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研究生:王聖云
研究生(外文):Sheng-Yun Wang
論文名稱:Baicalein抗失憶作用之研究
論文名稱(外文):Study on The Anti-amnesic Effects of Baicalein
指導教授:廖志飛廖志飛引用關係
指導教授(外文):Jyh-Fei Liao
學位類別:碩士
校院名稱:國立陽明大學
系所名稱:藥理學研究所
學門:醫藥衛生學門
學類:藥學學類
論文種類:學術論文
論文出版年:2004
畢業學年度:92
語文別:中文
中文關鍵詞:黃芩苷阿滋海默氏症學習和記憶類澱粉蛋白被動逃避行為試驗
外文關鍵詞:BaicaleinAlzheimer''''s diseaseLearning and memoryBeta amyloidStep-through passive avoidance test
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Baicalein 被報導在體外試驗中可有效保護培養之大鼠初級大腦皮質神經細胞受 b-amyloid peptide-(25-35) 之神經毒性傷害。為了研究 baicalein在體內是否有類似之作用,本研究以被動逃避行為試驗來探討baicalein 對於側腦室注射3 nmol b-amyloid peptide-(25-35) 引致 ICR 小鼠學習與記憶障礙之影響。因為先前研究發現,baicalein 可能作用在 GABAA 受器上的 benzodiazepine 結合處而在小鼠具有抗焦慮的作用,又benzodiazepine 藥物會產生失憶的副作用,所以本研究首先檢驗 baicalein 對於學習與記憶之影響。結果顯示與腹腔注射 benzodiazepine 藥物chlordiazepoxide (10 mg/kg) 不同,baicalein在訓練前 30 分鐘給予10-100 mg/kg 並不會產生失憶現象,並且 baicalein (10 mg/kg, i.p.) 在訓練前 30分鐘、訓練後立即、或測試前 30 分鐘給予,對於 scopolamine 或 b-amyloid peptide-(25-35) 所引致的失憶作用亦無改善的情形,顯示baicalein 對學習與記憶亦無促進作用。然而,如在 b-amyloid peptide-(25-35) 注射前 30 分鐘預處理單劑量baicalein (5 或 10 mg/kg, i.p.) 則可減弱 b-amyloid peptide-(25-35) 引致之失憶現象,但如在 b-amyloid peptide-(25-35) 注射後第 3 天或第 8 天給予baicalein則無此效果。如在 b-amyloid peptide-(25-35) 注射後第2天起連續每天給予baicalein (10 或 15 mg/kg, i.p.) 共7天或13天則可減弱 b-amyloid peptide-(25-35) 引致之失憶現象。同樣地連續多劑量給予而不是單劑量給予抗氧化劑 melatonin (10 mg/kg, i.p.) 亦有相似效果。此外,如以高鉀溶液刺激海馬迴切片乙醯膽鹼 (ACh) 釋放之程度當作海馬迴cholinergic 神經活性之指標,本研究發現在側腦室注射 b-amyloid peptide-(25-35) 後第十六天,海馬迴組織之cholinergic 神經活性會降低而脂質過氧化會增加。經連續後處理 baicalein 七天而明顯改善學習與記憶之小鼠,其海馬迴組織之 cholinergic 神經活性及脂質過氧化均被改善,但是預處理 baicalein者雖可改善學習與記憶障礙及海馬迴組織之 cholinergic 神經活性,卻無法改善脂質過氧化。造成此差異性之原因未明。綜合上述結果,本研究首度闡示 baicalein 在小鼠無促進學習與記憶之作用,但可預防或減緩b-amyloid peptide-(25-35) 對神經細胞所造成的傷害及產生學習與記憶的障礙,其作用機轉可能部份與 baicalein 之抗氧化作用有關。
Baicalein has been reported to protect cultured rat cortical neurons from b-amyloid peptide-(25-35)-induced toxicity in vitro. To study whether it has similar effect in vivo, the present study examined the effects of baicalein on b-amyloid peptide-(25-35) (3 nmol/mouse, i.c.v.)-induced impairment of learning and memory in ICR mice using the step-through passive avoidance test. Since baicalein may act on the benzodiazepine binding site of GABAA receptor to exert anxiolytic-like effect in mice as demonstrated in our previous study and benzodiazepine drugs have amnesic side-effect, this study first examined the effect of baicalein on learning and memory. Unlike the benzodiazepine drug chlordiazepoxide (10 mg/kg, i.p.), the results showed that baicalein (10-100 mg/kg, i.p.) had no significant amnesic effect when administered 30 min before the training trial. Furthermore, baicalein (10 mg/kg, i.p.) also had no significant effects on scopolamine (1 mg/kg, i.p.)- and b-amyloid peptide-(25-35)-induced amnesia, when administered 30 min before or immediately after the training trial, or 30 min before the retention test, indicating no facilitating effect on learning and memory. However, one dosage of baicalein (5 or 10 mg/kg, i.p.) attenuated b-amyloid peptide-(25-35)-induced amnesia when administered 30 min before but not on day 3 or day 8 after i.c.v b-amyloid peptide-(25-35) administration (as day 1). Baicalein (10 or 15 mg/kg, i.p.) also attenuated b-amyloid peptide-(25-35)-induced amnesia when administered once per day for 7 days or 13 days from day 2 after i.c.v. administration of b-amyloid peptide-(25-35). Similar results were obtained for an antioxidant melatonin (10 mg/kg, i.p.) when it was post-treated with multiple dosages but not single dosage. In addition, the present study also found a decrease in the cholinergic activity (using the extent of high K+-stimulated release of acetylcholine from hippocampal slices as an index) and an increase in the lipid peroxidation in the hippocampal tissues on day 16 after i.c.v. administration of b-amyloid peptide-(25-35). Post-treatment with baicalein for 7 days improved the learning and memory, cholinergic activity, and lipid peroxidation. In contrast, pretreatment with baicalein improved the learning and memory, cholinergic activity, but not lipid peroxidation. The reason for this discrepancy is unclear. In summary, the present study demonstrated for the first time that baicalein has no facilitating effect on the learning and memory, but has preventive or protective effect on b-amyloid peptide-(25-35)-induced neurotoxicity and impairment of learning and memory in mice. The action mechanism of baicalein may partially attribute to its antioxidant effect.
