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研究生:曾彥勳
研究生(外文):Yan-Shiun Tseng
論文名稱:以高脂飼糧誘導KK/HlJ與ICR雌性小鼠代謝異常之研究
論文名稱(外文):Study of High-Fat Diet Induced Metabolic Disorder in Female KK/HlJ and ICR Mice
指導教授:毛嘉洪
指導教授(外文):Frank Chiahung Mao
學位類別:碩士
校院名稱:國立中興大學
系所名稱:獸醫學系
學門:獸醫學門
學類:獸醫學類
論文種類:學術論文
論文出版年:2005
畢業學年度:93
語文別:中文
論文頁數:70
中文關鍵詞:飲食誘導肥胖 高脂飼糧 瘦體素 葡萄糖耐受性 鉻
外文關鍵詞:Diet-induced obesity High-fat diet Leptin Glucose intolerance Chromium
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本研究利用飲食誘導肥胖之動物模式,探討體內鉻元素分布的變化。由於雄性KK/HlJ小鼠具中度肥胖及高血糖與葡萄糖耐受性不良等症狀,因此被用於代謝異常之研究。基於逐漸受到重視之實驗動物使用觀念 (3R),實驗一首先探討雌性KK/HlJ小鼠是否同樣可做為一代謝異常之動物模式。經由高脂飼糧誘導後發現,KK/HlJ母鼠同樣會產生高血糖與葡萄糖耐受性不良的現象,顯示高脂飼糧誘導之KK/HlJ母鼠亦可作為代謝異常之動物模式。實驗二則進一步以飲食誘導肥胖模式觀察對ICR母鼠之影響,結果發現,高脂飼糧同樣會造成ICR母鼠禁食血糖與瘦體素顯著上升等代謝異常之現象。而餵食高脂飼糧的ICR母鼠股骨中鉻含量有下降的趨勢,血液中鉻含量則顯著的高於對照組。由於兩組攝食的鉻總量約略相當,且餵食高脂飼糧的ICR母鼠尿中鉻含量顯著的低於對照組,因此推測,當高脂飼糧導致代謝異常時,體內鉻元素可能是由骨中釋放至血液,送至其他組織,且減少鉻從尿液的排出,以協助各組織增加其代謝作用。
Diet-induced obese animal models were used in this study to explore the tissue chromium distribution. Male KK/HlJ mice are good metabolic disorder animal models due to their moderate obesity, hyperglycemia, and glucose intolerance properties. In this study, female KK/HlJ mice were used to explore their metabolic symptoms. After fed with high-fat diet, female KK/HlJ mice showed high blood glucose concentration and glucose intolerance. These results indicated that female KK/HlJ mice fed with high-fat diet could also be used as an abnormal metabolic animal model. Female ICR mice fed with high-fat diet were then studied. Higher fasting glucose and leptin concentration were found after high-fat diet induction. In tissue chromium distribution, after high-fat diet induction, female ICR mice showed a tendency of lower chromium content in bone, and significantly higher chromium concentration in blood than control group. Reduced chromium discharged from urine was also found in high-fat fed group. Since chromium ingestion in both groups are about equal, and high-fat diet can cause abnormal metabolism. As needed by increased metabolism, chromium is released from bone into blood, and is redistributed to other tissues.
中文摘要…………………………………………………………………I
英文摘要………………………………………………………………II
目次……………………………………………………………………III
圖次…………………………………………………………………VI
表次…………………………………………………………………VIII
第一章、緒言………………………………………………………………01
第二章、文獻探討……………………………………………………02
第一節 肥胖與代謝症候群………………………………………02
第二節 脂肪組織扮演內分泌器官的角色………………………04
一、Leptin……………………………………………………05
二、Resistin………………………………………………07
三、Adiponectin……………………………………………08
第三節 糖尿病的定義與分類……………………………………09
一、第1型糖尿病…………………………………………..10
二、第2型糖尿病……………………………………………10
三、續發於其他狀況之糖尿病……………………………...11
第四節 胰島素的作用與訊息傳遞………………………………12
一、胰島素………………………………………………….12
二、胰島素接受體…………………………………………....13
三、胰島素受體基質…………………………………………14
四、磷酸肌醇3’-激酶……………………………………….14
五、PTP1B/SHIP2/PTEN…………………………………….15
六、葡萄糖轉運蛋白…………………………………………15
第五節 鉻與血糖之相關性………………………………………16
一、鉻的簡介…………………………………………………16
二、鉻在體內的作用…………………………………………17
第六節 飲食誘導肥胖之動物模式………………………………18
第三章、實驗材料與方法……………………………………………..22
第一節 實驗動物、飼料成分與飼養環境………………..………22
第二節 試驗設計…………………………………………………24
實驗一、高脂飼糧對於KK/HlJ與ICR小鼠醣代謝之影響
..................................................................................24
實驗二、高脂飼糧對於雌性ICR小鼠體內鉻利用之影響
………………………………………………..……26
實驗三、高脂飼糧對於雌性ICR小鼠體內鉻分布之影響
………………………………………………..……27
第三節 樣品分析…………………………………………………29
一、血清樣品處理................................................................29
二、血清胰島素之測定........................................................29
三、血清瘦體素之測定……………………………………30
四、石墨爐式原子吸收光譜儀分析法……………………31
五、鉻之攝入與排出之總量計算方式……………………33
六、統計分析………………………………………………33
第四章、結果…………………………………………………………..34
實驗一、高脂飼糧對於KK/HlJ與ICR小鼠醣代謝之影響
..................................................................................34
實驗二、高脂飼糧對於雌性ICR小鼠體內鉻利用之影響
………………………………………………..……36
實驗三、高脂飼糧對於雌性ICR小鼠體內鉻分布之影響
………………………………………………..……37
第五章、討論……………………………………………………..……50
第六章、結論……………………………………………………..……55
參考文獻…………………………………………………………..……56
1.翟振綱。實驗小鼠遺傳。國家實驗動物繁殖及研究中心,1997。
2.藍啟仁、黃傳捷、楊末雄。石墨爐原子吸收光譜儀的分析原理與應用(一)石墨爐原子化器的特性與功能。科儀新知 15 : 49-61,1994。
3.Abraham AS, Sonnenblick M, Eini M. The action of chromium on serum lipids and on atherosclerosis in cholesterol fed rabbit. Atherosclerosis 42 : 185-195, 1982.

