,
Booker, S.V., Krush, A.J., Yardley, J.H. and Luk, G.D. (1987) Increased risk
of cancer in the Peutz-Jeghers syndrome. N Engl J Med, 316, 1511-1514.
Golshani, P. and Jones, E.G. (1999) Synchronized paroxysmal activity in the
developing thalamocortical network mediated by corticothalamic projections
and "silent" synapses. J Neurosci, 19, 2865-2875.
Gonzalez-Amaro, R., Garcia-Monzon, C., Garcia-Buey, L., Moreno-Otero, R., Alonso,
J.L., Yague, E., Pivel, J.P., Lopez-Cabrera, M., Fernandez-Ruiz, E. and
Sanchez-Madrid, F. (1994) Induction of tumor necrosis factor alpha
production by human hepatocytes in chronic viral hepatitis. J Exp Med, 179,
841-848.
Guttridge, D.C., Albanese, C., Reuther, J.Y., Pestell, R.G. and Baldwin, A.S., Jr.
(1999) NF-kappaB controls cell growth and differentiation through
transcriptional regulation of cyclin D1. Mol Cell Biol, 19, 5785-5799.
Guzek, J.W. (1965) [Contribution to the problem of the isolation of cell nuclei from
the liver in the white rat]. Acta Med Pol, 6, 179-184.
Habraken, Y., Piret, B. and Piette, J. (2001) S phase dependence and involvement of
NF-kappaB activating kinase to NF-kappaB activation by camptothecin.
Biochem Pharmacol, 62, 603-616.
Hamuro, M., Polan, J., Natarajan, M. and Mohan, S. (2002) High glucose induced
nuclear factor kappa B mediated inhibition of endothelial cell migration.
Atherosclerosis, 162, 277-287.
Harhaj, E.W., Good, L., Xiao, G., Uhlik, M., Cvijic, M.E., Rivera-Walsh, I. and Sun,
S.C. (2000) Somatic mutagenesis studies of NF-kappa B signaling in human T
cells: evidence for an essential role of IKK gamma in NF-kappa B activation
by T-cell costimulatory signals and HTLV-I Tax protein. Oncogene, 19,
1448-1456.
Hayes, A.J., Huang, W.Q., Mallah, J., Yang, D., Lippman, M.E. and Li, L.Y. (1999)
Angiopoietin-1 and its receptor Tie-2 participate in the regulation of
capillary-like tubule formation and survival of endothelial cells. Microvasc
Res, 58, 224-237.
Hemminki, A., Markie, D., Tomlinson, I., Avizienyte, E., Roth, S., Loukola, A.,
Bignell, G., Warren, W., Aminoff, M., Hoglund, P., Jarvinen, H., Kristo, P.,
Pelin, K., Ridanpaa, M., Salovaara, R., Toro, T., Bodmer, W., Olschwang, S.,
Olsen, A.S., Stratton, M.R., de la Chapelle, A. and Aaltonen, L.A. (1998) A
serine/threonine kinase gene defective in Peutz-Jeghers syndrome. Nature, 391,
184-187.
Hemminki, A., Tomlinson, I., Markie, D., Jarvinen, H., Sistonen, P., Bjorkqvist, A.M.,
Knuutila, S., Salovaara, R., Bodmer, W., Shibata, D., de la Chapelle, A. and
Aaltonen, L.A. (1997) Localization of a susceptibility locus for Peutz-Jeghers
syndrome to 19p using comparative genomic hybridization and targeted
linkage analysis. Nat Genet, 15, 87-90.
Hess, S., Gottfried, E., Smola, H., Grunwald, U., Schuchmann, M. and Engelmann, H.
(1998) CD40 induces resistance to TNF-mediated apoptosis in a fibroblast cell
line. Eur J Immunol, 28, 3594-3604.
Heyninck, K., De Valck, D., Vanden Berghe, W., Van Criekinge, W., Contreras, R.,
Fiers, W., Haegeman, G. and Beyaert, R. (1999) The zinc finger protein A20
inhibits TNF-induced NF-kappaB-dependent gene expression by interfering
with an RIP- or TRAF2-mediated transactivation signal and directly binds to a
novel NF-kappaB-inhibiting protein ABIN. J Cell Biol, 145, 1471-1482.
Heyninck, K., Kreike, M.M. and Beyaert, R. (2003) Structure-function analysis of the
A20-binding inhibitor of NF-kappa B activation, ABIN-1. FEBS Lett, 536,
135-140.
Higuchi, M. and Aggarwal, B.B. (1994) TNF induces internalization of the p60
receptor and shedding of the p80 receptor. J Immunol, 152, 3550-3558.
Hoeflich, K.P., Luo, J., Rubie, E.A., Tsao, M.S., Jin, O. and Woodgett, J.R. (2000)
Requirement for glycogen synthase kinase-3beta in cell survival and
NF-kappaB activation. Nature, 406, 86-90.
Hong, X., Xu, L., Li, X., Zhai, Z. and Shu, H. (2001) CSN3 interacts with IKKgamma
and inhibits TNF- but not IL-1-induced NF-kappaB activation. FEBS Lett, 499,
133-136.
