|
1.行政院國家科學委員會,領域策略研討會作業資料管輔領域策略規劃資料,2004。 2.T.C. Matsingou, M. Kapsokefalou, A. Salifoglou, Aqueous infusions of Mediterranean herbs exhibit antioxidant activity towards iron promoted oxidation of phospholipids, linoleic acid, and deoxyribose, Free Radic Res., vol.35(5), pp.593-605, 2001. 3.T.J. Whelan, M.J. Gray, P.J. Slonecker, R.A. Shalliker, M.A. Wilson, Study of the selectivity of reversed-phase columns for the separation of polycarboxylic acids and polyphenol compounds, J Chromatogr A., vol.1097(1-2), pp.148-56, 2005. 4.鄧正賢、張永勳,防己類藥材之品質評估及其指標成分之分析方法研究,中國醫藥學院,中國藥學研究所,2000。 5.C.L. Tsou, W.C. LI, Studies of the mechanism of action of polyphenol oxidase. I. Effect of organic solvents on the activity of polyphenol oxidase, Sci Sin., vol.7(4), pp.439-47, 1958. 6.T.C. Matsingou, M. Kapsokefalou, A. Salifoglou, Aqueous infusions of Mediterranean herbs exhibit antioxidant activity towards iron promoted oxidation of phospholipids, linoleic acid, and deoxyribose, Free Radic Res., vol.35(5), pp.593-605, 2001. 7.蔡宜珊、蔡吉政,IL-12及IL-16於牙周病的探討,高雄醫學大學,牙醫學研究所,2002。 8.楊博智、蕭哲志,Andrographolide抑制人類單核球細胞(THP-1)誘發第九型基質金屬酵素活化之機轉探討,台北醫學院,醫學研究所,2000。 9.王文信、吳啟瑞,金銀花及其成分木犀草素改善藥物誘發大鼠記憶障礙作用之研究,中國醫藥大學,中國藥學研究,2005。 10.C.J. Lee, S.S. Lee, S.C. Chen, F.M. Ho, W.W. Lin, Oregonin inhibits lipopolysaccharide-induced iNOS gene transcription and upregulates HO-1 expression in macrophages and microglia, Br J Pharmacol., vol.146(3), pp.378-88, 2005. 11.T. Tanaka, H. Makita, K. Kawabata, H. Mori, M. Kakumoto, K. Satoh, A. Hara, T. Sumida, T. Tanaka, H. Ogawa, Chemoprevention of azoxymethane-induced rat colon carcinogenesis by the naturally occurring flavonoids, diosmin and hesperidin, Carcinogenesis, vol.18(5), pp.957-65, 1997. 12.L. Delmulle, A. Bellahcene, W. Dhooge, F. Comhaire, F. Roelens, K. Huvaere, A. Heyerick, V. Castronovo, D. De Keukeleire, Anti-proliferative properties of prenylated flavonoids from hops (Humulus lupulus L.) in human prostate cancer cell lines, Phytomedicine, 2006 13.J. Xie, Q.Y. Chen, J.Y. Zhou, Study on mechanism of tea polyphenols in inducing human lung cancer cell apoptosis in vitro, Zhongguo Zhong, vol.25(3), pp.244-7, 2005. 14.A. Ahmed-Belkacem, A. Pozza, F. Munoz-Martinez, S.E. Bates, S. Castanys, F. Gamarro, A. Di Pietro, J.M. Perez-Victoria, Flavonoid structure-activity studies identify 6-prenylchrysin and tectochrysin as potent and specific inhibitors of breast cancer resistance protein ABCG2, Cancer Res., vol.65(11), pp.4852-60, 2005. 15.H.Z. Lee, H.W. Leung, M.Y. Lai, C.H. Wu, Baicalein induced cell cycle arrest and apoptosis in human lung squamous carcinoma CH27 cells, Anticancer Res., vol.25(2), pp.959-64, 2005. 16.Y.H. Huh, S.H. Kim, S.J. Kim, J.S. Chun, Differentiation status-dependent regulation of cyclooxygenase-2 expression and prostaglandin E2 production by epidermal growth factor via mitogen-activated protein kinase in articular chondrocytes, J Biol Chem., vol.278(11), pp.9691-7, 2003. 17.I. Wakabayashi, K. Yasui, Wogonin inhibits inducible prostaglandin E(2) production in macrophages, Eur J Pharmacol., vol.406(3), pp.477-81, 2000. 18.M.W. Lee, N.Y. Kim, M.S. Park, K.H. Ahn, S.H. Toh, D.R. Hahn, Y.C. Kim, H.T. Chung, Flavanoness with in vitro inducible nitric oxide synthesis inhibitory activity from Alnus hirsute, Planta Medica., vol.66, pp.551-553, 2000. 