人體皮膚老化速率是指皮膚的生理功能在經歷了諸多複雜因素的影響以及累積之後所呈現一連續性退化過程。過去的研究發現，加速皮膚老化速率的因素有：生物體的內在因素（如：遺傳基因、身體質量數變化、月經週期、疾病史、更年期）、外在環境與天候氣象因素（如：慢性日光曝曬的經驗）、社會文化型態與個人生活習性（如：飲食與運動習慣、接觸染髮劑經驗、個人皮膚清潔保養習性）等。因此根據皮膚生理學與皮膚影像特徵辨識之標準化檢測模型所獲得之分析結果才是推估膚質老化程度的重要指標。
本論文自2004年02月起，迄至2005年04月止，收集台灣地區北（207人）、中（60人）、南（71人）、東（24人）、東北（27人）各區之社區居民，並與各醫院美容中心或皮膚科合作，以設立檢測站採被動式取樣法，徵得受測者同意進行檢測分析。以Courage&Khazaka Cutometer MPA580皮膚分析儀進行皮膚生理學檢測，分別有：皮膚彈性、黑色素、紅色素、經皮水分散失、表皮水分含量、酸鹼值、表皮油脂量等七項測值，藉此建立台灣地區人體膚質資料庫；再輔以問卷調查個人基本資料、日常生活型態、個人及家族醫療疾病史、美容史以及個人皮膚清潔保養習性等九十八種變項，俾利深入探討影響國人膚質老化之相關因子。此外，關於皮膚影像處理的流程，則是在控制拍攝環境之光源、拍攝位置、色彩校正等標準化條件下，以數位攝影機擷取受測者全臉、左臉頰及右臉頰等三個區位之皮膚影像，以為皮膚影像特徵辨識及分類之基礎。
本論文應用SAS統計軟體將所獲得之國人皮膚生理學檢測數據、皮膚影像及膚質影響因子等三大資料庫，分別進行分析，單變項有t檢定、變異數分析、相關等，以及多變量則有相關、因素分析及標準複迴歸分析；依序建構了膚質老化測量系統與膚質老化因子相關指標，最後再整合此兩項量測系統，完成了台灣地區成年女性膚質老化程度預測模型之建構。
不論是探討皮膚生理結構與其功能性，抑或致力於搜尋影響膚質老化的相關因子；最終目的乃期望藉由研究結果的發表，為全人類創造既美觀又愉悅的生活品質。而本研究所建構之標準化檢測流程、分析方法、膚質老化分數為台灣地區首度嚐試，足以做為後續研究發展之重要參考。

Skin aging is a complex and continuous process that affects skin functions and appearance. The aging process may result from intrinsic, environmental, chronic sun exposure, lifestyle habits and gene factors contributing to the pace of skin aging. This study aims to construct predicting models for women skin aging quality by determining skin physiological attributes and images of women along with their lifestyle variables and historical medical conditions.
The main objective of this study is to construct standard protocol for skin testing procedure and to build up database for academic research and industrial applications. This study subjects will be sampled from residents visiting department of dermatology in hospital for reason other than severe dermatological problem on face. The distribution of samples will be proportionately from five parts of Taiwan such as North, Middle, South, Northeast, and East. All samples will be recruited cross-sectionally with volunteer basis.
This study has collected 389 female subjects from five distinguished regions of Taiwan ,counted as 207 in North, 60 in Middle,71 in South, 27 in Northeast, and 24 in East. The physiological attributes were included as viscoelasticity, melanin, erythema, transepidermal water loss, skin surface hydration, PH measurement, sebum on the skin surface, which were taken by Courage&Khazaka cutometer MPA 580. Visible front- and side- view facial images were taken using a digital camera standardized by positioning fixation and color correction to ensure consistency of images processing. Skin expert system,commercial digital image software, and statistics procedures were applied to manage major features of skin surface for further modeling.
The predicting model has shown that skin aging is affected by many factors such as body mass index, menopausal status, environmental, chronic sun exposure, history of hair dye, methods of daily skin care, skin color, and skin characteries.Regional variations were observed in this study, which showed diversified patterns for skin physiology and aging in various living environment regardless of their living styles. With the helps of information technologies, the skin aging can be predicted precisely and further interventions are diagnosable from the model. The study produce results which may impact greatly for dermatology and beauty industry in the future.

