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研究生:簡賀瑞
研究生(外文):Chien-Ho Jui
論文名稱:脊髓旁神經節到腹腔神經節與上腸繫膜神經節的神經投射
論文名稱(外文):PROJECTION FROM PARAVERTEBRAL CHAINS TO CELIAC AND SUPERIOR MESENTERIC GANGLIA
指導教授:王豐彬
指導教授(外文):Feng Bin Wang
學位類別:碩士
校院名稱:國立中正大學
系所名稱:心理學所
學門:社會及行為科學學門
學類:心理學類
論文種類:學術論文
論文出版年:2005
畢業學年度:93
語文別:英文
論文頁數:36
中文關鍵詞:脊髓旁神經節腹腔神經節上腸繫膜神經節
外文關鍵詞:PARAVERTEBRAL GANGLIACELIAC GANGLIASUPERIOR
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交感神經系統由連結到內臟的運動神經所組成 。從脊髓旁與脊髓前神經節至腸胃道的神經傳導路徑已有完整資料。臨床上, 胸腔與內臟的自主神經切除術分別用於控制多汗症與源自於長期胰臟炎與胰臟癌的腹腔疼痛。但對於脊髓旁與脊髓前神經節之間的連結了解甚少。本實驗把WGA-HRP分別注射到老鼠腹腔神經節(celiac ganglia, CG, N=6)或上腸繫膜神經節(superior mesenteric ganglion, SMG, N=6)來回溯位於脊髓旁神經節(paravertebral ganglia)的神經細胞。三天後, 將包括星狀神經節(stellate ganglion, SG)、脊髓旁神經節鏈(從位於胸腔脊髓第四節的神經節到第十一節,paravertebral chains, T4-T11)、內臟神經節(splanchnic ganglia, SPL)、CG、與SMG等交感神經連結取下,用來進行HRP-TMB反應。在神經追蹤劑注射後,可以染到從SPL到SG的所有交感神經節,雙側之間的細胞數目沒有差異。其分布主要在SG、T11、與SPL,而其神經細胞的平均數(CG, SMG)分別為:SPL (273±19, 336±15)、T11 (258±16, 216±24)、T10 (31.6±3.5, 42.2±6.2)、 T9 (26±1.7, 19.2±3.4)、T8 (11.2±1.2, 11.7±1)、T7 (9.4±1.3, 7.8±1.2)、T6 (5.8±0.8, 4.0±0.6)、T5 (2.4±0.5, 1.3±0.5)、T4 (0.9±0.3, 0.4±0.2)、以及SG (681±33, 582.1±25)。前端交感神經節有眾多神經元投射軸突經過尾端的腹腔神經節與上腸繫膜神經節,而到達腹腔臟器。存在這麼多神經投射路徑的事實,使得在做胸腔與內臟的自主神經切除術時,有必要對其副作用進行深入的評估。另外,從星狀神經節投射到腹腔臟器的神經路徑,可能在緊急狀況裡扮演著調節腹腔與四肢之間血流量的重要角色。
The sympathetic system consists of efferent neurons that innervate the viscera. Pathways issuing from the para- and pre-vertebral ganglia to the gastrointestinal tract have been well established. Clinically, thoracic and splanchnic sympathectomies have been used respectively as a treatment to control the hyperhidrosis and visceral pain that originates from chronic pancreatitis and pancreatic carcinoma. However, little is known on the connection between the paravertebral and prevertebral ganglia. Male Sprague-Dawley rats were injected with the WGA-HRP into the celiac (CG, N=6) or superior mesenteric ganglia (SMG, N=6) to retrogradely trace neurons in the paravertebral ganglia. Three days later, both sides of the sympathetic trunks, including stellate (SG), paravertebral chains (T4-T11), splanchnic (SPL), celiac, and superior mesenteric ganglia, were reserved for the HRP-TMB reaction. After tracer injection, neurons were labeled bilaterally in all of the sympathetic ganglia from the SPL up to the SG and mainly found in the stellate, T11, and splanchnic ganglia. The average numbers of neurons labeled in each sympathetic ganglion after ganglion (CG, SMG) injection were: SPL (273±19, 336±15), T11 (258±16, 216±24), T10 (31.6±3.5, 42.2±6.2), T9 (26±1.7, 19.2±3.4), T8 (11.2±1.2, 11.7±1.0), T7 (9.4±1.3, 7.8±1.2), T6 (5.8±0.8, 4.0±0.6), T5 (2.4±0.5, 1.3±0.5), T4 (0.9±0.3, 0.4±0.2), and SG (681±33, 582±25). The fact that numerous neurons project axons from the rostral sympathetic ganglia, bypass the caudal celiac and superior mesenteric ganglia, and presumably reach the abdominal viscera raises the assessment requirement for the side effects of the thoracic or splanchnic sympathectomy. Furthermore, neurons that project from the stellate ganglion to the abdominal viscera may play a role in shuffling the blood volumes between the abdomen and the limbs in the emergent conditions.
TABLE OF CONTENTS
Page
TABLE OF CONTENTS…………………………………………….. ii
LIST OF FIGURES…………………………………………………...iii
ABSTRACT…………………………………………………………...iv
INTRODUCTION…………………………………………………….1
MATERIALS AND METHODS……………………………………..7
RESULTS…………………………………………………………….10
DISCUSSION………………………………………………………..18
REFERENCE………………………………………………………...24
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