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研究生:李坤展
研究生(外文):Kuen-Jaan Lee
論文名稱:小波轉化偵測心臟希氏束訊號之研究
論文名稱(外文):A study of His bundle activity detection using wavelet transform
指導教授:高材高材引用關係
指導教授(外文):Tsair Kao
學位類別:碩士
校院名稱:國立陽明大學
系所名稱:醫學工程研究所
學門:工程學門
學類:生醫工程學類
論文種類:學術論文
論文出版年:2004
畢業學年度:92
語文別:英文
中文關鍵詞:希氏束小波轉換最佳基底選擇食道電極
外文關鍵詞:His bundle activityWavelet transformBest basis selectionEsophageal electrode
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一般體表心電圖無法觀測到房室傳導阻斷的位置,若要有正確地診斷,則必須透過侵入式導管來量測希氏束訊信號。多年來,以非侵入式方法測量心臟希氏束信號發生時間是研究上重要的課題。因為希氏束信號能量相當微弱,為了以非侵入性方式測量,多半學者採用信號平均法,提高體表心電信號訊雜比偵測希氏束信號,然而這些結果不太容易看的出希氏束信號位置,所以一直無法被臨床所採用。
本論文利用食道靠近心臟的特性,以食道電極記錄八個正常人與11個病人心電訊號,所有的實驗都有經過受測者的同意。在心電訊號中,以心房訊號的最大值當作參考點,選出每一跳心電訊號,並將每一跳訊號經過小波轉換,在轉換過程中,我們以最佳基底理論找出最適合此訊號的基底轉換,為了增加訊號的雜訊比,我們將每一跳的轉換後的時頻係數換算成頻譜,從平均頻譜圖轉換得到能量密度,找出心房與心室信號中最大能量的時間點(H’),這時間點就是食道希氏束信號能量最大點。
在正常人結果中,7筆資料中的希氏束到心室信號間距(H''V)都分部於正常範圍;在病人訊號中,有4筆資料因為電極擺放位置不佳而導致無法得到希氏束信號,其餘7筆資料結果顯示食道電極的心房到希氏束信號間距(AH'')與希氏束到心室信號間距,與導管結果相關係數r為0.95以上,且經過威爾考克森檢定(Wilcoxon signed-rank test),發現這兩種量測結果沒有明顯差異。偵測到的信號在時頻域分佈也符合希氏束信號特性。
根據我們實驗結果,只要電極擺放位置適當,且心房信號到心室信號間距(AV )大於34 msec,都能成功得到希氏束信號。
In the past, the location of cardiac conduction block could not be detected by surface ECG. Thus people always measured it by catheter. It is an important topic how the His activity could be detected by noninvasive measurement. The His activity is so weak, therefore, many studies have used signal averaging to increase SNR in surface leads. It was still not easy to detect the His, so that this method wasn’t be adopted in clinic.
In this study, we recorded esophageal ECG (EECG) with eight normal subjects and eleven AV block patients. We selected the maximum of atrial wave as reference point, and analyzed each beat’s EECG by wavelet transform. In wavelet transform, we selected the most suitable basis with the best basis selection algorithm. For increasing SNR, the square time-scale coefficients, the scalogram, were averaged beat-to-beat, and then the energy density was derived from the averaged scalogram. We found the maximum energy (H’) of His activity between the end of the atrial wave and the onset of the ventricular wave in the esophageal lead.
In our results, the intervals between H’ and the onset of ventricular wave were within normal range in seven healthy subjects. In AV block subjects, the His activity could not be detected in four subjects because the esophageal electrode was placed in incorrect position. In other subjects, we defined the intervals between the onset of atrial wave and the H’ as AH'', and between the H’ and the onset of ventricular wave as H''V. There were strong correlation (r > 0.95) between the AH'' and H''V of esophageal and intracardiac leads. These results of two measurements were not significantly different by Wilcoxon signed-rank test. And the time-frequency distribution of detected signal was similar to His activity characteristics.
According to our results, if the esophageal electrode was at suitable position and the interval AV was more than 34 msec, we could detect His activity accurately by our method.
References
[1] B. J. Scherlag, S. H. Lau, R. H. Helfant, W. D. Berkowitz, E. Stein, A. N. Damato, “Catheter technique for recording His bundle activity in man,” Circulation, Vol. 39, 13-18, 1969.
