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研究生:邵可雯
研究生(外文):Ke Wen, Shao
論文名稱:BRCA1及BRCA2的基因多型性對於台灣口腔癌發生的影響
論文名稱(外文):The SNOs in BRCA2/BRCA1 and their genetic susceptibility of oral cancer in Taiwan
指導教授:鄭恩加
學位類別:碩士
校院名稱:長庚大學
系所名稱:醫學生物技術研究所
學門:醫藥衛生學門
學類:醫學技術及檢驗學類
論文種類:學術論文
論文出版年:2007
畢業學年度:95
語文別:英文
中文關鍵詞:口腔癌
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In Taiwan, the incidence of oral cancer has become the 6th leading cancer, the 4th leading cancer in male (2006), and is still increasing in the recent years. The association of carcinogen exposure (alcohol, betel quid, cigarette smoking) with oral cancer has been widely reported. However, the patients who have no expose to those carcinogens also exist. It implies that genomic background may also affect the incidence of oral cancer. Many evidences reveal that the mutations or certain SNPs in BRCA1 or BRCA2, which play important roles in DNA repair mechanism, affect breast cancer formation. In this study, we investigate whether the SNPs of these two genes also associate with the susceptibility of oral cancer. Total of 140 oral cancer patients and 88 normal individuals were recruited for study. The blood DNA were extracted and subjected to genotype analysis of 30 alleles in BRCA1 and BRCA2 by using TaqMan 5’-nuclease assay method. Results show that only rs1148321 (p=0.01) and rs542551 (p=0.02) in BRCA2 were statistically differential distributed between normal and cancer groups. In rs1148321, the A/T or T/T genotype in the cancer group showed higher frequency, with the odds ratio 2.09 (95% confidence interval: 1.18-3.68). In rs542551, the A/G or G/G genotype in the cancer group showed higher frequency, with the odds ratio 1.95 (95% confidence interval: 1.10-3.44). These SNPs have no association with multiple cancer development, neither clinico- patholgical phenotype of oral cancer. These results suggest that SNPs of rs1148321 and rs542551 in BRCA2 may be contributing factors for the early development of oral cancer, however, independent with the later steps of the cancer progression.
Abstract 2
Introduction 3
Specific Aim and Experimental Design 13
Materials and Methods 14
Results 17
Discussion 23
References 26
Table 32
Figure 39
1. NW, J. A global view of the epidemiology of oral cancer. Oral Cancer: detection of patients and lesions at risk: 3-26, 1991.
2. Cancer facts and figures. Atlanta: American Cancer Society, 1997.
3. Daftary DK, M. P., Bhonsle RR, Gupta PC, Mehta FS, Pindborg JJ Risk factors and risk markers for oral cancers in high risk areas of the world. Oral Cancer: detection of patients and lesions at risk.: 29-63, 1991.
4. Schofield, M. J. and Hsieh, P. DNA mismatch repair: molecular mechanisms and biological function. Annu Rev Microbiol, 57: 579-608, 2003.
5. 黃振勳, 郭英雄. 口腔癌在台灣. 中華民國台灣醫學會. 1999.
6. Jayant K, N. P. Epidiology of oral cancer.: 1-17, 1991.
7. HW, K. A statistical study on oral carcinomas in Taiwan with emphasis on the relationship with betel nut chewing: A preliminary report. J Formosan Med Assoc, 75: 495-505, 1976.
8. Liao, C. T., Kang, C. J., Chang, J. T., Wang, H. M., Ng, S. H., Hsueh, C., Lee, L. Y., Lin, C. H., Cheng, A. J., Chen, I. H., Huang, S. F., and Yen, T. C. Survival of second and multiple primary tumors in patients with oral cavity squamous cell carcinoma in the betel quid chewing area. Oral Oncol, 2006.
9. Cianfriglia, F., Di Gregorio, D. A., and Manieri, A. Multiple primary tumours in patients with oral squamous cell carcinoma. Oral Oncol, 35: 157-163, 1999.
10. Day, G. L., Blot, W. J., Shore, R. E., Schoenberg, J. B., Kohler, B. A., Greenberg, R. S., Liff, J. M., Preston-Martin, S., Austin, D. F., McLaughlin, J. K., and et al. Second cancers following oral and pharyngeal cancer: patients' characteristics and survival patterns. Eur J Cancer B Oral Oncol, 30B: 381-386, 1994.