4.Allan MF, Eisen EJ, Pomp D. The M16 mouse : an outbred animal model of early onset polygenic obesity and diabesity. Obesity Research 12 : 1397-1407, 2004.

5.Allison DB Fontaine KR, Manson JE, Stevens J, VanItallie TB. Annual deaths attributable to obesity in the United States. Journal of American Medicine Association 282 : 1530-1538, 1999.

6.Anderson RA. Chromium, glucose intolerance and diabetes. Journal of the American College of Nutrition 17 : 548-555, 1998.

7.Anderson RA, Polansky MM, Bryden NA, Bhathena SJ, Canary JJ. Effects of supplemental chromium on patients with symptoms of reactive hypoglycemia. Metabolism 36 : 351-355, 1987.

8.Anonymous. Is chromium essential for humans? Nature Review 46 : 17-20, 1988.

9.Arita Y, Kihara S, Ouchi N, Takahashi M, Maeda K, Miyagawa J, Hotta K, Shimomura I, Nakamura T, Miyaoka K, Kuriyama H, Nishida M, Yamashita S, Okubo K, Matsubara K, Muraguchi M, Ohmoto Y, Funahashi T, Matsuzawa Y. Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity. Biochemical and Biophysical Research Communication 257 : 79-83, 1999.
10.Astrup A, Finer N. Redefining Type 2 diabetes : ‘Diabesity’ or obesity dependent diabetes mellitus? Obesity Review 1 : 57-59, 2000.

11.Bach JF. Insulin-dependent diabetes mellitus as an autoimmune disease. Endocrine Reviews 15 : 516-542, 1994.