柒、參考文獻
1. 王慧虹 (2003) 中藥水抽提物、去氫吳茱萸鹼與Dimemorfan抗失憶作用之研究。國立陽明大學藥理學研究所,博士論文,台北。
2. 江蘇新醫院 (1979) 黃芩。中藥大辭典,商務印書館香港分館,下冊:2017-2021。
3. Ahn, H. C., Lee, S. Y., Kim, J. W., Son, W. S., Shin, C. G. and Lee, B. J. (2001) Binding aspects of baicalein to HIV-1 integrase. Molecules & Cells 12:127-130.
4. Andersen, J. K. and Viswanath, V. (2000) Interplay between oxidative stress and calcium homeostasis in acute neuronal damage and neurodegenerative disease. In Poli, G. and Cadenas, E. (Eds) Free Radicals in Brain Pathophysiology. Marcel Dekker, Inc., New York, pp. 197-198.
5. Aisen P. S. (2000) Anti-inflammatory therapy for Alzheimer’s disease. Neurobiology of Aging 21:447-448.
6. Akama, K. T. and Van Eldik, L. J. (2000) b-Amyloid stimulation of inducible nitric-oxide synthase in astrocytes is interleukin-1b- and tumor necrosis factor-a (TNFa)-dependent, and involves a TNFa receptor-associated factor- and NFkB-inducing kinase-dependent signaling mechanism. Journal of Biological Chemistry 275:7918-7924.
7. Akiyama, H., Barger, S., Barnum, S., Bradt, B., Bauer, J., Cole, G. M., Cooper, N. R., Eikelenboom, P., Emmerling, M., Fiebich, B. L., Finch, C. E., Frautschy, S., Griffin, W.S.T., Hampel, H., Hull, M., Landreth, G., Lue, L. F., Mrak, R., Mackenzie, I. R., McGeer, P. L., O’Banion, M. K., Pachter, J., Pasinetti, G., Plata-Salaman, C., Rogers, J., Rydel, R., Shen, Y., Streit, W., Strohmeyer, R., Tooyoma, I., Muiswinkel, F. L. V., Veerhuis, R., Walker, D., Webster, S., Wegrzyniak, B., Wenk, G. and Wyss-Coray, T. (2000) Inflammation and Alzheimer’s disease. Neurobiology of Aging 21:383–421.
8. Awad, R., Arnason, J. T., Trudeau, V., Bergeron, C., Budzinski, J. W., Foster, B. C. and Merali, Z. (2003) Phytochemical and biological analysis of skullcap (Scutellaria lateriflora L.):a medicinal plant with anxiolytic properties. Phytomedicine 10:640-649.
9. Behl, C. (1999) Alzheimer’s disease and oxidative stress:implications for novel therapeutic approaches. Progress in Neurobiology 57:301-323.
10. Behl, C., Davis, J. B., Lesley, R. and Schubert, D. (1994a) Amyloid β peptide induces necrosis rather than apoptosis. Brain Research 645:253-264.
11. Behl, C., Davis, J. B., Lesley, R. and Schubert, D. (1994b) Hydrogen peroxide mediates amyloid b protein toxicity. Cell 77: 817-827.
12. Bernabeu, R., de Stein, M. L., Fin, C., Izquierdo, I. and Medina, J. H. (1995) Role of hippocampal NO in the acquisition and consolidation of inhibitory avoidance learning. Neuroreport 6:1498-1500.
13. Breitner, J. C. (1996) Inflammatory processes and anti-inflammatory drugs in Alzheimer’s disease:a current appraisal. Neurobiology of Aging 17:789-794.
14. Brzezinski, A. (1997) Melatonin in humans. New England Journal of Medicine 336:186-195.
15. Bush, A. I., Pettingell, W. H., Multhaup, G., Paradis, M. D., Vonsattel, J. P., Gusella, J. F., Beyreuther, K., Masters, C. and Tanzi, R. E. (1994) Rapid induction of Alzheimer Ab amyloid formation by zinc. Science 265:1464–1467.
16. Butenko, I. G., Gladtchenko, S. V. and Galushko, S. V. (1993) Anti-inflammatory properties and inhibition of leukotriene C4 biosynthesis in vitro by flavonoid baicalein from Scutellaria baicalensis Georgy roots. Agents & Actions 39:C49-51.
17. Butterfield, D. A., Drake, J., Pocernich, C. and Castegna, A. (2001) Evidence of oxidative damage in Alzheimer’s disease brain:central role for amyloid b peptide. Trends in Molecular Medicine 7:548-554.
18. Cardoso, S. M., Santos, S., Swerdlow, R. H. and Oliveira, C. R. (2001) Functional mitochondria are required for amyloid b-mediated neurotoxicity. The Federation of American Societies for Experimental Biology Journal 15:1439-41.
19. Chang W. S., Lee Y. J., Lu F. J., and Chiang H. C. (1993) Inhibitory effects of flavonoids on xanthine oxidase. Anticancer Research 13:2165-2170.
20. Chen, Y. C., Shen, S. C., Chen, L. G., Lee, T. J. and Yang, L. L. (2001) Wogonin, baicalin, and baicalein inhibition of inducible nitric oxide synthase and cyclooxygenase-2 gene expressions induced by nitric oxide synthase inhibitors and lipopolysaccharide. Biochemical Pharmacology 61:1417-1427.
21. Chen, Z. Y., Su, Y. L., Lau, C. W., Law, W. I. and Huang, Y. (1999) Endothelium-dependent contraction and direct relaxation induced by baicalein in rat mesenteric artery. European Journal of Pharmacology 374:41-47.
22. Cherny, R. A., Atwood, C. S., Xilinas, M. E., Gray, D. N., Jones, W. D., McLean, C. A., Barnham, K. J., Volitakis, I., Fraser, F. W., Kim, Y., Huang, X., Goldstein, L. E., Moir, R. D., Lim, J. T., Beyreuther, K., Zheng, H., Tanzi, R. E., Masters, C. L. and Bush, A. I. (2001) Treatment with a copper-zinc chelator markedly and rapidly inhibits b-amyloid accumulation in Alzheimer’s disease transgenic mice. Neuron 30:665–676.
23. Combs, C. K., Johnson, D. E., Karlo, J. C., Cannady, S. B. and Landreth, G. E. (2000) Inflammatory mechanisms in Alzheimer’s disease: inhibition of b-amyloid-stimulated proinflammatory responses and neurotoxicity by PPARg agonists. Journal of Neuroscience 20:558-567.