11. Moon, S., Holley, S., Bodiwala, D., Luscombe, C. J., French, M. E., Liu, S., Saxby, M. F., Jones, P. W., Fryer, A. A., and Strange, R. C. Associations between G/A1229, A/G3944, T/C30875, C/T48200 and C/T65013 genotypes and haplotypes in the vitamin D receptor gene, ultraviolet radiation and susceptibility to prostate cancer. Ann Hum Genet, 70: 226-236, 2006.
12. Falk RT, P. L., Brown LM, Mason TJ, Buffler PA, Fraumeni JF Jr Effect of smoking and alcohol consumption on laryngeal cancer risk in coastel Texas. Cancer Res, 49: 4024-4029, 1989.
13. Decker J, G. J. Risk factors in head and neck cancer. N Engl J Med, 306: 1151-1155.
14. Rothman KJ, C. C., Flanders D, et al. Epidemiology of laryngeal cancer. Epidemiol Rev 2, 195, 1980.
15. 黃湧澧, 林立民., 葛應欽 檳榔塊與口腔癌. 公共衛雜誌, 19: 371-383, 1993.
26
16. Singn AD, V. E. C. Buccal mucosal cancer in South India. Am J Roentgenol, 96: 6-14, 1996.
17. Jaffarey NA, Z. S., Jinah M. Preminary report on the association of chewing and smoking habits with oral lesions. JPMA, 19: 61-69, 1969.
18. KM, C. Betel nut chewing and mouth cancer in Taiwan. Observation of the oral mucosa in the betel nut chewers. J Formosan Med Assoc, 65: 79-85, 1966.
19. ATH, M. Betel cancer in Malaya. Med J Malaysia, 14: 162-165, 1960.
20. Jayant K, B. V., Sanghvi LD, Jussawala DJ Quantification of the role of smoking and chewing habits in oral, pharynx and oesophageous cancer. Br J Cancer, 35: 232-235, 1997.
21. Ko YC, H. Y., Lee CH, Chen MJ, Lin LM, Tsai CC Betel quid chewing, cigarette smoking and alcohol consumption related to oral cancer in Taiwan. J Oral Pathol Med, 24: 450-453, 1995.
22. MN, A. Getel quid and oral carcinogenesis. Sign Med J, 29: 589-593, 1998.
23. Sundqvist K, L. Y., Nair J, Bartsch H, Arvidson K, Graftstrom RC Cytotoxic and genotoxic effects of areca nut-related compounds in cultured human buccal epithelial cells. Cancer Res, 49: 5294-5298, 1989.
24. Trivedy, C. R., Craig, G., and Warnakulasuriya, S. The oral health consequences of chewing areca nut. Addict Biol, 7: 115-125, 2002.
25. Reichart, P. A. Oral cancer and precancer related to betel and miang chewing in Thailand: a review. J Oral Pathol Med, 24: 241-243, 1995.
26. Jeng, J. H., Chang, M. C., and Hahn, L. J. Role of areca nut in betel quid-associated chemical carcinogenesis: current awareness and future perspectives. Oral Oncol, 37: 477-492, 2001.
27. Shirname, L. P., Menon, M. M., Nair, J., and Bhide, S. V. Correlation of mutagenicity and tumorigenicity of betel quid and its ingredients. Nutr Cancer, 5: 87-91, 1983.
28. Betel-quid and areca-nut chewing and some areca-nut derived nitrosamines. IARC Monogr Eval Carcinog Risks Hum, 85: 1-334, 2004.
29. Risch, N. J. Searching for genetic determinants in the new millennium. Nature, 405: 847-856, 2000.
30. Erichsen, H. C. and Chanock, S. J. SNPs in cancer research and treatment. Br J Cancer, 90: 747-751, 2004.
31. Hao, B., Miao, X., Li, Y., Zhang, X., Sun, T., Liang, G., Zhao, Y., Zhou, Y., Wang, H., Chen, X., Zhang, L., Tan, W., Wei, Q., Lin, D., and He, F. A novel T-77C polymorphism in DNA repair gene XRCC1 contributes to diminished promoter activity and increased risk of non-small cell lung cancer. Oncogene, 2006.
27
32. Wagner K, H. K., Grzybowska E, Klaes R, Burwinkel B, Bugert P, Schmutzler RK, Wappenschmidt B, Butkiewicz D, Pamula J, Pekala W, Forsti A. Polymorphisms in genes involved in GH1 release and their association with breast cancer risk. Carcinogenesis, 2006.
