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研究生:曾豊育
研究生(外文):Li-Yu Tseng
論文名稱:人體主動脈體外流場特性解析
論文名稱(外文):Characterization of In Vitro Aortic Flow
指導教授:楊安石楊安石引用關係
指導教授(外文):An-Shik Yang
學位類別:碩士
校院名稱:大葉大學
系所名稱:機械工程研究所碩士班
學門:工程學門
學類:機械工程學類
論文種類:學術論文
論文出版年:2007
畢業學年度:95
語文別:中文
中文關鍵詞:主動脈弓生物流體力學分歧管數值模擬
外文關鍵詞:aortic archbiofluid mechanicsnumerical calculations
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主動脈、主動脈弓以及主動脈的三個主要分岔處是發生主動脈剝離與動脈粥樣硬化現象的高危險區域,形成這些病變的關鍵因素係因主動脈內複雜的血液流動特性對血管壁面所產生的壓力與異常剪應力所引起的。有鑒於此,本研究初期藉由核磁共振影像(Phase-Contrast Magnetic Resonance Imaging, PC-MRI數據由台中榮民總醫院提供),獲得一般正常人的主動脈弓外型,再利用快速成型(Rapid Prototyping, RP)技術製作成人體主動脈弓模型,經由體外主動脈弓實驗量測得到穩態條件下的流量與壓力,並作為數值模擬的幾何外型與邊界條件依據。本研究理論分析基於計算流體力學軟體ACE+®的三維、穩態、不可壓縮牛頓流體模型以進行數值計算,再藉由PC-MRI方法量測體外主動脈弓的速度分佈,及利用基礎粒子顯像(Particle Imaging)的方式觀察主動脈的三個主要分岔處之流場結構,前述實驗結果可用以驗證理論模型與計算程式的正確性。探討的重點是以穩態條件下主動脈、主動脈弓與主動脈三個主要分岔處的流場分布,用以決定血液於心臟脈動週期下的平均速度,有助於了解血管壁面剪應力與壓力分布的趨勢,並檢視速度分布、二次流變化等效應對壁面壓力和剪應力的影響,進而有效預測出主動脈血管壁面上較有可能發生主動脈剝離與動脈粥樣硬化的位置。本文之數值計算結果符合體外主動脈弓實驗所量測的數據分布,更說明了導致主動脈剝離與動脈粥樣硬化的相關血流動力因數與高危險區域。
Thoracic Aorta and its three branches at the aortic arch are the inceptive zones of the aortic dissection and atherosclerosis. Due to the complicate aortic flow nature, the geneses of these highly fatal diseases are the abnormal pressures and shear stresses acting upon the vascular intima. Hence, it is important to determine the distributions of wall shear stress and pressure to predict these aortic disorders. In this study, the Phase-Contrast Magnetic Resonance Imaging (PC-MRI) method was used to obtain the true geometry of a normal human thoracic aorta which can be converted into transparent thoracic aorta model by the rapid prototyping (RP) technique. The thoracic aorta model is then used in the in-vitro experiment and numerical computations. Numerical calculations were performed using the computational fluid dynamic (CFD) software ACE+® to determine the flow characteristics of the three-dimensional, steady, incompressible and Newtonian fluid in the thoracic aorta model. The boundary conditions at the inlet and the outlet of the aortic flow were specified from the measured data in the in-vitro experiment. The predictions were in reasonable agreement with the PC-MRI measured velocity profiles in the sagittal plane of the thoracic aorta model. The computed results suggest the preferential development of the early aortic dissection and atherosclerosis being in the areas of either maxima or minima of wall shear stress and pressure.
目錄

封面內頁
簽名頁
授權書                       iii
中文摘要                      iv
英文摘要                      vi
誌謝                        vii
目錄                        viii
圖目錄                       ix

第一章 緒論               1
1.1 研就動機               1
1.2 文獻回顧               4
1.3 研究目的               8
第二章 研究方法               9
2.1 實驗量測               9
2.2 統御方程式              13
2.3 邊界條件               11
2.4 數值方法               14
第三章 結果與討論            18
3.1 理論模型               18
3.2 網格解析 19
3.3 理論模型分析與驗證          20
3.4 心臟脈動週期內平均速度條件流場探討 22
第四章 結論               31
參考文獻               32
參考文獻

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