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研究生:張雅涵
研究生(外文):Ya-Han Chang
論文名稱:寡木醣對第2型糖尿病患者血脂肪影響之研究
論文名稱(外文):Study of xylooligosaccharide on blood lipidinfluence in type 2 diabetic patient
指導教授:黃延君
指導教授(外文):Yan-Jium Huang
學位類別:碩士
校院名稱:靜宜大學
系所名稱:食品營養研究所
學門:醫藥衛生學門
學類:營養學類
論文種類:學術論文
論文出版年:2006/02/
畢業學年度:94
語文別:中文
論文頁數:150
中文關鍵詞:低密度脂蛋白膽固醇三酸甘油酯總膽固醇第2型糖尿病寡木醣
外文關鍵詞:total cholesterolxylooligosaccharidetype 2 diabetes mellitus
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寡木醣(Xylooligosaccharide, XOS)為寡醣的一種,由2-6個木醣以β(1→4)鍵結所組成。少數動物實驗顯示寡木醣具有良好的降血脂作用。糖尿病在民國93年高居台灣地區十大死因第4名,其中第2型糖尿病佔總糖尿病人數的90-95%。第2型糖尿病患者常因血脂異常而引起各種併發症。本研究目的為探討寡木醣對第2型糖尿病患者血脂肪之影響。
實驗召募四十歲以上且肝腎功能正常的第2型糖尿病患者為受試對象,分為每天攝取2克葡萄糖的G2組、每天攝取2克寡木醣的X2組及每天攝取4克寡木醣的X4組,實驗為期八週且期間不改變其飲食及藥物治療。受試者經召募後進行飲食問卷調查,在實驗期第0週及第8週時進行體位、血壓及尿液檢查,並抽取禁食血液檢測血脂及血糖相關生化值,並於實驗期第2、第4及第6週時進行餐後2小時血糖及尿液檢查。
結果顯示三組受試者的體位、血壓、禁食血漿血糖及胰島素濃度於實驗前後間皆無顯著改變,X2組於實驗後的血清總膽固醇濃度(181.64±54.35 mg/dl vs. 154.1±47.83 mg/dl,p<0.01)及低密度脂蛋白膽固醇(131.5±44.28 mg/dl vs. 76.13±48.3 mg/dl,p<0.01)皆有顯著的降低,且HDL-C/LDL-C ratio有顯著增加(0.24±0.14 vs. 0.85±1.02,p<0.05);X4組於實驗後的血清三酸甘油酯(201.17 ± 186.09 mg/dl vs. 122.77 ±83.03 mg/dl,p<0.05)及低密度脂蛋白膽固醇(93.57 ± 42.75 mg/dl vs. 71.65 ± 33.12 mg/dl,p<0.05)皆有顯著降低,且且HDL-C/LDL-C ratio有顯著增加(0.49±0.39 vs. 0.68±0.47,p<0.05)。綜合以上結果發現,每天攝取寡木醣對血糖控制相關指標無顯著影響,但寡木醣可有效降低血清總膽固醇、三酸甘油酯及低密度脂蛋白膽固醇,尤其在血脂異常時的效果較為顯著,且每天只要攝取2克寡木醣即有改善血脂的功效。
Xylooligosaccharide is kind of oligosaccharide, and formed with 2-6 xylose molecules by β-1, 4 linkages. A few animal studies showed xylooligosaccharide also reduced blood lipids effectively. Diabetes mellitus was the 4th of top 10 cause of death in Taiwan, and type 2 diabetes mellitus accounted for 90-95% of the total number of diabetes patient. Type 2 diabetes mellitus was often caused by dyslipidemia to cause various complications. Purpose of the study was to investigate the effect of XOS on blood lipids in type 2 diabetes mellitus.
Subjects were recruited by above 40 yrs, normal liver function and no dialysis of type 2 diabetes mellitus. Subjects divided into three groups, one was taking of 2 g glucose group (G2 group), one was taking of 2 g XOS group (X2 group) and taking of 4 g XOS group (X4 group) for 8 weeks. After recruiting, subjects executed diet and life habit of questionnaire and evaluated anthropometric data, blood pressure, blood glucose, blood lipid profiles and urine measurements at 0 wk and 8 wk of experiment. At 2 wk, 4 wk and 6 wk of experiment, 2 hr postprandial blood glucose and urine was analyzed.
The results showed anthropometric parameter, blood pressure, fasting plasma glucose and insulin of three groups were no significantly change between baseline and final of experiment. After experiment, serum total cholesterol and low density lipoprotein cholesterol were significantly decreased and HDL-C/LDL-C ratio was significantly increased in X2 group. After experiment, serum triglyceride and low density lipoprotein cholesterol were obviously lower and HDL-C/LDL-C ratio was obviously rising in X4 group. Synthesize the above conclusion to find that consuming XOS did not affect index of blood glucose control significantly everyday. XOS reduced serum total cholesterol, triglyceride, and low density lipoprotein cholesterol effectively when blood lipid was unusual particularly, and got the efficiency of improving blood lipids only need to absorb 2 g of xylooligosaccharide everyday.
目錄
頁次
中文摘要 ……………………………………………………………... I
英文摘要 ……………………………………………………………... III
目錄 …………………………………………………………………... V
表目錄 ………………………………………………………………... VIII
第一章 緒論
第一節 研究動機 ……………………………………………..... 1
第二節 研究目的 ……………………………………………..... 3
第二章 文獻回顧
第一節 糖尿病之流行病學 ……………………………………. 4
第二節 寡醣的基本介紹 ………………………………………. 8
第三節 寡木醣的特性 …………………………………………. 11
第四節 寡醣的建議攝取量 ……………………………………. 13
第五節 寡醣的生理功能 ………………………………………. 14
一、 寡醣對腸道菌叢影響 ………………………………. 14
二、 寡醣對便袐及大腸癌之影響 ………………………. 17
三、 寡醣對礦物質吸收之影響 …………………………. 18