33. Dianzani I, G. L., Biava A, Giordano M, Bertolotti M, Betti M, Ferrante D, Guarrera S, Betta GP, Mirabelli D, Matullo G, Magnani C. Polymorphisms in DNA repair genes as risk factors for asbestos-related malignant mesothelioma in a general population study. Mutat Res, 2006.
34. Thellenberg-Karlsson, C., Lindstrom, S., Malmer, B., Wiklund, F., Augustsson-Balter, K., Adami, H. O., Stattin, P., Nilsson, M., Dahlman-Wright, K., Gustafsson, J. A., and Gronberg, H. Estrogen receptor beta polymorphism is associated with prostate cancer risk. Clin Cancer Res, 12: 1936-1941, 2006.
35. Wang SS, D. S., Cerhan JR, Hartge P, Severson RK, Cozen W, Lan Q, Welch R, Chanock SJ, Rothman N. Polymorphisms in oxidative stress genes and risk for non-Hodgkin lymphoma. Carcinogenesis, 2006.
36. Garcia-Closas, M., Malats, N., Real, F. X., Welch, R., Kogevinas, M., Chatterjee, N., Pfeiffer, R., Silverman, D., Dosemeci, M., Tardon, A., Serra, C., Carrato, A., Garcia-Closas, R., Castano-Vinyals, G., Chanock, S., Yeager, M., and Rothman, N. Genetic variation in the nucleotide excision repair pathway and bladder cancer risk. Cancer Epidemiol Biomarkers Prev, 15: 536-542, 2006.
37. Hu Z, S. M., Yuan J, Xu L, Wang F, Wang Y, Yuan W, Qian J, Ma H, Wang Y, Liu H, Chen W, Yang L, Jing G, Huo X, Chen F, Jin L, Wei Q, Huang W, Lu D, Wu T, Shen H. Polymorphisms in DNA damage binding protein 2 (DDB2) and susceptibility of primary lung cancer in Chinese. Carcinogenesis, 2006.
38. Manuguerra, M., Saletta, F., Karagas, M. R., Berwick, M., Veglia, F., Vineis, P., and Matullo, G. XRCC3 and XPD/ERCC2 Single Nucleotide Polymorphisms and the Risk of Cancer: A HuGE Review. Am J Epidemiol, 2006.
39. Kaminski, B. C., Grabenbauer, G. G., Sprung, C. N., Sauer, R., and Distel, L. V. Inter-relation of apoptosis and DNA double-strand breaks in patients with multiple primary cancers. Eur J Cancer Prev, 15: 274-282, 2006.
28
40. Madhusudan, S. and Middleton, M. R. The emerging role of DNA repair proteins as predictive, prognostic and therapeutic targets in cancer. Cancer Treat Rev, 31: 603-617, 2005.
41. Allinson, S. L., Dianova, II, and Dianov, G. L. Poly(ADP-ribose) polymerase in base excision repair: always engaged, but not essential for DNA damage processing. Acta Biochim Pol, 50: 169-179, 2003.
42. Dudas, A. and Chovanec, M. DNA double-strand break repair by homologous recombination. Mutat Res, 566: 131-167, 2004.
43. Lees-Miller, S. P. and Meek, K. Repair of DNA double strand breaks by non-homologous end joining. Biochimie, 85: 1161-1173, 2003.
44. Costa, R. M., Chigancas, V., Galhardo Rda, S., Carvalho, H., and Menck, C. F. The eukaryotic nucleotide excision repair pathway. Biochimie, 85: 1083-1099, 2003.
45. Hall, J. M., Lee, M. K., Newman, B., Morrow, J. E., Anderson, L. A., Huey, B., and King, M. C. Linkage of early-onset familial breast cancer to chromosome 17q21. Science, 250: 1684-1689, 1990.
46. Thompson, D. and Easton, D. The genetic epidemiology of breast cancer genes. J Mammary Gland Biol Neoplasia, 9: 221-236, 2004.
47. Miki, Y., Swensen, J., Shattuck-Eidens, D., Futreal, P. A., Harshman, K., Tavtigian, S., Liu, Q., Cochran, C., Bennett, L. M., Ding, W., and et al. A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1. Science, 266: 66-71, 1994.
