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研究生:陳姵伶
研究生(外文):Pei-Ling, Chen
論文名稱:體外震波治療儀對軟骨組織增生之探討
論文名稱(外文):The Effect of Extracorporeal Shock Wave Therapy on the Repair of Articular Cartilage
指導教授:溫志湧楊安石楊安石引用關係
學位類別:碩士
校院名稱:大葉大學
系所名稱:機械工程研究所碩士班
學門:工程學門
學類:機械工程學類
論文種類:學術論文
論文出版年:2007
畢業學年度:95
語文別:中文
論文頁數:41
中文關鍵詞:震波治療儀軟骨組織H&E細胞染色
外文關鍵詞:extracorporeal shock wave the rapycartilagerepairH&E stain
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本研究之目的為藉由水電式體外震波治療儀(Extracorporeal Shock Waves Therapy,ESWT ),觀察在施打震波後,對受損軟骨組織的修復能力。研究中將16隻紐西蘭白兔分成A、B兩組,在每隻白兔後腿膝蓋軟骨進行軟骨下硬骨鑽洞術。在手術兩週後以秀傳醫院的體外震波治療儀OssaTron® OSA 140進行震波治療,以施打震波的右膝蓋軟骨為實驗組,不施打震波的左膝蓋軟骨為對照組,A、B兩組白兔分別在施打震波後4週後與8週後,取出膝蓋軟骨組織進行H&E細胞染色分析,以評估震波治療對受損軟骨的修復能力。研究結果顯示,震波治療對缺損關節軟骨增生有正面效益,且B組的復原狀況也較A組明顯。
藉由此研究,可使國人對體外震波治療骨關節疾患有更深入的了解,進而在臨床推廣應用。相信隨著對這治療方法的逐漸瞭解,體外震波治療法也一定會受到重視。並期望在未來實驗中為加入細胞培養鋪路。
This study investigated the stimulative effect of extracorporeal shock wave therapy (ESWT) on the articular cartilage regeneration. Eight New Zealand rabbits were used and randomly assigned to A and B groups in the experiment, 4 rabbits for each group. An osteochondral defect, 3 mm in diameter and 3 mm in depth, was drilled in the patellar groove at the distal end of each femur. The left and right patellar defects were designated as the control and experimental samples, respectively. Only the right patellar defects (the experimental group) received 500 impulses of shock waves (at 14 kV) at one week after surgery. At 4 (group A) and 8 (group B) weeks after ESWT, cartilage repair was evaluated macroscopically and histologically. The preliminary results suggested that regeneration of articular cartilage defects might be promoted by ESWT, due to the release of growth-inducing substances such as basic fibroblast growth factor, insulin-like growth factor-I and transforming growth factor -+β.
目錄
封面
簽名頁
授權書 iii
中文摘要 iv
ABSTRACT v
誌謝 vi
目錄 vii
圖目錄 ix
表目錄 x

第一章 緒論 1
1.1 研究動機及目的 1
1.2 文獻回顧 1
1.2.1 關於體外震波 1
1.2.2 關於關節軟骨退化性關節炎 4
第二章 理論介紹 7
2.1 關於ESWT分析 7
2.1.1 ESWT之原理 7
2.1.2 ESWT 之理論 8
2.2 關於退化性關節炎分析 9
2.2.1 軟骨組成之基本理論 9
2.2.2 組織分層 10
2.2.3 軟骨受損之原因 11
2.2.4 震波治療骨關節疾患之作用機制 12
第三章 研究方法與步驟 14
3.1 震波治療儀震波研究 14
3.2 動物實驗方面研究方法 16
3.2.1 研究架構 16
3.2.2 實驗設備 19
3.2.3 實驗步驟 21
第四章 結果與討論 23
4.1 震波能量分析方面 23
4.1.1 電極棒之能量值分布 23
4.2 動物實驗方面 24
4.2.1 巨觀檢查 24
4.2.2 組織檢查 26
第五章 結論 29
5.1 震波方面 29
5.2 動物實驗方面 29
文獻探討 31
附錄 36
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