參考文獻
張振隆：實用生理學 (上)。台光出版社 p.p. 1146-1151(1991).
趙世彬、李文齡、蔡東璣、陳河吉、周大中：生物化學。藝軒圖書出版社 pp.236 (1996)
黃進明：中醫對B型肝炎的看法與治療。中國醫藥研究叢刊 第十九期 p.p. 11~20 (1998)翁鼎鈞：台灣產生藥高氏柴胡對大白鼠肝纖維化之保肝作用研究。高雄醫學大學天然藥物研究所碩士論文(2004)陳長堅：蜆粉或蜆精對四氯化碳誘發之肝障害大白鼠肝臟脂質過氧化的影響。國立台灣海洋大學食品科學系碩士論文(2003)袁家儀：綠藻對於大白鼠體內抗氧化狀態的影響。臺北醫學院保健營養學研究所碩士論文(2000)張馨方：銀杏、人參、五味子萃取物複方對四氯化碳誘發肝傷害老鼠肝功能的影響。臺北醫學大學 保健營養學系碩士論文(2005)陳雅琳：複方五味子芝麻萃取物對於四氯化碳誘導大白鼠肝損傷的影響。臺北醫學大學保健營養學研究所碩士論文(2004)徐曉萍：以四氯化碳誘導大鼠肝纖維化動物模式進行中醫傳統方劑－柴胡疏肝散變 方對於抑制肝纖維化之療效評估及作用機轉探討。國立中興大學獸醫學系碩士論文(2004)彭湘琦：雞精對大白鼠體內抗氧化狀態的影響。台北醫學院/保健營養學研究所碩士論文(2001)
洪銘育：杜仲葉(Eucommia ulmoides Oliv. leaves)與決明子(Cassia tora L.)水 萃取物對四氯化碳誘導大鼠肝損傷之謢肝及抗氧化功效評估。國立中興大學/食品科學系碩士論文(2003)Adams, D. O. & Hamilton, T. A. (1992) Macrophages as destructive cells in host defense.
In: Gallin, J. I., Goldstein, I. M., Synderman, R., eds. Inflammation: basic principles
and clinical correlates. New York: Raven. pp. 637-662.
Adjei, A. A., Yamamoto, S. & Kulkarni, A. (1995) Nucleic acid and/or their components : a possible role in immune function. J. Nutr. Sci. Vitaminol. 41: 1~16.
Ala-Kokko, L., Pihlajaniemi, T., Myers, J. C., Kivirikko, K. I. & Savolainen, E. R.
(1987) Geneexpression of type I, III and IV collagens in hepatic fibrosis induced
by dimethylnitrosamine in the rat. Biochem J. 244: 75–79.
Ames, B. N., Shigenaga, M. K. & Hagen, T. M. (1993) Oxidants, antioxidants and the degenerative disease of aging. Proc. Natl. Acad. Sci. 90: 7915-7922.
Arthur, M. J. P.(1994) Degradation of matrix proteins in liver fibrosis. Path Res Pratt . 190: 825-833.
Arthur, M. J.P., Mann, D.A. & Iredale, J. P. (1998) Tissue inhibitors of matrix metalloproteinase, hepatic stellate cells and liver fibrosis. J Gatro hepatol. 13: S33-38.
Aruoma, O. I. (1998) Free radical, oxidative stress, and antioxidants in human health and disease. J. Am. Oil Chem. Soc. 75: 119-213.
Atanasiu, R. L., Stea, D., Mateescu, M. A., Vergely, C., Dalloz, F., Briot, F., Maupoil, V. & Nadeau, R. (1998) Rochette L. Direct evidence of caeruloplasmin antioxidant properties. Mol Cell Biochem. 189: 127-35.
Benyon, R. C. & Arthur, M. J. (2001) Extracellular matrix degradation and the role of hepatic stellate cells. Semin Liver Dis. 21: 373-384.