48. Wooster, R., Bignell, G., Lancaster, J., Swift, S., Seal, S., Mangion, J., Collins, N., Gregory, S., Gumbs, C., and Micklem, G. Identification of the breast cancer susceptibility gene BRCA2. Nature, 378: 789-792, 1995.
49. BRCA1 and BRCA2 Pathways and Cancer Risk. Medscape General Medicine, 7: 60, 2005.
50. Rudkin, T. M. and Foulkes, W. D. BRCA2: breaks, mistakes and failed separations. Trends Mol Med, 11: 145-148, 2005.
51. Venkitaraman, A. R. Cancer susceptibility and the functions of BRCA1 and BRCA2. Cell, 108: 171-182, 2002.
52. Scully, R., Chen, J., Plug, A., Xiao, Y., Weaver, D., Feunteun, J., Ashley, T., and Livingston, D. M. Association of BRCA1 with Rad51 in mitotic and meiotic cells. Cell, 88: 265-275, 1997.
53. Wang, Y., Cortez, D., Yazdi, P., Neff, N., Elledge, S. J., and Qin, J. BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures. Genes Dev, 14: 927-939, 2000.
54. Bhattacharyya, A., Ear, U. S., Koller, B. H., Weichselbaum, R. R., and Bishop,
29
D. K. The breast cancer susceptibility gene BRCA1 is required for subnuclear assembly of Rad51 and survival following treatment with the DNA cross-linking agent cisplatin. J Biol Chem, 275: 23899-23903, 2000.
55. Venkitaraman, A. R. A growing network of cancer-susceptibility genes. N Engl J Med, 348: 1917-1919, 2003.
56. Xu, B., Kim, S., and Kastan, M. B. Involvement of Brca1 in S-phase and G(2)-phase checkpoints after ionizing irradiation. Mol Cell Biol, 21: 3445-3450, 2001.
57. Xu, B., O'Donnell, A. H., Kim, S. T., and Kastan, M. B. Phosphorylation of serine 1387 in Brca1 is specifically required for the Atm-mediated S-phase checkpoint after ionizing irradiation. Cancer Res, 62: 4588-4591, 2002.
58. Ting, N. S. and Lee, W. H. The DNA double-strand break response pathway: becoming more BRCAish than ever. DNA Repair (Amst), 3: 935-944, 2004.
59. Zhang, J. and Powell, S. N. The role of the BRCA1 tumor suppressor in DNA double-strand break repair. Mol Cancer Res, 3: 531-539, 2005.
60. Fu, Y. P., Yu, J. C., Cheng, T. C., Lou, M. A., Hsu, G. C., Wu, C. Y., Chen, S. T., Wu, H. S., Wu, P. E., and Shen, C. Y. Breast cancer risk associated with genotypic polymorphism of the nonhomologous end-joining genes: a multigenic study on cancer susceptibility. Cancer Res, 63: 2440-2446, 2003.
61. Garcia-Higuera, I., Kuang, Y., Naf, D., Wasik, J., and D'Andrea, A. D. Fanconi anemia proteins FANCA, FANCC, and FANCG/XRCC9 interact in a functional nuclear complex. Mol Cell Biol, 19: 4866-4873, 1999.
62. de Winter, J. P., van der Weel, L., de Groot, J., Stone, S., Waisfisz, Q., Arwert, F., Scheper, R. J., Kruyt, F. A., Hoatlin, M. E., and Joenje, H. The Fanconi anemia protein FANCF forms a nuclear complex with FANCA, FANCC and FANCG. Hum Mol Genet, 9: 2665-2674, 2000.
63. Meetei, A. R., de Winter, J. P., Medhurst, A. L., Wallisch, M., Waisfisz, Q., van de Vrugt, H. J., Oostra, A. B., Yan, Z., Ling, C., Bishop, C. E., Hoatlin, M. E., Joenje, H., and Wang, W. A novel ubiquitin ligase is deficient in Fanconi anemia. Nat Genet, 35: 165-170, 2003.
64. Meetei, A. R., Sechi, S., Wallisch, M., Yang, D., Young, M. K., Joenje, H., Hoatlin, M. E., and Wang, W. A multiprotein nuclear complex connects Fanconi anemia and Bloom syndrome. Mol Cell Biol, 23: 3417-3426, 2003.
