跳到主要內容

臺灣博碩士論文加值系統

(3.235.120.150) 您好!臺灣時間:2021/07/31 15:25
字體大小: 字級放大   字級縮小   預設字形  
回查詢結果 :::

詳目顯示

我願授權國圖
: 
twitterline
研究生:張育華
研究生(外文):Yu-Hua Chang
論文名稱:sGC刺激劑BAY41-2272影響人類嗜中性白血球MAPKs訊號傳遞路徑的機轉探討
論文名稱(外文):Effects of BAY 41-2272, a sGC Stimulator, on MAPKs Activation in Human Neutrophils
指導教授:黃聰龍黃聰龍引用關係
指導教授(外文):Tsong-Long Hwang
學位類別:碩士
校院名稱:長庚大學
系所名稱:天然藥物研究所
學門:醫藥衛生學門
學類:藥學學類
論文種類:學術論文
論文出版年:2007
畢業學年度:95
語文別:中文
論文頁數:80
中文關鍵詞:人類嗜中性白血球環狀核苷酸訊號傳遞
外文關鍵詞:human neutrophilcGMPMAPKs
相關次數:
  • 被引用被引用:0
  • 點閱點閱:118
  • 評分評分:
  • 下載下載:0
  • 收藏至我的研究室書目清單書目收藏:0
BAY 41-2272 (5-Cyclopropyl-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-4-ylamine),是一個和nitric oxide (NO) 不相關的soluble guanylyl cyclase (sGC) 刺激劑,被認為是一個可作為研究sGC/guanosine 3’,5’-cyclic monophosphate (cGMP) 訊號傳遞路徑的工具,也被視為是有治療心血管疾病潛力的一個新化合物。Mitogen-activated protein kinases (MAPKs) 在調節人類嗜中性白血球功能上扮演重要角色,包括化學趨性 (chemotaxis)、呼吸爆破 (respiratory burst)、胞吐作用 (exocytosis)、細胞激素的合成 (cytokine synthesis) 以及細胞凋亡 (apoptosis) 等細胞生理反應都受MAPKs訊號傳遞路徑所調控。然而,cGMP在人類嗜中性白血球中,對於MAPKs活化過程所扮演的角色目前仍存有許多爭議。因此,本論文探討在人類嗜中性白血球中,BAY 41-2272對p38、ERK1/2與JNK MAPKs活化的影響,並瞭解BAY 41-2272與NO對MAPKs活化的協同作用性;同時使用藥理性的致效劑與抑制劑來進行相關性研究。實驗結果顯示,BAY 41-2272在人類嗜中性白血球中確實可以增加sGC的活性和cGMP的形成,而且會大大提升sodium nitroprusside (SNP) 促進sGC活性、增加cGMP含量的能力。以BAY 41-2272 (1, 3 and 10 μM) 刺激人類嗜中性白血球會有濃度相關性顯著地活化MAPKs的作用。然而,令人驚訝的是,SNP不僅本身對MAPKs磷酸化沒有影響,亦無法加強BAY 41-2272活化MAPKs的作用,這樣的結果顯示BAY 41-2272與NO所造成細胞內cGMP含量顯著增加的協同作用,與對MAPKs的活化作用並不一致。進一步地,以一個可穿透細胞膜的cGMP類似物- dibutyryl cGMP單獨刺激細胞,發現不影響細胞內MAPKs活化。另外,sGC的抑制劑- ODQ亦無法抑制BAY 41-2272活化MAPKs。因此推論在人類嗜中性白血球中,BAY 41-2272是透過與sGC/cGMP不相關的訊號路徑來活化MAPKs。本論文的結果說明,當使用BAY 41-2272來探討活化sGC所造成的生理反應與臨床應用時,必須留意其可能造成與sGC/cGMP不相關的影響。
BAY 41-2272 (5-Cyclopropyl-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-4-ylamine), a novel nitric oxide (NO)-independent direct stimulator of soluble guanylyl cyclase (sGC), is a useful tool for investigating the signaling of guanosine 3’,5’-cyclic monophosphate (cGMP) and may offer a new approach for treating cardiovascular diseases. Mitogen-activated protein kinases (MAPKs) play an important role in modulating human neutrophil functions, including chemotaxis, respiratory burst, exocytosis, cytokine synthesis and apoptosis. However, the precise role of cGMP in regulating activation of MAPKs is still controversial. In the present study, the effects of BAY 41-2272 on activation of p38, ERK1/2 and JNK MAPKs were studied in human neutrophils. In particular, several pharmacological agonists and inhibitors as well as the synergistic action of BAY 41-2272 and NO were used to elucidate the action mechanisms in greater detail. BAY 41-2272 not only directly promoted sGC activity and cGMP formation but also dramatically potentiated sodium nitroprusside (SNP)-induced sGC activity and cGMP formation in human neutrophils. Treatment of neutrophils with BAY 41-2272 (1, 3 and 10 μM) resulted in a rapid and significant phosphorylation of MAPKs in a concentration-dependent manner. Surprisingly, SNP did not alter phosphorylation of MAPKs, and it failed to enhance the effects of BAY 41-2272. These data indicated that the synergistic increases in cGMP levels were not consistent with the MAPKs activation. Furthermore, dibutyryl cGMP, a membrane permeant cGMP analogue, didn’t elicit significant effects on MAPKs activation. In addition, ODQ, a sGC inhibitor, failed to inhibit BAY 41-2272-induced phosphorylation of MAPKs in human neutrophils. In summary, our data demonstrate that BAY 41-2272 activates MAPKs in human neutrophils by a cGMP-independent pathway. Caution thus needs to be used in attributing the BAY 41-2272-mediated response to the activation of sGC.
指導教授推薦書…………………………………
口試委員會審定書………………………………
授權書……………………………………………III
誌謝………………………………………………IV
縮寫表……………………………………………V
中文摘要…………………………………………VII
英文摘要…………………………………………VIII
目錄………………………………………………IX
研究動機…………………………………………1
壹、緒論…………………………………………3
貳、實驗材料與方法……………………………19
參、結果…………………………………………25
肆、討論…………………………………………32
伍、結論…………………………………………38
陸、附圖…………………………………………39
柒、參考文獻……………………………………62
Akgul, C., D.A. Moulding, and S.W. Edwards. 2001. Molecular control of neutrophil apoptosis. FEBS Lett. 487:318-22.
al-Essa, L., M. Niwa, K. Kohno, and K. Tsurumi. 1994. A proposal for purification of salivary polymorphonuclear leukocytes by combination of nylon mesh filtration and density-gradient method: a validation by superoxide- and cyclic AMP-generating responses. Life Sci. 55:PL333-8.
Anderson, R. 1995. The activated neutrophil--formidable forces unleashed. S Afr Med J. 85:1024-8.
Arndt, P.G., N. Suzuki, N.J. Avdi, K.C. Malcolm, and G.S. Worthen. 2004. Lipopolysaccharide-induced c-Jun NH2-terminal kinase activation in human neutrophils: role of phosphatidylinositol 3-Kinase and Syk-mediated pathways. J Biol Chem. 279:10883-91.
Avdi, N.J., J.A. Nick, B.B. Whitlock, M.A. Billstrom, P.M. Henson, G.L. Johnson, and G.S. Worthen. 2001. Tumor necrosis factor-alpha activation of the c-Jun N-terminal kinase pathway in human neutrophils. Integrin involvement in a pathway leading from cytoplasmic tyrosine kinases apoptosis. J Biol Chem. 276:2189-99.
Aviram, I., and M. Sharabani. 1989. Inositol lipids and phosphatidic acid inhibit cell-free activation of neutrophil NADPH oxidase. Biochem Biophys Res Commun. 161:712-9.