Hsiao, P.W., Fryer, C.J., Trotter, K.W., Wang, W. and Archer, T.K. (2003) BAF60a
mediates critical interactions between nuclear receptors and the BRG1
chromatin-remodeling complex for transactivation. Mol Cell Biol, 23,
6210-6220.
Hsu, H., Huang, J., Shu, H.B., Baichwal, V. and Goeddel, D.V. (1996a)
TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1
signaling complex. Immunity, 4, 387-396.
Hsu, H., Shu, H.B., Pan, M.G. and Goeddel, D.V. (1996b) TRADD-TRAF2 and
TRADD-FADD interactions define two distinct TNF receptor 1 signal
transduction pathways. Cell, 84, 299-308.
Hsu, H., Xiong, J. and Goeddel, D.V. (1995) The TNF receptor 1-associated protein
TRADD signals cell death and NF-kappa B activation. Cell, 81, 495-504.
Huang, Q., Yang, J., Lin, Y., Walker, C., Cheng, J., Liu, Z.G. and Su, B. (2004)
Differential regulation of interleukin 1 receptor and Toll-like receptor
signaling by MEKK3. Nat Immunol, 5, 98-103.
Hughes, D.P., Marron, M.B. and Brindle, N.P. (2003) The antiinflammatory
endothelial tyrosine kinase Tie2 interacts with a novel nuclear factor-kappaB
inhibitor ABIN-2. Circ Res, 92, 630-636.
Iimuro, Y., Gallucci, R.M., Luster, M.I., Kono, H. and Thurman, R.G. (1997)
Antibodies to tumor necrosis factor alfa attenuate hepatic necrosis and
inflammation caused by chronic exposure to ethanol in the rat. Hepatology, 26,
1530-1537.
Ito, T., Yamauchi, M., Nishina, M., Yamamichi, N., Mizutani, T., Ui, M., Murakami,
M. and Iba, H. (2001) Identification of SWI.SNF complex subunit BAF60a as
a determinant of the transactivation potential of Fos/Jun dimers. J Biol Chem,
276, 2852-2857.
Jaattela, M., Mouritzen, H., Elling, F. and Bastholm, L. (1996) A20 zinc finger
protein inhibits TNF and IL-1 signaling. J Immunol, 156, 1166-1173.
Jain, A., Ma, C.A., Liu, S., Brown, M., Cohen, J. and Strober, W. (2001) Specific
missense mutations in NEMO result in hyper-IgM syndrome with
hypohydrotic ectodermal dysplasia. Nat Immunol, 2, 223-228.
Janicke, R.U., Lee, F.H. and Porter, A.G. (1994) Nuclear c-Myc plays an important
role in the cytotoxicity of tumor necrosis factor alpha in tumor cells. Mol Cell
Biol, 14, 5661-5670.
Jenne, D.E., Reimann, H., Nezu, J., Friedel, W., Loff, S., Jeschke, R., Muller, O.,
Back, W. and Zimmer, M. (1998) Peutz-Jeghers syndrome is caused by
mutations in a novel serine threonine kinase. Nat Genet, 18, 38-43.
Jiang, Y., Woronicz, J.D., Liu, W. and Goeddel, D.V. (1999) Prevention of
constitutive TNF receptor 1 signaling by silencer of death domains. Science,
283, 543-546.
Karuman, P., Gozani, O., Odze, R.D., Zhou, X.C., Zhu, H., Shaw, R., Brien, T.P.,
Bozzuto, C.D., Ooi, D., Cantley, L.C. and Yuan, J. (2001) The Peutz-Jegher
gene product LKB1 is a mediator of p53-dependent cell death. Mol Cell, 7,
1307-1319.
Kaufmann, S.H. (1998) Cell death induced by topoisomerase-targeted drugs: more
questions than answers. Biochim Biophys Acta, 1400, 195-211.
Kim, I., Moon, S.O., Park, S.K., Chae, S.W. and Koh, G.Y. (2001) Angiopoietin-1
reduces VEGF-stimulated leukocyte adhesion to endothelial cells by reducing
ICAM-1, VCAM-1, and E-selectin expression. Circ Res, 89, 477-479.
Kim, I., Oh, J.L., Ryu, Y.S., So, J.N., Sessa, W.C., Walsh, K. and Koh, G.Y. (2002)
Angiopoietin-1 negatively regulates expression and activity of tissue factor in
endothelial cells. Faseb J, 16, 126-128.
Koblizek, T.I., Weiss, C., Yancopoulos, G.D., Deutsch, U. and Risau, W. (1998)
Angiopoietin-1 induces sprouting angiogenesis in vitro. Curr Biol, 8, 529-532.
Koszewski, N.J., Henry, K.W., Lubert, E.J., Gravatte, H. and Noonan, D.J. (2003)
Use of a modified yeast one-hybrid screen to identify BAF60a interactions
with the Vitamin D receptor heterodimer. J Steroid Biochem Mol Biol, 87,
223-231.
Kovalenko, A., Chable-Bessia, C., Cantarella, G., Israel, A., Wallach, D. and Courtois,
G. (2003) The tumour suppressor CYLD negatively regulates NF-kappaB
signalling by deubiquitination. Nature, 424, 801-805.