Bissell, D. M. (2001) Chronic liver in jury, TGF-β1, and cancer. Exp Mol Pathol 33: 179-190
Bissell, D.M., Roulot, D. & George, J. (2001) Transforming growth factor β and the liver. Hepatology. 34: 859-867
Boveris, A. & Cadenas, E. (2000) Mitochondrial production of hydrogen peroxide regulation by nitric oxide and the role of ubisemiquionoe. IUBMB Life 50: 245-250.
Boza, J. J., Jahoor, F. & Reeds, P. J. (1996) Ribonucleic acid nucleotides in maternal
and fetal tissues derive almost exclusively from sythesis de novo in pregnant mice. J. Nutr. 126(7): 1749-58.
Brenner, D. A., Waterboer, T., Chio, S. K., Lindquist, J. N., Stefanovic, B., Burchard,
E.,Yamauchi, M., Gillan, A, & Rippe, R. A. (2000) New aspects of hepatic
fibrosis. J Hepatol 32: 32-38.
Burridge, P. W., Woods, R. A. & Henderson, J. F. (1976) Utilization of dietary nucleic
acid purines for nucleotide and nucleic acid synthesis in the mouse. Can. J. Biochem. 54(5): 500-6.
Burt, A. D. & Day. (2000) Pathophysiology of the liver. In: MacSween RN, Burt AD,
Portmann BC, Ishak KG, Scheuer PJ, Anthony PP, eds. Pathology of the liver (4th ed). Harcourt Publishers Limited. 67-106.
Cadenas, E. (1995) Mechanisms of oxygen activation and reactive oxygen species detoxificiation. In “Oxidative Stress and Antioxidant Defenses in Biology”pp.1-61.
Carver, J. D. (1994) Dietary nucleotides : cellular immune, intestinal and hepatic
system effects. J. Nutr. 124(Suppl): 144S-148S.
Carver, J. D. & Walker, W. A. (1995) The role of nucleotides in human nutrition. J. Nutr.
Biochem. 6: 58-72.
Cesbron, J. Y., Capron, A., Vargaftig, B. B., Lagarde, M., Pincemail, J., Braquet, P., Toelman, H. & Joseph, M. (1987) Platelets mediate the action of diethylcarbamazine on microfilariae. Nature 325: 533-536.
Camps, J., Bargallo, T., Gimenez, A., Alie, S., Caballeria, J., Pares, A., Joven, J., Masana, L. & Rodes, J. (1992) Relationship between hepatic lipid peroxidation and fibrogenesis in carbon tetrachloride-treated rats: effect o zinc administration. Clin Sci (Lond). 83: 695-700.
Chance B., Sies H. and Boveris A. ( 1979) Hydroperoxide metabolism in mammalian organs. Physiol Rev 59: 527-605.
Charles, T., Buren, M. D. & Rudolph, F. (1997) Dietary nucleotides: a conditional
requirment. Nutrition 13(5): 470-472.
Chen, T. H., Hung, H. P., Matsumoto, Y., Wu, S. H., Wang, M. F., Chung, S. Y., Uezu,
K., Moriyama, T., Uezu, E., Korin, T., Sato, S. & Yamamoto, S. (1996) Effects of
dietary nucleoside-nucleotide mixture on memory in aged and young memory
deficient mice. Life Sci. 59: PL 325-330.
Chidambara-Murthy, K.N., Jayaprakasha, G. K. & Singh, R. P. (2002) Studies on
antioxidant activity of pomegranate (Punica granatum) peel extract using in vivo
models. J Agric Food Chem. 50: 4791-4795.
Cohen, G. & Hochstein, P. (1963) Glutathione peroxidase: The primary agent for the
elimination of hydrogen peroxide in erythrocytes. Biochemistry. 2: 1420-1428.
Connolly, G. P. & Duley, J. A. (1999) Uridine and its nucleotides: biological actions,
therapeutic potentials. Trends Pharmacol. Sci. 20: 218-255.