Bawankule, D.U., K. Sathishkumar, K.K. Sardar, D. Chanda, A.V. Krishna, V.R. Prakash, and S.K. Mishra. 2005. BAY 41-2272 [5-cyclopropyl-2-[1-(2-fluoro-benzyl)-1H-pyrazolo[3,4-b]pyridine-3-yl]pyri midin-4-ylamine]-induced dilation in ovine pulmonary artery: role of sodium pump. J Pharmacol Exp Ther. 314:207-13.
Becker, E.M., C. Alonso-Alija, H. Apeler, R. Gerzer, T. Minuth, U. Pleiss, P. Schmidt, M. Schramm, H. Schroder, W. Schroeder, W. Steinke, A. Straub, and J.P. Stasch. 2001. NO-independent regulatory site of direct sGC stimulators like YC-1 and BAY 41-2272. BMC Pharmacol. 1:13.
Becker, E.M., P. Schmidt, M. Schramm, H. Schroder, U. Walter, M. Hoenicka, R. Gerzer, and J.P. Stasch. 2000. The vasodilator-stimulated phosphoprotein (VASP): target of YC-1 and nitric oxide effects in human and rat platelets. J Cardiovasc Pharmacol. 35:390-7.
Bennett, B.L., D.T. Sasaki, B.W. Murray, E.C. O'Leary, S.T. Sakata, W. Xu, J.C. Leisten, A. Motiwala, S. Pierce, Y. Satoh, S.S. Bhagwat, A.M. Manning, and D.W. Anderson. 2001. SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase. Proc Natl Acad Sci U S A. 98:13681-6.
Berkow, R.L., D. Wang, J.W. Larrick, R.W. Dodson, and T.H. Howard. 1987. Enhancement of neutrophil superoxide production by preincubation with recombinant human tumor necrosis factor. J Immunol. 139:3783-91.
Bettinger, B.T., and D.C. Amberg. 2007. The MEK kinases MEKK4/Ssk2p facilitate complexity in the stress signaling responses of diverse systems. J Cell Biochem. 101:34-43.
Boerrigter, G., and J.C. Burnett, Jr. 2007. Nitric oxide-independent stimulation of soluble guanylate cyclase with BAY 41-2272 in cardiovascular disease. Cardiovasc Drug Rev. 25:30-45.
Boerrigter, G., L.C. Costello-Boerrigter, A. Cataliotti, T. Tsuruda, G.J. Harty, H. Lapp, J.P. Stasch, and J.C. Burnett, Jr. 2003. Cardiorenal and humoral properties of a novel direct soluble guanylate cyclase stimulator BAY 41-2272 in experimental congestive heart failure. Circulation. 107:686-9.
Bonny, C., A. Oberson, S. Negri, C. Sauser, and D.F. Schorderet. 2001. Cell-permeable peptide inhibitors of JNK: novel blockers of beta-cell death. Diabetes. 50:77-82.
Borges de Oliveira-Junior, E., S.M. Thomazzi, J. Rehder, E. Antunes, and A. Condino-Neto. 2007. Effects of BAY 41-2272, an activator of nitric oxide-independent site of soluble guanylate cyclase, on human NADPH oxidase system from THP-1 cells. Eur J Pharmacol. 567:43-9.
Brancho, D., N. Tanaka, A. Jaeschke, J.J. Ventura, N. Kelkar, Y. Tanaka, M. Kyuuma, T. Takeshita, R.A. Flavell, and R.J. Davis. 2003. Mechanism of p38 MAP kinase activation in vivo. Genes Dev. 17:1969-78.
Brinkmann, V., U. Reichard, C. Goosmann, B. Fauler, Y. Uhlemann, D.S. Weiss, Y. Weinrauch, and A. Zychlinsky. 2004. Neutrophil extracellular traps kill bacteria. Science. 303:1532-5.
Brioni, J.D., M. Nakane, G.C. Hsieh, R.B. Moreland, T. Kolasa, and J.P. Sullivan. 2002. Activators of soluble guanylate cyclase for the treatment of male erectile dysfunction. Int J Impot Res. 14:8-14.
Bromberg, Y., and E. Pick. 1985. Activation of NADPH-dependent superoxide production in a cell-free system by sodium dodecyl sulfate. J Biol Chem. 260:13539-45.
Browning, D.D., M.P. McShane, C. Marty, and R.D. Ye. 2000. Nitric oxide activation of p38 mitogen-activated protein kinase in 293T fibroblasts requires cGMP-dependent protein kinase. J Biol Chem. 275:2811-6.
Browning, D.D., N.D. Windes, and R.D. Ye. 1999. Activation of p38 mitogen-activated protein kinase by lipopolysaccharide in human neutrophils requires nitric oxide-dependent cGMP accumulation. J Biol Chem. 274:537-42.
Brunetti, M., N. Mascetra, S. Manarini, N. Martelli, C. Cerletti, P. Musiani, F.B. Aiello, and V. Evangelista. 2002. Inhibition of cGMP-dependent protein kinases potently decreases neutrophil spontaneous apoptosis. Biochem Biophys Res Commun. 297:498-501.
Caramori, G., and A. Papi. 2004. Oxidants and asthma. Thorax. 59:170-3.
Cavicchioni, G., A. Fraulini, M. Turchetti, K. Varani, S. Falzarano, B. Pavan, and S. Spisani. 2005. Biological activity of for-Met-Leu-Phe-OMe analogs: relevant substitutions specifically trigger killing mechanisms in human neutrophils. Eur J Pharmacol. 512:1-8.
Chen, L.W., M.W. Lin, and C.M. Hsu. 2005. Different pathways leading to activation of extracellular signal-regulated kinase and p38 MAP kinase by formyl-methionyl-leucyl-phenylalanine or platelet activating factor in human neutrophils. J Biomed Sci. 12:311-9.
Coffey, R.D., K.W. Mooney, G.L. Cromwell, and D.K. Aaron. 1994. Biological availability of phosphorus in defluorinated phosphates with different phosphorus solubilities in neutral ammonium citrate for chicks and pigs. J Anim Sci. 72:2653-60.
Condliffe, A.M., E. Kitchen, and E.R. Chilvers. 1998. Neutrophil priming: pathophysiological consequences and underlying mechanisms. Clin Sci (Lond). 94:461-71.
Corriveau, C.C., P.J. Madara, A.L. Van Dervort, M.M. Tropea, R.A. Wesley, and R.L. Danner. 1998. Effects of nitric oxide on chemotaxis and endotoxin-induced interleukin-8 production in human neutrophils. J Infect Dis. 177:116-26.
Dallegri, F., and L. Ottonello. 1997. Tissue injury in neutrophilic inflammation. Inflamm Res. 46:382-91.
Davis, R.J. 2000. Signal transduction by the JNK group of MAP kinases. Cell. 103:239-52.
Denninger, J.W., J.P. Schelvis, P.E. Brandish, Y. Zhao, G.T. Babcock, and M.A. Marletta. 2000. Interaction of soluble guanylate cyclase with YC-1: kinetic and resonance Raman studies. Biochemistry. 39:4191-8.
Derijard, B., J. Raingeaud, T. Barrett, I.H. Wu, J. Han, R.J. Ulevitch, and R.J. Davis. 1995. Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms. Science. 267:682-5.
Deruelle, P., V. Balasubramaniam, A.M. Kunig, G.J. Seedorf, N.E. Markham, and S.H. Abman. 2006. BAY 41-2272, a direct activator of soluble guanylate cyclase, reduces right ventricular hypertrophy and prevents pulmonary vascular remodeling during chronic hypoxia in neonatal rats. Biol Neonate. 90:135-44.