12.Bai Y, Zhang S, Kim KS, Lee JK, Kim KH. Obese gene expression alters the ability of 30A5 preadipocytes to respond to lipogenic hormones. Journal of Biological Chemistry 271 : 13939-13942, 1996.

13.Baldwin SA. Mammalian passive glucose transporters: members of an ubiquitous family of active and passive transport proteins. Biochimica et Biophysica acta 1154 : 17-49, 1993.

14.Baron AD. Impaired glucose tolerance as a disease. The American Journal of Cardiology 88 : 16H-19H, 2001.

15.Berg AH, Combs TP, Du X, Brownlee M, Scherer PE. The adipocyte-secreted protein Acrp30 enhances hepatic insulin action. Nature Medicine 7 : 947-953, 2001.

16.Bjorntorp P, Holm G, Rosmond R. Hypothalamic arousal, insulin resistance and type 2 diabetes mellitus. Diabetic Medicine 16 : 373-383, 1999.

17.Brockmann GA, Bevova MR. Using mouse models to dissect the genetics of obesity. Trends in Genetics 18 : 367-376, 2002.

18.Brown RO, Forloines-Lynn S, Cross RE and Heizer WD. Chromium deficiency after long-term total parenteral nutrition. Digestive Disease and Science 31 : 661-664, 1986.

19.Bruun JM. Regulation of interleukin-8 production and gene expression in human adipose tissue in vitro. Journal of Clinical Endocrinology and Metabolism 86 : 1267-1273, 2001.


20.Büren J, Liu HX, Jensen J, Eriksson JW. Dexamethasone impairs insulin signalling and glucose transport by depletion of insulin receptor substrate-1, phosphatidylinositol 3-kinase and protein kinase B in primary cultured rat adipocytes. European Journal of Endocrinology 146 : 419-429, 2002.

21.Caro JF, Kolaczynski JW, Nyce MR, Ohannesian JP, Opentanova I, Goldman WH, Lynn RB, Zhang PL, Sinha MK, Considine RV. Decreased cerebrospinal-fluid/serum leptin ratio in obesity: a possible mechanism for leptin resistance. Lancet 348 : 159-161, 1996.

22.Cheatham B, Kahn CR. Insulin action and the insulin signaling network. Endocrine Reviews 16 : 117-142, 1995.

23.Clodfelder BJ, Upchurch RG, Vincent JB. A comparison of the insulin-sensitive transport of chromium in healthy and model diabetic rats. Journal of Inorganic Biochemistry 98 : 522-533, 2004.

24.Cohen B, Novick D, Rubinstein M. Modulation of insulin activities by leptin. Science 274 : 1151-1152, 1996.

25.Considine RV, Considine EL, Williams CJ, Hyde TM, Caro JF. The hypothalamic leptin receptor in humans: identification of incidental sequence polymorphisms and absence of the db/db mouse and fa/fa rat mutations. Diabetes 45 : 992-994, 1996.

26.Czech MP, Corvera S. Signaling mechanisms that regulate glucose transport. Journal of Biological Chemistry 274 : 1865-1868, 1999.

27.Davies S, McLaren HJ, Hunnisett A, Howard M. Age-related decreases in chromium levels in 51,665 hair, sweat and serum samples from 40,872 patients-implications for the prevention of cardiovascular disease and type II diabetes mellitus. Metabolism 46 : 469-473, 1997.



28.Ding W, Chai Z, Duan P, Feng W, Qian Q. Serum and urine chromium concentrations in elderly diabetes. Biological Trace Element Research 63 : 231-237, 1998.

29.Eaton RP, Kipnis DM. Effects of high-carbohydrate diets on lipid and carbohydrate metabolism in the rat. The American Journal of Physiology 217 : 1160-1168, 1969.

30.Fehmann HC, Berghofer P, Brandhorst D, Brandhorst H, Hering B, Bretzel RG, Goke B. Leptin inhibition of insulin secretion from isolated human islets. Acta Diabetological 34 : 249-252, 1997.

