(3.236.222.124) 您好!臺灣時間:2021/05/08 07:14
字體大小: 字級放大   字級縮小   預設字形  
回查詢結果

詳目顯示:::

我願授權國圖
: 
twitterline
研究生:簡柏仁
研究生(外文):Bo-Ren
論文名稱:牙科植體用新型氫氧基磷灰石/鈦複合漸層之性質
論文名稱(外文):Properties of novel hydroxyapatite/titanium gradient coatings for dental implantations
指導教授:丁信智
學位類別:碩士
校院名稱:中山醫學大學
系所名稱:口腔材料科學研究所
學門:醫藥衛生學門
學類:牙醫學類
論文種類:學術論文
論文出版年:2007
畢業學年度:95
語文別:中文
論文頁數:44
相關次數:
  • 被引用被引用:0
  • 點閱點閱:193
  • 評分評分:系統版面圖檔系統版面圖檔系統版面圖檔系統版面圖檔系統版面圖檔
  • 下載下載:0
  • 收藏至我的研究室書目清單書目收藏:0
氫氧基磷灰石鍍層己經使用在承載負荷的硬組織植體應用上。本研究利用電漿噴鍍技術製造功能性HA/Ti漸層在Ti6Al4V基材上,以改善鍍層-基材界面特性。這種漸層方式是採用底層為Ti鍵結層,表層為HA層,中間則是HA/Ti混合層,混合層是以改變Ti和HA粉末的輸入速率和粉量,將Ti含量隨著厚度增加而減少。在本論文中,將探討HA/Ti漸層及其經過後續熱處理,對其抗腐蝕性、塗層-基材之界面穩定性、與鍵結強度有何影響。實驗的結果指出功能性漸層的表面化學性質和形態跟純HA鍍層相似。但漸層的鍵結強度則較優於HA單層。疲勞循環測試發現HA鍍層鍵結強度顯著下降23%,然而在一百萬次的循環載荷下的HA/Ti漸層並沒有明顯的強度減少。適當的熱處理讓漸層的非晶質磷酸鈣結晶化。在模擬體液下電化學測量的結果也指出在疲勞測試後,漸層比單獨HA鍍層有較好的性質。經熱處理後抗腐蝕性提高。經600oC熱處理,不但能夠增加結晶性和降低鍍層缺陷,而且增加鍵結強度,噴鍍後熱處理可提升HA/Ti漸層品質。

Hydroxyapatite coating have been used as load-bearing implant
applications. The aim of this work is to deposit functionally graded HA/Ti
layers using plasma spray to improve the coating-substrate interface
properties. In addition to the Ti bondcoat and the top HA biolayer, the
alternating layers were created by means of changing the feeding rate and
input powder of Ti and HA. The stability of the graded coatings such as
corrosion resistance and fatigue, and bonding strength of the potential
graded coatings without and with post-deposition heat treatment were
examined. Results showed that surface chemistry and morphology of the
graded coatings were similar to those of monolithic HA coatings. The
bonding strength values of the as-sprayed graded coating were much
superior to those of monolithic HA coatings. The cyclic fatigue did have a
statistically significant effect on bond strength of monolithic HA coatings,
with a decrease of 23%. However, the graded coatings were able to survive 1
million cycles of loading in air without significantly reduced bond strength.
The in vitro electrochemical measurement results also indicated that the
graded coatings had a more beneficial and desired behavior than monolithic
HA coatings after fatigue. An appropriate heat treatment resulted in
recrystallization of amorphous calcium phosphate of as-sprayed coatings.
The enhancement of the resistance to corrosion took place after heat
treatment. Consequently, we concluded that the heat treatment at 600℃,
endowing with increased crystallinity and the reduced defects as well as
enhanced bond strength, may be a suitable post-deposition treatment method
to promote the characteristics of graded HA/Ti coatings.