24. Coyle, J. and Kershaw, P. (2001) Galantamine, a cholinesterase inhibitor that allosterically modulates nicotinic receptors:effects on the course of Alzheimer’s disease. Biological Psychiatry 49:289–299.
25. Coyle, J. T., Price, D. L. and DeLong, M. R. (1983) Alzheimer’s disease:a disorder of cortical cholinergic innervation. Science 219:1184-1190.
26. Crapper-McLachlan, D. R., Dalton, A. J., Kruck, T. P. A., Bell, M. Y., Smith, W. L. and Kalow, W. (1991) Intramuscular desferrioxmine in patients with Alzheimer’s disease. Lancet 337:1304–1308.
27. Culhane N. S. (2003) Estrogen plus progestin may increase incidence of dementia. Journal of Family Practice 52:754-755.
28. Cummings, J. L, and Kaufer, D. (1996) Neuropsychiatric aspects of Alzheimer’s disease:the cholinergic hypothesis revisited. Neurology 47:876-883.
29. Danysz, W. and Parsons C. G. (2003) The NMDA receptor antagonist memantine as a symptomatological and neuroprotective treatment for Alzheimer’s disease:preclinincal evidence. International Journal of Geriatric Psychiatry 18:S23-S32.
30. Davies, L., Wolska, B., Hilbich, C., Multhaup, G., Martins, R., Simms, G., Beyreuther, K. and Masters, C. L. (1988) A4 amyloid protein deposition and the diagnosis of Alzheimer’s disease: prevalence in aged brains determined by immunocytochemistry compared with conventional neuropathologic techniques. Neurology 38:1688-1693.
31. DeKosky, S. T., Scheff, S. W. and Markesbery, W. R. (1985) Laminar organization of cholinergic circuits in human frontal cortex in Alzheimer’s disease and aging. Neurology 35:1425-1431.
32. de Leon, M., Golomb, J., George, A., Convit, A., Rusinek, H., et al. (1993) Hippocampal formation atrophy:Prognostic significance for Alzheimer’s disease. In Corain, B., Iqbal, K., Nicolini, M., Winblad, B., Wisniewski, H. and Zatta, P. (Eds.) Alzheimer’s Disease:Advances in Clinical and Brain Research. Wiley, New York, pp.35-46.
33. Du Yan, S., Zhu, H., Fu, J., Yan, S. F., Roher, A., Tourtellotte, W. W., Rajavashisth, T., Chen, X., Godman, G. C., Stern, D. and Schmidt, A. M. (1997) Amyloid-b peptide-receptor for advanced glycation endproduct interaction elicits neuronal expression of macrophage-colony stimulating factor: a proinflammatory pathway in Alzheimer’s disease. Proceedings of the National Academy of Sciences of the United States of America 94: 5296-5301.
34. Dumery, L., Bourdel, F., Soussan, Y., Fialkowsky, A., Viale, S., Nicolas, P. and Reboud-Ravaux, M. (2001) b-Amyloid protein aggregation:its implication in the physiopathology of Alzheimer’s disease. Pathologie et Biologie 49:72–85.
35. Ferrarese, C., Begni, B., Canevari, C., Zoia, C., Piolti, R., Frigo, M., Appollonio, I. and Frattola, L. (2000) Glutamate uptake is decreased in platelets from Alzheimer''s disease patients. Annals of Neurology 47:641-643.
36. Gao Z., Huang K., and Xu H. (2001) Protective effects of flavonoids in the roots of Scutellaria baicalensis Georgi against hydrogen peroxide-induced oxidative stress in HS-SY5Y cells. Pharmacological Research 43:173-178.
37. Gao Z., Huang K., Yang X., and Xu H. (1999) Free radical scavenging and antioxidant activities of flavonoids extracted from the radix of Scutellaria baicalensis Georgi. Biochimica et Biophysica Acta 1472:643-650.
38. Gaykema, R. P., Nyakas, C., Horvath, E., Hersh, L. B., Majtenyi, C. and Luiten, P. G. (1992) Cholinergic fiber aberrations in nucleus basalis lesioned rat and Alzheimer’s disease. Neurobiology of Aging 13:441-448.
39. Giacobini, E. (1990) Cholinergic receptors in human brain: effects of aging and Alzheimer’s disease. Journal of Neuroscience Research 27:548-560.
40. Gluck, M. A. and Myers, C. E. (1998) Psychobiological models of hippocampal function in fearning and memory. In Martinez, J. and Kesner, R. (Eds) Neurobiology of Learning and Memory. Academic Press, Inc. New York, pp. 417-448.
41. Golde, T. E. (2002) Inflammation takes on Alzheimer’s disease. Nature Medicine 8:936-938.
42. Good, T. A., Smith, D. O. and Murphy, R. M. (1996) b-Amyloid peptide blocks the fast inactivating K+ current in rat hippocampal neurons. Biophysical Journal 70:296–304.
43. Haas, J., Hagenlocher, B. S., Biessmann, A. and Wildemann, B. (2002) Inducible nitric oxide synthase and argininosuccinate synthetase:co-induction in brain tissue of patients with Alzheimer’s dementia and following stimulation with b-amyloid 1-42 in vitro. Neuroscience Letters 322:121-125.
44. Hamada H., Hiramatsu M., Edamatsu R., and Mori A. (1993) Free radical scavenging action of baicalein. Archives of Biochemistry and Biophysics 306:261-266.
45. Hardy, J. and Allsop, D. (1991) Amyloid deposition as the central event in the etiology of Alzheimer’s disease. Trends in Pharmacological Sciences 12:383-388.
46. Harkany, T., Mulder, J., Sasvari, M., Abraham, I., Konya, C., Zarandi, M., Penke, B., Luiten, P. G. M. and Nyakas, C. (1999) N-Methyl-D-aspartate receptor antagonist MK-801 and radical scavengers protect cholinergic nucleus basalis neurons against b-amyloid neurotoxicity. Neurobiology of Disease 6:109-121.
47. Haroutunian, V., Barnes, E. and Davis, K. L. (1985) Cholinergic modulation of memory in rats. Psychopharmacology 87:266-271.
48. Harrington, C. R. and Wischik, C. M. (1994) Molecular pathobiology of Alzheimer’s disease. In Burns, A. and Levy, R. (Eds.) Dementia, First edition. Chapman and Hall Medical, London, pp. 209-238.
49. Harris, M. E., Wang, Y. N., Pedigo, N. W., Hensley, K., Butterfield, D. A. and Carncy, J. M. (1996) Amyloid b Peptide (25-35) Inhibits Na+-dependent glutamate uptake in rat hippocampal astrocyte cultures. Journal of Neurochemistry 67:277-286.