31.Feng W, Ding W, Qian Q, Chai Z. Use of the enriched stable isotope Cr-50 as a tracer to study the metabolism of chromium (III) in normal and diabetes rats. Biological Trace Element Research 63 : 129-138, 1998.

32.Fisler JS, Warden CH. Mapping of mouse obesity genes : a generic approach to a complex trait. Journal of Nutrition 127 : 1909S-1916S, 1997.

33.Flier JS. Leptin expression and action: new experimental paradigms. Proceedings of the National Academy of Science of the United States of America 94 : 4242-4245, 1997.

34.Flegal KM, Carroll MD, Kuczmarski RJ, Johnson CL. Overweight and obesity in the United States: prevalence and trends, 1960-1994. International Journal of Obesity and Related Metabolic Disorders 22 : 39-47, 1998.

35.Friedman, JM, Halaas JL. Leptin and the regulation of body weight in mammals. Nature 395 : 763-770, 1998.






36.Fruebis J, Tsao TS, Javorschi S, Ebbets-Reed D, Erickson MR, Yen FT, Bihain BE, Lodish HF. Proteolytic cleavage product of 30-kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in mice. Proceedings of the National Academy of Science of the United States of America 98 : 2005-2010, 2001.

37.Garvey WT. Glucose transport and NIDDM. Diabetes Care 15 : 396-417, 1992.

38.Göke B. Implications of blood glucose, insulin resistance and beta-cell function in impaired glucose tolerance. Diabetes Research and Clinical Practice 40 Supplement : S15-20, 1998.

39.Gong DW, Bi S, Pratley RE, Weintraub BD. Genomic structure and promoter analysis of the human obese gene. Journal of Biological Chemistry 271 : 3971-3974, 1996.

40.Goudet G, Delhalle S, Biemar F, Martial JA, Peer B. Functional and cooperative interaction between the homeodomain PDX1, Pbx, and Prep1 factor on the somatostatin promoter. Journal of Biological Chemistry 274 : 4067-4073, 1999.

41.Gunn TM, Miller KA, He L, Hyman RW, Davis RW, Azarani A, Schlossman SF, Duke-Cohan JS, Barsh GS. The mouse mahogany locus encodes a transmembrane form of human attractin. Nature 398 : 152-156, 1999.

42.Haj FG, Verveer PJ, Squire A, Neel BG, Bastiaens PI. Imaging sites of receptor dephosphorylation by PTP1B on the surface of the endoplasmic reticulum. Science 295 : 1708-1711, 2002.

43.Hanrahan JP, Eisen EJ, Legates JE. Effects of population size and selection intensity on short-tern selection for postweaning gain in mice. Genetics 73 : 513-530, 1973.



44.Harris MI, Eastman RC, Cowie CC, Flegal KM, Eberhardt MS. Comparison of diabetes diagnostic categories in the U.S. population according to the 1997 American Diabetes Association and 1980-1985 World Health Organization diagnostic criteria. Diabetes Care 20 : 1859-1862, 1997.

45.Hotamisligil GS, Shargill NS, Spiegelman BM. Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science 259 : 87-91, 1993.

46.Hu E, Liang P, Spiegelman BM. AdipoQ is a novel adipose-specific gene dysregulated in obesity. Journal of Biological Chemistry 271 : 10697-20703, 1996.

47.Hwang IS, Ho H, Hoffman BB, Reaven GM. Fructose-induced insulin resistance and hypertension in rats. Hypertension 10 : 512-516, 1987.

48.Ikeda H. KK mouse. Diabetes Research and Clinical Practice 24 : S313-S316, 1994.

49.Isse N, Ogawa Y, Tamura N, Masuzaki H, Mori K, Okazaki T, Satoh N, Shigemoto M, Yoshimasa Y, Nishi S, et al., Structural organization and chromosomal assignment of the human obese gene. Journal of Biological Chemistry 270 : 27728-27733, 1995.

