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研究生:莊欣怡
研究生(外文):Hsin-Yi Chuang
論文名稱:烷基酚類職業暴露族群之生物偵測研究
論文名稱(外文):Biomonitoring of Alkylphenols Exposure for Occupational Groups
指導教授:陳美蓮陳美蓮引用關係毛義方毛義方引用關係
指導教授(外文):Mei-Lien ChenI-Fang Mao
學位類別:碩士
校院名稱:國立陽明大學
系所名稱:環境衛生研究所
學門:醫藥衛生學門
學類:公共衛生學類
論文種類:學術論文
論文出版年:2004
畢業學年度:92
語文別:英文
中文關鍵詞:壬基苯酚辛基苯酚雙丁基苯酚職業暴露生物偵測
外文關鍵詞:nonylphenol4-tert-octylphenol24-di-tert-butylphenoloccupational exposurebiological monitoring
相關次數:
  • 被引用被引用:6
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  • 下載下載:42
  • 收藏至我的研究室書目清單書目收藏:2
烷基酚類主要為非離子型介面活性劑以及塑膠添加物之降解產物,如壬基苯酚、辛基苯酚以及雙丁基苯酚。研究證實他們廣泛地存在於環境之中,且可能干擾人體荷爾蒙的平衡。近年來有些研究即針對人體中烷基酚類濃度進行分析方法的開發,然而職業族群長期潛在的暴露對於體內烷積酚類濃度的影響關係資料闕如。
本研究分析纖維染整工人、清潔業工人尿液及血漿樣本中壬基苯酚、辛基苯酚、雙丁基苯酚的濃度,與一般族群:辦公室工作人員、TDI工廠員工以及學生之體內烷基酚類濃度進行比較。在下班後收集的尿液樣本中,纖維染整工人壬基苯酚、辛基苯酚、雙丁基苯酚的濃度分別為37.02±45.92 ng/mL、2.27±2.92 ng/mL、 13.37±15.72 ng/mL;清潔工人為5.39±3.51 ng/mL、3.70±2.77 ng/mL、3.92±4.79 ng/mL;辦公室人員為3.74±11.36 ng/mL、8.72±24.54 ng/mL、20.33±79.88 ng/mL;學生族群為最低,依序分別為4.40±5.99 ng/mL、1.46±1.01 ng/mL、1.46±1.20 ng/mL。血漿樣本部分,本研究僅收集清潔工人、TDI廠員工以及學生族群於上班期間之血漿樣本,清潔工人血漿中烷基苯酚、辛基苯酚及雙丁基苯酚的濃度分別為45.97±27.75 ng/g、15.53±2.17 ng/g、25.10±5.83 ng/g;TDI工人則為3.69±4.15 ng/g、 3.08±2.32 ng/g、5.50±2.00 ng/g;學生族群為43.18±37.31 ng/g、13.54±12.25 ng/g、 22.88±12.50 ng/g。
本研究發現纖維染整工人於工作期間暴露高濃度之壬基苯酚,其中於現場作業使用染整助劑的員工體內壬基苯酚濃度顯著高於非現場作業的員工。清潔工人並未出現預期的高體內烷基酚類濃度,可能原因為此兩種行業對於介面活性劑的使用方法不同,如稀釋的比例及使用量。本研究亦為第一篇針對台灣地區一般人口體內烷基酚類濃度分析之研究,發現台灣地區人口體內壬基苯酚、辛基苯酚濃度高於其他國家的研究結果;雙丁基苯酚的檢出率亦相當高。台灣地區清潔劑與塑膠製品的廣泛使用,可能造成環境中大量的烷基酚類污染情形,其所引起的公共衛生衝擊值得更進一步的探討。
本研究成功地應用生物偵測方法進行職業族群的體內烷基酚類濃度分析,此方法可以完整地反應所有暴露來源對於人體造成的健康衝擊。本研究建立台灣地區居民之烷基酚類生物濃度資料,顯示烷基酚類對人體可能造成的健康衝擊值得關心。
Alkylphenols (APs) are the biodegradation products of an extensively used group of non-ionic surfactants and plastic additives. These biodegradation compounds, 4-nonylphenol (NP), 4-tert-octylphenol (OP) and 2,4-di-tert-butylphenol (DTBP), adversely affect human health because they disrupt the endocrine system. Several investigations have reported the ubiquity of APs in the environment and increasing concern about their effects on human health.
Some studies have found the presence of APs in human biological samples. However, no information is available on the relationship between occupational exposure and internal levels. This study addresses the internal concentrations of NP, OP and DTBP of two occupational groups – textile workers and housekeepers. Office workers, college students and TDI workers are the control groups. Urine samples are collected from textile workers, housekeepers, college students and office workers. Plasma samples are collected from housekeeping workers, college students and TDI workers.
The average urinary concentrations of NP, OP and DTBP in end-of-shift samples of textile workers are 37.02±45.92 ng/mL, 2.27±2.92 ng/mL and 13.37±15.72 ng/mL, respectively. Those of housekeeping workers are 5.39±3.51 ng/mL, 3.70±2.77 ng/mL and 3.92±4.79 ng/mL. The average urinary NP, OP and DTBP of the end-of-shift samples collected from office workers are 3.74±11.36 ng/mL, 8.72±24.54 ng/mL and 20.33±79.88 ng/mL. The mean concentrations of college students are the lowest, being 4.40±5.99 ng/mL, 1.46±1.01 ng/mL and 1.46±1.20 ng/mL, respectively. The plasma concentrations of NP, OP and DTBP for housekeeping workers are 45.97±27.75 ng/g, 15.53±2.17 ng/g and 25.10±5.83 ng/g; they are 43.18±37.31 ng/g, 13.54±12.25 ng/g and 22.88±12.50 ng/g for college students, and 3.69±4.15 ng/g, 3.08±2.32 ng/g and 5.50±2.00 ng/g for TDI workers.
This work demonstrates that textile workers suffer high exposure to NP because their post-shift urinary levels are significantly higher than the pre-shift levels; those of the field workers significantly exceed those of the clerks. Housekeeping workers do not exhibit the expectedly high NP concentrations. The difference between the results of NP exposure between these two groups may follow from the different manipulations of surfactants. This study is also the first on internal APs concentrations of the general Taiwanese population. OP and NP of Taiwanese herein exceed the values obtained in previous studies in other countries; DTBP is commonly detected in participants. Large amounts of APs have polluted the environment because plastics and detergents have been extensively used. The potentially harmful impact on public health has been noted.
Biological monitoring has been successfully applied to assess occupational NP exposure. It is a powerful method for determining the unequivocal internal levels via various exposure routes. This study established valuable information on biological AP levels for Taiwanese. The health impact of alkylphenols must be considered.
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