50. Hebert, L. E., Scherr, P. A., Bienias, J. L., Bennett, D. A and Evans, D. A. (2003) Alzheimer disease in the U.S. population:Prevalence estimates using the 2000 census. Archives of Neurology 60:1119 – 1122.
51. Hensley, K., Hall, N., Subramaniam, R., Cole, P., Harris, M., Aksenov, M., Aksenova, M., Gabbita, S. P., Wu, J. F. and Carney, J. M. (1995) Brain regional correspondence between Alzheimer''s disease histopathology and biomarkers of protein oxidation. Journal of Neurochemistry 65:2146-2156.
52. Higgins, G. A., Large, C. H., Rupniak, H. T. and Barnes, J. C. (1997) Apolipoprotein E and Alzheimer’s disease:a review of recent studies. Pharmacology Biochemistry and Behavior 56:675-685.
53. Hong, T., Jin, G. B., Cho, S. and Cyong, J. C. (2002) Evaluation of the anti-inflammatory effect of baicalein on dextran sulfate sodium-induced colitis in mice. Planta Medica 68:268-271.
54. Hoshi, M., Takashima, A., Murayama, M., Yasutake, K., Yoshida, N., Ishiguro, K., Hoshino, T. and Imahori, K. (1997) Nontoxic amyloid b peptide 1-42 suppresses acetylcholine synthesis. Possible role in cholinergic dysfunction in Alzheimer’s disease. Journal of Biological Chemistry 272:2038-2041.
55. Huang, H. C., Wang, H. R. and Hsieh, L. M. (1994) Antiproliferative effect of baicalein, a flavonoid from a Chinese herb, on vascular smooth muscle cell. European Journal of Pharmacology 251:91-93.
56. Huang, K. C. (1999) Antibacterial, antiviral, and antifungal herbs. In Huang K.C. (ed) The Pharmacology of Chinese Herbs, CRC Press, Boca Raton, FL, pp. 385-386.
57. Hwang, Y. S., Shin, C. Y., Huh, Y. and Ryu, J. H. (2002) Hwangryun-Hae-Dok-tang (Huanglian-Jie-Du-Tang) extract and its constituents reduce ischemia-reperfusion brain injury and neutrophil infiltration in rats. Life Sciences 71:2105-2117.
58. Impey, S. Obrietan, K. and Storm, D. R. (1999) Making new connections:Role of ERK/MAP kinase signaling in neuronal plasticity. Neuron 23:11-14.
59. Inestrosa, N. C., Alvarez, A., Perez, C. A., Moreno, R. D., Vicente, M., Linker, C., Casanueva, O. I., Soto, C. and Garrido, J. (1996) Acetylcholinesterase accelerates assembly of amyloid b-peptides into Alzheimer’s fibrils:possible role of the peripheral site of the enzyme. Neuron 16:881–891.
60. Ishige K., Schubert D., and Sagara Y. (2001) Flavonoids protect neuronal cells from oxidative stress by three distinct mechanisms. Free Radical Biology and Medicine 30:433-446.
61. Ivins, K. J., Ivins, J. K., Sharp, J. P. and Cotman, C. W. (1999) Multiple pathways of apoptosis in PC12 cells. CrmA inhibits apoptosis induced by b-amyloid. Journal of Biological Chemistry 274:2107-2112.
62. Iwatsubo, T., Odaka, A., Suzuki, N., Mizusawa, H., Nukina, N. and Ihara, Y. (1994) Visualization of Ab42(43) and Ab40 in senile plaques with end-specific Ab monoclonals:evidence that an initially deposited species is Ab 42(43). Neuron 13:45-53.
63. Janus, C., Pearson, J., McLaurin. J. Mathews, P. M., Jiang, Y., Schmidt, S. D., Chishti, M. A., Horne, P., Heslin, D., French, J., Mount, H. T. J., Nixon, R. A., Mercken, M., Bergeron, C., Fraser, P. E., George-Hyslop, P. S. and Westaway, D. (2000) Ab peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer’s disease. Nature 408:979-982.
64. Jarrett, J. T., Berger, E. P. and Lansbury, P. T. Jr (1993) The carboxyl terminus of the b amyloid protein is critical for the seeding of amyloid formation:implications for the pathogenesis of Alzheimer’s disease. Biochemistry 32:4693-4697.
65. Jarvis, B. and Figgitt, D. P. (2003) Memantine. Drugs Aging 20:465-476.
66. Jones, K. R., Black, M. J. and Oorschot, D. E. (1998) Do aluminium and/or glutamate induce Alzheimer PHF-like formation? An electron microscopic study. Journal of Neurocytology 27:59-68.
67. Junien, J. L., Roman, F. J., Brunelle, G. and Pascaud, X. (1991) JO1784, a novel sigma ligand, potentiates [3H]acetylcholine release from rat hippocampal slices. European Journal of Pharmacology 200:343-345.
68. Justine, A., Levin-Allerhand, C. E., Lominska, J. W. and Jonathan, D. S. (2002) 17a-Estradiol and 17b-estradiol treatments are effective in lowering cerebral amyloid-b levels in Ab PPSWE transgenic mice. Journal of Alzheimer’s Disease 4:449-457.
69. Kandel, E. R. (2001) The molecular biology of memory storage:A dialogue between genes and synapses. Science 294:1030-1038.
70. Kang, J., Lemaire, H. G.., Unterbeck, A., Salbaum, J. M., Masters, C. L., Grzeschik, K. H., Multhaup, G.., Beyreuther, K. and Muller-Hill, B. (1987) The precursor of Alzheimer’s disease amyloid A4 protein resembles a cell-surface receptor. Nature 325:733-736.
71. Kar, S., Issa, A. M., Seto, D., Auld, D. S., Collier, B. and Quirion, R. (1998) Amyloid b-peptide inhibits high-affinity choline uptake and acetylcholine release in rat hippocampal slices. Journal of Neurochemistry 70: 2179-2187.
72. Kar, S., Seto, D., Gaudreau, P. and Quirion, R. (1996) b-Amyloid-related peptides inhibit potassium-evoked acetylcholine release from rat hippocampal slices. Journal of Neuroscience 16: 1034-1040.
