臺灣博碩士論文加值系統

睡眠呼吸中止症 (sleep apnea syndrome)近數十年來逐漸爲人所重視的一種疾病，患者在睡眠中會發生偶發的呼吸暫停，因而導致睡眠中反覆的覺醒(arousals)，或同時引起血氧濃度降低的現象。除了有嗜睡、智力下降、記憶力減退、陽萎、人格改變、判斷力變差、大腦弁鄍２`等後遺症。更嚴重者甚至有致命的危險
現階段要判定病患是否為睡眠呼吸中止症患者，除了從外表上病徵來判斷，尚需加上長時間的儀器觀察。所謂長時間的儀器觀察，即是將病患送至睡眠醫療中心，以多種精密的儀器及專業的醫護人員做病患的睡眠狀態分析記錄，記錄病患是在哪個階段的睡眠狀態，如快速動眼期或熟睡期等，以及病患的血氧含量與呼吸狀態。
正因為觀察睡眠呼吸中止症需讓病患入住到醫院中一至二天甚至更久，所需耗費的時間及人力物力甚巨。所以本篇論文以一般容易取得的消費性電子零件，整合原有之理論基礎，來達成便宜實用的系統，讓一般消費者能自行觀測記錄睡眠中血氧飽和的狀態以及每分鐘脈搏數，並可將相關的記錄資訊提供給醫師，作為病況的診斷參考之用。
本論文係利用帶氧血紅素對紅光及紅外光的反應特性差異，來達成免侵入人體即可量測人體血液中血氧的飽和濃度，並進一步利用所測得之信號，將之記錄成可供分析之資訊。此外將所測得之血壓波信號作運算處理即可得知受測者每分鐘的脈搏數，
整個系統之流程為，利用紅光及紅外光的發射驅動電路將紅光及紅外光送入手指，接著由接收電路將所接收的生理信號濾波並放大成可用之血壓波訊號，然後由A/D Converter將類比訊號轉換成數位訊號，並傳入DSP作訊號的血液含氧量分析記錄。

Sleep apnea syndrome is one of the diseases that people pay much attention gradually in decades of years. The patient has accidental breath suspend during his sleep. This situation will cause the patients arousals from their sleep repeatedly and cause the oxygen concentration of blood to drop. The sleep apnea syndrome will get the sequela such as somnolence, intellectual deterioration, the ability of memorize decrease, impotence, human dignity change, judgment go down, and the cerebrum become abnormal. More seriously, the sleep apnea syndrome will cause fatal dangerous.
Now, if we want to determine the patient who has sleep apnea syndrome or not, we can not only determine from the patient’s externalism symptoms but also observe the patient with instruments for a long period. The long period instrument observation make the patient live in the sleep medical science center and analyzing the patient’s sleeping situation, breath situation and oxygen concentration of blood are analyzed by precise instruments and professional medical workers.
For observing a patient who has the sleep apnea syndrome, the patient has to live in the sleep medical science center one or two days. It will cost lots of time and money. Thus, in this paper we use the normal consumption components and link up with the basic theory to complete a cheap and practical system. Patients can observe and record the situation of the blood’s oxygen concentration by themselves and then give recorded information to the doctor as reference material of patient’s condition diagnosis.
In this paper we utilize the difference in response feature between the red light and infrared to determine the Arterial oxygen saturation (SaO2) without encroach human’s body. After that, the measured signal is recorded and analyzed.
The architecture of the system includes three parts. First, the emitter circuit emits the red light and infrared light into patient’s finger by turns. Second, the receiver circuit filters and amplifies the received physiology signal and converts it into the signals of blood pressure signal. Finally, the A/D converter convert the analog signal to digital signal and transfer the digital signals to the DSP to analyze the oxygenation of blood.

第一章 緒論……………………………………………………………1
第一節 前言………………………………………………………………1
第二節 研究目的與動機……………………………………………………1
第二章 研究背景與基本原理…………………………………………………2
第一節 睡眠呼吸中止症……………………………………………………2
第二節 血氧濃度理論及量測………………………………………………4
第三章 系統架構及硬體設計………………………………………………12
第一節 系統架構……………………………………………………………12
第二節 硬體設計部分……………………………………………………14
第三節 數位訊號處理嵌入式系統………………………………………20
第四章 演算法則與軟體設計部分…………………………………………26
第一節開發軟體及演算流程..……………………………………………26
第二節 軟體設計……………………………………………………………28
第五章 操作結果………………………………………………………………41
第六章 結論與未來發展………………………………………………………49
參考文獻…………………………………………………………………………50

[1] Gastaut, H, Tassarini, CA, Duron, B. “Ploygraphic study of the episodic diurnal and nocturnal (hypnic and respitory) manifestation of the Pickwick syndrome”. Brain Res 1965, p.167.

[2] Stoohs R, Guilleminault C: “Cardiovascular changes associated with the obstructive sleep apnea syndrome”. J Appl Physio pp.582-589, 1992.

[3] Sullivan CE, Issa FG, Berthon-Jones M, et al: “Reversal of obstructive sleep apnea by continuous positive airway pressure applied through the nares”. Lancet pp. 862-865, 1981.

[4] J.G.Webster,“Medical instrument:application and design”, Houghtion Mifflin , 1992.

[5] Mauro R. Ushizima, Sérgio S. Mühlen, and Idágene A. Cestari* “ A Low-Cost Transmittance Transducer for Measurement of Blood Oxygen Saturation in Extracorporeal Circuits”, IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, VOL. 48, NO. 4, pp.495-499, APRIL 2001

[6] Thomas Edrich*, M. Flaig, Reinhold Knitza, and Gerhard Rall , “Pulse Oximetry: An Improved In Vitro Model that Reduces Blood Flow-Related Artifacts”, IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, VOL. 47, NO. 3, pp.338-343, MARCH 2000

[7] SETSUO TAKATANI, HIROYUKI NODA, HISATERU TAKANO AND TETSUZO AKUTSU ,”A Miniature Hybrid Reflection Type Optical Seneor for Measurement of Hemoglobin Content and Oxygen Saturation of Whole Blood”, IEEE TRANSATIONS ON BIOMEDICAL ENGINEERING VOL.35, NO.3, pp.187-198 MARCH 1988 .

[8] TEXAS INSTRUMENTS ,〝CCS User Guide”.

[9] TEXAS INSTRUMENTS ,〝TMS320C54X User Guide”.

[10] 孫宗瀛,謝鴻琳 ” TMS320C5x DSP原理設計與應用 ”, 全華科技圖書股份有限公司, 民國88年

[11]“DSP 320C542 C語言實作“, 長高電腦圖書 民國九十年十一月初版

[12] 吳燿光╱陳濘宏 “睡眠呼吸中止症的後遺症” http://www.cgmh.com.tw/intr/intr2/c313a/snoring_&_sleep_apnea.htm

[13] http://66.102.7.104/ls.berkeley.edu/mail/berkeleyedu/0223.html

[14] http://www.cgmh.org.tw/intr/intr2/c313a/D.htm

[15] http://elchem.kaist.ac.kr/vt/chem-ed/spec/beerslaw.htm

[16] 劉昌賢” Design of real-time DSP-based heart rate variability analyzer”長庚大學電機工程研究所碩士論文, 民國91年.