總目錄
致謝.............................................................................................................I
中文摘要................................................................................................... II
Abstract ...................................................................................................III
總目錄......................................................................................................IV
表目錄......................................................................................................VI
圖目錄.................................................................................................... VII
第一章 文獻回顧......................................................................................1
1-1 生醫骨科材料.................................................................... 1
1-2 鈦金屬................................................................................ 2
1-3 氫氧基磷灰石的基本性質................................................. 5
1-3-1 氫氧基磷灰石的合成............................................... 5
1-3-2 氫氧基磷灰石在室溫下水溶液中的穩定性........... 7
1-4 人工牙根............................................................................ 8
1-4-1 人工牙根表面之探討............................................... 9
1-4-2 人工牙根之表面技術............................................. 10
1-4-3 電漿噴塗技術......................................................... 13
1-4-4 電漿噴塗陶瓷塗層之性質..................................... 15
1-4-5 影響塗層性質的電漿噴塗參數............................. 15
1-5 電漿噴鍍氫氧基磷灰石鍍層........................................... 16
1-5-1 氫氧基磷灰石於高溫下之穩定性......................... 16
1-5-2 氫氧基磷灰石之生物親合性................................. 17
第二章 實驗步驟....................................................................................18
2-1 電漿噴塗塗層製程.......................................................... 18
2-2 電漿噴度後熱處理.......................................................... 19
2-3 相組成和顯微結構分析................................................... 19
2-4 噴塗層鍵結強度測定和疲勞測試................................... 20
2-5 電化學測試...................................................................... 20
2-6 統計學分析...................................................................... 20
第三章 結果與討論................................................................................22
3-1 電漿噴鍍後之成份組成分析........................................... 22
3-2 顯微結構.......................................................................... 26
3-3 疲勞測試和熱處理之鍵結強度....................................... 28
3-4 電化學測試...................................................................... 30
V
第四章 結論............................................................................................35
第五章 參考文獻....................................................................................36
VI
表目錄
圖一、 商業HA 粉末及HA 鍍層、HA/Ti 漸層表面之X 光繞射結果
(H:apatite;A:α-TCP;B:β-TCP:C:CaO)......................23
圖二、商業HA 粉末及HA 鍍層、HA/Ti 漸層表面之複利葉紅外線
光譜結果..........................................................................................23
圖三、電漿噴塗後(a)及其分別於400℃(b)、500℃(c)、600℃(d)及700
℃(e)下進行後續熱處理,塗層表面之X 光繞射結果 (H:
apatite;A:α-TCP;B:β-TCP;C:CaO)..............................25
圖四、電漿噴塗後(a)及其分別於400℃(b)、500℃(c)、600℃(d)及700
℃(e)下進行後續熱處理,塗層表面之複利葉紅外線光譜結果...25
圖五、(a)漸層噴鍍截面SEM 微結構圖及(b)漸層噴鍍縱向Ti、Ca 與
P 之元素分析結果...........................................................................26
圖六、漸層噴鍍(a)及其分別於400℃(b)、500℃(c)、600℃(d)及700
℃(e)下進行後續熱處理,噴塗層截面SEM 微結構圖................27
圖七、漸層噴鍍及其分別於400℃、500℃、600℃及700℃下進行後
續熱處理,噴塗層與基材之結合強度...........................................29
圖八、HA 鍍層在疲勞測試(a)前、(b)後及HA/Ti 鍍層在疲勞(c)前、
(d)後開路電位圖.............................................................................31
圖九、HA 鍍層在疲勞測試(a)前、(b)後及HA/Ti 鍍層在疲勞(c)前、
(d)後典型極化曲線圖......................................................................31
圖十、漸層鍍層(a)、及其分別於400℃、500℃、600℃及700℃下進
行後續熱處理,在除氧之Hank’s balanced salt solution 下所得開
路電位圖..........................................................................................33
圖十一、漸層鍍層(a)、及其分別於400℃、500℃、600℃及700℃下
進行後續熱處理,所得典型極化曲線圖.......................................34
VII


1.M. Jarcho, "Calcium phosphate ceramics as hard tissue prosthetics", Clin. Orthop., 157:259-278, 1981.
2.L. L. Hench, "Bioceramics: from concept to Clinic", J. Am. Ceram. Soc., 74:1487-1510, 1991.
3.P.-I. Branemark, B. O. Hansson, R. Adell, U. Breine, J. Lindstrom, O. Hallen, and A. Ohman, "Osseointegrated implants in the treatment of the endentulous jaw", Scand. J. Plast. Reconstruc. Surg., 11:16, 1977.