50.Jang M, Mistry A, Swick AG, Romsos DR. Leptin rapidly inhibits hypothalamic neuropeptide Y secretion and stimulates corticotropin-releasing hormone secretion in adrenalectomized mice. Journal of Nutrition 130 : 2813-2820, 2000.

51.Jeejeebhoy KN. The role of chromium in nutrition and therapeutics and as a potential toxin. Nutrition Review 57 : 329-335, 1999.

52.Jiao S, Cole TG, Kitchens RT, Pfleger B, Schonfeld G. Genetic heterogeneity of plasma lipoproteins in the mouse: control of low density lipoprotein particle sizes by genetic factors. Journal of Lipid Research 31 : 467-477, 1990.
53.Kahn BB, Flier JS. Obesity and insulin resistance. Journal of Clinical Investigation 106 : 473-481, 2000.

54.Kahn CR. Insulin resistance, insulin insensitivity, and insulin unresponsiveness: a necessary distinction. Metabolism 27 : 1893-1902, 1978.

55.Kelly MA, Rayner ML, Mijovic CH, Barnett AH. Molecular aspects of type I diabetes. Molecular Pathology 56 : 1-10, 2003.

56.Kissebah AH, Sonnenberg GE, Myklebust J, Goldstein M, Broman K, James RG, Marks JA, Krakower GR, Jacob HJ, Weber J, Martin L, Blangero J, Comuzzie AG. Quantitative trait loci on chromosomes 3 and 17 influence phenotypes of the metabolic syndrome. Proceedings of the National Academy of Science of the United States of America 97 : 14478-14483, 2000.

57.Kleyn PW, Fan W, Kovats SG, Lee JJ, Pulido JC, Wu Y, Berkemeier LR, Misumi DJ, Holmgren L, Charlat O, Woolf EA, Tayber O, Brody T, Shu P, Hawkins F, Kennedy B, Baldini L, Ebeling C, Alperin GD, Deeds J, Lakey ND, Culpepper J, Chen H, Glucksmann-Kuis MA, Carlson GA, Duyk GM, Moore KJ. Identification and characterization of the mouse obesity gene tubby: a member of a novel gene family. Cell 19 : 281-290, 1996.

58.Kondo K, Nozawa K, Tomita T, Ezaki K. Inbred strains resulting from Japanese mice. Bulletin of the Experimental Animals 6 : 107-112, 1957.

59.Kopelman PG. Obesity as a medical problem. Nature 404 : 635-643, 2000.

60.Luppi P, Trucco M. Immunological models of type 1 diabetes. Hormone Research 52 : 1-10, 1999.




61.Maeda K, Okubo K, Shimomura I, Funahashi T, Matsuzawa Y, Matsubara K. cDNA cloning and expression of a novel adipose specific collagen-like factor, apM1 (adipose most abundant gene transcript 1). Biochemical and Biophysical Research Communications 221 : 286-289, 1996.

62.Maffei M, Halaas J, Ravussin E, Pratley RE, Lee GH, Zhang Y, Fei H, Kim S, Lallone R, Ranganathan S, et al. Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects. Nature Medicine 1 : 1155-1161, 1995.

63.Matsuzawa Y, Funahashi T, Nakamura T. Molecular mechanism of metabolic syndrome X : Contribution of adipocytokines adipocyte-derived bioactive substances. Annals of the New York Academy of Sciences 892 : 146-154, 1999.

64.Matthew DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment : insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in men. Diabetologia 28 : 412-419, 1985.

65.Mertz W. Chromium in human nutrition. Journal of Nutrition 123 : 626-633, 1993.

66.Mertz W. Chromium occurrence and function in biological systems. Physiological Reviews 49 : 163-239, 1969.

67.Mertz W. Effects and metabolism of glucose tolerance factor. Nutrition Review 33 : 129-135, 1975.

68.Miller MW, Duhl DM, Vrieling H, Cordes SP, Ollmann MM, Winkes BM, Barsh GS. Cloning of the mouse agouti gene predicts a secreted protein ubiquitously expressed in mice carrying the lethal yellow mutation. Genes and Development 7 : 454-467, 1993.