Connor, W. E. & Lin, D. S. (1982) The effect of shellfish in the diet upon the plasma
lipid levels in humans. Metabolism 31:1046-1051.
Crawford, J. M. & Roderick, N. M. (2000) Cirrhosis. In: MacSween RN, Burt AD,
Portmann BC, Ishak KG, Scheuer PJ, Anthony PP, eds. Pathology of the liver (4th ed). Harcourt Publishers Limited. 575-620.
Davies, K. J. A. (1986) Intracellular proteolytic systems may function as secondary antioxidant defenses : a hypothesis. J. Free Rad. Biol. Med. 2: 155-173.
Deisseroth, A. A. L. (1970) Dounce, Catalase : physical and chemical properties, mechanism of catalysis, and physiological role. Physiol. Rev. 50: 319-375.
Desmet, V. J. (1987) Cholestasis: Extrahepatic obstruction and secondary biliary
cirrhosis. In: MacSween RNM, Anthony PP, Scheuer PJ, eds. Pathology of the liver
(2nd ed.). Edinburgh: Churchill Livingstone. 364-423.
Esterbauer, H., Dieber-Rotheneder, M. & Striegl. (1991) Role of vitamin E preventing
the oxidation of low-density lipoprotein. Am J Clin Nutr 53: 314s-321s.
Finazzi-Agro, A., Menichelli, A., Persiani, M., Biancini, G. & Delprincipe, D. (1982) Hydrogen peroxide release from human blood platelets. Biochim, Biophys. Acta. 718: 21-25.
Finkel, T. & Holbrook, N. J. (2000) Oxidants, oxidative stress and the biology of ageing. Nature. 408: 239-247.
Frankel, E. N. (1991) Recent advances in lipid oxidation. J. Sci. Food Agric.
54:495-511.
Friedman, S. (1993) The cellular basis of hepatic fibrosis mechanisms and treatment
strategies. N Engl J Med 328: 1828-1835.
Friedman, S., Roll, F. J., Boyles, J., Arenson, D. M. & Bissell, D. M.(1989) Maintenance of differentiated phenotype of cultured rat hepatic lipocytes by basement membrane matrix. J Biol Chem. 264: 10756-10762.
Gressner, A. M. (1996) Mediators of hepatic fibrogenesis. Hepatogastroenterology.
43: 92-103.
Grimble, G. K. (1994) Dietary nucleotides and gut mucosal defence. Gut 35 (1 Suppl):
S46-51.
Gordon, M. H. (1990) The mechanism of antioxidant action in vitro. In“Food antioxidants”,ed. By B. J. F. Hudson, Chapter 1. pp.1-18.
Haggerty, H. G. & Holsapple, M. P. (1990) Role of metabolism in
dimethylnitrosamine induced immunosuppression: a review. Toxicology. 63:
1–23.
Halliwell, B. & Chirico, S. (1993) Lipid peroxidation: its mechanism, measurement and significance. Am J Clin Nutr. 57: 715S-725S.
Halliwell, B. & Gutteridge, J. M. C. (1985) Oxygen radicals and the nervous system. TINS. 8: 22-29.
Halliwell, B. & Gutteridge, J. M. C. (1989) Free radicals, ageing and disease. In“Free Radicals in Biology and Medicine”. Gutteridge Chart. 8. pp.484-487.
Halliwell, B. & Gutteridge, J. M. C. (1998) Antioxidant defense. Free Radicals in Biology and Medicine. pp. 105-245. Oxford University press Inc., New York.
Halliwell, B., Gutteridge, J. M. C. & Cross, C. E. (1992) Free radicals, antioxidants and human disease : where are we now ? J. Lab. Clin. Med. 119(6): 598-620.
Halliwell, B., Murcia, M. A., Chirico, S. & Arouma, O. L. (1995) Free radical and antioxidants in food and in vivo. Crit. Rev. Food Sci. Nutr. 35: 7-20.
Halliwell, B. (1996) Antioxidants in human health and disease. Ann Rev Nutr 1: 33-50.
