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研究生(外文):De-Kuan Chang
論文名稱(外文):Identification of a Novel Peptide Specifically Binding to Lung Cancer for Targeted Therapy
外文關鍵詞:tumor-homing peptidesNSCLC
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The most common cancers worldwide are lung (12.3 % of all cancers), breast (10.4 %) and colorectal cancer (9.4 %). Lung cancer is the predominant cause of cancer deaths in industrialized countries with a high death rate. The five-year survival rate is less than 15 % for patients with advanced non-small-cell lung cancer (NSCLC). Lack of tumor specificity remains a major problem with chemotherapies in that side effects prevent the delivery of essential dosages of drugs to eliminate majority cancer cells. In this report, we describe the isolation of a 12-mer peptide (P5-2) specifically binding to NSCLC from peptide-presenting phage libraries. The phage displayed P5-2 (PC5-2) were able to bind to NSCLC cell lines and did not bind to normal cells. In SCID mice bearing NSCLC xenografts, the PC5-2 could target to the tumor mass specifically. The homing activity of PC5-2 clones could be further competitively inhibited by synthetic P5-2. Furthermore, the P5-2-Lipo-vinorelbine (VNB) repressed tumor growth better than Lipo-VNB and without side effect. These results indicate that P5-2 enhanced the therapeutic efficacy of the drug against lung cancer xenografts in SCID mice. This tumor-specific peptide has a potential for targeted drug delivery to treat lung cancer and may be useful for designing targeted gene transfer vectors as well as diagnostic tools for this disease.
Materials and methods…………10
Discussion ………………………23
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