69.Miller SG, De Vos P, Guerre-Millo M, Wong K, Hermann T, Staels B, Briggs MR, Auwerx J. The adipocyte specific transcription factor C/EBPalpha modulates human ob gene expression. Proceedings of the National Academy of Science of the United States of America 93 : 5507-5511, 1996.

70.Mills E, Kuhn CM, Feinglos MN, Surwit R. Hypertension in CB57BL/6J mouse model of non-insulin-dependent diabetes mellitus. The American Journal of Physiology 264 : R73-R78, 1993.

71.Mohamed-Ali V. Subcutaneous adipose tissue releases interleukin-6, but not tumor necrosis factor-, in vivo. Journal of Clinical Endocrinology and Metabolism 82 : 4196-4200, 1997.

72.Mooradian AD. Obesity : a rational target for managing diabetes mellitus. Growth Hormone IGF Research 11 : 79-83, 2001.

73.Morris BW, Griffiths H, Kemp GJ. Correlations between abnormalities in chromium and glucose metabolism in a group of diabetics. Clinical Chemistry 34 : 1525-1526, 1988.

74.Mossop RT. Effect of chromium (III) on fasting blood glucose, HDL cholesterol levels in diabetes. The Central African Journal of Medicine 29 : 80-82, 1983.

75.Muller G, Ertl J, Gerl M, Preibisch G. Leptin impairs metabolic actions of insulin in isolated rat adipocytes. Journal of Biological Chemistry 272 : 10585-10593, 1997.

76.Myers MG, Backer JM Jr, Sun XJ, Shoelson S, Hu P, Schlessinger J, Yoakim M, Schaffhausen B, White MF. IRS-1 activates phosphatidylinositol 3’-kinase by associating with src homology 2 domains of p85. Proceedings of the National Academy of Sciences of the United States of America 89 : 10350-10354, 1992.




77.Nagaev I, Smith U. Insulin resistance and type 2 diabetes are not related to resistin expression in human fat cells or skeletal muscle. Biochemical and Biophysical Research Communications 285 : 561-564, 2001.

78.Naggert JK, Fricker LD, Varlamov O, Nishina PM, Rouille Y, Steiner DF, Carroll RJ, Paigen BJ, Leiter EH. Hyperproinsulinaemia in obese fat/fat mice associated with a carboxypeptidase E mutation which reduces enzyme activity. Nature Genetics 10 : 135-142, 1995.

79.Nakano Y, Tobe T, Choi-Miura NH, Mazda T, Tomita M. Isolation and characterization of GPB28, a novel gelatin-binding protein purified from human plasma. Journal of biochemistry 120 : 803-812, 1996.

80.Nam SY, Kratzsch J, Kim KW, Kim KR, Lim SK, Marcus C. Cerebrospinal fluid and plasma concentrations of leptin, NPY, and alpha-MSH in obese women and their relationship to negative energy balance. The Journal of Clinical Endocrinology and Metabolism 86 : 4849-4853, 2001.

81.Nielsen FH. Chromium. In : Shils ME, Olson JA, Shike M.,eds. Modern nutrition in health and disease. Philadelphia : Lea and Febiger 264-268, 1994.

82.Nikkila EA, Ojala K. Induction of hyperglyceridemia by fructose in the rat. Life Science 4 : 937-943, 1965.

83.Nishina PM, Lowe S, Verstuyft J, Naggert JK, Kuypers FA, Paigen B. Effects of dietary fats from animal and plant sources on diet-induced fatty streak lesions in C57BL/6J mice. Journal of Lipid Research 34 : 1413-1422, 1993.

84.Olefsky JM. LIlly lecture 1980. Insulin resistance and insulin action. An in vitro and in vivo perspective. Diabetes 30 : 148-162, 1981.



85.Olson AL, Pessin JE. Structure, function, and regulation of the mammalian facilitative glucose transporter gene family. Annual Review of Nutrition 16 : 235-256, 1996.