Huang, Y.T., Chang, S. P., Lin, H. C., Yang, M. C. M. & Hong, C. Y. (1997) Inositol
phosphate responses in portal veins from portal hypertensive rats: receptor- and
nonreceptor-mediated responses. J Hepatol. 26: 376-81.
Hsiao, G., Lin, Y. H., Lin, C. H., Chou, D. S., Lin, W. C. & Sheu, J. R. (2001) The
protective effects of PMC against chronic carbon tetrachloride-induced
hepatotoxicity in vivo. Biol pharm bull. 24: 1271-1276.
Ichinose, T., Miller, M. D. & Shibamoto, T. (1994) Determination of free malonaldehyde formed in liver microsomes upon CCl4 oxidation. J. Appl. Toxicol. 14: 453-455.
Imlay, J. A. & Fridovich (1991) Assay of metabolic superoxide production in Escherichia coli. 266: 6957-6968.
Iuliano, L., Pratico, D., Ghiselli, A., Bonavita, M. S. & Violi, F. (1991) Superoxide dismutase triggers activation of primed platelets. Arch. Iochem. Biophys. 289: 180-183.
Karen, M. S. & Clarence, A. R. (1996) Surgical techniques for extravascular occlusion of intrahepatic shunts. Compend Contin. Educ. Small. Anim. Pract. 18: 745-754.
Knapen, M. F. M., Zusterzeel, P. L. M., Peters, W. H. M. & Steegers, E. A. P. (1999) Glutathione and glutathione-related enzymes in reproduction: a review. Eur J Obstet Gynecol Reprod Biol. 82(2): 171-84.
Kelly, F. J., Mudway, I. & Krishna, M. T. (1995) The free radical basis of air pollution focus on ozone. Respir Med 89: 647-656.
Kerr, M. E., Bender, C. M. & Monti, E. J. (1996) An introduction to oxygen free radicals. Heart and Lung. 25: 200-11.
Kim, S. G., Nam, S. Y., Chung, H. C., Hong, S. Y. & Jung, K. H. (1995) Enhanced
effectiveness of dimethyl-4, 4’-dimethoxy-5,6,5’,6’,-dimethylene.
dioxylbiphenyl-2,2’-dicarboxylate in combination with garlic oil against
experimental hepatic injury in rats and mice. J. Pharm. Pharmacol. 47: 678-682.
Klebanoff, S. J. (1988) Phagocytic cells: products of oxygen metabolism. In:Gallin, J. I., Goldstein, I. M., Synderman, R. eds. Inflammation: Basic principles and clinical correlates. New York Raven. pp.319-444.
Kono, Y. & Fridovich, I. (1982) Superoxide radicals inhibit catalase. J. Biol. Chem. 257: 5751-5754.
Kountouras, J., Billing, B. H. & Scheuer, P. J. (1984) Prolonged bile duct obstruction: a
new experimental model for cirrhosis in the rat. Br J Exp Pathol. 65: 305-311.
Lawerence, R.A. & Burk, R. F. (1976) Glutathione peroxidase activity in selenium-deficient rat liver. Biochem.Biophys.Res.Commun. 71: 952-958.
LeSage, G., Glaser, S. & Alpini, G. (2001) Regulation of cholangiocyte proliferation.
Liver. 21: 73-80.
Leoncini, G., Maresca, M. & Colao, C. (1991) Oxidative metabolism of human platelets. Biochem. Int. 25: 647-655.
Liou, W., Chang, L. Y., Geuze, H. .J, Strous, G. J., Crapo, J. D. & Slot, J. W. (1993) Distribution of CuZn superoxide dismutase in rat liver. Free Radic Biol Med. 14: 201-7.
Lippman, R. D. (1983) Lipid peroxidation and metabolism in aging. In: Rothstein, M. (Ed.), Review of biological research in aging. Vol.1. Alan R. Liss, New York. pp.315-342.
