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研究生:王鶴森
研究生(外文):Ho-Seng Wang
論文名稱:濾泡與黃體期間從事中等強度運動對血漿飢餓素及瘦體素濃度的影響
論文名稱(外文):Effects of moderate exercise on plasma ghrelin and leptin concentrations during the follicular and luteal phase
指導教授:林正常林正常引用關係
指導教授(外文):Jung-Charng Lin
學位類別:博士
校院名稱:國立臺灣師範大學
系所名稱:體育學系
學門:教育學門
學類:專業科目教育學類
論文種類:學術論文
論文出版年:2006
畢業學年度:94
語文別:中文
論文頁數:88
中文關鍵詞:飢餓素瘦體素濾泡期黃體期中等強度運動
外文關鍵詞:ghrelinleptinfollicular phaseluteal phasemoderate exercise
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摘 要
飢餓素 (ghrelin) 和瘦體素 (leptin) 不僅在能量恆定和食慾的調控上扮演重要的角色,而且和月經週期可能也有關係。目的︰探討女性於濾泡與黃體期間從事單次中等強度運動對血漿飢餓素及瘦體素濃度的影響。方法:受試者為13名具有規律月經週期及正常體重(身體質量指數:20.7±1.5 kg/m2)的大學體育系女生,所有受試者分別需在濾泡前期及黃體中期各進行一次60% VO2max,持續時間45分鐘之中等強度運動,運動前需隔夜禁食,然後於進食統一提供之早餐(353 Kcal;碳水化合物:67.6%、脂肪:23.1 %、蛋白質:9.3 %)30分鐘後進行運動。在濾泡期之運動測量前一天,實施一次控制實驗,實施程序與中等強度運動測量相同,惟並不實際進行運動。安靜空腹、運動期每15分鐘及運動結束後45分鐘的恢復期每15分鐘,以留置針採血檢測飢餓素及瘦體素。結果:黃體期安靜空腹時之瘦體素濃度 (10.63±6.55 ng/ml) 顯著高於濾泡期 (7.19±3.12 ng/ml; p<.05),而且此種差距無論在運動中或運動後皆依然存在。另外,飢餓素濃度雖不受月經週期的影響,但在運動結束後有顯著下降之情形發生,恢復期飢餓素濃度之曲線下面積為36185.12±15428.01 pg/ml45min,比運動期之39932.81±18083.37pg/ml45min減少約10 % (p<.05)。結論:1. 瘦體素不受到單次運動的影響而改變,但會因月經週期而有所不同,因此有關瘦體素的研究應該將月經週期納入考量,以獲得較精確之結果。2.飢餓素不受濾泡或黃體期的影響,但在單次中等強度運動後會有顯著下降的情形發生,因此運動或許有抑制食慾的作用存在。
Abstract

Leptin and ghrelin not only play an important role in appetite and energy homeostasis but may relate to menstrual cycle. Purpose: This study was designed to determine the effects of moderate exercise and menstrual cycle phase on plasma leptin and ghrelin concentrations. Methods: Thirteen young females with regular menstrual cycle and normal weight (body mass index: 20.7±1.5 kg/m2) were recruited for this study. All subjects had standardized breakfast (353 Kcal;carbohydrate: 67.6%, fat: 23.1 %, protein: 9.3 %) and 30 minutes later, performed two 45-minute cycle ergometer tests at 60% of VO2max after overnight fasting—the first test during the early follicular phase and the second during the middle luteal phase. Moreover, a control trial was conducted before or after the exercise day of the follicular phase at the same time that excluded exercise. Venous blood samples were collected at resting, every 15 minutes during exercise period and every 15 minutes for 45 minutes recovery period. Results: The mean of resting leptin values in the luteal phase were significantly higher (10.63±6.55 ng/ml) than those in the follicular phase (7.19±3.12 ng/ml; p<.05) and were not actually affected by the acute exercise. Resting ghrelin values showed no difference between the follicular phase and the luteal phase, but significantly decreased 10 % during recovery period compared to exercise period (AUC: 36185.12 ±15428.01 vs. 39932.81±18083.37 pg/ml45min; p<.05). Conclusions: 1.The luteal phase differs from follicular phase on leptin values, so further study should control this difference to obtain more accurate results. 2. The fact that plasma ghrelin concentrations decrease after acute moderate exercise may suggest that exercise has the function to suppress the appetite.
目 次
中文摘要 ............................................ i
英文摘要 ............................................ ii
謝 誌 ............................................ iii
目 次 ............................................ iv
圖 次 ............................................ vii
表 次 ............................................ viii

第壹章、緒論
一、問題背景………………………………………………………………… 1
二、研究目的………………………………………………………………… 5
三、名詞操作性定義………………………………………………………… 5
第貳章、文獻探討
一、月經週期的界定及其與運動代謝反應的關係………………………… 7
二、瘦體素及其生理功能…………………………………………………… 10
三、瘦體素與運動…………………………………………………………… 13
四、飢餓素與其影響因子…………………………………………………… 14
五、飢餓素與運動…………………………………………………………… 17
六、飢餓素與月經週期……………………………………………………… 20
七、瘦體素、胰島素及飢餓素參與能量恆定調節的機制………………… 22
八、本章總結………………………………………………………………… 23
第參章、方法與步驟
一、受試者…………………………………………………………………… 26
二、實驗時間………………………………………………………………… 26
三、實驗地點………………………………………………………………… 26
四、實驗方法與步驟………………………………………………………… 27
五、採血及血液分析………………………………………………………… 32
六、資料處理………………………………………………………………… 35
第肆章、結果
一、受試者基本資料………………………………………………………… 37
二、血漿飢餓素……………………………………………………………… 38
三、血漿瘦體素……………………………………………………………… 40
四、血清生長激素…………………………………………………………… 42
五、血清胰島素……………………………………………………………… 43
六、血糖……………………………………………………………………… 45
七、血清三酸甘油酯………………………………………………………… 46
八、其他生理指標…………………………………………………………… 48
九、瘦體素及飢餓素與身體組成及其他血液指標之關係………………… 52
第伍章、討論
一、濾泡與黃體期安靜時之血漿瘦體素及飢餓素濃度…………………… 53
二、濾泡與黃體期進行中等強度運動對瘦體素濃度之影響……………… 58
三、濾泡與黃體期進行中等強度運動對飢餓素濃度之影響……………… 61
四、結論與建議……………………………………………………………… 64