86.Ortmeyer HK, Bodkin NL, Hansen BC. Insulin-mediated glycogen synthase activity in muscle of spontaneously insulin-resistant and diabetic monkey. The American Journal of Medicine 334 : 292-295, 1993.

87.Pessin JE, Saltiel AR. Signaling pathways in insulin action : molecular targets of insulin resistance. Journal of Clinical Investigation 106 : 165-169, 2000.

88.Pinero-Pilona A, Raskin P. Idiopathic Type 1 diabetes. Journal of Diabetes Complications 15 : 328-335, 2001.

89.Pomp D, Nielsen MK. Quantitive genetics of energy balance—lessons from animal models. Obesity Research 7 : 106-110, 1999.

90.Quarry-Horn JL, Evans BJ, Kerrigan JR. Type 2 diabetes mellitus in youth. The Journal of School Nursing 4 : 195-203, 2003.

91.Qu D, Ludwig DS, Gammeltoft S, Piper M, Pelleymounter MA, Cullen MJ, Mathes WF, Przypek R, Kanarek R, Maratos-Flier E. A role for melanin-concentrating hormone in the central regulation of feeding behaviour. Nature 380 : 243-247, 1996.

92.Reaven GM. Banting lecture 1988. Role of insulin resistance in human disease. Diabetes 37 : 1595-1607, 1988.

93.Rebuffe-Scrive M, Surwit R, Feinglos M, Kuhn C, Rodin J. Metabolism : Clinical and Experimental 42 : 1405-1409, 1993.

94.Samad F, Loskuttof DJ. Elevated expression of transforming growth factor-b in adipose tissue from obese mice. Molecular Medicine 2 : 568-582, 1996.

95.Scherer PE. A novel serum protein similar to C1q, produced exclusively in adipocytes. Journal of Biological Chemistry 270 : 26746-26749, 1995.

96.Schroeder HA, Nason AP, Tipton IH. Chromium deficiency as a factor in atherosclerosis. Journal of Chronic Disease 23 : 123-142, 1970.

97.Schwartz K and Mertz W. Chromium III and the glucose tolerance factor. Archives of Biochemistry and Biophysics 85 : 292-295, 1959.

98.Shepherd PR, Withers, DJ, Siddle K. Phosphoinositide 3-kinase : the key switch mechanism in insulin signaling. The Biochemical Journal 333 : 471-490, 1998.

99.Shimabukuro M, Koyama K, Chen G, Wang MY, Trieu F, Lee Y, Newgard CB, Unger RH. Direct antidiabetic effect of leptin through triglyceride depletion of tissues. Proceedings of the National Academy of Science of the United States of America 94 : 4637-4641, 1997.

100.Stearns DM. Is chromium a trace essential metal? Biofactors 11 : 149-162, 1999.

101.Stephens TW, Basinski M, Bristow PK, Bue-Valleskey JM, Burgett SG, Craft L, Hale J, Hoffmann J, Hsiung HM, Kriauciunas A, et al. The role of neuropeptide Y in the antiobesity action of the obese gene product. Nature 377 : 530-532, 1995.

102.Steppan CM. The hormone resistin links obesity to diabetes. Nature 409 : 307-312, 2001.

103.Steppan CM, Lazar MA. Resistin and obesity-associated insulin resistance. Trends in Endocrinology and Metabolism 10 : 9-13, 2001.




104.Taketomi S, Tsuda M, Matsuo T, Iwatsuka H, and Suzuoki Z. Alterations of hepatic enzyme activities in KK and yellow KK mice with various diabetic states. Hormone and Metabolism Research 5 : 333-339, 1973.

105.Tartaglia LA, Dembski M, Weng X, Deng N, Culpepper J, Devos R, Richards GJ, Campfield LA, Clark FT, Deeds J, Muir C, Sanker S, Moriarty A, Moore KJ, Smutko JS, Mays GG, Wool EA, Monroe CA, Tepper RI. Identification and expression cloning of a leptin receptor, OB-R. Cell 83 : 1263-1271, 1995.