Deruelle, P., T.R. Grover, L. Storme, and S.H. Abman. 2005. Effects of BAY 41-2272, a soluble guanylate cyclase activator, on pulmonary vascular reactivity in the ovine fetus. Am J Physiol Lung Cell Mol Physiol. 288:L727-33.
Dewas, C., M. Fay, M.A. Gougerot-Pocidalo, and J. El-Benna. 2000. The mitogen-activated protein kinase extracellular signal-regulated kinase 1/2 pathway is involved in formyl-methionyl-leucyl-phenylalanine-induced p47phox phosphorylation in human neutrophils. J Immunol. 165:5238-44.
Dhawan, P., A. Bell, A. Kumar, C. Golden, and K.D. Mehta. 1999. Critical role of p42/44(MAPK) activation in anisomycin and hepatocyte growth factor-induced LDL receptor expression: activation of Raf-1/Mek-1/p42/44(MAPK) cascade alone is sufficient to induce LDL receptor expression. J Lipid Res. 40:1911-9.
Downey, G.P., J.R. Butler, H. Tapper, L. Fialkow, A.R. Saltiel, B.B. Rubin, and S. Grinstein. 1998. Importance of MEK in neutrophil microbicidal responsiveness. J Immunol. 160:434-43.
Downey, G.P., T. Fukushima, L. Fialkow, and T.K. Waddell. 1995. Intracellular signaling in neutrophil priming and activation. Semin Cell Biol. 6:345-56.
Dumitrascu, R., N. Weissmann, H.A. Ghofrani, E. Dony, K. Beuerlein, H. Schmidt, J.P. Stasch, M.J. Gnoth, W. Seeger, F. Grimminger, and R.T. Schermuly. 2006. Activation of soluble guanylate cyclase reverses experimental pulmonary hypertension and vascular remodeling. Circulation. 113:286-95.
El Benna, J., J. Han, J.W. Park, E. Schmid, R.J. Ulevitch, and B.M. Babior. 1996. Activation of p38 in stimulated human neutrophils: phosphorylation of the oxidase component p47phox by p38 and ERK but not by JNK. Arch Biochem Biophys. 334:395-400.
Ervens, J., G. Schultz, and R. Seifert. 1991. Differential regulation of chemoattractant-induced superoxide formation in human neutrophils by cell-permeant analogues of cyclic AMP and cyclic GMP. Biochem Soc Trans. 19:59-63.
Evgenov, O.V., F. Ichinose, N.V. Evgenov, M.J. Gnoth, G.E. Falkowski, Y. Chang, K.D. Bloch, and W.M. Zapol. 2004. Soluble guanylate cyclase activator reverses acute pulmonary hypertension and augments the pulmonary vasodilator response to inhaled nitric oxide in awake lambs. Circulation. 110:2253-9.
Evgenov, O.V., P. Pacher, P.M. Schmidt, G. Hasko, H.H. Schmidt, and J.P. Stasch. 2006. NO-independent stimulators and activators of soluble guanylate cyclase: discovery and therapeutic potential. Nat Rev Drug Discov. 5:755-68.
Faurschou, M., and N. Borregaard. 2003. Neutrophil granules and secretory vesicles in inflammation. Microbes Infect. 5:1317-27.
Filippi, S., C. Crescioli, G.B. Vannelli, A. Fazzini, A. Natali, J.P. Riffaud, M. Maggi, and F. Ledda. 2003. Effects of NCX 4050, a new NO donor, in rabbit and human corpus cavernosum. Int J Androl. 26:101-8.
Frasch, S.C., J.A. Nick, V.A. Fadok, D.L. Bratton, G.S. Worthen, and P.M. Henson. 1998. p38 mitogen-activated protein kinase-dependent and -independent intracellular signal transduction pathways leading to apoptosis in human neutrophils. J Biol Chem. 273:8389-97.
Friebe, A., and D. Koesling. 2003. Regulation of nitric oxide-sensitive guanylyl cyclase. Circ Res. 93:96-105.
Friebe, A., F. Mullershausen, A. Smolenski, U. Walter, G. Schultz, and D. Koesling. 1998. YC-1 potentiates nitric oxide- and carbon monoxide-induced cyclic GMP effects in human platelets. Mol Pharmacol. 54:962-7.
Friebe, A., G. Schultz, and D. Koesling. 1996. Sensitizing soluble guanylyl cyclase to become a highly CO-sensitive enzyme. Embo J. 15:6863-8.
Friebe, A., B. Wedel, C. Harteneck, J. Foerster, G. Schultz, and D. Koesling. 1997. Functions of conserved cysteines of soluble guanylyl cyclase. Biochemistry. 36:1194-8.
Fumagalli, L., H. Zhang, A. Baruzzi, C.A. Lowell, and G. Berton. 2007. The Src family kinases Hck and Fgr regulate neutrophil responses to N-formyl-methionyl-leucyl-phenylalanine. J Immunol. 178:3874-85.
Garthwaite, J., E. Southam, C.L. Boulton, E.B. Nielsen, K. Schmidt, and B. Mayer. 1995. Potent and selective inhibition of nitric oxide-sensitive guanylyl cyclase by 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one. Mol Pharmacol. 48:184-8.
Gerzer, R., E. Bohme, F. Hofmann, and G. Schultz. 1981. Soluble guanylate cyclase purified from bovine lung contains heme and copper. FEBS Lett. 132:71-4.
Gladis-Villanueva, M., and K. Schror. 1996. Synergistic inhibition of human polymorphonuclear function by prostaglandin E1 and linsidomine. J Pharm Pharmacol. 48:706-11.
Grill, B., and J.W. Schrader. 2002. Activation of Rac-1, Rac-2, and Cdc42 by hemopoietic growth factors or cross-linking of the B-lymphocyte receptor for antigen. Blood. 100:3183-92.
Grinstein, S., and W. Furuya. 1992. Chemoattractant-induced tyrosine phosphorylation and activation of microtubule-associated protein kinase in human neutrophils. J Biol Chem. 267:18122-5.
Haas, M., A. Askari, and Z. Xie. 2000. Involvement of Src and epidermal growth factor receptor in the signal-transducing function of Na+/K+-ATPase. J Biol Chem. 275:27832-7.
Hale, K.K., D. Trollinger, M. Rihanek, and C.L. Manthey. 1999. Differential expression and activation of p38 mitogen-activated protein kinase alpha, beta, gamma, and delta in inflammatory cell lineages. J Immunol. 162:4246-52.
Hampton, M.B., A.J. Kettle, and C.C. Winterbourn. 1998. Inside the neutrophil phagosome: oxidants, myeloperoxidase, and bacterial killing. Blood. 92:3007-17.
Hampton, M.B., and C.C. Winterbourn. 1995. Modification of neutrophil oxidant production with diphenyleneiodonium and its effect on bacterial killing. Free Radic Biol Med. 18:633-9.
Han, J., J.D. Lee, Y. Jiang, Z. Li, L. Feng, and R.J. Ulevitch. 1996. Characterization of the structure and function of a novel MAP kinase kinase (MKK6). J Biol Chem. 271:2886-91.
Hazzalin, C.A., R. Le Panse, E. Cano, and L.C. Mahadevan. 1998. Anisomycin selectively desensitizes signalling components involved in stress kinase activation and fos and jun induction. Mol Cell Biol. 18:1844-54.
Hii, C.S., Z.H. Huang, A. Bilney, M. Costabile, A.W. Murray, D.A. Rathjen, C.J. Der, and A. Ferrante. 1998. Stimulation of p38 phosphorylation and activity by arachidonic acid in HeLa cells, HL60 promyelocytic leukemic cells, and human neutrophils. Evidence for cell type-specific activation of mitogen-activated protein kinases. J Biol Chem. 273:19277-82.