4.T. Albrektsson, P.-I. Branemark, H.-A. Hansson, and J. Lindstrom, "Osseo-integrated titanium implants. Requirements for ensuring a long-lasting, direct bone-to-implant anchorage in man", Acta Orthop. Scand., 52:155-170, 1981.
5.C. Johansson, J. Lausmaa, M. Ask, H-A. Hansson, and T. Albrektsson, "Ultra-structural differences of the interface zone between bone and Ti6A14V or commercially pure titanium", J. Biomed. Eng., 11:3-8, 1989.
6.J. W. McCutchen, J. P. Collier, and M. B. Mayer, "Osseointegration of titanium implants in total hip arthroplasty", Clin. Orthop., 261:114-125, 1990.
7.G. L. de Lange, C. de Putter, and F. L. J. A. de Wijs, "Histological and ultra-structural appearance of the hydroxyapatite-bone interface", J. Biomed. Mater. Res., 24:829-845, 1990.
8.H. A. Hoogendoom, W. Renooij, L. M. A. Akkermans, W. Visser, and P. Wittebol, "Long-term study of large ceramic implants (porous hydroxyapatite) in dog femora", Clin. Orthop., 187:281-288, 1983.
9.C. A. van Blitterswijk, S. C. Hesseling, J. J. Grote, H. K. Koerten, and K. de Groot, "The biocompatibility of hydroxyapatite ceramic: A study of retrieved human middle ear implants", J. Biomed. Mater. Res., 24:433-453, 1990.
10.K. de Groot, C. P. A. T. Klein, J. G. C. Wolke, and J. M. A. de Blieck-Hoger-vorst, "Chemistry of calcium phosphate bioceramics", in "CRC Handbook of Bioactive Ceramics", 2:3-16,1990.
11.R. E. Holmes, R. W. Bucholz, and V. Mooney, "Porous hydroxyapatite as a bone-graft substitute in metaphyseal defects", J. Bone Joint Surg., 68A:904-911, 1986.
12.R. W. Bucholz, A. Cariton, and R. Holmes, "Interporous hydroxyapatite as a bone graft substitute in tibial plateau fractures", Clin. Orthop., 240:53-62, 1989.
13.T. Kokubo, "Bioactive glass ceramics: properties and applications", Biomaterials, 12:155-163, 1991.
14.S. Kotani, Y. Fujita, T. Kitsugi, T. Nakamura, and T. Yamamuro, "Bone bonding mechanism of p -tricalcium phosphate", J. Biomed. Mater. Res., 25:1303-1315, 1991.
15.M. Neo, S. Kotani, Y. Fujita, T. Nakamura, and T. Yamamuro, "Differences in ceramic-bone interface between surface-active ceramics and resorbable ceramics: A study by scanning and transmission electron microscopy", J. Biomed. Mater. Res., 26:255-267, 1992.
16.H. J. Agins, N. W. Alcock, M. Bansal, E. A. Salvati, P. D. Jr. Wilson, P. M. Pellicci, and P. G. Bullough, "Metallic wear in failed titanium-alloy total hip replacements. A histological and quantitative analysis", J. Bone Joint Surg., 70A:347-356, 1988.
17.J. Black, H. Sherk, J. Bonini, W. R. Rostoker, F. Schajowicz, and J.O. Galante, "Metallosis associated with a stable titanium-alloy femoral component in total hip replacement. A case report", J. Bone Joint Surg.,72A:126-130, 1990.
18.J. D. Witt, and M. Swann, "Metal wear and tissue response in failed titanium alloy total hip arthroplasty", J. Bone Joint Surg., 73B:559-563, 1991.
19.Liu X., Chu P.K., Ding Ch., "Surface modification of titanium, titanium alloys, and related materials for biomedical applications", Materials Science and Engineering R. 47:49-121, 2004.
20.Zhang F., Huang N., Yang P., Zeng X., Mao Y., Zheng Z., Zhou Z., "Blood compatibility of titanium oxide prepared by ion-beam-enhanced deposition", Surface and Coatings Technology , 84:476-479, 1996.
21.Smith C. J. E., Hughes A.N., "The corrosion fatigue behavior of a titanium-6 aluminum-4 vanadium alloy", Eng. Med., 7:158-171, 1966.
