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研究生:趙如蘭
研究生(外文):Ju-Lan Chao
論文名稱:果蠅eyg基因功能及其控制機轉之探討
論文名稱(外文):Function and regulation of eye gone in Drosophila eye development
指導教授:孫以瀚孫以瀚引用關係
指導教授(外文):Y. Henry Sun
學位類別:博士
校院名稱:國立陽明大學
系所名稱:遺傳學研究所
學門:生命科學學門
學類:生物訊息學類
論文種類:學術論文
論文出版年:2004
畢業學年度:92
語文別:英文
中文關鍵詞:眼睛發育
外文關鍵詞:eygeye developmentDrosophila
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eye gone (eyg)基因可轉譯出 一PAX蛋白,此蛋白包含一不完整的paired domain及完整的homeodomain。當eyg發生突變時會造成果蠅眼睛變小或眼睛完全消失,反之利用dpp-GAL4誘使eyg基因在異位表達,可誘導一小的獨立複眼在果蠅正常眼睛的腹側發生。經由突變及異位表達可推論,eyg 基因在果蠅早期眼睛發育扮演不可或缺之角色。本論文探討eyg 基因在眼睛發育的主要功能及其可能之控制機轉。我們發現eyg 基因在眼睛細胞分裂時是必須的,此功能是受到Notch 基因的調控。此外eyg 基因會抑制wg 及omb 基因的表現,此二者為負向調控果蠅眼睛的生長。在果蠅早期眼睛發育中ey 基因為主要決定因素之一,我们發現eyg 基因可取代其部份功能,且在誘導異位複眼發生上有加成效果。同時也發現eyg 基因可誘導dac 及eya基因的表現,dac基因為眼睛分化的標的基因。綜合上述之實驗結果,可以得知eyg 基因在眼睛細胞生長及分化皆有其貢獻。
eyg gene encodes a novel Pax protein (transcriptional factor) that is most closely related to Pax-6 but lacks the N-terminal end of the pair domain. eyg mutant lost most of head structure and missexpression of eyg caused the ectopic eye in the ventral region of head cuticle. These observations suggest that eyg plays an important role in early eye development. In this work, I characterized the function of eyg. First, eyg is a downstream effector for Notch-mediated cellular proliferation of eye disc. Secondly, eyg decreases the transcriptional level of wg and omb, which are the inhibitory force in eye growth. Thirdly, eyg substitutes partially the function of ey and induces the expression of dac and eya. Fourthy, eyg and dpp act cooperatively to induce the ectopic eye in the antennal disc. In conclusion, Eyg plays an essential role in growth control and is a mediator from proliferation to differentiation for eye development in Drosophila.
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