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研究生:林孟聰
研究生(外文):Meng-Tsung LIN
論文名稱:攝護腺癌強度調控放射治療之劑量驗證
論文名稱(外文):Dose Verification for Intensity Modulated Radiotherapy of Prostate Cancer
指導教授:王愛義王愛義引用關係
學位類別:碩士
校院名稱:元培科學技術學院
系所名稱:影像醫學研究所
學門:醫藥衛生學門
學類:醫學技術及檢驗學類
論文種類:學術論文
論文出版年:2007
畢業學年度:95
語文別:中文
中文關鍵詞:強度調控放射治療劑量驗證二維陣列式二極體
外文關鍵詞:intensity modulated radiotherapy (IMRT)dosimetry verificationtwo-dimensional diode array
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摘要
對於強度調控放射治療(intensity modulated radiotherapy, IMRT)來說,欲做好治療前的劑量驗證(dosimetry verification),通常需經歷一段艱辛的過程,除了品保人員需努力不懈之外,如何選擇使用準確又有效率的儀器設備也是一大關鍵。本研究主要是使用二維陣列式二極體(two-dimensional diode array)偵檢器做為劑量驗證工具,並評估此儀器在日常IMRT之劑量驗證所扮演的角色。
臨床的治療計畫完成後,利用治療計畫系統內建之新增驗證計畫(create verification plan)功能,將與治療計畫相同的設定條件,從病患影像轉植到固態水假體影像上,重新運算獲得新的結果。然後,分析治療計畫在假體內的劑量分佈情形,分為點劑量驗證及平面劑量分佈驗證。在放射治療的劑量驗證方面,經常使用游離腔及驗證底片作為驗證工具,故在二維二極體偵檢器的應用上,選擇游離腔作為點劑量驗證比較工具,而驗證底片則作為平面劑量驗證與二維二極體偵檢器做比較的工具。
二極體偵檢器的劑量響應與Wellhofer cc01游離腔的劑量響應做比較,兩者之間的劑量誤差皆在百分之二以內,甚至更好。二極體偵檢器無論是再現性、劑量線性或是劑量率依存性,都表現得非常穩定,在劑量線性方面,甚至能達到400 cGy皆維持良好的線性關係。二維二極體偵檢器實際量測結果與治療計畫系統運算結果作比較,相對劑量的吻合度皆可達94%以上,透過量測結果分析,可以用來修正治療計畫,使劑量誤差減至最小。因此,善加利用MapCHECK強大劑量驗證功能,可降低日常IMRT劑量驗證過程中的工作負荷,提昇劑量驗證的品質。
Abstract
The dosimetry verification of intensity modulated radiotherapy (IMRT) dosimetry is a laborious task. The goal of this work is to evaluate the dosimetric characteristics of a new two-dimensional diode array and assess the role it can play in routine IMRT dosimetry verification.
Hybridize the patient plan to a solid water phantom using the "create verification plan" in the Eclipse treatment planning system and re-calculate the dose distribution in the phantom. Typically, the dosimetry verification process consists of verifying the absolute dose delivered to a reference point, and also the relative planar isodose distribution. Measurements of relative beam dosimetry were made with the diode array and compared with those made with film and ion chamber.
The diode array response is linear with dose up to 400 cGy. Clinical performance of the MapCheck for relative and absolute dosimetry is demonstrated with prostate IMRT plans, and compares well with film and ion chamber measurements. The MapCheck offers the dosimetric characteristics required for performing both relative and absolute dose measurements. Its use in the clinic can simplify and reduce the IMRT dosimetry verification workload.
目次
摘要 I
Abstract II
致謝 III
目次 IV
表目錄 VI
圖目錄 VII
第一章 緒論 1
第一節 前言 1
第二節 研究目的 4
第三節 實驗架構 5
第二章 實驗材料與理論基礎 6
第一節 二極體偵檢器(Diode) 6
第二節 MapCHECKTM儀器詳細規格 8
第三節 MapCHECK與游離腔之比較 10
第四節 劑量驗證底片 12
第五節 高劑量底片驗證掃描器 12
第六節 固態水假體(solid water phantom) 14
第三章 實驗步驟與方法 15
第一節 背景值量測(background) 15
第二節 相對劑量校正(array calibration) 15
第三節 絕對劑量校正(dose calibration) 17
第四節 劑量線性與劑量率反應 18
第五節 不同照野與不同射源至偵檢器表面距離 19
第六節 點劑量驗證 19
第七節 臨床治療計畫實測(面劑量驗證) 20
第四章 結果與討論 22
第五章 結論 29
參考文獻 31
附錄 34
索引 35
參考文獻
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