Krause, A., Holtmann, H., Eickemeier, S., Winzen, R., Szamel, M., Resch, K.,
Saklatvala, J. and Kracht, M. (1998) Stress-activated protein kinase/Jun
N-terminal kinase is required for interleukin (IL)-1-induced IL-6 and IL-8
gene expression in the human epidermal carcinoma cell line KB. J Biol Chem,
273, 23681-23689.
Kwak, H.J., Lee, S.J., Lee, Y.H., Ryu, C.H., Koh, K.N., Choi, H.Y. and Koh, G.Y.
(2000) Angiopoietin-1 inhibits irradiation- and mannitol-induced apoptosis in
endothelial cells. Circulation, 101, 2317-2324.
Laherty, C.D., Perkins, N.D. and Dixit, V.M. (1993) Human T cell leukemia virus
type I Tax and phorbol 12-myristate 13-acetate induce expression of the A20
zinc finger protein by distinct mechanisms involving nuclear factor kappa B. J
Biol Chem, 268, 5032-5039.
Lavon, I., Goldberg, I., Amit, S., Landsman, L., Jung, S., Tsuberi, B.Z., Barshack, I.,
Kopolovic, J., Galun, E., Bujard, H. and Ben-Neriah, Y. (2000) High
susceptibility to bacterial infection, but no liver dysfunction, in mice
compromised for hepatocyte NF-kappaB activation. Nat Med, 6, 573-577.
Lee, E.G., Boone, D.L., Chai, S., Libby, S.L., Chien, M., Lodolce, J.P. and Ma, A.
(2000) Failure to regulate TNF-induced NF-kappaB and cell death responses
in A20-deficient mice. Science, 289, 2350-2354.
Lee, S.Y. and Choi, Y. (1997) TRAF-interacting protein (TRIP): a novel component
of the tumor necrosis factor receptor (TNFR)- and CD30-TRAF signaling
complexes that inhibits TRAF2-mediated NF-kappaB activation. J Exp Med,
185, 1275-1285.
Leist, M., Gantner, F., Bohlinger, I., Tiegs, G., Germann, P.G. and Wendel, A. (1995)
Tumor necrosis factor-induced hepatocyte apoptosis precedes liver failure in
experimental murine shock models. Am J Pathol, 146, 1220-1234.
Leist, M., Gantner, F., Naumann, H., Bluethmann, H., Vogt, K., Brigelius-Flohe, R.,
Nicotera, P., Volk, H.D. and Wendel, A. (1997) Tumor necrosis
factor-induced apoptosis during the poisoning of mice with hepatotoxins.
Gastroenterology, 112, 923-934.
Lemon, B. and Tjian, R. (2000) Orchestrated response: a symphony of transcription
factors for gene control. Genes Dev, 14, 2551-2569.
Leonardi, A., Chariot, A., Claudio, E., Cunningham, K. and Siebenlist, U. (2000)
CIKS, a connection to Ikappa B kinase and stress-activated protein kinase.
Proc Natl Acad Sci U S A, 97, 10494-10499.
Li, Q. and Verma, I.M. (2002) NF-kappaB regulation in the immune system. Nat Rev
Immunol, 2, 725-734.
Li, X., Commane, M., Nie, H., Hua, X., Chatterjee-Kishore, M., Wald, D., Haag, M.
and Stark, G.R. (2000) Act1, an NF-kappa B-activating protein. Proc Natl
Acad Sci U S A, 97, 10489-10493.
Li, X., Yang, Y. and Ashwell, J.D. (2002) TNF-RII and c-IAP1 mediate
ubiquitination and degradation of TRAF2. Nature, 416, 345-347.
Li, X.H., Fang, X. and Gaynor, R.B. (2001) Role of IKKgamma/nemo in assembly of
the Ikappa B kinase complex. J Biol Chem, 276, 4494-4500.
Li, Y., Kang, J., Friedman, J., Tarassishin, L., Ye, J., Kovalenko, A., Wallach, D. and
Horwitz, M.S. (1999) Identification of a cell protein (FIP-3) as a modulator of
NF-kappaB activity and as a target of an adenovirus inhibitor of tumor
necrosis factor alpha-induced apoptosis. Proc Natl Acad Sci U S A, 96,
1042-1047.
Lin, Y., Devin, A., Rodriguez, Y. and Liu, Z.G. (1999) Cleavage of the death domain
kinase RIP by caspase-8 prompts TNF-induced apoptosis. Genes Dev, 13,
2514-2526.
Linder, S., Nelson, D., Weiss, M. and Aepfelbacher, M. (1999) Wiskott-Aldrich
syndrome protein regulates podosomes in primary human macrophages. Proc
Natl Acad Sci U S A, 96, 9648-9653.
Liu, H., Lo, C.R. and Czaja, M.J. (2002) NF-kappaB inhibition sensitizes hepatocytes
to TNF-induced apoptosis through a sustained activation of JNK and c-Jun.
Hepatology, 35, 772-778.
Liu, L.F., Duann, P., Lin, C.T., D'Arpa, P. and Wu, J. (1996) Mechanism of action of
camptothecin. Ann N Y Acad Sci, 803, 44-49.
Liu, W.K., Chien, C.Y., Chou, C.K. and Su, J.Y. (2003) An LKB1-interacting protein
negatively regulates TNFalpha-induced NF-kappaB activation. J Biomed Sci,
10, 242-252.