19.J. Tao, T. Morikawa, I. Toguchida, S. Ando, H. Matsuda, M. Yoshikawa, Inhibitors of nitric oxide production from the bark of Myrica rubra: structures of new biphenyl type Flavanones glycosides and taraxerane type triterpene, Bioorg, Med. Chem., vol.10, pp.4005-4012, 2002. 20.T. Morikawa, J. Tao, I. Toguchida, H. Matsuda, M. Yoshikawa, Structures of new cyclic Flavanoness and inhibitors of nitric oxide production from Japanese folk medicine Acer nikoense, J. Natural Products, vol.66, pp.86-91, 2003. 21.K.S. Chun, K.K. Park, J. Lee, M. Kang, Y.J. Surh, Inhibition of mouse skin tumor promotion by anti-inflammatory Flavanoness derived from Alpinia oxyphylla Miquel ( Zingiberaceae), Oncol. Res., vol.13, pp.37-45, 2002. 22.B.J. Goh, B.T Tan., W.M. Hon, K.H. Lee, H.E. Khoo, Nitric oxide synthase and heme oxygenase expressions in human liver cirrhosis, World J Gastroenterol., vol.12(4), pp.588-94, 2006. 23.R.C. Yang, C.Y. Chang, T.S. Lu, S.C. Chen, Effects of hyperthermia pretreatment on expression of heme oxygenase-1 and nitric oxide synthase in rats subjected to experimental anaphylactic shock., Chin J Physiol., vol.48(4), pp.193-9, 2005. 24.Y.S. Chi, H. Lim, H. Park, H.P. Kim, Effects of wogonin, a plant flavone from Scutellaria radix, on skin inflammation: in vivo regulation of inflammation-associated gene expression., Biochem Pharmacol., vol.66(7) pp.1271-8,2003. 25.F.M. Ho, C.C. Lai, L.J. Huang, T.C. Kuo, C.M. Chao, W.W. Lin, The anti-inflammatory carbazole, LCY-2-CHO, inhibits lipopolysaccharide-induced inflammatory mediator expression through inhibition of the p38 mitogen-activated protein kinase signaling pathway in macrophages., J Pharmacol., vol. 141(6), pp.1037-47, 2004. 26.A. Rajzman, Residues of biphenyl in citrus fruits, Residue Rev., vol.8 pp.1-73, 1965. 27.中華人民共和國國家藥典委員會,中華人民共和國藥典ㄧ部,化學工業出版社589-598, 2005。 28.呂俠卿,中藥鑑別大全,中華人民共和國湖南科學技術出版社。145-9, 2002, 29.A.R. Proteggente, A.S. Pannala, G. Paganga, L. Van Buren, E. Wagner, S. Wiseman, F. Van De Put, C. Dacombe, C.A. Rice-Evans, The antioxidant activity of regularly consumed fruit and vegetables reflects their phenolic and vitamin C composition, Free Radic Res., vol.36(2), pp.217-33, 2002. 30.R. Edenharder, J.W. Sager, H. Glatt, E. Muckel, K.L. Platt, Protection by beverages, fruits, vegetables, herbs, and flavonoids against genotoxicity of 2-acetylaminofluorene and 2-amino-1-methyl-6-phenylimidazo [4,5-b]pyridine (PhIP) in metabolically competent V79 cells, Mutat Res., vol.521(1-2) pp.57-72, 2002. 31.C.J. Lee, S.S. Lee, S.C. Chen, F.M. Ho, W.W. Lin, Oregonin inhibits lipopolysaccharide-induced iNOS gene transcription and upregulates HO-1 expression in macrophages and microglia.Br J Pharmacol., vol.146(3), pp.378-88, 2005. 32.M.T. Lin, R.C. Lee, P.C. Yang, F.M. Ho, M.L. Kuo, Cyclooxygenase-2 inducing Mcl-1-dependent survival mechanism in human lung adenocarcinoma CL1.0 cells. Involvement of phosphatidylinositol 3-kinase/Akt pathway. J Biol Chem., vol. 276(52) pp.48997-9002, 2001. 33.C.I. Dumur, N.P. Koritschoner, A. Flury, G. Panzetta-Dutari, J.L. Bocco, L.C. Patrito, Differential Expression of a Tumor Necrosis Factor Receptor-Related Transcript in Gestational Trophoblastic Diseases in Women, Biology of Reproduction, vol.59, pp.621-625, 1998. 