López-Navarro, A. T., Gil, A. & Sanchez-Pozo, A. (1995) Derivation of dietary
nucleotides results in a transient decrease in acid-soluble nucleotides and RNA
concentration in rat liver. J. Nutr. 125(8): 2090-5.
López-Navarro, A., Gil, A. & Sanchez-Pozo, A. (1997) Age-related effects of dietary
nucleotides on liver nucleic acid content in rats. Ann. Nutr. Metab. 41(5): 324-30.
Luckey, S.W. & Petersen, D. R. (2001) Activation of kupffer cells during course
carbon tetrachloride-induced liver injury and fibrosis in rats. Exp Mole patho 71:
226-240.
MacSween, R. N., Desmet, V. J., Roskams, T. & Scothorne, R. J. Developmental anatomy and normal structure. In: MacSween RN, Burt AD, Portmann BC, Ishak
KG, Scheuer PJ, Anthony PP, eds. Pathology of the liver (4th ed). Harcourt Publishers Limited, 1-66.
Maldonado, V., Chan, L., Melendez, J., Rincon, A. R., Zhu, H. J. & Panduro, A. (1994) Regulation of apo B mRNA expression in liver and intestine during liver regeneration induced by CCl4. Biochim. Biophys. Acta. 1211: 1-6.
Mann, D.A. & Smart, D. E. (2002) Transcription regulation of hepatic stellate cell
activation. Gut 50: 891-896.
Marcus, A. J., Silk, S. T., Safier, L. B. & Ullmann, H. L. (1977) Superoxide production and reducing acyivity in human platelets. J. Clin. Invest. 59: 149-158.
Mario, C., Cinzia, S., Giuseppe, B. & Lucia, C. (2002) Iron release, oxidative stress and eryyhrocyte ageing. Free Radic Med. 32 (7): 568-76.
Mates, J. M., Perez-Gomez, C. & Castro, I. N. (1999) Antioxidant enzymes and human disease. Clin. Biochem. 32:595-603.
Mathie, R.T. & Wheatley, A. M. (2000) Liver blood flow: physiology, measurement
and clinical relevance. In: Blumgart LH, Fong Y, eds. Surgery of the liver and
biliary tract (3th ed). London: Harcourt Publisher. 85-108.
Matinez-Hernandez, A. & Amenta, P. S. (1993) The hepatic extracellular matrix I.
Components and distruction in normal liver. Virchows Arch A Pathol Anat
Histopathol. 423: 1-11.
McCaughan C.E., Van der Vielt A. and O’Neill C. (1999) Photodynamic therapy-a review. Drugs Aging 15: 49-69.
McCord, J. (2000) The evolution of free radicals and oxidative stress. Am J Med. 108:
652-9.
Meyer, A. S. & Isaksen, A. (1995) Application of enzymes as food antioxidants. Trends in Food Sci. & Tech. 6: 300-304.
Milani, S., Herbst, H., Schuppan, D. & Heinrichs, O.E. (1995) Cell source of
extracellular matrix proteins in normal and fibrotic liver .Studies of gene
expression by in situ hybridization. J Hepatol. 22: 71-76.
Millward, G. H. & Jezequel, A. M. (1985) Normal histology and structure in liver and biliary disease. 2nd ed., Edited by R. Eright, G. H. Philadelphia. pp.13-44.
Morrissey, P. A. and O’Brien, N. M. 1998. Dietary antioxidants in health and disease. Int. Dairy J. 8: 463-472.
Mourelle, M., Villalon, C. & Amezcua, J. L.(1988) Protective effect of colchicine on acute liver damage induced by carbon tetrachloride. J Hepatol. 6: 337-342.
Muoio. D. M., Seefeld, K., Witters, L. A. & Coleman, R. A. (1999) AMP-activated kinase reciprocally regulates triacylglycerol synthesis and fatty acid oxidation in liver and muscle: evidence that sn-glycerol-3-phosphate acyltransferase is a novel target. Biochem J. 338: 783-791
Nakane, T., Asayama, K. & Kodera, K. (1998) Effect of selenium deficiency on cellular
and extracellular glutathione peroxidases: immunochemical detection and mRNA
analysis in rat kidney and serum. Free Radic Biol Med. 25: 504-11.