Madrid, L.V., Wang, C.Y., Guttridge, D.C., Schottelius, A.J., Baldwin, A.S., Jr. and
Mayo, M.W. (2000) Akt suppresses apoptosis by stimulating the
transactivation potential of the RelA/p65 subunit of NF-kappaB. Mol Cell Biol,
20, 1626-1638.
Makris, C., Godfrey, V.L., Krahn-Senftleben, G., Takahashi, T., Roberts, J.L.,
Schwarz, T., Feng, L., Johnson, R.S. and Karin, M. (2000) Female mice
heterozygous for IKK gamma/NEMO deficiencies develop a dermatopathy
similar to the human X-linked disorder incontinentia pigmenti. Mol Cell, 5,
969-979.
Marignani, P.A., Kanai, F. and Carpenter, C.L. (2001) LKB1 associates with Brg1
and is necessary for Brg1-induced growth arrest. J Biol Chem, 276,
32415-32418.
May, M.J., D'Acquisto, F., Madge, L.A., Glockner, J., Pober, J.S. and Ghosh, S.
(2000) Selective inhibition of NF-kappaB activation by a peptide that blocks
the interaction of NEMO with the IkappaB kinase complex. Science, 289,
1550-1554.
May, M.J., Marienfeld, R.B. and Ghosh, S. (2002) Characterization of the Ikappa
B-kinase NEMO binding domain. J Biol Chem, 277, 45992-46000.
Mehenni, H., Blouin, J.L., Radhakrishna, U., Bhardwaj, S.S., Bhardwaj, K., Dixit,
V.B., Richards, K.F., Bermejo-Fenoll, A., Leal, A.S., Raval, R.C. and
Antonarakis, S.E. (1997) Peutz-Jeghers syndrome: confirmation of linkage to
chromosome 19p13.3 and identification of a potential second locus, on
19q13.4. Am J Hum Genet, 61, 1327-1334.
Mehenni, H., Gehrig, C., Nezu, J., Oku, A., Shimane, M., Rossier, C., Guex, N.,
Blouin, J.L., Scott, H.S. and Antonarakis, S.E. (1998) Loss of LKB1 kinase
activity in Peutz-Jeghers syndrome, and evidence for allelic and locus
heterogeneity. Am J Hum Genet, 63, 1641-1650.
Mercurio, F., Murray, B.W., Shevchenko, A., Bennett, B.L., Young, D.B., Li, J.W.,
Pascual, G., Motiwala, A., Zhu, H., Mann, M. and Manning, A.M. (1999)
IkappaB kinase (IKK)-associated protein 1, a common component of the
heterogeneous IKK complex. Mol Cell Biol, 19, 1526-1538.
Mercurio, F., Zhu, H., Murray, B.W., Shevchenko, A., Bennett, B.L., Li, J., Young,
D.B., Barbosa, M., Mann, M., Manning, A. and Rao, A. (1997) IKK-1 and
IKK-2: cytokine-activated IkappaB kinases essential for NF-kappaB activation.
Science, 278, 860-866.
Meyer, C.F., Wang, X., Chang, C., Templeton, D. and Tan, T.H. (1996) Interaction
between c-Rel and the mitogen-activated protein kinase kinase kinase 1
signaling cascade in mediating kappaB enhancer activation. J Biol Chem, 271,
8971-8976.
Miller, W.E., Mosialos, G., Kieff, E. and Raab-Traub, N. (1997) Epstein-Barr virus
LMP1 induction of the epidermal growth factor receptor is mediated through a
TRAF signaling pathway distinct from NF-kappaB activation. J Virol, 71,
586-594.
Moll, T., Czyz, M., Holzmuller, H., Hofer-Warbinek, R., Wagner, E., Winkler, H.,
Bach, F.H. and Hofer, E. (1995) Regulation of the tissue factor promoter in
endothelial cells. Binding of NF kappa B-, AP-1-, and Sp1-like transcription
factors. J Biol Chem, 270, 3849-3857.
Mosselmans, R., Hepburn, A., Dumont, J.E., Fiers, W. and Galand, P. (1988)
Endocytic pathway of recombinant murine tumor necrosis factor in L-929
cells. J Immunol, 141, 3096-3100.
Muto, Y., Nouri-Aria, K.T., Meager, A., Alexander, G.J., Eddleston, A.L. and
Williams, R. (1988) Enhanced tumour necrosis factor and interleukin-1 in
fulminant hepatic failure. Lancet, 2, 72-74.
Naar, A.M., Lemon, B.D. and Tjian, R. (2001) Transcriptional coactivator complexes.
Annu Rev Biochem, 70, 475-501.
Nakano, H., Shindo, M., Sakon, S., Nishinaka, S., Mihara, M., Yagita, H. and
Okumura, K. (1998) Differential regulation of IkappaB kinase alpha and beta
by two upstream kinases, NF-kappaB-inducing kinase and mitogen-activated
protein kinase/ERK kinase kinase-1. Proc Natl Acad Sci U S A, 95,
3537-3542.
Natoli, G., Costanzo, A., Guido, F., Moretti, F., Bernardo, A., Burgio, V.L., Agresti,
C. and Levrero, M. (1998) Nuclear factor kB-independent cytoprotective
pathways originating at tumor necrosis factor receptor-associated factor 2. J
Biol Chem, 273, 31262-31272.