22.Maloney W.J., Jasty M., Harris W.H., Galante J.O., Callaghan J.J., "Endosteal erosion in association with stable uncemented femoral components", Bone Joint Surg Am., 72(7):1025-34, 1990.
23.Sousa S.R., Barbosa M.A., "Effect of hydroxyapatite thickness on metal ionrelease from Ti6Al4V substrates", Biomaterials, 17(4):397-404, 1996.
24.Yen S.K., Huang T.Y., "Characterization of the electrolytic ZrO2 coating on Ti-6Al-4V", Materials Chemistry and Physics, 56(3): 214-221, 1998.
25.Bauer G., "Biochemical aspects ofosseo-integration", in "CRC Handbook of Bioactive Ceramics", 1:81-97, 1990.
26.Driessens F.C.M., "Formation and stability of calcium phosphates in relation to the phase composition of the mineral in calcified tissue", in "Bioceramic of Calcium Phosphate", pp.1-32, 1983.
27.Jarcho M., Bolen C.H., Thomas M.B., Bobick J., Kay J. F., and Doremus R. H, "Hydroxyapatite synthesis and characterization in dense polycrystalline form", J. Mater. Sci., 11:2027-2035, 1976.
28.Kijima T. and Tsutsumi M., "Preparation and thermal properties of dense poly-crystalline oxyhydroxyapatite", J. Am. Cera. Soc., 62:455-460, 1979.
29.de With G., H. J. A. Vandijk, N. Hattu, and K. Prijs, "Preparation, micro-structure and mechanical properties of dense polycrystalline hydroxyapatite", J. Mater. Sci., 16:1592-1598, 1981.
30.Zhou J., Zhang X., Chen J., Zeng S., and de Groot K., "High temperature characteristics of synthetic hydroxyapatite", J. Mater. Sci.: Mater. Med., 4:83-85, 1993.
31.American Ceramic Society, "Phase Diagrams for Ceramists", 5:pp.321-322, 1983.
32.Newesely H. , "High temperature behavior of hydroxy and fluorapatite" J. Oral Rehab. 4:97, 1977.
33.Brånemark P, Breine U, Adell R, Hansson BQ, Lindstrom J and Olsson A, "Intraosseous anchorage of dental prostheses I Experimental studies", Scand J Plast Recontr Surg, 3: 81, 1969
34.Davies JE: Bone Engineering: 2000. Toronto. Volume 2.
35.Dziedzic DM. Beaty KB, Brown GN, Heylmunt T, Davies JE. Bone growth in metallic bone healing chambers In: smith DC et al, eds. Proceedings of the 5th Biomaterials Congress, Toronto Ontario : University of Toronto Press; 2:124, 1996.
36.Lazzara RJ, Testori T, Trisi P, Porter SS, Weinstein PL. "A human histological analysis of osseotite and machined surfaces using implants with two opposing surfaces", Jnt J Periodont Restor Dent. 19:117-129, 1999.
37.Partenfeder U., Engel A., Russel C., "A pyrolytic route for the formation of hydroxyapatite/fluoroapatite solid solutions", J. Mater. Sci. Mater. Med., 4:292, 1993.
38.Vercaigne S., Wolke J.G.C., Naert I., Jansen J.A., "Histomorphometrical and mechanical evaluation of titanium plasma-spray-coated implants placed in the cortical bone of goats", J. Biomed. Mater. Res., 41: 41, 1998.
39.丁信智, "電漿披覆生醫陶瓷鍍層", 焊接園地, 11(4): 62-69, 2001
40.de Groot K., Geesink C.P.A.T, Klein C.P.A.T, and Serekian P, "Plasma sprayed coatings of hydroxylapatite", J. Biomed. Mater. Res., 1987;21;1375
41.Longo F. N., " Second national conference on thermal spray ", American Society for Metals, pp.1, 1984.
42.Clare J. H., "Metal Handbook", American Society for Metals, pp.361, 1982.
43.Safai S. and Herman H., "Ultra Rapid Quenching", Treatise in MaterialScience and Technology, 1981.
44.Schmücker M., Schneider H., Poorteman,M. Cambier F., and Meinhold R., "Constitution of mullite glasses produced by ultra-rapid quenching of plasma-sprayed melts", Journal of the European Ceramic Society, 15(12):1201-1205, 1995.