73. Kimura, Y., Okuda, H. and Arichi, S. (1987) Effects of baicalein on leukotriene biosynthesis and degranulation in human polymorphonuclear leukocytes. Biochimica et Biophysica Acta 922:278-86,
74. Kimura, Y., Yokoi, K., Matsushita, N. and Okuda, H. (1997) Effects of flavonoids isolated from scutellariae radix on the production of tissue-type plasminogen activator and plasminogen activator inhibitor-1 induced by thrombin and thrombin receptor agonist peptide in cultured human umbilical vein endothelial cells. Journal of Pharmacy and Pharmacology 49:816-822.
75. Klegeris, A. and McGeer, P. L. (1997) b-Amyloid protein enhances macrophage production of oxygen free radicals and glutamate. Journal of Neuroscience Research 49:229-235.
76. Lai, M. K., Lai, O. F., Keene, J., Esiri, M. M., Francis, P. T., Hope, T. and Chen, C. P. (2001) Psychosis of Alzheimer’s disease is associated with elevated muscarinic M2 binding in the cortex. Neurology 57:805-811.
77. Law, A., Gauthier, S. and Quirion R. (2001) Neuroprotective and neurorescuing effects of isoform specific nitric oxide synthase inhibitors, nitric oxide scavenger, and antioxidant against b-amyloid toxicity. British Journal of Pharmacology 133: 1114-1124.
78. Lebeau, A., Esclaire, F., Rostene, W. and Pelaprat, D. (2001) Baicalein protects cortical neurons from b-amyloid (25-35) induced toxicity. NeuroReport 12:2199-2202.
79. Lee, B. H., Lee, S. J., Kang, T. H., Kim, D. H., Sohn, D. H., Ko, G. I. and Kim, Y. C. (2000) Baicalein:an in vitro antigenotoxic compound from Scutellaria baicaleinis. Planta Medica 66:70-71
80. Lee, H. H., Yang, L. L., Wang, C. C., Hu, S. Y., Chang, S. F. and Lee, Y. H. (2003) Differential effects of natural polyphenols on neuronal survival in primary cultured central neurons against glutamate- and glucose deprivation-induced neuronal death. Brain Research 986:103-113.
81. Liao, J. F., Hung, W. Y. and Chen, C. F. (2003) Anxiolytic-like effects of baicalein and baicalin in the Vogel conflict test in mice. European Journal of Pharmacology 464:141-146.
82. Liao, J. F.. Wang, H. H., Chen, M. C., Chen, C. C. and Chen C. F. (1998) Benzodiazepine binding site-interactive flavones from Scutellaria baicalensis root. Planta Medica 64:571-572.
83. Lin, C. C. and Shieh D. E. (1996) The anti-inflammatory activity of Scutellaria rivularis extracts and its active components, baicalin, baicalein and wogonin. American Journal of Chinese Medicine 24:31-36.
84. Lovell, M. A., Teesdale, W. J., Campbell, J. L. and Markesbery, W. R. (1998) Copper, iron and zinc in Alzheimer’s disease senile plaques. Journal of the Neurological Sciences 158:47–52.
85. Luo, Y., Bolon, B., Kahn, S., Bennett, B. D., Babu-Khan, S., Denis, P., Fan, W., Kha, H., Zhang, J., Gong, Y., Martin, L., Louis, J. C., Yan, Q., Richards, W. G., Citron, M. and Vassar, R. (2001) Mice deficient in BACE1, the Alzheimer’s b-secretase, have normal phenotype and abolished b-amyloid generation. Nature Neuroscience 4:231-232.
86. Mantyh, P. W., Ghilardi, J. R., Rogers, S., DeMaster, E., Allen, C. J., Stimson, E. R. and Maggio, J. E. (1993) Aluminum, iron and zinc ions promote aggregation of physiological concentrations of b-amyloid peptide. Journal of Neurochemistry 61:1171–1174.
87. Mark, R. J., Hensley, K., Butterfield, D. A. and Mattson, M. P. (1995) Amyloid b-peptide impairs ion-motive ATPase activities:evidence for a role in loss of neuronal Ca2+ homeostasis and cell death. The Journal of Neuroscience 15:6239–6249.
88. Mash, D. C., Flynn, D. D. and Potter, L. T. (1985) Loss of M2 muscarine receptors in the cerebral cortex in Alzheimer’s disease and experimental cholinergic denervation. Science 228:1115-1117.
89. Masliah, E., Alford, M., DeTeresa, R., Mallory, M. and Hansen, L. (1996) Deficient glutamate transport is associated with neurodegeneration in Alzheimer''s disease. Annals of Neurology 40:759-766.
90. Mattson, M. P., Barger, S. W., Cheng, B., Lieberburg, I., Smith-Swintosky, V. L. and Rydel, R. E. (1993) b-Amyloid precursor protein metabolites and loss of neuronal Ca2+ homeostasis in Alzheimer''s disease. Trends in Neurosciences 16:409-414.
91. Mattson, M. P., Cheng, B., Davis, D., Bryant, K., Lieberburg, I. and Rydel, R. E. (1992) b-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity. The Journal of Neuroscience 12:376–389.
92. Maurice, T., Lockhart, B. P. and Privat, A. (1996) Amnesia induced in mice by centrally administered b-amyloid peptides involves cholinergic dysfunction. Brain Research 706:181-193.
93. Mayes, A. R. (1995) Memory and amnesia. Behavioural Brain Research 66:29-36.
94. McDonald, D. R., Brunden, K. R. and Landreth, G. E. (1997) Amyloid fibrils activate tyrosine kinase-dependent signaling and superoxide production in microglia. The Journal of Neuroscience 17:2284-2294.
95. McDonald, R. J. and White, N. M. (1993) A triple dissociation of memory systems:hippocampus, amygdala, and dorsal striatum. Behavioral Neuroscience 107:3-22.
96. McGeer, E. G. and McGeer, P. L. (1999) Inflammation of the brain in Alzheimer’s disease:implications for therapy. Journal of Leukocyte Biology 65:409-415.
97. McGeer, P. L. Schulzer, M. and McGeer, E. G. (1996) Arthritis and anti-inflammatory agents as possible protective factors for Alzheimer’s disease:a review of 17 epidemiologic studies. Neurology 47:425-432.
98. McLean, C. A., Herny, R. A., Fraser, F. W., Fuller, S. J., Smith, M. J., Beyreuther, K., Bush, A. I. and Masters, C. L. (1999) Soluble pool of Ab amyloid as a determinant of severity of neurodegeneration in Alzheimer’s disease. Annals of Neurology 46:860–866.