[2] E. J. Berbari, R. Lazzara, P. Samet, B. J. Scherlag, “Noninvasive technique for detection of electrical activity during the P-R segment,” Circulation, Vol. 48, 1005-1013, 1973.
[3] N. C. Flowers, R. C. Hand., P. C. Orander, C. B. Miller, M. O. Walden, L. G. Horan., “Surface recording of electrical activity from the region of the bundle of His, Am. J. Cardiol., Vol. 33, 384-389, 1974.
[4] E. J. Berbari, S. M. Collins, Y. Salu, R. Arzbaecher, “Orthogonal surface lead recording of His-Purkinje activity: comparison of actual and simulated waveforms, ” IEEE trans. biomed. eng., Vol. 30, 160-167, 1983.
[5] E. J. Berbari, R. Lazzara, B. J. Scherlag, “The effects of filtering the His-Purkinje system electrocardiogram,” IEEE trans. biomed. eng., Vol. 26, 82-85, 1979.
[6] Y. Hishimoto, T. Sawayama, “Non-invasive recording of His bundle potential in man,” Brit. Heart J., Vol. 37, 384, 1975.
[7] H. A. M. Al-Nashash, S. W. Kelly, D. J. E. Taylor, “Beat-to-beat detection of His-Purkinje system signals using adaptive filters,” Med. & Bio. Eng. & computer, Vol. 26, 117-125, 1988.
[8] O. Meste, H. Rix, “Detection of late potentials by means of wavelet transform,” IEEE eng. in medicine and biology society 11th conf. ECG signal processing II, Vol. 29, 28-29, 1989.
[9] S. Burrus, Introduction to wavelets and wavelet transforms, New Jersey: Prentice Hall, 1st ed., 1997.
[10] S. G. Mallat, “A Theory for Multiresolution Signal Decomposition: The Wavelet Representation,” IEEE Transactions on Pattern Analysis and Machine Intelligence, Vol. 11, 674-693, 1989.
[11] R. R. Coifman and M. V. Wickerhauser, “Entropy-based algorithms for best basis selection,” IEEE Transactions on Signal Processing, Vol. 41, 713-718, 1992.
[12] P. F. Binkley, C. A. Bush, A. J. Kolibash, R. D. Magorien, R. L. Hamlin, C. V. Leier, “The anatomic relationship of the esophageal lead to the left atrium,” PACE, Vol. 5, 853-859, 1982.
[13] E. N. Prystowsky, L. C. Pritchett, J. J. Gallagher, “Origin of the atrial electrogram recorded from the esophagus,” Circulation, Vol. 61, 1017-1023, 1980.
[14] E. J. Berbari, S. M. Collins, R. Arzbaecher, “Evaluation of esophageal electrodes for recording His-Purkinje activity based upon signal variance,” IEEE trans. biomed. eng., Vol. 33, 922-928, 1986.
[15] J. M. Sheu, “Time-frequency analysis on detecting His activity,” National Yang-Ming University Master thesis, 2000.
[16] http://cyber.felk.cvut.cz/gerstner/biolab/bio_web/tech/KP/WaveletTh
eory.pdf
[17] S. Qian, D. Chen, Joint time-frequency analysis -- methods and applications, Prentice Hall PTR, 1996.
[18] E. J. Berbari, B. J. Scherlag, R. Lazzara, “A computerized technique to record new components of the electrocardiogram,” Proc. IEEE, Vol. 65, 799-802, 1977.
[19] http://hpk.felk.cvut.cz/~xnovakd1/doc/ECGthesis.pdf
[20] http://www.nist.gov/speech/tests/sigtests/wilcoxon.htm
[21] http://www.bio.psu.edu/Courses/Fall2002/Biol142/EKG/ECG.html
[22] V. Arthur, S. James, L. Dorothy, Human physiology, MC Graw Hill, 8th ed., 2001.
[23] http://rnbob.tripod.com/electroc.htm
[24] N. C. Flowers, M. B. Shvartsman, M. B. Kennelly, G. S. Sohi and L. G. Horan, “Surface recordings of His-Purkinje activity on an every beat basis without digital averaging,” Circulation, Vol. 63, 948-957, 1981.
[25] Y. T. Chen, Clinical cardiology, Nanzando, 1ed. 1982.
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