65. Garcia-Higuera, I., Taniguchi, T., Ganesan, S., Meyn, M. S., Timmers, C., Hejna, J., Grompe, M., and D'Andrea, A. D. Interaction of the Fanconi anemia proteins and BRCA1 in a common pathway. Mol Cell, 7: 249-262, 2001.
66. Vandenberg, C. J., Gergely, F., Ong, C. Y., Pace, P., Mallery, D. L., Hiom, K., and Patel, K. J. BRCA1-independent ubiquitination of FANCD2. Mol Cell, 12: 30
247-254, 2003.
67. Bruun, D., Folias, A., Akkari, Y., Cox, Y., Olson, S., and Moses, R. siRNA depletion of BRCA1, but not BRCA2, causes increased genome instability in Fanconi anemia cells. DNA Repair (Amst), 2: 1007-1013, 2003.
68. Wang, X. and D'Andrea, A. D. The interplay of Fanconi anemia proteins in the DNA damage response. DNA Repair (Amst), 3: 1063-1069, 2004.
69. Thorlacius, S., Olafsdottir, G., Tryggvadottir, L., Neuhausen, S., Jonasson, J. G., Tavtigian, S. V., Tulinius, H., Ogmundsdottir, H. M., and Eyfjord, J. E. A single BRCA2 mutation in male and female breast cancer families from Iceland with varied cancer phenotypes. Nat Genet, 13: 117-119, 1996.
70. Struewing, J. P., Hartge, P., Wacholder, S., Baker, S. M., Berlin, M., McAdams, M., Timmerman, M. M., Brody, L. C., and Tucker, M. A. The risk of cancer associated with specific mutations of BRCA1 and BRCA2 among Ashkenazi Jews. N Engl J Med, 336: 1401-1408, 1997.
71. Cancer risks in BRCA2 mutation carriers.The Breast Cancer Linkage Consortium. J Natl Cancer Inst, 91: 1310-1316, 1999.
72. Thompson, D. and Easton, D. F. Cancer Incidence in BRCA1 mutation carriers. J Natl Cancer Inst, 94: 1358-1365, 2002.
73. Seo, J. H., Cho, D. Y., Ahn, S. H., Yoon, K. S., Kang, C. S., Cho, H. M., Lee, H. S., Choe, J. J., Choi, C. W., Kim, B. S., Shin, S. W., Kim, Y. H., Kim, J. S., Son, G. S., Lee, J. B., and Koo, B. H. BRCA1 and BRCA2 germline mutations in Korean patients with sporadic breast cancer. Hum Mutat, 24: 350, 2004.
74. Saxena, S., Szabo, C. I., Chopin, S., Barjhoux, L., Sinilnikova, O., Lenoir, G., Goldgar, D. E., and Bhatanager, D. BRCA1 and BRCA2 in Indian breast cancer patients. Hum Mutat, 20: 473-474, 2002.
75. Kawahara, M., Sakayori, M., Shiraishi, K., Nomizu, T., Takeda, M., Abe, R., Ohuchi, N., Takenoshita, S., and Ishioka, C. Identification and evaluation of 55 genetic variations in the BRCA1 and the BRCA2 genes of patients from 50 Japanese breast cancer families. J Hum Genet, 49: 391-395, 2004.
76. Chen, X., Truong, T. T., Weaver, J., Bove, B. A., Cattie, K., Armstrong, B. A., Daly, M. B., and Godwin, A. K. Intronic alterations in BRCA1 and BRCA2: effect on mRNA splicing fidelity and expression. Hum Mutat, 27: 427-435, 2006.
77. K, S. Histological typing of tumours of the upper respiratory tract and ear. International Histological Classification of Tumours (2nd ed). Spring-Verlag, 1991.
78. Fleming ID, C. J., Henson DE, Hutter RVP, Kennedy BJ, Murphy GP, O’Sullivan B, Sobin L, Yarbro JW, editors AJCC Cancer Staging Manual (5th 31
ed). Lippincott Williams Wilkins. 1998.
79. Friedman, L. S., Szabo, C. I., Ostermeyer, E. A., Dowd, P., Butler, L., Park, T., Lee, M. K., Goode, E. L., Rowell, S. E., and King, M. C. Novel inherited mutations and variable expressivity of BRCA1 alleles, including the founder mutation 185delAG in Ashkenazi Jewish families. Am J Hum Genet, 57: 1284-1297, 1995.
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