Hirano, S., R.S. Rees, and R.R. Gilmont. 2002. MAP kinase pathways involving hsp27 regulate fibroblast-mediated wound contraction. J Surg Res. 102:77-84.
Ho, A.K., K. Hashimoto, and C.L. Chik. 1999. 3',5'-cyclic guanosine monophosphate activates mitogen-activated protein kinase in rat pinealocytes. J Neurochem. 73:598-604.
Hoenicka, M., E.M. Becker, H. Apeler, T. Sirichoke, H. Schroder, R. Gerzer, and J.P. Stasch. 1999. Purified soluble guanylyl cyclase expressed in a baculovirus/Sf9 system: stimulation by YC-1, nitric oxide, and carbon monoxide. J Mol Med. 77:14-23.
Hofman, P. 2004. Molecular regulation of neutrophil apoptosis and potential targets for therapeutic strategy against the inflammatory process. Curr Drug Targets Inflamm Allergy. 3:1-9.
Hood, J., and H.J. Granger. 1998. Protein kinase G mediates vascular endothelial growth factor-induced Raf-1 activation and proliferation in human endothelial cells. J Biol Chem. 273:23504-8.
Huang, R., J.P. Lian, D. Robinson, and J.A. Badwey. 1998. Neutrophils stimulated with a variety of chemoattractants exhibit rapid activation of p21-activated kinases (Paks): separate signals are required for activation and inactivation of paks. Mol Cell Biol. 18:7130-8.
Humbert, P., F. Niroomand, G. Fischer, B. Mayer, D. Koesling, K.D. Hinsch, H. Gausepohl, R. Frank, G. Schultz, and E. Bohme. 1990. Purification of soluble guanylyl cyclase from bovine lung by a new immunoaffinity chromatographic method. Eur J Biochem. 190:273-8.
Hwang, T.L., H.W. Hung, S.H. Kao, C.M. Teng, C.C. Wu, and S.J. Cheng. 2003. Soluble guanylyl cyclase activator YC-1 inhibits human neutrophil functions through a cGMP-independent but cAMP-dependent pathway. Mol Pharmacol. 64:1419-27.
Ichijo, H., E. Nishida, K. Irie, P. ten Dijke, M. Saitoh, T. Moriguchi, M. Takagi, K. Matsumoto, K. Miyazono, and Y. Gotoh. 1997. Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways. Science. 275:90-4.
Inoue, T., D.L. Boyle, M. Corr, D. Hammaker, R.J. Davis, R.A. Flavell, and G.S. Firestein. 2006. Mitogen-activated protein kinase kinase 3 is a pivotal pathway regulating p38 activation in inflammatory arthritis. Proc Natl Acad Sci U S A. 103:5484-9.
Iordanov, M.S., D. Pribnow, J.L. Magun, T.H. Dinh, J.A. Pearson, S.L. Chen, and B.E. Magun. 1997. Ribotoxic stress response: activation of the stress-activated protein kinase JNK1 by inhibitors of the peptidyl transferase reaction and by sequence-specific RNA damage to the alpha-sarcin/ricin loop in the 28S rRNA. Mol Cell Biol. 17:3373-81.
Irving, E.A., and M. Bamford. 2002. Role of mitogen- and stress-activated kinases in ischemic injury. J Cereb Blood Flow Metab. 22:631-47.
Jenei, V., R.K. Deevi, C.A. Adams, L. Axelsson, D.G. Hirst, T. Andersson, and K. Dib. 2006. Nitric oxide produced in response to engagement of beta2 integrins on human neutrophils activates the monomeric GTPases Rap1 and Rap2 and promotes adhesion. J Biol Chem. 281:35008-20.
Jiang, Y., C. Chen, Z. Li, W. Guo, J.A. Gegner, S. Lin, and J. Han. 1996. Characterization of the structure and function of a new mitogen-activated protein kinase (p38beta). J Biol Chem. 271:17920-6.
Jinnouchi, A., Y. Aida, K. Nozoe, K. Maeda, and M.J. Pabst. 2005. Local anesthetics inhibit priming of neutrophils by lipopolysaccharide for enhanced release of superoxide: suppression of cytochrome b558 expression by disparate mechanisms. J Leukoc Biol. 78:1356-65.
Jozsef, L., T. Khreiss, A. Fournier, J.S. Chan, and J.G. Filep. 2002. Extracellular signal-regulated kinase plays an essential role in endothelin-1-induced homotypic adhesion of human neutrophil granulocytes. Br J Pharmacol. 135:1167-74.
Kaminska, B. 2005. MAPK signalling pathways as molecular targets for anti-inflammatory therapy--from molecular mechanisms to therapeutic benefits. Biochim Biophys Acta. 1754:253-62.
Kamisaki, Y., S. Saheki, M. Nakane, J.A. Palmieri, T. Kuno, B.Y. Chang, S.A. Waldman, and F. Murad. 1986. Soluble guanylate cyclase from rat lung exists as a heterodimer. J Biol Chem. 261:7236-41.
Kasper, B., E. Brandt, M. Ernst, and F. Petersen. 2006. Neutrophil adhesion to endothelial cells induced by platelet factor 4 requires sequential activation of Ras, Syk, and JNK MAP kinases. Blood. 107:1768-75.
Kato, T., and S. Kitagawa. 2006. Regulation of neutrophil functions by proinflammatory cytokines. Int J Hematol. 84:205-9.
Kawabata, K., T. Hagio, and S. Matsuoka. 2002. The role of neutrophil elastase in acute lung injury. Eur J Pharmacol. 451:1-10.
Kelicen, P., I. Cantuti-Castelvetri, C. Pekiner, and K.E. Paulson. 2002. The spin trapping agent PBN stimulates H2 O2 -induced Erk and Src kinase activity in human neuroblastoma cells. Neuroreport. 13:1057-61.
Kerstjens, H.A., and W. Timens. 2003. Phosphodiesterase 4 inhibitors: antiinflammatory therapy for chronic obstructive pulmonary disease at last? Am J Respir Crit Care Med. 168:914-5.
Kharitonov, V.G., V.S. Sharma, D. Magde, and D. Koesling. 1999. Kinetics and equilibria of soluble guanylate cyclase ligation by CO: effect of YC-1. Biochemistry. 38:10699-706.
Kilpatrick, L.E., S. Sun, D. Mackie, F. Baik, H. Li, and H.M. Korchak. 2006. Regulation of TNF mediated antiapoptotic signaling in human neutrophils: role of delta-PKC and ERK1/2. J Leukoc Biol. 80:1512-21.
Kim, H.P., S.W. Ryter, and A.M. Choi. 2006. CO as a cellular signaling molecule. Annu Rev Pharmacol Toxicol. 46:411-49.
Ko, F.N., C.C. Wu, S.C. Kuo, F.Y. Lee, and C.M. Teng. 1994. YC-1, a novel activator of platelet guanylate cyclase. Blood. 84:4226-33.
Kobayashi, S.D., J.M. Voyich, C. Burlak, and F.R. DeLeo. 2005. Neutrophils in the innate immune response. Arch Immunol Ther Exp (Warsz). 53:505-17.
Kobayashi, S.D., J.M. Voyich, and F.R. DeLeo. 2003. Regulation of the neutrophil-mediated inflammatory response to infection. Microbes Infect. 5:1337-44.
Koesling, D., M. Russwurm, E. Mergia, F. Mullershausen, and A. Friebe. 2004. Nitric oxide-sensitive guanylyl cyclase: structure and regulation. Neurochem Int. 45:813-9.
Koglin, M., and S. Behrends. 2003. A functional domain of the alpha1 subunit of soluble guanylyl cyclase is necessary for activation of the enzyme by nitric oxide and YC-1 but is not involved in heme binding. J Biol Chem. 278:12590-7.