45.Keller T., Margadant N., Pirling T., Riegert-Escribano M.J., and Wagner W., "Residual stress determination in thermally sprayed metallic deposits by neutron diffraction", Materials Science and Engineering A, 373:33-44, 2004.
46.Sampath S., Neiser R.A., and Herman H., "A structural investigation of a plasma sprayed Ni-Cr based alloy coating", Journal of Materials Research, 8:78-86,1993.
47.Tsui YC, Doyle C, Clyne TW. "Plasma sprayed hydroxyapatite coatings on titanium substrates Part 2: optimization of coating properties", Biomaterials, 19(22):2031-2043, 1998
48.Weng J, Cal T, Chen J, Zhang X. "Significance of water promoting amorphous to crystalline conversion of apatite in plasma sprayed coatings", J Mater Sci Lett, 14:211-3, 1995.
49."Phase Diagrams for Ceramists", American Ceramic Society, 4th Printing, p.106, 1979.
50.Geesink R.G.T., de Groot K., and Klein C.P.A.T., "Chemical implant fixation using hydroxy-apatite coatings", Clin. Orthop., 225:147-170, 1987.
51.Lemons J.E., "Hydroxyapatite Coatings", Clin. Orthop., 235:220-223, 1988.
52.Thomas K.A., Kay J.F., Cook S.D., and Jarcho M., "The effect of surface macrotexture and hydroxyapatite coating on the mechanical strength and histologic profils of titanium implant materials", J. Biomed. Mater. Res., 21:1395-1414, 1987.
53.Buser D., Schenk R.K., Steinemann S., Fiorellini J.P., Fox C.H., and Stich H., "Influence of surface characteristics on bone integration of titanium implants. A histomorphometric study in miniature pigs", J. Biomed. Mater. Res., 25:889-902, 1991.
54.Jansen J.A., van de Waerden J.P.C.M., Wolke J.G.C., and de Groot K., "Histologic evaluation of the osseous adaptation to titanium and hydroxy-apatite-coated titanium implants", J. Biomed. Mater. Res., 25:973-989, 1991.
55.Soballe K., Hansen E.S., Rasmussen H.B., Pedersen C.M., and Bunger C., "Hydroxyapatite coating enhances fixation of porous coated implants", Acta Orthop. Scand., 61(4):299-306, 1990.
56.Cook S.D., Thomas K.A., Kay J.F., and Jarcho M., "Hydroxyapatite-coated porous titanium for use as an orthopedic biologic attachment system", Clin. Orthop., 230:303-312, 1988
57.Pourbaix M., "Electrochemical corrosion of metallic biomaterials", Biomaterials, 5:122-34,1984.
58.Zheng X, Huang M, Ding C., "Bond strength of plasma sprayed hydroxyapatite/Ti composite coatings", Biomaterials, 21:841-849, 2000.
59.Radin SR, Ducheyne P., "Plasma spraying induced changes of calcium phosphate ceramic characteristics and the effect on in vitro stability", J Mater Sci: Mater Med, 3:33-42, 1992.
60. Flowler BO, Moreno EC, Brown WE., "Infra-red spectra of hydroxyapatite, octacalcium phosphate and pyrolysed calcium phosphate", Arch Oral Biol, 11:477-92, 1966;.
61.Arends J, Christoffersen J, Christoffersen MR, Eckert H, Fowler BO, Heughebaert JC, Nancollas GH, Yesinowski JP, Zawacki SJ., "A calcium hydroxyapatite precipitated from an aqueous solution", J Crystal Growth, 84:515-32, 1987.
62.Ding SJ, Huang TH, Kao CT., "Immersion behavior of plasma-sprayed modified hydroxyapatite coatings after heat treatment", Surf Coat Tech, 165:248-57, 2003.
63.Chou L, Marek B, Wagner WR., "Effects of hydroxylapatite coating crystallinity on biosolubility, cell attachment efficiency and proliferation in vitro", Biomaterials, 20:977-85, 1999.
64.Weng J, Cal T, Chen J, Zhang X., "Significance of water promoting amorphous to crystalline conversion of apatite in plasma sprayed coatings", J Mater Sci Lett, 14:211-3, 1995.