106.Tuman RW, Bilbo JT, Doisy RJ. Comparison and effects of natural and synthetic glucose tolerance factor in normal and genetically diabetic mice. Diabetes 27 : 49-56, 1978.

107.Turton MD, O'Shea D, Gunn I, Beak SA, Edwards CM, Meeran K, Choi SJ, Taylor GM, Heath MM, Lambert PD, Wilding JP, Smith DM, Ghatei MA, Herbert J, Bloom SR. A role for glucagon-like peptide-1 in the central regulation of feeding. Nature 379 : 69-72, 1996.

108.Urberg M, Benyi J, John R. Hypocholesterolemic effects of nicotinic acid and chromium supplementation. The Journal of Family Practice 27 : 603-606, 1988.

109.Van Heek M, Compton DS, France CF, Tedesco RP, Fawzi AB, Graziano MP, Sybertz EJ, Strader CD, Davis HR Jr. Diet-induced obese mice develop peripheral, but not central, resistance to leptin. The Journal of Clinical Investigation 99 : 385-390, 1997.

110.Vincent JB. Mechanisms of chromium action : low-molecular-weight chromium-binding substance. Journal of the American College of Nutrition 18 : 6-12, 1999.

111.Vincent JB. The biochemistry of chromium. Journal of Nutrition 130 : 715-718, 2000.


112.Wajchenberg BL. Subcutaneous and visceral adipose tissue: their relation to the metabolic syndrome. Endocrine Review 21 : 697-738, 2000.

113.Walker M. Obesity, insulin resistance, and its link to non-insulin dependent diabetes mellitus. Metabolism 44 : 18-20, 1995.

114.Wang Z, Zhou YT, Kakuma T, Lee Y, Kalra SP, Kalra PS, Pan W, Unger RH. Leptin resistance of adipocytes in obesity: role of suppressors of cytokine signaling. Biochemical and Biophysical Research Communications 277 : 20-26, 2000.

115.Way JM, Gorgun CZ, Tong Q, Uysal KT, Brown KK, Harrington WW, Oliver WR Jr, Willson TM, Kliewer SA, Hotamisligil GS. Adipose tissue resistin expression is severely suppressed in obesity and stimulated by peroxisome proliferator-activated receptor gamma agonists. Journal of Biological Chemistry 276 : 25651-25653, 2001.

116.Weiss R, Dufour S, Taksali SE et al. Prediabetes in youth : a syndrome of impaired glucose tolerance, severe insulin resistance, and altered myocellular and abdominal fat partitioning. Lancet 362 : 951-957, 2003.

117.White MF. Insulin signaling in health and disease. Science 302 : 1710-1711, 2003.

118.Yamamoto A, Wada O, Suzuki H. Purification and properties of biologically active chromium complex from bovine colostrum. American Institute of Nutrition 118 : 39-45, 1988.

119.Yamauchi T, Kamon J, Waki H, Terauchi Y, Kubota N, Hara K, Mori Y, Ide T, Murakami K, Tsuboyama-Kasaoka N, Ezaki O, Akanuma Y, Gavrilova O, Vinson C, Reitman ML, Kagechika H, Shudo K, Yoda M, Nakano Y, Tobe K, Nagai R, Kimura S, Tomita M, Froguel P, Kadowaki T. The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nature Medicine 7 : 941-946, 2001.

120.Yamauchi T, Kamon J, Minokoshi Y, Ito Y, Waki H, Uchida S, Yamashita S, Noda M, Kita S, Ueki K, Eto K, Akanuma Y, Froguel P, Foufelle F, Ferre P, Carling D, Kimura S, Nagai R, Kahn BB, Kadowaki T. Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase. Nature Medicine 8 : 1288-1295, 2002.

121.Zavaroni I, Sander S, Scott S, Reaven GM. Effect of fructose feeding on insulin secretion and insulin action in the rat. Metabolism 29 : 970-973, 1980.

122.Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM. Positional cloning of the mouse obese gene and its human homologue. Nature 372 : 425-432, 1994.
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