34.www.chimed.info/ herb_details.php?id=1194 35.H. Didier, R. Thierry, Initial responses to endotoxins and Gram-negative bacteria, Clinica Chimica Acta, vol.323, pp.59-72, 2002. 36.F. Gremo, V. Sogos, M.G. Ennas, A. Meloni, T. Persichini, M. Colasanti, G.M. Lauro, Features and functions of human microglia cells, Adv.Exp.Med.Biol, vol.429, pp.79–97, 1997. 37.G. Stoll, S. Jander, The role of microglia and macrophages in the pathophysiology of the CNS, Prog. Neurobiol., vol.58, pp.233–247, 1999. 38.F. Gonzalez-Scarano, G. Baltuch, Microglia as mediators of inflammatory and degenerative diseases, Annu. Rev. Neurosci., vol.22, pp.219–240, 1999. 39.L. Minghetti, G. Levi, Microglia as effector cells in brain damage and repair: focus on prostanoids and nitric oxide, Prog. Neurobiol, vol.54, pp.99–125, 1998. 40.J. W. Jyoti, A. S. Julie, L. F. Philip, A. P. Zachary, A. Mini, P. Usha, N. G. Alma , C. D. Loren, J. B. Paul, P2X7 nucleotide receptor: Modulation of LPS-induced macrophage signaling and mediator production, Drug Development Research, vol.53(2-3), pp.91–104, 2001. 41.C. Galanos, Physical state and biological activity of lipopolysaccharides. Toxicity and immunogenicity of the lipid A component. Z Immunitatsforsch Exp Klin Immunol, vol.149(2-4), pp.214–229, 1975. 42.Y. A. Knirel, Polysaccharide antigens of Pseudomonas aeruginosa, Crit Rev Microbiol., vol.17, pp.273-304, 1990. 43.F.M. Unger, The chemistry and biological significance of 3-deoxy-D-manno-2-octulosonic acid (KDO). Adv. Carbohydr. Chem. Biochem., vol.38, pp.323-388, 1981. 44.Alvin Fox, Microbioligy and immunology on-line university of south Carolina school of medicine, March 27, 2006. 45.C. Galanos, J. Roppel, J. Weckesser, E.T. Rietschel, H. Mayer, Biological Activities of Lipopolysaccharides and Lipid A from Rhodospirillaceae, Infect Immun., vol.16(2), pp.407–412, 1977. 46.Sherry, Cachectin/Tumor Necrosis Factor Exerts Endocrine, Paracrine, and Autocrine Control of Inflammatory Responses, Journal of Cell Biology, vol.107 pp.1269-1277, 1988. 47.M.M. Jepson, J.M. Pell, P.C. Bates, D.J. Millward, The effects of endotoxaemia on protein metabolism in skeletal muscle and liver of fed and fasted rats, Biochem J., vol.235(2), pp.329–336, 1986. 48.A.F. Samdani, T.M. Dawson, V.L. Dawson, Nitric oxide synthase in models of focal ischemia, Stroke, vol.28 pp.1283-8, 1997. 49.J.S. Stamler, Redox signaling: nitrosylation and related target interactions of nitric oxide, Cell, vol. 78, pp.931-6, 1994. 50.Y.M. Kim, C.A. Bombeck, T.R. Billiar, Nitric oxide as a bifunctional regulator of apoptosis, Circ Res., vol. 84, pp.253-6, 1999. 51.K.S. Christopherson, D.S. Bredt, Perspectives series: nitric oxide and nitric oxide synthases. nitric oxide in excitable tissues: physiological roles and disease, J Clin Invest., vol. 100 pp.2424-9, 1997. 52.W.M. Hon, H.E. Khoo, S. Moochhala, Nitric oxide in septic shock: directions for future therapy? Ann Acad Med Singapore., vol. 27(3) pp.414-21, 1998. 53.M.A. Lee, L. Cai, N. Hubner, Y.A. Lee, K. Lindpaintner, Tissue�nand development-specific expression of multiple alternatively spliced transcripts of rat neuronal nitric oxide synthase, J Clin Invest.; vol. 100(6) pp.1507-12, 1997. 54.G.J. Gross, S.T. O'Rourke, L.R. Pelc, D.C. Warltier, Myocardial and endothelial dysfunction after multiple, brief coronary occlusions: role of oxygen radicals, Am. J. Physiol., vol. 263(6 Pt 2), pp.H1703-9, 1992. 