Niki, E. 1991. Action of ascorbic acid as a scavenger of active and stable oxygen radicals. Ame. J. of Clin. Nutr. 54(6): 1119-1124.
Nunez, M. C., Ayudarte, M. V., Gil, A. & Suarez, M. D. (1993) Effect of dietary
nucleotides on the fatty acid composition of rat liver microsomes. Arch. Int. Physiol.
Biochim. Biophys. 101(2): 123-8.
Ozturk, O. & Gumusle, S. (2004) Changes in glucose-6-phosphate dehydrogenase, copper, zinc-superoxide dismutase and catalase activities, glutathione and its metabolizing enzymes, and lipid peroxidation in rat erythrocytes with age. Exp Gerontol. 39(2): 211-6.
Ogino, T., Packer, L. & Traber M. (1999) Oxidant stress and host oxidant defense mechanism. Nutritional Oncology. 18: 253-75.
Ogoshi, S., Iwasa, M., Yonezawa, T. & Tamiya, T. (1985) Effect of nucleotide and
nucleoside mixture on rats given total parenteral nutrition after 70% hepatectomy. J.
Parent. Enter Nutr. 9: 339-342.
Palomero, J., Galan, A. I., Munoz, M. E., Tunon, M. J., Gnozalez-Gallego, J. & Jimenez,
R. (2001) Effects of aging on the susceptibility to the toxic effects of cyclosporin A
in rat.Changes in liver glutathione and antioxidant enzymes. Free Radic Biol Med.
30: 836-845.
Papa, S. & Skulachev, V. P. (1997) Reactive oxygen species, mitochondria, apoptosis and aging. Mol. Cell. Biochem. 174: 305-319.
Pencil, S.D., Brattin, E. A., Glender, E. A. J. & Recknagel, R. O. (1984) Evidence against a role for disturbed hepatocellular calcium homeostasis in the fatty liver of carbon tetrachloride hepatotoxicity. Biochem Pharmacol. 33: 2419-2423.
Poli, G., Gravela, E., Albano, E. & Diazani, M. D. (1979) Studies of fatty liver with isolated hepatocytes. Ⅱ. The action of carbon tetrachloride on lipid peroxidation, protein, and triglyceride synthesis and secretion. Exp. Mol. Pathol. 30:116-127.
Poyre, J.L. & Mccay, P.B. (1980) Confirmation of assifnment of the trichloromethyl
radical spin adduct detected by spin-trapping during 13C-carbon tetrachloride
metabolism in vitro and in vivo. Biochem Biophys Res Commun 94: 1154-1160.
Pozo, A. S., Romirez, M., Gil, A., Maldomado, J., Biervliet, J. P. V. & Rosseneu, M.
(1995) Dietary nucleotides enhance plasma lecithin cholesterol acyl transferase
activity and apolipoprotein A-Ⅳ concentration in preterm newborn infants. Pediatr.
Res. 37: 328-333.
Prakasam, A., Sethupathy, S. & Lalitha, S. (2001) Plasma and RBCs antioxidant status in
occupational male pesticide sprayers. Clinica Chimica Acta. 310: 107-112.
Rajesh, M. G. & Latha, M. S. (2004) Preliminary evaluation of the antihepatotoxic
activity of Kamilari, a polyherbal formulaton. J Ethnopharmacol. 91: 99-104.
Ramkumar, K. M., Rajesh, R. & Anuradha, C. V. (2003) Food restriction attenuates
blood lipid peroxidation in carbon tetrachloride-intoxicated rats. Nutrition. 19:
358-362.
Recknagel, R. O. (1983) A new direction in the study of carbon tetrachloride hepatotoxicity. Life Sci. 33: 401-408.