Neumann, M., Tsapos, K., Scheppler, J.A., Ross, J. and Franza, B.R., Jr. (1992)
Identification of complex formation between two intracellular tyrosine kinase
substrates: human c-Rel and the p105 precursor of p50 NF-kappa B. Oncogene,
7, 2095-2104.
Neurath, M.F., Pettersson, S., Meyer zum Buschenfelde, K.H. and Strober, W. (1996)
Local administration of antisense phosphorothioate oligonucleotides to the p65
subunit of NF-kappa B abrogates established experimental colitis in mice. Nat
Med, 2, 998-1004.
Nezu, J., Oku, A. and Shimane, M. (1999) Loss of cytoplasmic retention ability of
mutant LKB1 found in Peutz-Jeghers syndrome patients. Biochem Biophys
Res Commun, 261, 750-755.
Nony, P., Gaude, H., Rossel, M., Fournier, L., Rouault, J.P. and Billaud, M. (2003)
Stability of the Peutz-Jeghers syndrome kinase LKB1 requires its binding to
the molecular chaperones Hsp90/Cdc37. Oncogene, 22, 9165-9175.
Opipari, A.W., Jr., Hu, H.M., Yabkowitz, R. and Dixit, V.M. (1992) The A20 zinc
finger protein protects cells from tumor necrosis factor cytotoxicity. J Biol
Chem, 267, 12424-12427.
Ozes, O.N., Mayo, L.D., Gustin, J.A., Pfeffer, S.R., Pfeffer, L.M. and Donner, D.B.
(1999) NF-kappaB activation by tumour necrosis factor requires the Akt
serine-threonine kinase. Nature, 401, 82-85.
Perkins, N.D. (2000) The Rel/NF-kappa B family: friend and foe. Trends Biochem Sci,
25, 434-440.
Petrie, H.T. (2000) Induction and control of thymic lymphopoiesis and homeostasis.
Semin Immunol, 12, 419-420.
Pober, J.S. and Cotran, R.S. (1990a) Cytokines and endothelial cell biology. Physiol
Rev, 70, 427-451.
Pober, J.S. and Cotran, R.S. (1990b) The role of endothelial cells in inflammation.
Transplantation, 50, 537-544.
Pommier, Y., Pourquier, P., Fan, Y. and Strumberg, D. (1998) Mechanism of action
of eukaryotic DNA topoisomerase I and drugs targeted to the enzyme.
Biochim Biophys Acta, 1400, 83-105.
Poyet, J.L., Srinivasula, S.M., Lin, J.H., Fernandes-Alnemri, T., Yamaoka, S.,
Tsichlis, P.N. and Alnemri, E.S. (2000) Activation of the Ikappa B kinases by
RIP via IKKgamma /NEMO-mediated oligomerization. J Biol Chem, 275,
37966-37977.
Read, M.A., Whitley, M.Z., Williams, A.J. and Collins, T. (1994) NF-kappa B and I
kappa B alpha: an inducible regulatory system in endothelial activation. J Exp
Med, 179, 503-512.
Regnier, C.H., Song, H.Y., Gao, X., Goeddel, D.V., Cao, Z. and Rothe, M. (1997)
Identification and characterization of an IkappaB kinase. Cell, 90, 373-383.
Reid, J.D. (1974) Intestinal carcinoma in the Peutz-Jeghers syndrome. Jama, 229,
833-834.
Rothe, M., Xiong, J., Shu, H.B., Williamson, K., Goddard, A. and Goeddel, D.V.
(1996) I-TRAF is a novel TRAF-interacting protein that regulates
TRAF-mediated signal transduction. Proc Natl Acad Sci U S A, 93,
8241-8246.
Rothwarf, D.M., Zandi, E., Natoli, G. and Karin, M. (1998) IKK-gamma is an
essential regulatory subunit of the IkappaB kinase complex. Nature, 395,
297-300.
Rudolph, D., Yeh, W.C., Wakeham, A., Rudolph, B., Nallainathan, D., Potter, J., Elia,
A.J. and Mak, T.W. (2000) Severe liver degeneration and lack of NF-kappaB
activation in NEMO/IKKgamma-deficient mice. Genes Dev, 14, 854-862.
Sachatello, C.R., Pickren, J.W. and Grace, J.T., Jr. (1970) Generalized juvenile
gastrointestinal polyposis. A hereditary syndrome. Gastroenterology, 58,
699-708.
Sapkota, G.P., Kieloch, A., Lizcano, J.M., Lain, S., Arthur, J.S., Williams, M.R.,
Morrice, N., Deak, M. and Alessi, D.R. (2001) Phosphorylation of the protein
kinase mutated in Peutz-Jeghers cancer syndrome, LKB1/STK11, at Ser431
by p90(RSK) and cAMP-dependent protein kinase, but not its farnesylation at
Cys(433), is essential for LKB1 to suppress cell vrowth. J Biol Chem, 276,
19469-19482.
Sarma, V., Lin, Z., Clark, L., Rust, B.M., Tewari, M., Noelle, R.J. and Dixit, V.M.
(1995) Activation of the B-cell surface receptor CD40 induces A20, a novel
zinc finger protein that inhibits apoptosis. J Biol Chem, 270, 12343-12346.