Komalavilas, P., P.K. Shah, H. Jo, and T.M. Lincoln. 1999. Activation of mitogen-activated protein kinase pathways by cyclic GMP and cyclic GMP-dependent protein kinase in contractile vascular smooth muscle cells. J Biol Chem. 274:34301-9.
Krump, E., J.S. Sanghera, S.L. Pelech, W. Furuya, and S. Grinstein. 1997. Chemotactic peptide N-formyl-met-leu-phe activation of p38 mitogen-activated protein kinase (MAPK) and MAPK-activated protein kinase-2 in human neutrophils. J Biol Chem. 272:937-44.
Kuroki, M., and J.T. O'Flaherty. 1997. Differential effects of a mitogen-activated protein kinase kinase inhibitor on human neutrophil responses to chemotactic factors. Biochem Biophys Res Commun. 232:474-7.
Kutsuna, H., K. Suzuki, N. Kamata, T. Kato, F. Hato, K. Mizuno, H. Kobayashi, M. Ishii, and S. Kitagawa. 2004. Actin reorganization and morphological changes in human neutrophils stimulated by TNF, GM-CSF, and G-CSF: the role of MAP kinases. Am J Physiol Cell Physiol. 286:C55-64.
Kyriakis, J.M., and J. Avruch. 2001. Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation. Physiol Rev. 81:807-69.
Lad, P.M., M.M. Glovsky, J.H. Richards, P.A. Smiley, and B. Backstrom. 1985. Regulation of human neutrophil guanylate cyclase by metal ions, free radicals and the muscarinic cholinergic receptor. Mol Immunol. 22:731-9.
Lamothe, M., F.J. Chang, N. Balashova, R. Shirokov, and A. Beuve. 2004. Functional characterization of nitric oxide and YC-1 activation of soluble guanylyl cyclase: structural implication for the YC-1 binding site? Biochemistry. 43:3039-48.
Lawrence, D.W., and K.B. Pryzwansky. 2001. The vasodilator-stimulated phosphoprotein is regulated by cyclic GMP-dependent protein kinase during neutrophil spreading. J Immunol. 166:5550-6.
Lee, J.C., J.T. Laydon, P.C. McDonnell, T.F. Gallagher, S. Kumar, D. Green, D. McNulty, M.J. Blumenthal, J.R. Heys, S.W. Landvatter, and et al. 1994. A protein kinase involved in the regulation of inflammatory cytokine biosynthesis. Nature. 372:739-46.
Lee, K., and W.J. Esselman. 2002. Inhibition of PTPs by H(2)O(2) regulates the activation of distinct MAPK pathways. Free Radic Biol Med. 33:1121-32.
Lee, W.L., R.E. Harrison, and S. Grinstein. 2003. Phagocytosis by neutrophils. Microbes Infect. 5:1299-306.
Li, Z., G. Zhang, R. Feil, J. Han, and X. Du. 2006. Sequential activation of p38 and ERK pathways by cGMP-dependent protein kinase leading to activation of the platelet integrin alphaIIb beta3. Blood. 107:965-72.
Liao, C.H., J.T. Cheng, and C.M. Teng. 2005. Interference of neutrophil-platelet interaction by YC-1: a cGMP-dependent manner on heterotypic cell-cell interaction. Eur J Pharmacol. 519:158-67.
Lin, A., A. Minden, H. Martinetto, F.X. Claret, C. Lange-Carter, F. Mercurio, G.L. Johnson, and M. Karin. 1995. Identification of a dual specificity kinase that activates the Jun kinases and p38-Mpk2. Science. 268:286-90.
Lohmann, S.M., A.B. Vaandrager, A. Smolenski, U. Walter, and H.R. De Jonge. 1997. Distinct and specific functions of cGMP-dependent protein kinases. Trends Biochem Sci. 22:307-12.
Martin, E., K. Czarnecki, V. Jayaraman, F. Murad, and J. Kincaid. 2005. Resonance Raman and infrared spectroscopic studies of high-output forms of human soluble guanylyl cyclase. J Am Chem Soc. 127:4625-31.
Mayer-Scholl, A., P. Averhoff, and A. Zychlinsky. 2004. How do neutrophils and pathogens interact? Curr Opin Microbiol. 7:62-6.
McCubrey, J.A., M.M. Lahair, and R.A. Franklin. 2006. Reactive oxygen species-induced activation of the MAP kinase signaling pathways. Antioxid Redox Signal. 8:1775-89.
McLaughlin, N.J., A. Banerjee, M.R. Kelher, F. Gamboni-Robertson, C. Hamiel, F.R. Sheppard, E.E. Moore, and C.C. Silliman. 2006. Platelet-activating factor-induced clathrin-mediated endocytosis requires beta-arrestin-1 recruitment and activation of the p38 MAPK signalosome at the plasma membrane for actin bundle formation. J Immunol. 176:7039-50.
McLeish, K.R., C. Knall, R.A. Ward, P. Gerwins, P.Y. Coxon, J.B. Klein, and G.L. Johnson. 1998. Activation of mitogen-activated protein kinase cascades during priming of human neutrophils by TNF-alpha and GM-CSF. J Leukoc Biol. 64:537-45.
Mergia, E., A. Friebe, O. Dangel, M. Russwurm, and D. Koesling. 2006. Spare guanylyl cyclase NO receptors ensure high NO sensitivity in the vascular system. J Clin Invest. 116:1731-7.
Miller, L.N., M. Nakane, G.C. Hsieh, R. Chang, T. Kolasa, R.B. Moreland, and J.D. Brioni. 2003. A-350619: a novel activator of soluble guanylyl cyclase. Life Sci. 72:1015-25.
Mocsai, A., B. Banfi, A. Kapus, G. Farkas, M. Geiszt, L. Buday, A. Farago, and E. Ligeti. 1997. Differential effects of tyrosine kinase inhibitors and an inhibitor of the mitogen-activated protein kinase cascade on degranulation and superoxide production of human neutrophil granulocytes. Biochem Pharmacol. 54:781-9.
Mocsai, A., Z. Jakus, T. Vantus, G. Berton, C.A. Lowell, and E. Ligeti. 2000. Kinase pathways in chemoattractant-induced degranulation of neutrophils: the role of p38 mitogen-activated protein kinase activated by Src family kinases. J Immunol. 164:4321-31.
Moodie, S.A., M.J. Paris, W. Kolch, and A. Wolfman. 1994. Association of MEK1 with p21ras.GMPPNP is dependent on B-Raf. Mol Cell Biol. 14:7153-62.
Moriguchi, T., N. Kuroyanagi, K. Yamaguchi, Y. Gotoh, K. Irie, T. Kano, K. Shirakabe, Y. Muro, H. Shibuya, K. Matsumoto, E. Nishida, and M. Hagiwara. 1996. A novel kinase cascade mediated by mitogen-activated protein kinase kinase 6 and MKK3. J Biol Chem. 271:13675-9.
Mulsch, A., J. Bauersachs, A. Schafer, J.P. Stasch, R. Kast, and R. Busse. 1997. Effect of YC-1, an NO-independent, superoxide-sensitive stimulator of soluble guanylyl cyclase, on smooth muscle responsiveness to nitrovasodilators. Br J Pharmacol. 120:681-9.
Nahas, N., T.F. Molski, G.A. Fernandez, and R.I. Sha'afi. 1996. Tyrosine phosphorylation and activation of a new mitogen-activated protein (MAP)-kinase cascade in human neutrophils stimulated with various agonists. Biochem J. 318 ( Pt 1):247-53.