65.Chen J, Tong W, Cao Y, Feng J, Zhang X., "Effect of atmosphere on phase transformation in plasma-sprayed hydroxyapatite coatings during heat treatment", J Biomed Mater Res, 34:15-20, 1997.
66.Dong ZL, Khor KA, Quek CH, White TJ, Cheang P., "TEM and STEM analysis on heat-treated and in vitro plasma-sprayed hydroxyapatite/Ti-6Al-4V composite coatings", Biomaterials, 24:97-105, 2003.
67.Chen J, Tong W, Cao Y, Feng J, Zhang X., "Effect of atmosphere on phase transformation in plasma-sprayed hydroxyapatite coatings during heat treatment", J Biomed Mater Res, 34:15-20, 1997.
68.Erkmen ZE., "The effect of heat treatment on the morphology of D-Gun sprayed hydroxyapatite coatings", J Biomed Mater Res, 48:861-8, 1999.
69.Boenig, H.V., "Plasma science and technology", Cornell University Press., 16-35, 1982.
70.Chen J, Tong W, Cao Y, Feng J, Zhang X., "Effect of atmosphere on phase transformation in plasma-sprayed hydroxyapatite coatings during heat treatment", J Biomed Mater Res, 34:15-20, 1997.
71.Geesink RGT., "Hydroxyapatite-coated total hip prostheses", Clin Orthop, 261:39-58, 1990.
72.Chen CC, Ding SJ., "Effect of heat treatment on characteristics of plasma sprayed hydroxyapatite coatings", Mater Transact 47(3):935-40, 2006.
73.Lynn AK, DuQuesnay DL., "Hydroxyapatite-coated Ti-6Al-4V Part 2: the effects of post-deposition heat treatment at low temperatures", Biomaterials, 23:1947-53, 2002.
74.Li H, Kohr KA, Cheang P., "Properties of heat-treated calcium phosphate coatings deposited by high-velocity oxy-fuel (HVOF) spray", Biomaterials, 23:2105-12, 2002.
75.Geesink RGT., "Hydroxyapatite-coated total hip prostheses" Clin Orthop, 261:39-58, 1990.
76.Sergo V, Sbaizero O, Clarke DR., "Mechanical and chemical consequences of the residual sresses in plasma sprayed hydroxyapatite coatings", Biomaterials, 18:477-82, 1997.
77.Brossa F, Cigada A, Chiesa R, Paracchini L, Consonni C, "Post-deposition treatment effects on hydroxyapatite vacuum plasma spray coatings", J Mater Sci: Mater Med, 5:855-7, 1994.
78.Espanol M, Guipont V, Khor KA, Jeandin M, Llorca-Isern N., "Eeffect of heat treatment on high pressure plasma sprayed hydroxyapatite coatings", Surf Eng, 18:213-8, 2002.
79.Gross KA, Berndt CC, Herman H. "Amorphous phase formation in plasma-sprayed hydroxyapatite coatings", J Biomed Mater Res, 39:407-4, 1998.
80.Wen J, Leng Y, Chen J, Zhang C., "Chemical gradient in plasma-sprayed HA coatings", Biomaterials, 21:1339-43,2000.
81.Lee YP, Wang CK, Huang TH, Chen CC, Kao CT, Ding SJ., "In vitro characterization of postheat-treated plasma-sprayed hydroxyapatite coatings", Surf Coat Technol, 197:367-74, 2005.
82.Sridhar TM, Kamachi Mudali U, Subbaiyan M. "Preparation and characterisation of electrophoretically deposited hydroxyapatite coatings on type 316L stainless steel", Corros Sci, 45:237-52, 2003.
83.Celik E, Ozdemir I, Avci E, Tsunekawa Y. "Corrosion behaviour of plasma sprayed coatings", Surf Coat Technol, 193:297-302, 2005.
84.Cao Y, Weng J, Chen J, Feng J, Yang Z, Zhang X. "Water vapour-treated hydroxyapatite coatings after plasma spraying and their characteristics", Biomaterials, 17:419-24, 1996.


QRCODE
 
 
 
 
 
                                                                                                                                                                                                                                                                                                                                                                                                               
第一頁 上一頁 下一頁 最後一頁 top
系統版面圖檔 系統版面圖檔