Schmidt-Supprian, M., Bloch, W., Courtois, G., Addicks, K., Israel, A., Rajewsky, K.
and Pasparakis, M. (2000) NEMO/IKK gamma-deficient mice model
incontinentia pigmenti. Mol Cell, 5, 981-992.
Schutze, S., Machleidt, T., Adam, D., Schwandner, R., Wiegmann, K., Kruse, M.L.,
Heinrich, M., Wickel, M. and Kronke, M. (1999) Inhibition of receptor
internalization by monodansylcadaverine selectively blocks p55 tumor
necrosis factor receptor death domain signaling. J Biol Chem, 274,
10203-10212.
Schwabe, R.F. and Brenner, D.A. (2002) Role of glycogen synthase kinase-3 in
TNF-alpha-induced NF-kappaB activation and apoptosis in hepatocytes. Am J
Physiol Gastrointest Liver Physiol, 283, G204-211.
Seino, K., Setoguchi, Y., Ogino, T., Kayagaki, N., Akiba, H., Nakano, H., Taniguchi,
H., Takada, Y., Yuzawa, K., Todoroki, T., Fukuchi, Y., Yagita, H., Okumura,
K. and Fukao, K. (2001) Protection against Fas-mediated and tumor necrosis
factor receptor 1-mediated liver injury by blockade of FADD without loss of
nuclear factor-kappaB activation. Ann Surg, 234, 681-688.
Shearman, M.S., Ragan, C.I. and Iversen, L.L. (1994) Inhibition of PC12 cell redox
activity is a specific, early indicator of the mechanism of
beta-amyloid-mediated cell death. Proc Natl Acad Sci U S A, 91, 1470-1474.
Slowik, M.R., Min, W., Ardito, T., Karsan, A., Kashgarian, M. and Pober, J.S. (1997)
Evidence that tumor necrosis factor triggers apoptosis in human endothelial
cells by interleukin-1-converting enzyme-like protease-dependent and
-independent pathways. Lab Invest, 77, 257-267.
Smahi, A., Courtois, G., Vabres, P., Yamaoka, S., Heuertz, S., Munnich, A., Israel, A.,
Heiss, N.S., Klauck, S.M., Kioschis, P., Wiemann, S., Poustka, A., Esposito,
T., Bardaro, T., Gianfrancesco, F., Ciccodicola, A., D'Urso, M., Woffendin, H.,
Jakins, T., Donnai, D., Stewart, H., Kenwrick, S.J., Aradhya, S., Yamagata, T.,
Levy, M., Lewis, R.A. and Nelson, D.L. (2000) Genomic rearrangement in
NEMO impairs NF-kappaB activation and is a cause of incontinentia pigmenti.
The International Incontinentia Pigmenti (IP) Consortium. Nature, 405,
466-472.
Smith, D.P., Rayter, S.I., Niederlander, C., Spicer, J., Jones, C.M. and Ashworth, A.
(2001) LIP1, a cytoplasmic protein functionally linked to the Peutz-Jeghers
syndrome kinase LKB1. Hum Mol Genet, 10, 2869-2877.
Smith, D.P., Spicer, J., Smith, A., Swift, S. and Ashworth, A. (1999) The mouse
Peutz-Jeghers syndrome gene Lkb1 encodes a nuclear protein kinase. Hum
Mol Genet, 8, 1479-1485.
Song, H.Y., Rothe, M. and Goeddel, D.V. (1996) The tumor necrosis factor-inducible
zinc finger protein A20 interacts with TRAF1/TRAF2 and inhibits NF-kappaB
activation. Proc Natl Acad Sci U S A, 93, 6721-6725.
Spigelman, A.D., Murday, V. and Phillips, R.K. (1989) Cancer and the Peutz-Jeghers
syndrome. Gut, 30, 1588-1590.
Sporn, S.A., Eierman, D.F., Johnson, C.E., Morris, J., Martin, G., Ladner, M. and
Haskill, S. (1990) Monocyte adherence results in selective induction of novel
genes sharing homology with mediators of inflammation and tissue repair. J
Immunol, 144, 4434-4441.
Stanger, B.Z., Leder, P., Lee, T.H., Kim, E. and Seed, B. (1995) RIP: a novel protein
containing a death domain that interacts with Fas/APO-1 (CD95) in yeast and
causes cell death. Cell, 81, 513-523.
Stehlik, C., Fiorentino, L., Dorfleutner, A., Bruey, J.M., Ariza, E.M., Sagara, J. and
Reed, J.C. (2002) The PAAD/PYRIN-family protein ASC is a dual regulator
of a conserved step in nuclear factor kappaB activation pathways. J Exp Med,
196, 1605-1615.
Stein, B. and Baldwin, A.S., Jr. (1993) Distinct mechanisms for regulation of the
interleukin-8 gene involve synergism and cooperativity between C/EBP and
NF-kappa B. Mol Cell Biol, 13, 7191-7198.
Suri, C., McClain, J., Thurston, G., McDonald, D.M., Zhou, H., Oldmixon, E.H., Sato,
T.N. and Yancopoulos, G.D. (1998) Increased vascularization in mice
overexpressing angiopoietin-1. Science, 282, 468-471.