頁次
四、 寡醣對預防齟齒之作用 …………………………..... 19
五、 寡醣對血脂肪之影響 ……………………………..... 20
六、 寡醣對血糖調控之影響 …………………………..... 27
第三章 材料與方法
第一節 實驗材料 ……………………………………………..... 31
一、 食用材料 …………………………………………..... 31
二、 化學藥品 …………………………………………..... 32
三、 實驗儀器 …………………………………………..... 33
第二節 實驗設計及方法 ……………………………………..... 34
一、 實驗對象 …………………………………………..... 34
二、 食用材料之包裝及貯存 …………………………..... 35
三、 實驗流程 …………………………………………..... 36
第三節 檢測原理及方法 ……………………………………..... 36
第四節 生活及飲食習慣之問卷調查 ………………………..... 44
第五節 統計方法 ……………………………………………..... 46
第四章 結果
第一節 受試者基本資料 ……………………………………..... 49

頁次
第二節 生活習慣及日常飲食之問卷調查 …………………..... 52
第三節 體位測量 ……………………………………………..... 57
第四節 血壓測量 ……………………………………………..... 57
第五節 血液生化值 …………………………………………..... 57
第六節 尿液檢測 ……………………………………………..... 59
第七節 相關性分析 …………………………………………..... 60
第八節 問卷之信度、效度分析 ……………………………..... 61
第五章 討論 ………………………………………………………... 62
第六章 結論 ………………………………………………………... 71
第七章 參考文獻
一、 中文文獻 ………………………………………………..... 72
二、 英文文獻 ………………………………………………..... 73
附錄一、寡木醣之分析報告說明書 ………………………………... 108
附錄二、靜宜大學人體試驗審議通過證明書 ………………………119
附錄三、國軍台中總醫院人體試驗審查通過證明書 ……………... 120
附錄四、受試者參與本研究之人體試驗同意書 …………………... 121
附錄五、糖尿病患者的生活習慣及日常飲食之問卷調查 ………... 122

表目錄
頁次
表1. 寡醣對於血脂影響之人體試驗 ……………………………….. 26
表2. 受試者之個人資料 …………………………………………….. 86
表3. 受試者之個人病史 …………………………………………….. 87
表4. 受試者之家族病史 …………………………………………….. 88
表5. 受試者之飲食型態分佈 ……………………………………….. 89
表6. 受試者之飲酒習慣分佈 ……………………………………….. 90
表7. 受試者之抽煙習慣分佈 ……………………………………….. 91
表8. 受試者之運動及排便習慣分佈 ……………………………….. 92
表9. 受試者之外食與主食習慣分佈 ……………………………….. 93
表10. 受試者之含糖飲料攝取習慣分佈 …………………………… 94
表11. 受試者之零食攝取習慣分佈 ……………………………….... 95
表12. 受試者之宵夜攝取習慣分佈 ………………………………… 96
表13. 受試者之蔬果攝取習慣分佈 ………………………………… 97
表14. 受試者之蛋奶類攝取習慣分佈 ……………………………… 98
表15. 受試者之食用油攝取習慣分佈 ……………………………… 99
表16. 受試者之健康食品攝取習慣分佈 …………………………… 100

頁次
表17. 實驗前後之體位測量 ………………………………………… 101
表18. 實驗前後之血壓測量 ……………………………………….... 102
表19. 實驗期之血糖相關指標 ……………………………………… 103
表20. 實驗前後之血脂檢測值 ……………………………………… 104
表21-1. 受試者尿液檢測值之分佈-1 ………………………………... 105
表21-2. 受試者尿液檢測值之分佈-2 ………………………………... 106
表22. 皮爾森相關係數分析 ………………………………………… 107
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