引用文獻……………………………………………………………………… 66

附錄一 受試者同意書………………………………………………………… 72
附錄二 健康情況調查表……………………………………………………… 75
附錄三 瘦體素 (leptin) 之檢測步驟…………………………………… 76
附錄四 飢餓素 (ghrelin) 之檢測步驟…………………………………… 77
附錄五 不同週期之progesterone濃度變異數分析摘要表……………… 78
附錄六 不同週期之E2濃度變異數分析摘要表……………………………… 78
附錄七 不同週期之LH濃度變異數分析摘要表……………………………… 78
附錄八 不同週期之FSH濃度變異數分析摘要表…………………………… 79
附錄九 濾泡與黃體期在不同時段之血清飢餓素濃度變異數分析摘要表… 79
附錄十 濾泡期與控制實驗在不同時段之血清飢餓素濃度變異數分析摘
要表…………………………………………………………………… 79
附錄十一 濾泡與黃體期在不同時段之血清瘦體素濃度變異數分析摘要
表……………………………………………………………………… 80
附錄十二 濾泡期與控制實驗在不同時段之血清瘦體素濃度變異數分析摘要
表……………………………………………………………………… 80
附錄十三 濾泡與黃體期在不同時段之生長激素濃度變異數分析摘要表… 81
附錄十四 濾泡期與控制實驗在不同時段之生長激素濃度變異數分析摘要
表……………………………………………………………………… 81
附錄十五 濾泡與控制實驗在不同時段之生長激素濃度單純主要效果分析摘要
表……………………………………………………………………… 82
附錄十六 濾泡與黃體期在不同時段之血清胰島素濃度變異數分析摘要
表……………………………………………………………………… 82
附錄十七 濾泡與控制實驗在不同時段之血清胰島素濃度變異數分析摘要
表……………………………………………………………………… 83
附錄十八 濾泡與控制實驗在不同時段之血清胰島素濃度單純主要效果分析摘
要表…………………………………………………………………… 83
附錄十九 濾泡與黃體期在不同時段之血糖濃度變異數分析摘要表……… 84
附錄二十 濾泡與控制實驗在不同時段之血糖濃度變異數分析摘要表…… 84
附錄二十一 濾泡與黃體期在不同時段之三酸甘油酯濃度變異數分析摘要
表……………………………………………………………………… 85
附錄二十二 濾泡與控制實驗在不同時段之三酸甘油酯濃度變異數分析摘要
表……………………………………………………………………… 85
附錄二十三 濾泡與控制實驗在不同時段之三酸甘油酯濃度單純主要效果分析
摘表…………………………………………………………………… 86
附錄二十四 濾泡與黃體期在不同時段之呼吸交換率變異數分析摘要表… 86
附錄二十五 濾泡與黃體期在不同時段之耗氧量變異數分析摘要表……… 87
附錄二十六 濾泡與黃體期在不同時段之換氣量變異數分析摘要表……… 87
附錄二十七 濾泡與黃體期在不同時段之心跳率變異數分析摘要表……… 88

圖 次
圖1 月經週期間之生殖激素濃度變化圖…………………………………… 8
圖2 飢餓素的結構…………………………………………………………… 15
圖3 實驗流程圖……………………………………………………………… 27
圖4 最大攝氧量測量流程圖………………………………………………… 29
圖5 受試者之ㄧ接受60% VO2max中等強度運動測量的情形……………… 31
圖6 中等強度運動實驗及採血流程圖……………………………………… 33
圖7 不同週期在不同時段之血漿飢餓素濃度變化………………………… 39
圖8 不同週期安靜(空腹)時之血漿瘦體素濃度比較…………………… 40
圖9 不同週期在不同時段之血漿瘦體素濃度變化………………………… 42
圖10 不同週期在不同時段之血清生長激素濃度變化……………………… 43
圖11 不同週期在不同時段之血清胰島素濃度變化………………………… 44
圖12 不同週期在不同時段之血糖濃度變化………………………………… 45
圖13 不同週期在不同時段之三酸甘油酯濃度變化………………………… 47
圖14 不同週期在不同時段之呼吸交換率變化……………………………… 48
圖15 不同週期在不同時段之耗氧量變化…………………………………… 49
圖16 不同週期在不同時段之換氣量變化…………………………………… 50
圖17 不同週期在不同時段之心跳率變化…………………………………… 51

表 次
表一 受試者基本資料表…………………………………………………… 37
表二 不同週期生殖相關激素濃度變化表……………………………………38
表三 瘦體素及飢餓素與身體組成及其他血液指標之相關係數表……… 52
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