Swinney, D.C., Xu, Y.Z., Scarafia, L.E., Lee, I., Mak, A.Y., Gan, Q.F., Ramesha,
C.S., Mulkins, M.A., Dunn, J., So, O.Y., Biegel, T., Dinh, M., Volkel, P.,
Barnett, J., Dalrymple, S.A., Lee, S. and Huber, M. (2002) A small molecule
ubiquitination inhibitor blocks NF-kappa B-dependent cytokine expression in
cells and rats. J Biol Chem, 277, 23573-23581.
Tadokoro, N., Koibuchi, N., Ohtake, H., Kawatsu, T., Kato, Y., Yamaoka, S. and
Kumasaka, T. (1995) Expression of prolactin gene in human decidua during
pregnancy studied by in situ hybridization histochemistry. Endocr J, 42,
537-543.
Tadros, A., Hughes, D.P., Dunmore, B.J. and Brindle, N.P. (2003) ABIN-2 protects
endothelial cells from death and has a role in the antiapoptotic effect of
angiopoietin-1. Blood, 102, 4407-4409.
Tang, G., Yang, J., Minemoto, Y. and Lin, A. (2001) Blocking caspase-3-mediated
proteolysis of IKKbeta suppresses TNF-alpha-induced apoptosis. Mol Cell, 8,
1005-1016.
Tewari, M., Wolf, F.W., Seldin, M.F., O'Shea, K.S., Dixit, V.M. and Turka, L.A.
(1995) Lymphoid expression and regulation of A20, an inhibitor of
programmed cell death. J Immunol, 154, 1699-1706.
Thurston, G., Rudge, J.S., Ioffe, E., Zhou, H., Ross, L., Croll, S.D., Glazer, N.,
Holash, J., McDonald, D.M. and Yancopoulos, G.D. (2000) Angiopoietin-1
protects the adult vasculature against plasma leakage. Nat Med, 6, 460-463.
Thurston, G., Suri, C., Smith, K., McClain, J., Sato, T.N., Yancopoulos, G.D. and
McDonald, D.M. (1999) Leakage-resistant blood vessels in mice
transgenically overexpressing angiopoietin-1. Science, 286, 2511-2514.
Tiainen, M., Ylikorkala, A. and Makela, T.P. (1999) Growth suppression by Lkb1 is
mediated by a G(1) cell cycle arrest. Proc Natl Acad Sci U S A, 96,
9248-9251.
Tomlinson, I.P. and Houlston, R.S. (1997) Peutz-Jeghers syndrome. J Med Genet, 34,
1007-1011.
Trompouki, E., Hatzivassiliou, E., Tsichritzis, T., Farmer, H., Ashworth, A. and
Mosialos, G. (2003) CYLD is a deubiquitinating enzyme that negatively
regulates NF-kappaB activation by TNFR family members. Nature, 424,
793-796.
Van Huffel, S., Delaei, F., Heyninck, K., De Valck, D. and Beyaert, R. (2001)
Identification of a novel A20-binding inhibitor of nuclear factor-kappa B
activation termed ABIN-2. J Biol Chem, 276, 30216-30223.
Vanden Berghe, W., Plaisance, S., Boone, E., De Bosscher, K., Schmitz, M.L., Fiers,
W. and Haegeman, G. (1998) p38 and extracellular signal-regulated kinase
mitogen-activated protein kinase pathways are required for nuclear
factor-kappaB p65 transactivation mediated by tumor necrosis factor. J Biol
Chem, 273, 3285-3290.
Verma, I.M., Stevenson, J.K., Schwarz, E.M., Van Antwerp, D. and Miyamoto, S.
(1995) Rel/NF-kappa B/I kappa B family: intimate tales of association and
dissociation. Genes Dev, 9, 2723-2735.
Wajant, H., Henkler, F. and Scheurich, P. (2001) The TNF-receptor-associated factor
family: scaffold molecules for cytokine receptors, kinases and their regulators.
Cell Signal, 13, 389-400.
Wang, S., Nath, N., Minden, A. and Chellappan, S. (1999) Regulation of Rb and E2F
by signal transduction cascades: divergent effects of JNK1 and p38 kinases.
Embo J, 18, 1559-1570.
Wang, W., Cote, J., Xue, Y., Zhou, S., Khavari, P.A., Biggar, S.R., Muchardt, C.,
Kalpana, G.V., Goff, S.P., Yaniv, M., Workman, J.L. and Crabtree, G.R.
(1996a) Purification and biochemical heterogeneity of the mammalian
SWI-SNF complex. Embo J, 15, 5370-5382.
Wang, W., Xue, Y., Zhou, S., Kuo, A., Cairns, B.R. and Crabtree, G.R. (1996b)
Diversity and specialization of mammalian SWI/SNF complexes. Genes Dev,
10, 2117-2130.
Wang, Y., Perrault, A.R. and Iliakis, G. (1997) Down-regulation of DNA replication
in extracts of camptothecin-treated cells: activation of an S-phase checkpoint?
Cancer Res, 57, 1654-1659.
Wesselborg, S., Bauer, M.K., Vogt, M., Schmitz, M.L. and Schulze-Osthoff, K. (1997)
Activation of transcription factor NF-kappaB and p38 mitogen-activated
protein kinase is mediated by distinct and separate stress effector pathways. J
Biol Chem, 272, 12422-12429.