Nakamae-Akahori, M., T. Kato, S. Masuda, E. Sakamoto, H. Kutsuna, F. Hato, Y. Nishizawa, M. Hino, and S. Kitagawa. 2006. Enhanced neutrophil motility by granulocyte colony-stimulating factor: the role of extracellular signal-regulated kinase and phosphatidylinositol 3-kinase. Immunology. 119:393-403.
Nakane, M. 2003. Soluble guanylyl cyclase: physiological role as an NO receptor and the potential molecular target for therapeutic application. Clin Chem Lab Med. 41:865-70.
Nanamori, M., J. Chen, X. Du, and R.D. Ye. 2007. Regulation of leukocyte degranulation by cGMP-dependent protein kinase and phosphoinositide 3-kinase: potential roles in phosphorylation of target membrane SNARE complex proteins in rat mast cells. J Immunol. 178:416-27.
Nick, J.A., N.J. Avdi, S.K. Young, C. Knall, P. Gerwins, G.L. Johnson, and G.S. Worthen. 1997. Common and distinct intracellular signaling pathways in human neutrophils utilized by platelet activating factor and FMLP. J Clin Invest. 99:975-86.
Niggli, V. 2003a. Microtubule-disruption-induced and chemotactic-peptide-induced migration of human neutrophils: implications for differential sets of signalling pathways. J Cell Sci. 116:813-22.
Niggli, V. 2003b. Signaling to migration in neutrophils: importance of localized pathways. Int J Biochem Cell Biol. 35:1619-38.
O'Donnell, B.V., D.G. Tew, O.T. Jones, and P.J. England. 1993. Studies on the inhibitory mechanism of iodonium compounds with special reference to neutrophil NADPH oxidase. Biochem J. 290 ( Pt 1):41-9.
Okayama, N., L. Coe, T. Oshima, M. Itoh, and J.S. Alexander. 1999. Intracellular mechanisms of hydrogen peroxide-mediated neutrophil adherence to cultured human endothelial cells. Microvasc Res. 57:63-74.
Pal, B., and T. Kitagawa. 2005. Interactions of soluble guanylate cyclase with diatomics as probed by resonance Raman spectroscopy. J Inorg Biochem. 99:267-79.
Parenti, A., L. Morbidelli, X.L. Cui, J.G. Douglas, J.D. Hood, H.J. Granger, F. Ledda, and M. Ziche. 1998. Nitric oxide is an upstream signal of vascular endothelial growth factor-induced extracellular signal-regulated kinase1/2 activation in postcapillary endothelium. J Biol Chem. 273:4220-6.
Park, S.W., M.W. Sung, D.S. Heo, H. Inoue, S.H. Shim, and K.H. Kim. 2005. Nitric oxide upregulates the cyclooxygenase-2 expression through the cAMP-response element in its promoter in several cancer cell lines. Oncogene. 24:6689-98.
Partrick, D.A., E.E. Moore, P.J. Offner, D.R. Meldrum, D.Y. Tamura, J.L. Johnson, and C.C. Silliman. 2000. Maximal human neutrophil priming for superoxide production and elastase release requires p38 mitogen-activated protein kinase activation. Arch Surg. 135:219-25.
Patel, I.S., T.A. Seemungal, M. Wilks, S.J. Lloyd-Owen, G.C. Donaldson, and J.A. Wedzicha. 2002. Relationship between bacterial colonisation and the frequency, character, and severity of COPD exacerbations. Thorax. 57:759-64.
Pearson, G., F. Robinson, T. Beers Gibson, B.E. Xu, M. Karandikar, K. Berman, and M.H. Cobb. 2001. Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions. Endocr Rev. 22:153-83.
Porto, B.N., L.S. Alves, P.L. Fernandez, T.P. Dutra, R.T. Figueiredo, A.V. Graca-Souza, and M.T. Bozza. 2007. Heme induces neutrophil migration and reactive oxygen species generation through signaling pathways characteristic of chemoatactic receptors. J Biol Chem.
Priviero, F.B., J.S. Baracat, C.E. Teixeira, M.A. Claudino, G. De Nucci, and E. Antunes. 2005. Mechanisms underlying relaxation of rabbit aorta by BAY 41-2272, a nitric oxide-independent soluble guanylate cyclase activator. Clin Exp Pharmacol Physiol. 32:728-34.
Pryzwansky, K.B., and E.P. Merricks. 1998. Chemotactic peptide-induced changes of intermediate filament organization in neutrophils during granule secretion: role of cyclic guanosine monophosphate. Mol Biol Cell. 9:2933-47.
Pryzwansky, K.B., T.A. Wyatt, and T.M. Lincoln. 1995. Cyclic guanosine monophosphate-dependent protein kinase is targeted to intermediate filaments and phosphorylates vimentin in A23187-stimulated human neutrophils. Blood. 85:222-30.
Pryzwansky, K.B., T.A. Wyatt, H. Nichols, and T.M. Lincoln. 1990. Compartmentalization of cyclic GMP-dependent protein kinase in formyl-peptide stimulated neutrophils. Blood. 76:612-8.
Pyriochou, A., and A. Papapetropoulos. 2005. Soluble guanylyl cyclase: more secrets revealed. Cell Signal. 17:407-13.
Raingeaud, J., A.J. Whitmarsh, T. Barrett, B. Derijard, and R.J. Davis. 1996. MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway. Mol Cell Biol. 16:1247-55.
Rajendran, S., Y.Y. Chirkov, D.J. Campbell, and J.D. Horowitz. 2005. Angiotensin-(1-7) enhances anti-aggregatory effects of the nitric oxide donor sodium nitroprusside. J Cardiovasc Pharmacol. 46:459-63.
Rane, M.J., S.L. Carrithers, J.M. Arthur, J.B. Klein, and K.R. McLeish. 1997. Formyl peptide receptors are coupled to multiple mitogen-activated protein kinase cascades by distinct signal transduction pathways: role in activation of reduced nicotinamide adenine dinucleotide oxidase. J Immunol. 159:5070-8.
Reeves, E.P., H. Lu, H.L. Jacobs, C.G. Messina, S. Bolsover, G. Gabella, E.O. Potma, A. Warley, J. Roes, and A.W. Segal. 2002. Killing activity of neutrophils is mediated through activation of proteases by K+ flux. Nature. 416:291-7.
Ridnour, L.A., J.S. Isenberg, M.G. Espey, D.D. Thomas, D.D. Roberts, and D.A. Wink. 2005. Nitric oxide regulates angiogenesis through a functional switch involving thrombospondin-1. Proc Natl Acad Sci U S A. 102:13147-52.
Rodriguez-Fonseca, C., R. Amils, and R.A. Garrett. 1995. Fine structure of the peptidyl transferase centre on 23 S-like rRNAs deduced from chemical probing of antibiotic-ribosome complexes. J Mol Biol. 247:224-35.
Sakamoto, K., F. Kuribayashi, M. Nakamura, and K. Takeshige. 2006. Involvement of p38 MAP kinase in not only activation of the phagocyte NADPH oxidase induced by formyl-methionyl-leucyl-phenylalanine but also determination of the extent of the activity. J Biochem (Tokyo). 140:739-45.
Schaeffer, E.M., J. Debnath, G. Yap, D. McVicar, X.C. Liao, D.R. Littman, A. Sher, H.E. Varmus, M.J. Lenardo, and P.L. Schwartzberg. 1999. Requirement for Tec kinases Rlk and Itk in T cell receptor signaling and immunity. Science. 284:638-41.
Schlossmann, J., and F. Hofmann. 2005. cGMP-dependent protein kinases in drug discovery. Drug Discov Today. 10:627-34.
Schnyder, B., P.C. Meunier, and B.D. Car. 1998. Inhibition of kinases impairs neutrophil activation and killing of Staphylococcus aureus. Biochem J. 331 ( Pt 2):489-95.
