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研究生:陳政宏
研究生(外文):Chen-Hung Chen
論文名稱:醫學影像處理運用在輔助阿茲海默氏症之診斷
論文名稱(外文):Assisting the Diagnosis of Alzheimer''s Disease by Medical Image Processing
指導教授:蔡英徳邱志遠邱志遠引用關係
指導教授(外文):Yin-Te TsaiJr-Yuan Chiou
學位類別:碩士
校院名稱:靜宜大學
系所名稱:資訊管理學系研究所
學門:電算機學門
學類:電算機一般學類
論文種類:學術論文
論文出版年:2005/06/
畢業學年度:93
語文別:中文
論文頁數:57
中文關鍵詞:磁振造影知能篩檢測驗阿茲海默氏症診斷系統醫學影像處理阿茲海默氏症腦萎縮海馬迴
外文關鍵詞:cognitive abilities screening instrumentmedical image processingmagnetic resonance imaginghippocampusAlzheimer’s diseasecerebrum
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台灣社會已是高齡化社會,依內政部社會司的統計,截至93年2月份為止,全台已有210萬的老年人口,佔人口總數的9.29%,根據統計老人失智症的盛行率約為2至4%,全國總計約有四萬二千至八萬四千名失智老人,其中約五至九成為阿茲海默氏症,也就是說國內約有二萬一千名至七萬五千名病患,並且每年國內新增失智症病患則約在一萬五千名左右,造成社會沉重的負擔須長期的醫療與照顧,引發我們利用醫學影像處理技術,來輔助阿茲海默氏症之診斷的研究動機。
本實驗採類實驗設計,研究對象包括阿茲海默氏症病人與老年的健康志願者各5名,共計10名。所有的病人及志願者均接受詳細的神經心理評估及知能篩檢測驗(CASI),利用GE廠牌1.5T Singa Horizon LX的核磁共振斷層掃描儀(MRI)作頭部三維立體T1 加權磁振影像掃描,蒐集受測者頭部之組織影像,運用醫學影像處理技術作量測腦萎縮(海馬迴/大腦的容積比),最後透過SPSS10.0統計軟體分析找出經由知能篩檢測驗常模轉換判定為正常或不正常病患與腦萎縮的相關性。
最後我們印證腦萎縮(海馬迴/大腦的容積比)確實與阿茲海默氏症有非常顯著關聯性,同時設計阿茲海默氏症之診斷系統,未來只要將三維立體T1 加權磁振影像掃描的頭部影像資料,透過醫學影像處理方式取得海馬迴與大腦之容積,就可以診斷阿茲海默氏症。
關鍵字:阿茲海默氏症、知能篩檢測驗(CASI)、磁振造影、醫學影像處理、腦萎縮、海馬迴、阿茲海默氏症診斷系統
Taiwan has been becoming an elderly society. According to the data publised on Feb. 2004 from Department of Social Affairs, Ministry of Interior indicated the population of individual age over 65 was up to 2.1 million, greater than 9.29%. The prevalence of dementia in the elderly society was about 2 to 4 % (around 42 and 84 thousands in Taiwan), in which the Alzheimer''s disease (AD) was about 50 to 90 %. In other words, there were about 21 to 75 thousands who suffered from dementia. Furthermore, the number of the dementia has increased about 15 thousands for each year. The cost of AD is huge including long–term medical and home care, as well as loss in quality of life. The main purpose of this study is to develop a computer program which assists diagnosis technique for AD based on magnetic resonance (MR) imaging.
In the study, there were five patients with AD and five healthy elderly volunteers to examine cognitive abilities screening instrument (CASI version C-2.0, 1997) and MR imaging diagnosis. The three dimensional MR Tl-weighted images of whole brain were acquired by a 1.5 T MR scanner (GE Singa Horizon LX). Through the comparison of the volumetric ratio between hippocampus and cerebrum, an index for the brain atrophy was found. By using the SPSS10.0 statistic analysis software, those are closely related to the non-demented one or demented one which were derived from CASI cutoff scores for different demographic groups.
Finally, we conclude that the relation between the AD and the index of the brain atrophy is significant. In future, it is possible to diagnose AD by using this medical image processing method which the only data for both volumes of hippocampus and cerebrum are needed.
Key word: Alzheimer''s disease; cognitive abilities screening instrument; magnetic resonance imaging; medical image processing; brain atrophy; hippocampus; Assisting the Diagnosis of Alzheimer''s Disease.
第一章、緒論.........................................................1
1.1 研究動機...................................................1
1.2 文獻探討...................................................2
1.3 研究目的...................................................4
1.4 論文架構...................................................5
第二章、名詞解釋.....................................................6
2.1 認識阿茲海默氏症(Alzheimer''s Disease)......................6
2.2 磁振造影(MRI)原理..........................................8
2.3 知能篩檢測驗(CASI)........................................12
2.4 頭腦與海馬迴的構造、功能..................................15
2.5 醫學影像..................................................18
2.6 統計分析..................................................19
第三章、研究內容與方法..............................................21
3.1 題材的補充收集與審視......................................21
3.2 醫學影像處理與資料演算法..................................21
3.3 資料分析..................................................21
3.4 阿茲海默氏症之診斷系統....................................22
第四章、研究成果....................................................23
4.1 受測者基本性質............................................23
4.2 實驗設計..................................................24
4.3 實驗結果..................................................49
第五章、結論與未來發展..............................................53
參考文獻............................................................54
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