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研究生(外文):Hsin-Yi Chuang
論文名稱(外文):Biomonitoring of Alkylphenols Exposure for Occupational Groups
指導教授(外文):Mei-Lien ChenI-Fang Mao
外文關鍵詞:nonylphenol4-tert-octylphenol24-di-tert-butylphenoloccupational exposurebiological monitoring
  • 被引用被引用:6
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本研究分析纖維染整工人、清潔業工人尿液及血漿樣本中壬基苯酚、辛基苯酚、雙丁基苯酚的濃度,與一般族群:辦公室工作人員、TDI工廠員工以及學生之體內烷基酚類濃度進行比較。在下班後收集的尿液樣本中,纖維染整工人壬基苯酚、辛基苯酚、雙丁基苯酚的濃度分別為37.02±45.92 ng/mL、2.27±2.92 ng/mL、 13.37±15.72 ng/mL;清潔工人為5.39±3.51 ng/mL、3.70±2.77 ng/mL、3.92±4.79 ng/mL;辦公室人員為3.74±11.36 ng/mL、8.72±24.54 ng/mL、20.33±79.88 ng/mL;學生族群為最低,依序分別為4.40±5.99 ng/mL、1.46±1.01 ng/mL、1.46±1.20 ng/mL。血漿樣本部分,本研究僅收集清潔工人、TDI廠員工以及學生族群於上班期間之血漿樣本,清潔工人血漿中烷基苯酚、辛基苯酚及雙丁基苯酚的濃度分別為45.97±27.75 ng/g、15.53±2.17 ng/g、25.10±5.83 ng/g;TDI工人則為3.69±4.15 ng/g、 3.08±2.32 ng/g、5.50±2.00 ng/g;學生族群為43.18±37.31 ng/g、13.54±12.25 ng/g、 22.88±12.50 ng/g。
Alkylphenols (APs) are the biodegradation products of an extensively used group of non-ionic surfactants and plastic additives. These biodegradation compounds, 4-nonylphenol (NP), 4-tert-octylphenol (OP) and 2,4-di-tert-butylphenol (DTBP), adversely affect human health because they disrupt the endocrine system. Several investigations have reported the ubiquity of APs in the environment and increasing concern about their effects on human health.
Some studies have found the presence of APs in human biological samples. However, no information is available on the relationship between occupational exposure and internal levels. This study addresses the internal concentrations of NP, OP and DTBP of two occupational groups – textile workers and housekeepers. Office workers, college students and TDI workers are the control groups. Urine samples are collected from textile workers, housekeepers, college students and office workers. Plasma samples are collected from housekeeping workers, college students and TDI workers.
The average urinary concentrations of NP, OP and DTBP in end-of-shift samples of textile workers are 37.02±45.92 ng/mL, 2.27±2.92 ng/mL and 13.37±15.72 ng/mL, respectively. Those of housekeeping workers are 5.39±3.51 ng/mL, 3.70±2.77 ng/mL and 3.92±4.79 ng/mL. The average urinary NP, OP and DTBP of the end-of-shift samples collected from office workers are 3.74±11.36 ng/mL, 8.72±24.54 ng/mL and 20.33±79.88 ng/mL. The mean concentrations of college students are the lowest, being 4.40±5.99 ng/mL, 1.46±1.01 ng/mL and 1.46±1.20 ng/mL, respectively. The plasma concentrations of NP, OP and DTBP for housekeeping workers are 45.97±27.75 ng/g, 15.53±2.17 ng/g and 25.10±5.83 ng/g; they are 43.18±37.31 ng/g, 13.54±12.25 ng/g and 22.88±12.50 ng/g for college students, and 3.69±4.15 ng/g, 3.08±2.32 ng/g and 5.50±2.00 ng/g for TDI workers.
This work demonstrates that textile workers suffer high exposure to NP because their post-shift urinary levels are significantly higher than the pre-shift levels; those of the field workers significantly exceed those of the clerks. Housekeeping workers do not exhibit the expectedly high NP concentrations. The difference between the results of NP exposure between these two groups may follow from the different manipulations of surfactants. This study is also the first on internal APs concentrations of the general Taiwanese population. OP and NP of Taiwanese herein exceed the values obtained in previous studies in other countries; DTBP is commonly detected in participants. Large amounts of APs have polluted the environment because plastics and detergents have been extensively used. The potentially harmful impact on public health has been noted.
Biological monitoring has been successfully applied to assess occupational NP exposure. It is a powerful method for determining the unequivocal internal levels via various exposure routes. This study established valuable information on biological AP levels for Taiwanese. The health impact of alkylphenols must be considered.
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