99. Miguel-Hidalgo, J. J., Alvarez, X. A., Cacabelos, R. and Quack, G. (2002) Neuroprotection by memantine against neurodegeneration induced by b-amyloid (1-40). Brain Research 958:210-221.
100. Morgan, D., Diamond, D. M., Gottschall, P. E., Ugen, K. E., Dickey, C., Hardy, J., Duff, K., Jantzen, P., DiCarlo, G., Wilcock, D., Connor, K., Hatcher, J., Hope, C., Gordon, M. and Arendash, G. W. (2000) Ab peptide vaccination prevents memory loss in an animal model of Alzheimer’s disease. Nature 408:982-985.
101. Morishima, Y., Gotoh, Y., Zieg, J., Barrett, T., Takano, H., Flavell, R., Davis, R. J., Shirasaki, Y. and Greenberg, M. E. (2001) b-Amyloid induces neuronal apoptosis via a mechanism that involves the c-Jun N-terminal kinase pathway and the induction of Fas ligand. The Journal of Neuroscience. 2:7551–7560.
102. Morris, R. G., Garrud, P., Rawlins, J. N. and O''Keefe, J. (1982) Place navigation impaired in rats with hippocampal lesions. Nature 297:681-683.
103. Mudd, L. M., Torres, J., Lopez, T. F. and Montague, J. (1998) Effects of growth factors and estrogen on the development of septal cholinergic neurons from the rat. Brain Research Bulletin 45:137-142.
104. Munoz, F. J. and Inestrosa, N. C. (1999) Neurotoxicity of acetylcholinesterase amyloid b-peptide aggregates is dependent on the type of Ab peptide and the AChE concentration present in the complexes. Federation of European Biochemical Societies Letters 450:205–209.
105. Murgolo, N. J., Brown, J. E., Bayne, M. L. and Strader, C. D. (1996) Presenilin mutations in Alzheimer’s disease:molecular models suggest a potential functional locus. Trends in Pharmacological Science 17:389-393.
106. Nabeshima, T., Tohyama, K., Ichihara, K. and Kameyama, T. (1990) Attenuation of benzodiazepine-induced passive avoidance deficit by post-training administration of muscimol:interaction with the cholinergic neuronal system. European Journal of Pharmacology 182:555-560.
107. Nicoll, J. A., Wilkinson, D., Holmes, C., Steart, P., Markham, H. and Weller, R. O. (2003) Neuropathology of human Alzheimer disease after immunization with amyloid-b peptide:a case report. Nature Medicine 9:448-452.
108. Nie, D., Nemeth, J., Qiao, Y., Zacharek, A., Li, L., Hanna, K., Tang, K., Hillman, GG., Cher, ML., Grignon, DJ. and Honn, KV. (2003) Increased metastatic potential in human prostate carcinoma cells by overexpression of arachidonate 12-lipoxygenase. Clinical & Experimental Metastasis 20:657-663.
109. Ohkawa, H., Ohishi, N. and Yagi, K. (1979) Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Analytical Biochemistry 95:351-358.
110. Ono, K., Nakane, H., Fukushima, M., Chermann, J. C. and Barre-Sinoussi, F. (1989) Inhibition of reverse transcriptase activity by a flavonoid compound, 5,6,7-trihydroxyflavone. Biochemical & Biophysical Research Communications 160:982-987.
111. Pedersen, W. A., Kloczewiak, M. A. and Blusztajn, J. K. (1996) Amyloid b-protein reduces acetylcholine synthesis in a cell-line derived from cholinergic neurons of the basal forebrain. Proceedings of the National Academy of Sciences of the United States of America 93: 8068-8071.
112. Rapoport, M., Dawson, H. N., Binder, L. I., Vitek, M. P. and Ferreira, A. (2002) Tau is essential to b-amyloid-induced neurotoxicity. Proceedings of the National Academy of Sciences of the United States of America 99:6364-6369.
113. Rapoport, M. and Ferreira, A. (2000) PD98059 prevents neurite degeneration induced by fibrillar b-amyloid in mature hippocampal neurons. Journal of Neurochemistry 74:125–133.
114. Reinikainen, K. J., Riekkinen, P. J., Halonen, T. and Laakso, M. (1987) Decreased muscarinic receptor binding in cerebral cortex and hippocampus in Alzheimer’s disease. Life Sciences 41:453-461.
115. Reiter, R. J. (1995) The role of the neurohormone melatonin as a buffer against macromolecular oxidative damage. Neurochemistry International 27:453-460.
116. Rinne, J. O., Lonnberg, P., Marjamaki, P. and Rinne, U. K. (1989) Brain muscarinic receptor subtypes are differently affected in Alzheimer’s disease and Parkinson''s disease. Brain Research 483:402-406.
117. Rogers, J., Cooper, N. R., Webster, S., Schultz, J., McGeer, P. L., Styren, S. D., Civin, W. H., Brachova, L., Bradt, B., Ward P. and Lieberburg, I. (1992) Complement activation by b-amyloid in Alzheimer disease. Proceedings of the National Academy of Sciences of the United States of America 89:10016-10020.
118. Rogers, J., Kirby, L. C., Hempelman, S. R., Berry, D. L., McGeer, P. L., Kaszniak, A. W., Zalinski, J., Cofield, M., Mansukhani, L., and Willson, P. (1993) Clinical trial of indomethacin in Alzheimer’s disease. Neurology 43:1609-1611.
119. Rossner, S., Ueberham, U., Schliebs, R., Perez-Polo, J. R. and Bigl, V. (1998) The regulation of amyloid precursor protein metabolism by cholinergic mechanisms and neurotrophin receptor signaling. Progress in Neurobiology 56:541–569.
120. Saitoh, T., Sundsmo, M., Roch, J. M., Kimura, N., Cole, G., Schubert, D., Oltersdorf, T. and Schenk, D. B. (1989) Secreted form of amyloid b protein precursor is involved in the growth regulation of fibroblasts. Cell 58:615-622
121. Salvemini, D. (1997) Regulation of cyclooxygenase enzymes by nitric oxide. Cellular and Molecular Life Sciences 53:576-582.
122. Sano, M., Ernesto, C., Thomas, R.G., Klauber, M. R., Schafer, K., Grundman, M., Woodbury, P., Growdon, J., Cotman, C. W., Pfeiffer, E., Schneider, L. S. and Thal, L. J. (1997) A controlled traial of selegiline, alpha-tocopherol, or both as treatment for Alzheimer’s disease. The New England Journal of Medicine 336:1216-1222.