書名頁 I
論文口試委員審定書 II
教育部授權書 III
國科會授權書 IV
國家圖書館授權書 V
中文摘要 VI
英文摘要 VIII
誌謝 X
目錄 XII
表目錄 XV
圖目錄 XVII
第一章緒論 1
第一節研究背景 1
壹、美容市場現況 1
貳、膚質檢測狀況 1
第二節研究動機 2
第三節研究目的 3
第二章文獻探討 4
第一節醫學美容與膚質檢測 4
壹、皮膚美容產業介紹 4
貳、皮膚美容產業與膚質測定之關係 4
參、皮膚生理學與膚質測定 5
肆、皮膚膚質與影響因子 8
伍、膚質檢測儀器 10
第二節資訊工具之應用 12
壹、數位影像處理系統 12
貳、統計資訊軟體 12
第三章研究方法 15
第一節研究設計 15
第二節 研究架構…………………………………………………………………16
第三節皮膚生理學檢測標準流程 18
壹、檢測前準備 18
貳、潔膚標準步驟 18
參、皮膚檢測標準步驟 19
第四節問卷設計 22
第五節檢測穩定之確保因素 22
第六節影像資料擷取、儲存設備及攝錄流程建立 22
第七節資料處理及統計分析 22
第四章、研究材料 25
第一節儀器設備 25
壹、本研究主要設備 25
貳、環境校正設備：電子溫濕度計二組 26
參、資訊支援軟硬體設備（表4.2） 26
肆、運送及固定設備（表4.3）： 28
第二節消耗性材料（表4.4）： 28
第五章、結果 29
第一節樣本特性描述 29
壹、基本人口學特性 29
貳、地理分佈 33
參、日常生活習性 37
肆、個人美容史 43
伍、個人疾病史 44
陸、個人自覺膚色及膚質狀況 46
柒、皮膚清潔保養習性 47
捌、參加測試前一天之影響因子分佈狀況 49
第二節皮膚生理學測量系統 50
壹、皮膚生理學測值 50
貳、皮膚生理學測量系統 52
第三節皮膚影像特徵測量系統 55
壹、皮膚影像特徵值 55
貳、皮膚影像特徵測量系統 56
第四節膚質老化量表 61
第五節年代年齡別與膚質老化測量系統之相關 63
第六節膚質老化程度之相關變項 66
壹、膚質影響因子與膚質老化程度之相關 66
貳、測試區域別與膚質老化程度之相關 74
第七節膚質老化程度預測模型建構 75
第六章討論 77
第一節執行標準化檢測流程之研究效益 77
第二節結果討論 77
壹、研究樣本特性 77
貳、檢測結果 77
第三節研究限制 83
壹、研究設計及材料 83
貳、檢測環境 84
參、標準檢測流程 84
肆、分析結果 84
第七章結論與建議 86
第一節結論 86
第二節建議 86
第八章、參考文獻 88
附錄 90
附錄一：長庚紀念醫院同意臨床試驗證明書 90
附錄二：募集參加皮膚生理學檢測預約海報之內容 91
附錄三：募集參加皮膚生理學檢測預約之海報 91
附錄四：參加台灣地區人體皮膚生理學檢測之預約名單 92
附錄五：接受皮膚生理學檢測之同意書 93
附錄六：檢測環境溫溼度監控記錄單 95
附錄七：皮膚生理學檢測報告單 96
附錄八：正確洗手示範 97
附錄九：日常皮膚美容保養衛教資訊 98
附錄十：台灣人體膚質資料庫問卷 100
附錄十一：攝錄影像之標準化流程 109
附錄十二：格式化辨識標籤 109
附錄十三：皮膚影像特徵值量表 110
附錄十三(續)：皮膚影像特徵值量表 111
附錄十三(續)：皮膚影像特徵值量表 112
附錄十三(續)：皮膚影像特徵值量表 113

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