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研究生:黃奐璋
研究生(外文):Huan-Jang Huang
論文名稱:極化光學斷層干涉儀應用於生物組織線性雙折射特性之量測
論文名稱(外文):The Measurement of Linear Birefringence Parameters of Human Tissue Using Polarization Sensitive Optical Coherence Tomography
指導教授:周晟周晟引用關係
指導教授(外文):Chien Chou
學位類別:碩士
校院名稱:國立陽明大學
系所名稱:放射醫學科學研究所
學門:醫藥衛生學門
學類:醫學技術及檢驗學類
論文種類:學術論文
論文出版年:2004
畢業學年度:92
語文別:中文
中文關鍵詞:干涉儀線性雙折射極化
外文關鍵詞:InterferameterLinear birefringencePolarization
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  • 被引用被引用:0
  • 點閱點閱:202
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  • 收藏至我的研究室書目清單書目收藏:0
  人體大部分組成成分為膠原蛋白,其中相關研究最多且最簡單的膠原蛋白結構為Type Ⅰ collagen,目前已大量被應用在生醫材料上,然而此類膠原蛋白與低劑量游離輻射反應相關的論文仍然極缺乏,大多是低劑量游離輻射照射人體後產生生理反應、DNA改變影響或存活率的統計值。
  極化感知光學同調斷層攝影術(Polarization sensitive optical coherence tomography,PS-OCT),此架構本身已具有微米級的解析力,又將之配合外差干涉技術,如此不但能夠同時獲得反射訊號大小及雙折射變化,更能夠提升PS-OCT的靈敏度及準直性。本實驗室希望能成功架設此架構,並使用此架構更靈敏的來觀察熱及低劑量游離輻射影響線性雙折射物質後之變化。
  我們分別使用植物及動物兩種生物樣本從本質上來觀察雙折射訊號,最後使用熱及游離輻射兩樣變因來對動物樣本作觀察,由實驗結果可知雙折射訊號來源可分為intrinsic及form birefringence,而PS-OCT對於觀察游離輻射照射動物樣本反應並不明顯,對於原因及機制尚有待討論。
Human’s tissue is mainly composed of collagen, and research topics are mostly about Type Ⅰ collagen which is broadly used in biomaterial. Otherwise, a great part of research is about physiological reflection after low-dose ionizing radiation irradiating human body, influence of DNA change, and statistics of survival rates. Therefore, the relation between collagen and low-dose ionizing radiation is very important but unclear.
Polarization sensitive optical coherence tomography(PS-OCT) with heterodyne technology has micro-meter scale resolution, so not only can we get reflection signal and birefringence change at the same time, but also enhance the sensitivity and collimation of PS-OCT. We hope to set up PS-OCT successfully and use it to observe the reaction after heat and low-dose ionizing radiation influencing human body more sensitively in our laboratory.
We used both plant and animal samples to observe the birefringence signal. From observing animal samples using heat and ionizing radiation as variables, we can find the source of signal coming from intrinsic birefringence and form birefringence, but PS-OCT is not an effective tool to observe the reflection after ionizing radiation irradiating animal samples. For this reason, we still need further research.
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