123. Schenk, D., Barbour, R., Dunn, W., Gordon, G., Grajeda, H., Guido, T., Hu, K., Huang, J., Johnson-Wood, K., Khan, K., Kholodenko, D., Lee, M., Liao, Z., Lieberburg, I., Motter, R., Mutter, L., Soriano, F., Shopp, G., Vasquez, N., Vandevert, C., Walker, S., Wogulis, M., Yednock, T., Games, D. and Seubert, P. (1999) Immunization with amyloid-b attenuates Alzheimer-disease-like pathology in the PDAPP mouse. Nature 400: 173-177.
124. Schrattenholz, A., Pereira, E. F., Roth, U., Weber, K. H., Albuquerque, E. X. and Maelicke, A. (1996) Agonist responses of neuronal nicotinic acetylcholine receptors are potentiated by a novel class of allosterically acting ligands. Molecular Pharmacology 49:1–6.
125. Schubert, D. and Behl, C. (1993) The expression of amyloid b protein precursor protects nerve cells from b-amyloid and glutamate toxicity and alters their interaction with the extracellular matrix. Brain Research 629:275-282.
126. Schubert, D., Behl, C., Lesley, R., Brack, A., Dargusch, R., Sagara, Y. and Kimura, H. (1995) Amyloid peptides are toxic via a common oxidative mechanism. Proceedings of the National Academy of Sciences of the United States of America 92:1989-1993.
127. Scoville, W. B. and Milner, B. (1957). Loss of recent memory after bilateral hippocampal lesions. Journal of Neurology, Neurosurgery, and Psychiatry 20:11-21.
128. Selkoe, D. J. (1991) The molecular pathology of Alzheimer’s disease. Neuron 6:487-498.
129. Selkoe, D. J. (1993) Physiological production of the b-amyloid protein and the mechanism of Alzheimer’s disease. Trends in Neurosciences 16:403-409.
130. Shen, Y. C., Chiou, W. F., Chou, Y. C. and Chen, C. F. (2003) Mechanisms in mediating the anti-inflammatory effects of baicalin and baicalein in human leukocytes. European Journal of Pharmacology 465:171-181.
131. Shen, Y. X., Xu, S. Y., Wei, W., Sun, X. X., Liu, L. H., Yang, J. and Dong, C. (2002) The protective effects of melatonin from oxidative damage induced by amyloid beta-peptide 25-35 in middle-aged rats. Journal of Pineal Research 32:85-89.
132. Shieh, D. E., Liu, L. T., and Lin, C. C. (2000) Antioxidant and free radical scavenging effects of baicalein, baicalin and wogonin. Anticancer Research 20:2861-2865.
133. Silva, A. J. (2003) Molecular and cellular cognitive studies of the role of synaptic plasticity in memory. Journal of Neurobiology. 54:224-237.
134. Soto, C., Kindy, M. S., Baumann, M. and Frangione, B. (1996) Inhibition of Alzheimer''s amyloidosis by peptides that prevent b-sheet conformation. Biochemical and Biophysical Research Communications. 226:672-680.
135. Soto, C., Sigurdsson, E. M., Morelli, L., Kumar, R. A., Castano, E. M.and Frangione, B. (1998) b-Sheet breaker peptides inhibit fibrillogenesis in a rat brain model of amyloidosis: implications for Alzheimer''s therapy. Nature Medicine. 4:822-826.
136. Squire, L. (1987) Memory and Brain. Oxford University Press, New York.
137. Strooper, B. D. and Annaert, W. (2001) Presenilins and the intramembrane proteolysis of proteins:facts and fiction. Nature Cell Biology 3:E221-E225.
138. Suh, Y. H. and Checler, F. (2002) Amyloid precursor protein, presenilins, and a-synuclein:molecular pathogenesis and pharmacological applications in Alzheimer’s disease. Pharmacological Reviews 54:469-525.
139. Suk, K., Lee, H., Kang, S. S., Cho, G. J. and Choi, W. S. (2003) Flavonoid baicalein attenuates activation-induced cell death of brain microglia. Journal of Pharmacology and Experimental Therapeutics 305:638-645.
140. Suzuki, T., Nonaka, H., Fujimoto, K. and Kawashima, K. (1994) Tacrine increases stimulation-evoked acetylcholine release from rat hippocampal slices. Japanese Journal of Pharmacology 65:337-342.
141. Swartzwelder, H. S., Tilson, H. A., McLamb, R. L. and Wilson, W. A. (1987) Baclofen disrupts passive avoidance retention in rats. Psychopharmacology 92:398-401.
142. Sweatt, J. D. and Weeber, E. J. (2003) Genetics of childhood disorders:LII. Learning and memory, part 5:human cognitive disorders and the ras/ERK/CREB pathway. Journal of the American Academy of Child and Adolescent Psychiatry 42:873-876.
143. Takizawa, H., DelliPizzi, A. M. and Nasjletti, A. (1998) Prostaglandin I2 contributes to the vasodepressor effect of baicalein in hypertensive rats. Hypertension 31:866-871.
144. Tariot, P. N., Farlow, M. R., Grossberg, G. T., Graham, S. M., McDonald, S. and Gergel, I. (2004) Memantine treatment in patients with moderate to severe Alzheimer disease already receiving donepezil: a randomized controlled trial. The Journal of the American Medical Association 291:317-24, 2004
145. Telegdy, G. and Kokavszky, R. (1997) The role of nitric oxide in passive avoidance learning. Neuropharmacology 36:1583-1587.
146. Thinakaran, G. (1999) The role of presenilins in Alzheimer’s disease. Journal of Clinical Investigation 104:1321-1327.
147. Thorns, V. and Masliah, E. (1999) Evidence for neuroprotective effects of acidic fibroblast growth factor in Alzheimer’s disease. Journal of Neuropathology & Experimental Neurology 58:296-306.
148. Tohyama, K., Nabeshima, T., Ichihara, K. and Kameyama, T. (1991) Involvement of GABAergic systems in benzodiazepine-induced impairment of passive avoidance learning in mice. Psychopharmacology 105:22-26.
149. Tong, W. G., Ding, X. Z. and Adrian, T. E. (2002) The mechanisms of lipoxygenase inhibitor-induced apoptosis in human breast cancer cells. Biochemical & Biophysical Research Communications 296:942-948.