Roxborough, H.E., Mercer, C. & McMaster, D. (1999) Plasma glutathione peroxidase activity is reduced in haemodialysis patients. Nephron. 81: 278-83.
Rudolph, F. B. (1994) The biochemistry and physiology of nucleotides. J. Nutr. 124:
124S-127S.
Sachan, D. S. & Dodson, W. L. (1992) Effects of L-carnitine on carbon
tetrachloride-induced changes in serum and liver lipids and acylcarnitines. J.
Environ. Pathol. Toxicol. Oncol. 11 (3): 125-129.
Safary A, Beck J.(2000) Vaccination against hepatitis B: current challenges for Asian countries and future directions. J Gastroenterol Hepatol. 15: 396-401.
Saito, J. M. & Maher, J. J.(2000) Bile duct ligation in rats Induces biliary expression
of cytokine-induced neutrophil chemoattractant. Gasteroenterology. 118:
1157–1168.
Salvemini, D., De Nucci, G., Sneddon, J. M. & Vane, J. R. (1989) Superoxide anions enhance platelet adhesion and aggregation. Br. J. Pharmacol. 97: 1145-1150.
Sanderson, I. R. & He, Y. (1994) Nucleotide uptake and metabolism by intestinal
epithelial cells. J. Nutr. 124: 131S-137S.
Sandstrom, J., Nilsson, P., Karlsson, K. & Marklund, S. L. (1994) 10-fold increase in human plasma extracellular superoxide dismutase content caused by a mutation in heparin- binding domain. J Biol Chem 269: 19163-19166.
Sato, M., Suzuki, S. & Seno, H. (2003) Hepatic stellate cells: Characteristics in cell biology and phenotype. Cell Struct Funct. 28: 105-112.
Saxena, R., Theise, N.D. & Crawford, J. M. (1999) Microanatomy of the human
liver-exploring the hidden interfaces. Hepatology 30: 1339-1346
Scand, J. (1996) Animal models of liver fibrosis. Gastroenterol. 31: 1137-1143.
Schuppan, D. (1990) Structure of the extracellular matrix in normal and fibrotic liver:
collagens and glycoproteins. Seminar liver dis. 10: 1-10.
Seakins, A. & Robinson, D. S. (1963) The effect of the administration of carbon tetrachloride on the formation of plasma lipoproteins in the rat. Biochem J. 86: 401-407.
Shek, F. W. & Benyon, R. C. (2004) How can transforming growth factor beta be targeted usefully to combat liver fibrosis? Eur J Gastroenterol Hepatol. 16: 123-126
Shiba, M., Shimizu, I., Yasuda, M., Ii, K. & Ito, S. (1998) Expression of type I and
type III collagens during the course of dimethylnitrasamine-induced hepatic
fibrosis in rats. Liver 18: 196-204.
Simic, M. G. (1988) Mechanisms of inhibition of free-radical processes in mutagenesis and carcinogenesis. Mutat. Res. 202: 377-386.
Sipes, I. G., El Sisi, A. E., Simm, W. W., Mobley, S. A. & Eamnest, D. L. (1989) Role of
reactive oxygen species secreted carbon tetrachloride hepatotoxity by
hypervitaminosis A. Cells of the hepatic sinusoid ,Vol 2, Kupffer cell foundation,
Rijwijik, pp.376-379
Sohal, R. S. & Weindruch, R. (1996) Oxidative stress, caloric restriction, and aging. Science. 273(5271): 59-63.
Sonoda, T. & Tatibana, M. (1978) Metabolic fate of pyrimidines and purines in dietary
nucleic acids ingested by mice. Biochim. Biophys. Acta. 521(1): 55-66.
Stadtman, E. R. (1992) Protein oxidation and aging. Secience 257(28): 1220-1224.
Stickel, F., Brinkhaus, B., krahmer, N., Seitz, H. K., Hahn, E. G. & Schuppan, D.
(2002) Antifibrotic properties of botanicals in chronic liver disease.