Whelan, J., Ghersa, P., Hooft van Huijsduijnen, R., Gray, J., Chandra, G., Talabot, F.
and DeLamarter, J.F. (1991) An NF kappa B-like factor is essential but not
sufficient for cytokine induction of endothelial leukocyte adhesion molecule 1
(ELAM-1) gene transcription. Nucleic Acids Res, 19, 2645-2653.
Wisdom, R., Johnson, R.S. and Moore, C. (1999) c-Jun regulates cell cycle
progression and apoptosis by distinct mechanisms. Embo J, 18, 188-197.
Wissing, D., Mouritzen, H. and Jaattela, M. (1998) TNF-induced mitochondrial
changes and activation of apoptotic proteases are inhibited by A20. Free Radic
Biol Med, 25, 57-65.
Woronicz, J.D., Gao, X., Cao, Z., Rothe, M. and Goeddel, D.V. (1997) IkappaB
kinase-beta: NF-kappaB activation and complex formation with IkappaB
kinase-alpha and NIK. Science, 278, 866-869.
Xiao, G., Harhaj, E.W. and Sun, S.C. (2000) Domain-specific interaction with the I
kappa B kinase (IKK)regulatory subunit IKK gamma is an essential step in
tax-mediated activation of IKK. J Biol Chem, 275, 34060-34067.
Xu, Y., Bialik, S., Jones, B.E., Iimuro, Y., Kitsis, R.N., Srinivasan, A., Brenner, D.A.
and Czaja, M.J. (1998) NF-kappaB inactivation converts a hepatocyte cell line
TNF-alpha response from proliferation to apoptosis. Am J Physiol, 275,
C1058-1066.
Yamamoto, Y. and Gaynor, R.B. (2001) Therapeutic potential of inhibition of the
NF-kappaB pathway in the treatment of inflammation and cancer. J Clin
Invest, 107, 135-142.
Yamaoka, S., Courtois, G., Bessia, C., Whiteside, S.T., Weil, R., Agou, F., Kirk, H.E.,
Kay, R.J. and Israel, A. (1998) Complementation cloning of NEMO, a
component of the IkappaB kinase complex essential for NF-kappaB activation.
Cell, 93, 1231-1240.
Yang, J., Boerm, M., McCarty, M., Bucana, C., Fidler, I.J., Zhuang, Y. and Su, B.
(2000) Mekk3 is essential for early embryonic cardiovascular development.
Nat Genet, 24, 309-313.
Yang, J., Lin, Y., Guo, Z., Cheng, J., Huang, J., Deng, L., Liao, W., Chen, Z., Liu, Z.
and Su, B. (2001) The essential role of MEKK3 in TNF-induced NF-kappaB
activation. Nat Immunol, 2, 620-624.
Ye, J., Xie, X., Tarassishin, L. and Horwitz, M.S. (2000) Regulation of the
NF-kappaB activation pathway by isolated domains of FIP3/IKKgamma, a
component of the IkappaB-alpha kinase complex. J Biol Chem, 275,
9882-9889.
Ylikorkala, A., Rossi, D.J., Korsisaari, N., Luukko, K., Alitalo, K., Henkemeyer, M.
and Makela, T.P. (2001) Vascular abnormalities and deregulation of VEGF in
Lkb1-deficient mice. Science, 293, 1323-1326.
Zandi, E., Rothwarf, D.M., Delhase, M., Hayakawa, M. and Karin, M. (1997) The
IkappaB kinase complex (IKK) contains two kinase subunits, IKKalpha and
IKKbeta, necessary for IkappaB phosphorylation and NF-kappaB activation.
Cell, 91, 243-252.
Zetoune, F.S., Murthy, A.R., Shao, Z., Hlaing, T., Zeidler, M.G., Li, Y. and Vincenz,
C. (2001) A20 inhibits NF-kappa B activation downstream of multiple Map3
kinases and interacts with the I kappa B signalosome. Cytokine, 15, 282-298.
Zhang, S.Q., Kovalenko, A., Cantarella, G. and Wallach, D. (2000) Recruitment of
the IKK signalosome to the p55 TNF receptor: RIP and A20 bind to NEMO
(IKKgamma) upon receptor stimulation. Immunity, 12, 301-311.
Zhao, Q. and Lee, F.S. (1999) Mitogen-activated protein kinase/ERK kinase kinases 2
and 3 activate nuclear factor-kappaB through IkappaB kinase-alpha and
IkappaB kinase-beta. J Biol Chem, 274, 8355-8358.
Zhong, H., May, M.J., Jimi, E. and Ghosh, S. (2002) The phosphorylation status of
nuclear NF-kappa B determines its association with CBP/p300 or HDAC-1.
Mol Cell, 9, 625-636.
Zhong, H., SuYang, H., Erdjument-Bromage, H., Tempst, P. and Ghosh, S. (1997)
The transcriptional activity of NF-kappaB is regulated by the
IkappaB-associated PKAc subunit through a cyclic AMP-independent
mechanism. Cell, 89, 413-424.
Zhong, H., Voll, R.E. and Ghosh, S. (1998) Phosphorylation of NF-kappa B p65 by
PKA stimulates transcriptional activity by promoting a novel bivalent
interaction with the coactivator CBP/p300. Mol Cell, 1, 661-671.
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