55.J.S. Stamler, Redox signaling: nitrosylation and related target interactions of nitric oxide, Cell, vol. 78 pp.931-6, 1994. 56.Y.M. Kim, C.A. Bombeck, T.R. Billiar, Nitric oxide as a bifunctional regulator of apoptosis, Circ Res., vol. 84 pp.253-6, 1999. 57.L.C. Green, D.A. Wagner, J. Glogowski, P.L. Skipper, J.S. Wishnok, S.R. Tannenbaum, Analysis of nitrate, nitrite, and [15N] nitrate in biological fluids, Anal Biochem, vol. 126 pp.131–8, 1982. 58.W.F. Doe, P.M. Henson, Macrophage stimulation by bacterial lipopolysaccharides. I. Cytolytic effect on tumor target cells., J Exp Med.; vol. 148(2) pp.544-56, 1978. 59.http://www.activemotif.com/catalog/cell_biology/no 60.web.chemistry.gatech.edu/. ../page_protein.html 61.www.bj-ok.com/ index/p1/p112.htm 62.S.L. HSIU, C.W. TSAO, Y.C. TSAI, H.J. HO, L.P.D. CHAO, Determinations of Morin, Quercetin and Their Conjugate Metabolites in Serum, Biol. Pharm. Bull., vol.24(8), pp.967—969,2001. 63.C.L. Hsieh, P.D.L. Chao, S.H. Fang, Morin sulphates/glucuronides enhance macrophage function in microgravity culture system, European Journal of Clinical Investigation, vol.35, pp.591–596, 2005. 64.A.R. Amin, P.E. Di Cesare, P. Vyas, M. Attur, E. Tzeng, T.R. Billiar, S.A. Stuchin, S.B. Abramson, The expression and regulation of nitric oxide synthase in human osteoarthritis-affected chondrocytes: evidence for up-regulated neuronal nitric oxide synthase, J Exp Med. vol. 182(6), 2097-102, 1995. 65.D. Pape, P. Linee, P. Lacroix, H. Allain, J.M. Reymann, J.B. Le Polles, J. Van den Driessche, Effect of ascorbic acid during acute iterative anoxia, hypothesis of an anti-oxidizing mechanism of action in comparison with the effect of hydroquinone, C R Seances Soc Biol Fil., vol, 174(1), pp.45-5, 1980. 66.Y. Nihro, H. Miyataka, T. Sudo, H. Matsumoto, T. Satoh, 3-O-alkylascorbic acids as free-radical quenchers: synthesis and inhibitory effect on lipid peroxidation, J Med Chem., vol.34(7) pp.2152-7, 1991. 67.M.G. Espey, K.M. Miranda, R.M. Pluta, D.A. Wink, Nitrosative capacity of macrophages is dependent on nitric-oxide synthase induction signals. J Biol Chem.; vol. 275(15), pp.11341-7, 2000. 68.Q.W. Xie, R. Whisnant, C. Nathan, Promoter of the mouse gene encoding calcium-independent nitric oxide synthase confers inducibility by interferon gamma and bacterial lipopolysaccharide., J Biol Chem. vol. 275(15), pp.11341-7, 2000. 69.R. M. Barrios, K. Chadee, Novel regulation of cyclooxygenase-2 expression and prostaglandin E2 production by IFN-gamma in human macrophages. J Immunol.; vol. 161(5), pp.2441-8, 1998. 70.G. Levi, L. Minghetti, F. Aloisi, Regulation of prostanoid synthesis in microglial cells and effects of prostaglandin E2 on microglial functions, vol. 80(11), pp.899-904, 1998. 71.M. Hori, M. Kita, S. Torihashi, S. Miyamoto, K.J. Won, K. Sato, H. Ozaki, Karaki H., Upregulation of iNOS by COX-2 in muscularis resident macrophage of rat intestine stimulated with LPS., Am J Physiol Gastrointest Liver Physiol., vol. 280(5), pp.G930-8, 2001. 72.P.A. Bal, G.C. Brown, Inflammatory neurodegeneration mediated by nitric oxide from activated glia-inhibiting neuronal respiration, causing glutamate release and excitotoxicity, J Neurosci., vol. 21(17), pp.6480-91, 2001.
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