臺灣博碩士論文加值系統

Xestovanin A是由一種名為Xestospongia Vanillia的海綿中所單離出來的，並且發現這種天然物具有抗菌之效果。本篇重點在於該如何合成Xestovanin A的部份骨架xestovanin glycoside，其是由?Rhamanaose及?Fucose所組成之雙醣組合，在自然界中是非常少見的組合。本實驗利用修飾過之單醣藉由不同試劑及條件所造成之不同? β選擇性來合成出4種不同位向之雙醣。

Xestovanin A have been isolated from extracts of the marine sponge Xestospongia Vanillia, and it shows antifungal activity. How to synthetic xestovanin glycoside, a part of Xestovanin A, was a point of this thesis. Xestovanin glycoside composed of ?Rhamanaose and ?Fucose is a very rare combination in nature. Modified sugars within different regents and conditions could yield four different kinds of disaccharides by ? β selectivity

一、 緒論
1. 四大類型之醣的合成難度…………………………………………………..1
2. β-gluco-type coupling………………………………………………………...2
3. β-manno-type coupling……………………………………………………… 4
二、 研究動機…………………………………………………………………………7
三、 結果與討論………………………………………………………………………9
1. 雙醣合成……………………………………………………………………..9
2. 四雙醣之比較………………………………………………………………32
四、 實驗部份………………………………………………………………………..36
1. 實驗儀器……………………………………………………………………36
2. ㄧ般的實驗方法……………………………………………………………37
3. 合成步驟……………………………………………………………………38
參考文獻……………………………………………………………………………..61
附圖…………………………………………………………………………………..63

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