150. Tran, M. H., Yamada, K., Olariu, A., Mizuno, M., Ren, X. H. and Nabeshima, T. (2001) Amyloid b-peptide induces nitric oxide production in rat hippocampus: association with cholinergic dysfunction and amelioration by inducible nitric oxide synthase inhibitors. The Federation of American Societies for Experimental Biology Journal 15: 1407-1409.
151. Ueng, Y. F., Shyu, C. C., Liu, T. Y., Oda, Y., Lin, Y. L., Liao, J. F. and Chen, C. F. (2001) Protective effects of baicalein and wogonin against benzo[a]pyrene- and aflatoxin B(1)-induced genotoxicities. Biochemical Pharmacology 62:1653-1660.
152. Van Gool, W. A., Weinstein, H. C., Scheltens, P., Walstra, G. J. and Scheltens, P. K. (2001) Effect of hydroxychloroquine on progression of dementia in early Alzheimer’s disease:an 18-month randomised, double-blind, placebo-controlled study. Lancet 358:455-60.
153. Varadarajan S, Yatin S, Aksenova M, and Butterfield A. D (2000) Alzheimer’s amyloid b peptide-associated free radical oxidative stress and neurotoxicity. Journal of Structural Biology 130:184–208.
154. Velez-Pardo, C., Jimenez, D. R. M. and Lopera, F. (1998) Familial Alzheimer’s disease:oxidative stress, b-amyloid, presenilins, and cell death. General Pharmacology 31:675-681.
155. Vijayalaxmi., Thomas, C. R Jr., Reiter, R. J. and Herman, T. S. (2002) Melatonin:from basic research to cancer treatment clinics. Journal of Clinical Oncology 20:2575-2601.
156. Voytko, M. L. (1996) Cognitive functions of the basal forebrain cholinergic system in monkeys:memory or attention? Behavioural Brain Research 75:13-25.
157. Wakabayashi, I. (1999) Inhibitory effects of baicalein and wogonin on lipopolysaccharide induced nitric oxide production in macrophages. Pharmacology and Toxicology 84:288-291.
158. Wang, H. H., Liao, J. F. and Chen, C. F. (2001) Dehydroevodiamine attenuate b-amyloid peptide-induced amnesia in mice. European Journal of Pharmacology 413:221-225.
159. Weggen, S., Eriksen, J. L., Das, P., Sagi, S. A., Wang, R., Pietrzik, C. U., Findlay, K. A., Smith, T. E., Murphy, M. P., Bulter, T., Kan, D. E., Marquez-Sterling, M., Golde, T. E. and Koo, E. H. (2001) A subset of NSAIDs lower amyloidgenic Ab42 independently of cyclooxygenase activity. Nature 414:212-216.
160. Weisgraber, K. H. and Mahley, R. W. (1996) Human apolipoprotein E:the Alzheimer’s disease connection. The Federation of American Societies for Experimental Biology Journal 10:1485-1494.
161. Whithouse, P. J., Price, D. L., Struble, R. G., Clark, A. W., Coyle, A. W. and Delon, M. R. (1982) Alzheimer’s disease and senile dementia:loss of neurons in the basal forebrain. Science 215:1237-1239.
162. Wolfman, C., Viola, H., Paladini, A., Dajas, F. and Medina, J. H. (1994) Possible anxiolytic effects of chrysin, a central benzodiazepine receptor ligand isolated from Passiflora coerulea. Pharmacology, Biochemistry & Behavior 47:1-4.
163. Wu, J. A., Attele, A. S., Zhang, L. and Yuan, C. S. (2001) Anti-HIV activity of medicinal herbs:usage and potential development. American Journal of Chinese Medicine 29:69-81.
164. Wu, A., Derrico, C. A., Hatem, L. and Colvin, R. A. (1997) Alzheimer’s amyloid-b peptide inhibits sodium/calcium exchange measured in rat and human brain plasma membrane vesicles. Neuroscience 80:675–684.
165. Yaffe, K., Sawaya, G., Lieberburg, I. and Grady, D. (1998) Estrogen therapy in postmenopausal women:effects on cognitive function and dementia. The Journal of the American Medical Association 279:688–695.
166. Yamada, K., Tanaka, T., Han, D., Senzaki, K., Kameyama, T. and Nabeshima, T. (1999) Protective effects of idebenone and a-tocopherol on b-amyloid-(1-42)-induced learning and memory deficits in rats: implication of oxidative stress in b-amyloid-induced neurotoxicity in vivo. European Journal of Neuroscience 11:83-90.
167. Yamatsuji, T., Matsui, T., Okamoto, T., Komatsuzaki, K., Takeda, S., Fukumoto, H., Iwatsubo, T., Suzuki, N., Asami-Odaka, A., Ireland, S., Kinane, B. T., Giambarella, U. and Nishimoto, I. (1996) G protein-mediated neuronal DNA fragmentation induced by familial Alzheimer’s disease-associated mutants of APP. Science 272:1349-1352.
168. Yan, J. J., Cho, J. Y., Kim, H. S., Kim, K. L., Jung, J. S., Huh, S. O., Suh, H. W., Kim, Y. H. and Song, D. K. (2001) Protection against b-amyloid peptide toxicity in vivo with long-term administration of ferulic acid. British Journal of Pharmacology 133:89-96.
169. Yan, S. D., Chen, X., Fu, J., Chen, M., Zhu, H., Roher, A., Slattery, T., Zhao, L., Nagashima, M., Morser, J., Migheli, A., Nawroth, P., Stern, D. and Schmidt, A. M. (1996) RAGE and amyloid-b peptide neurotoxicity in Alzheimer''s disease. Nature 382:685-691.
170. Yankner, B. A., Duffy, L. K. and Kirschner, D. A. (1990) Neurotrophic and neurotoxic effects of amyloid b protein: reversal by tachykinin neuropeptides. Science 250:279-282.
171. Zarrindast, M. R., Sadegh, M. and Shafaghi, B. (1996) Effects of nicotine on memory retrieval in mice. European Journal of Pharmacology 295:1-6..
172. Zhang, D. Y., Wu, J., Ye, F., Xue, L., Jiang, S., Yi, J., Zhang, W., Wei, H., Sung, M., Wang, W. and Li, X. (2003) Inhibition of cancer cell proliferation and prostaglandin E2 synthesis by Scutellaria baicalensis. Cancer Research 63:4037-4043.
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