Schrammel, A., S. Behrends, K. Schmidt, D. Koesling, and B. Mayer. 1996. Characterization of 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one as a heme-site inhibitor of nitric oxide-sensitive guanylyl cyclase. Mol Pharmacol. 50:1-5.
Selvatici, R., S. Falzarano, A. Mollica, and S. Spisani. 2006. Signal transduction pathways triggered by selective formylpeptide analogues in human neutrophils. Eur J Pharmacol. 534:1-11.
Seo, M., Y.I. Lee, C.H. Cho, C.D. Bae, I.H. Kim, and Y.S. Juhnn. 2002. Bi-directional regulation of UV-induced activation of p38 kinase and c-Jun N-terminal kinase by G protein beta gamma-subunits. J Biol Chem. 277:24197-203.
Servitja, J.M., M.J. Marinissen, A. Sodhi, X.R. Bustelo, and J.S. Gutkind. 2003. Rac1 function is required for Src-induced transformation. Evidence of a role for Tiam1 and Vav2 in Rac activation by Src. J Biol Chem. 278:34339-46.
Sethi, S., and M. Dikshit. 2000. Modulation of polymorphonuclear leukocytes function by nitric oxide. Thromb Res. 100:223-47.
Severina, I.S., N.V. Pyatakova, A.Y. Shchegolev, and G.V. Ponomarev. 2006. YC-1-like potentiation of NO-dependent activation of soluble guanylate cyclase by derivatives of protoporphyrin IX. Biochemistry (Mosc). 71:340-4.
Shafer, L.M., and L.W. Slice. 2005. Anisomycin induces COX-2 mRNA expression through p38(MAPK) and CREB independent of small GTPases in intestinal epithelial cells. Biochim Biophys Acta. 1745:393-400.
Shaulian, E., and M. Karin. 2002. AP-1 as a regulator of cell life and death. Nat Cell Biol. 4:E131-6.
Shin, I., S. Kim, H. Song, H.R. Kim, and A. Moon. 2005. H-Ras-specific activation of Rac-MKK3/6-p38 pathway: its critical role in invasion and migration of breast epithelial cells. J Biol Chem. 280:14675-83.
Sim, S., T.S. Yong, S.J. Park, K.I. Im, Y. Kong, J.S. Ryu, D.Y. Min, and M.H. Shin. 2005. NADPH oxidase-derived reactive oxygen species-mediated activation of ERK1/2 is required for apoptosis of human neutrophils induced by Entamoeba histolytica. J Immunol. 174:4279-88.
Siow, Y.L., G.B. Kalmar, J.S. Sanghera, G. Tai, S.S. Oh, and S.L. Pelech. 1997. Identification of two essential phosphorylated threonine residues in the catalytic domain of Mekk1. Indirect activation by Pak3 and protein kinase C. J Biol Chem. 272:7586-94.
Soh, J.W., Y. Mao, L. Liu, W.J. Thompson, R. Pamukcu, and I.B. Weinstein. 2001. Protein kinase G activates the JNK1 pathway via phosphorylation of MEKK1. J Biol Chem. 276:16406-10.
Stasch, J.P., E.M. Becker, C. Alonso-Alija, H. Apeler, K. Dembowsky, A. Feurer, R. Gerzer, T. Minuth, E. Perzborn, U. Pleiss, H. Schroder, W. Schroeder, E. Stahl, W. Steinke, A. Straub, and M. Schramm. 2001. NO-independent regulatory site on soluble guanylate cyclase. Nature. 410:212-5.
Suzuki, K., T. Hasegawa, C. Sakamoto, Y.M. Zhou, F. Hato, M. Hino, N. Tatsumi, and S. Kitagawa. 2001a. Cleavage of mitogen-activated protein kinases in human neutrophils undergoing apoptosis: role in decreased responsiveness to inflammatory cytokines. J Immunol. 166:1185-92.
Suzuki, K., M. Hino, F. Hato, N. Tatsumi, and S. Kitagawa. 1999. Cytokine-specific activation of distinct mitogen-activated protein kinase subtype cascades in human neutrophils stimulated by granulocyte colony-stimulating factor, granulocyte-macrophage colony-stimulating factor, and tumor necrosis factor-alpha. Blood. 93:341-9.
Suzuki, K., M. Hino, H. Kutsuna, F. Hato, C. Sakamoto, T. Takahashi, N. Tatsumi, and S. Kitagawa. 2001b. Selective activation of p38 mitogen-activated protein kinase cascade in human neutrophils stimulated by IL-1beta. J Immunol. 167:5940-7.
Swain, S.D., S.L. Helgerson, A.R. Davis, L.K. Nelson, and M.T. Quinn. 1997. Analysis of activation-induced conformational changes in p47phox using tryptophan fluorescence spectroscopy. J Biol Chem. 272:29502-10.
Syrbu, S.I., W.H. Waterman, T.F. Molski, D. Nagarkatti, J.J. Hajjar, and R.I. Sha'afi. 1999. Phosphorylation of cytosolic phospholipase A2 and the release of arachidonic acid in human neutrophils. J Immunol. 162:2334-40.
Takami, M., V. Terry, and L. Petruzzelli. 2002. Signaling pathways involved in IL-8-dependent activation of adhesion through Mac-1. J Immunol. 168:4559-66.
Teixeira, C.E., F.B. Priviero, J. Todd, Jr., and R.C. Webb. 2006a. Vasorelaxing effect of BAY 41-2272 in rat basilar artery: involvement of cGMP-dependent and independent mechanisms. Hypertension. 47:596-602.
Teixeira, C.E., F.B. Priviero, and R.C. Webb. 2006b. Molecular mechanisms underlying rat mesenteric artery vasorelaxation induced by the nitric oxide-independent soluble guanylyl cyclase stimulators BAY 41-2272 [5-cyclopropyl-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimi din-4-ylamine] and YC-1 [3-(5'-hydroxymethyl-2'-furyl)-1-benzyl Indazole]. J Pharmacol Exp Ther. 317:258-66.
ten Hove, W., L.A. Houben, J.A. Raaijmakers, M. Bracke, and L. Koenderman. 2007. Differential regulation of TNFalpha and GM-CSF induced activation of P38 MAPK in neutrophils and eosinophils. Mol Immunol. 44:2492-6.
Teramoto, H., O.A. Coso, H. Miyata, T. Igishi, T. Miki, and J.S. Gutkind. 1996. Signaling from the small GTP-binding proteins Rac1 and Cdc42 to the c-Jun N-terminal kinase/stress-activated protein kinase pathway. A role for mixed lineage kinase 3/protein-tyrosine kinase 1, a novel member of the mixed lineage kinase family. J Biol Chem. 271:27225-8.
Tintinger, G., H.C. Steel, and R. Anderson. 2005. Taming the neutrophil: calcium clearance and influx mechanisms as novel targets for pharmacological control. Clin Exp Immunol. 141:191-200.
Torres, M., F.L. Hall, and K. O'Neill. 1993. Stimulation of human neutrophils with formyl-methionyl-leucyl-phenylalanine induces tyrosine phosphorylation and activation of two distinct mitogen-activated protein-kinases. J Immunol. 150:1563-77.
Ueda, S., H. Masutani, H. Nakamura, T. Tanaka, M. Ueno, and J. Yodoi. 2002. Redox control of cell death. Antioxid Redox Signal. 4:405-14.
VanUffelen, B.E., B.M. de Koster, P.J. Van den Broek, J. VanSteveninck, and J.G. Elferink. 1996. Modulation of neutrophil migration by exogenous gaseous nitric oxide. J Leukoc Biol. 60:94-100.