Hepatogastroenterology. 49: 1102-1108.
Sturgill, M. G. & Lambert, G. H. (1997) Xenobiotic-induced hepatotoxity: mechanism of
liver injury and methods of monitoring hepaticfunction. Clin. Chem. 43: 1512-1526.
Stralin, P. & Marklund, S. L. (1994) Effects of oxidative stress on expression of
extracellular superoxide dismutase, CuZn-superoxide dismutase and
Mn-superoxide dismutase in human dermal fibroblasts. Biochem J. 298: 347-52.
Recknagel, R. O. & Glende, E. A. Jr. (1973) Carbon tetrachloride hepatotoxicity: an example of lethal cleavage. CRC Crit. Rev. Toxicol. 2: 263-268.
Richard, S. S. (1999) Clinical anatomy for medical study. Lippincott Williams & Wilkins. pp. 212-219.
Tamayo, R.P. (1983) Is cirrhosis of the liver experimentally produced by CCl4 and
adequate model of human cirrhosis. Hepatology 3: 112-120.
Tsai, L.Y., Lee, K. T., Tasi, S. M., Lee, S. C. & Yu, H. S.(1993) Changes of lipid peroxide levels in blood and liver tissue of patients with obstructive jaundice. Clin Chim Acta. 215: 41-50.
Tsukamoto, H., Matsuoka, M. & French, S. W. (1990) Experimental models of hepatic
fibrosis: A review. Semin Liver Dis. 10: 56-65.
Ursini, F., Maiorino, M., Brigelius-Flohe，, R., Aumann, K. D., Roveri, A., Schomburg, D. & Flohe，, L. (1995) Diversity of glutathione peroxidases. Meth. Enzymol. 252: 38-53.
Velmurugan, B., Bhuvaneswari, V., Balasenthil, S. & Nagini, S. (2001) Lycopene, an
antioxidant carotenoid modulates glutathione-dependent hepatic biotransformation
enzymes during experimental gastric carcinogenesis. Nutri. Res. 21: 1117-1124.
Vitorica, J., Machado, A. & Satrustegui, J. (1984) Age-dependent variations in peroxide- utilizing enzymes from rat brain mitochondria and cytoplasm. J. Neurochem. 42: 351- 356.
Wakasugi, J., Tawara, K., Katami, K., Ikeda, T. & Tomikawa, M. (1985) Action of malotilate on reduced serum cholesterol level in rats with carbon tetrachloride-induced liver damage. Jpn. J. Pharmacol. 38: 391-401.
Wanless, I. R. (1999) Physioanatomic considerations. In: Schiff ER, Sorrell MF, Maddrey
WC, eds. Disease of liver (8th ed). Philadelphia: Lippincott-Raven Publisher. 3-37.
Warner, H. R. (1994) Superoxide dismutase, aging, and degenerative disease. Free Rad. Biol. Med. 17(3): 249-258.
Weber, L. W. D., Boll, M. & Stampfl, A. 2003. Hepatotoxicity and mechanism of action
of haloalkanes: carbon tetrachloride as a toxicological model. Crit. Rev. Toxicol.
33(2): 105–136.
Wisse, E. (1970) An electron microscopic study of the fenestrated dothelial lining of rat liver sinusoid. J. Ultrastruct. Res. 31: 125-150.
Woolliams, J. A., Wiener, G., Anderson, P. H. & McMurray. C. H.(1983) Research in
Veterinary Science. 34: 253-256.
Young, I. S. & Woodside, J. V. (2001) Antioxidants in health and disease. J Clin Pathol. 54: 176-86.
Yu, B. P. (1994) Cellular defenses against damage from reactive oxygen species. Physiol. Rev. 74: 139-162.
Zhu, W. & Fung, P. C. W. (2000) The roles played by crucial freeradicals like lipid free
radicals, nitric oxide, and enzymes NOS andNADPH in CCl4-induced acute liver
injury of mice. Free Radical Biol. & Med. 29: 870-880.