Wanikiat, P., D.F. Woodward, and R.A. Armstrong. 1997. Investigation of the role of nitric oxide and cyclic GMP in both the activation and inhibition of human neutrophils. Br J Pharmacol. 122:1135-45.
Ward, R.A., M. Nakamura, and K.R. McLeish. 2000. Priming of the neutrophil respiratory burst involves p38 mitogen-activated protein kinase-dependent exocytosis of flavocytochrome b558-containing granules. J Biol Chem. 275:36713-9.
Werner, C.G., V. Godfrey, R.R. Arnold, G.L. Featherstone, D. Bender, J. Schlossmann, M. Schiemann, F. Hofmann, and K.B. Pryzwansky. 2005. Neutrophil dysfunction in guanosine 3',5'-cyclic monophosphate-dependent protein kinase I-deficient mice. J Immunol. 175:1919-29.
Werz, O., E. Burkert, B. Samuelsson, O. Radmark, and D. Steinhilber. 2002. Activation of 5-lipoxygenase by cell stress is calcium independent in human polymorphonuclear leukocytes. Blood. 99:1044-52.
Weston, C.R., and R.J. Davis. 2007. The JNK signal transduction pathway. Curr Opin Cell Biol. 19:142-9.
Whitmarsh, A.J., and R.J. Davis. 1996. Transcription factor AP-1 regulation by mitogen-activated protein kinase signal transduction pathways. J Mol Med. 74:589-607.
Whitmarsh, A.J., and R.J. Davis. 2007. Role of mitogen-activated protein kinase kinase 4 in cancer. Oncogene. 26:3172-84.
Wiedow, O., and U. Meyer-Hoffert. 2005. Neutrophil serine proteases: potential key regulators of cell signalling during inflammation. J Intern Med. 257:319-28.
Winston, B.W., E.D. Chan, G.L. Johnson, and D.W. Riches. 1997. Activation of p38mapk, MKK3, and MKK4 by TNF-alpha in mouse bone marrow-derived macrophages. J Immunol. 159:4491-7.
Witko-Sarsat, V., P. Rieu, B. Descamps-Latscha, P. Lesavre, and L. Halbwachs-Mecarelli. 2000. Neutrophils: molecules, functions and pathophysiological aspects. Lab Invest. 80:617-53.
Wu, C.C., F.N. Ko, S.C. Kuo, F.Y. Lee, and C.M. Teng. 1995. YC-1 inhibited human platelet aggregation through NO-independent activation of soluble guanylate cyclase. Br J Pharmacol. 116:1973-8.
Wyatt, T.A., T.M. Lincoln, and K.B. Pryzwansky. 1991. Vimentin is transiently co-localized with and phosphorylated by cyclic GMP-dependent protein kinase in formyl-peptide-stimulated neutrophils. J Biol Chem. 266:21274-80.
Xiong, W., L.Z. Kojic, L. Zhang, S.S. Prasad, R. Douglas, Y. Wang, and M.S. Cynader. 2006. Anisomycin activates p38 MAP kinase to induce LTD in mouse primary visual cortex. Brain Res.
Yang, T., A. Zhang, A. Pasumarthy, L. Zhang, Z. Warnock, and J.B. Schnermann. 2006. Nitric oxide stimulates COX-2 expression in cultured collecting duct cells through MAP kinases and superoxide but not cGMP. Am J Physiol Renal Physiol. 291:F891-5.
Yazawa, S., H. Tsuchiya, H. Hori, and R. Makino. 2006. Functional characterization of two nucleotide-binding sites in soluble guanylate cyclase. J Biol Chem. 281:21763-70.
Yu, H., S.J. Suchard, R. Nairn, and R. Jove. 1995. Dissociation of mitogen-activated protein kinase activation from the oxidative burst in differentiated HL-60 cells and human neutrophils. J Biol Chem. 270:15719-24.
Yu, K., Y.N. Chen, C.P. Ravera, W. Bayona, C.M. Nalin, and R. Mallon. 1997. Ras-dependent apoptosis correlates with persistent activation of stress-activated protein kinases and induction of isoform(s) of Bcl-x. Cell Death Differ. 4:745-55.
Yuo, A., E. Okuma, S. Kitagawa, and F. Takaku. 1997. Tyrosine phosphorylation of p38 but not extracellular signal-regulated kinase in normal human neutrophils stimulated by tumor necrosis factor: comparative study with granulocyte-macrophage colony-stimulating factor. Biochem Biophys Res Commun. 235:42-6.
Zhao, Y., P.E. Brandish, M. DiValentin, J.P. Schelvis, G.T. Babcock, and M.A. Marletta. 2000. Inhibition of soluble guanylate cyclase by ODQ. Biochemistry. 39:10848-54.
Zhou, Y.M., H. Kutsuna, K. Suzuki, F. Hato, and S. Kitagawa. 2003. Serine protease inhibitors inhibit superoxide release and adherence in human neutrophils stimulated by granulocyte-macrophage colony-stimulating factor and tumor necrosis factor-alpha. Int J Hematol. 77:253-8.
Zu, Y.L., J. Qi, A. Gilchrist, G.A. Fernandez, D. Vazquez-Abad, D.L. Kreutzer, C.K. Huang, and R.I. Sha'afi. 1998. p38 mitogen-activated protein kinase activation is required for human neutrophil function triggered by TNF-alpha or FMLP stimulation. J Immunol. 160:1982-9.
QRCODE
 
 
 
 
 
                                                                                                                                                                                                                                                                                                                                                                                                               
第一頁 上一頁 下一頁 最後一頁 top
無相關論文
 
1. 戴傳文、許文耀(1991):社區居民對精神病患的概念與態度。中華心理衛生學刊,5(2),71-87。
2. 戴傳文(1998):我國精神衛生工作的發展。護理雜誌,45(1),5-11。
3. 鄭夙芬、文榮光、吳就君(1997):社區心理衛生教育內容建構之初探。衛生教育論文集刊,10,82-96。
4. 鄭夙芬(1997):如何將心理衛生教育落實於社區。社區發展季刊,77,118-131。
5. 蔡文正、龔佩珍、翁瑞宏、石賢彥(2004):基層醫師與民眾之服務品質認知落差分析。醫務管理期刊,5(4),385-402。
6. 楊聰財、李明濱、吳英璋、魯中興、陳韺、吳文正(2004a):社區心理衛生中心的歷史沿革。北市醫學雜誌,1(4),13-30。
7. 陳正男、曾倫崇(2002):醫療服務品質與顧客滿意度關係之研究-以台南地區的醫院為例。長榮學報,6(1),89-103。
8. 楊聰財、李明濱、吳英璋、魯中興、陳韺、吳文正(2004b):臺中與南投社區心理衛生中心運作型態之比較研究。北市醫學雜誌,1(4),468-479。
9. 楊漢湶(1993):精神衛生法之立法過程。健康教育,71,5-8。
10. 楊聰財、李明濱、吳英璋、魯中興、陳韺、吳文正(2005):台灣地區社區心理衛生中心之運作型態。北市醫學雜誌,2(4),348-359。
11. 唐文慧(1997):精神衛生法之立法過程—政體取向分析。中華心理衛生學刊,10(1),1-27。
12. 洪月嬌、胡正申(1999):國軍「心理衛生服務」內容評估-以德爾法技術(Delphi Technique)研究。軍事社會科學半年刊,4,125-165。
13. 簡文英(2001):社區諮商模式與學校輔導工作。輔導通訊,65,44-50。
14. 張德聰、黃正旭(2001):「張老師」網路諮商求助者之特性分析與未來展望。輔導季刊,37(4),28-31。
15. 姚克明、林豐雄、吳聖良、洪百薰與陳茄娜(1992):台灣省三所社區心理衛生中心之功能及績效之評估。公共衛生,18(4),310-323。